{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T20:17:20Z","timestamp":1784233040303,"version":"3.55.0"},"reference-count":29,"publisher":"Royal Society of Chemistry (RSC)","issue":"47","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":293,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81503358"],"award-info":[{"award-number":["81503358"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703821"],"award-info":[{"award-number":["81703821"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>\n                    The phytochemical investigation of the extract from the rhizomes of\n                    <jats:italic>Polygonum amplexicaule<\/jats:italic>\n                    led to the isolation of thirty compounds, including a new flavanone. The proliferation, differentiation, and mineralizaton activity were tested.\n                  <\/jats:p>","DOI":"10.1039\/d5ra04691b","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T10:43:26Z","timestamp":1761043406000},"page":"40021-40029","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A new flavanone and other constituents from the rhizomes of\n                    <i>Polygonum amplexicaule<\/i>\n                    var. sinense and their effect on osteoblastic MC3T3-E1 cells"],"prefix":"10.1039","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2511-2155","authenticated-orcid":false,"given":"Xi-peng","family":"Li","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, China"},{"name":"School of Basic Medical Sciences, Huaihua Key Laboratory of Ion Channels and Complex Diseases, Hunan University of Medicine, Huaihua, Hunan, 418000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-zhou","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Hunan Cancer Hospital, Changsha 410013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Huaihua Key Laboratory of Ion Channels and Complex Diseases, Hunan University of Medicine, Huaihua, Hunan, 418000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-yu","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Huaihua Key Laboratory of Ion Channels and Complex Diseases, Hunan University of Medicine, Huaihua, Hunan, 418000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-xia","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Huaihua Key Laboratory of Ion Channels and Complex Diseases, Hunan University of Medicine, Huaihua, Hunan, 418000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-lei","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Huaihua Key Laboratory of Ion Channels and Complex Diseases, Hunan University of Medicine, Huaihua, Hunan, 418000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-yuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of Hunan University of Medicine, Huaihua, Hunan, 418099, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7936-1594","authenticated-orcid":false,"given":"Gen-yun","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Huaihua Key Laboratory of Ion Channels and Complex Diseases, Hunan University of Medicine, Huaihua, Hunan, 418000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5RA04691B\/cit1\/1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1600\/036364408783887456","volume":"33","author":"Sanchez","year":"2008","journal-title":"Syst. Bot."},{"key":"D5RA04691B\/cit2\/1","first-page":"1528","volume":"19","author":"Zhang","year":"2019","journal-title":"Chin. J. Hosp. Pharm."},{"key":"D5RA04691B\/cit3\/1","first-page":"1961","volume":"33","author":"Aziz","year":"2020","journal-title":"Pak. J. Pharm. Sci."},{"key":"D5RA04691B\/cit4\/1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3724\/SP.J.1009.2012.00028","volume":"10","author":"Tantry","year":"2012","journal-title":"Chin. J. Nat. Med."},{"key":"D5RA04691B\/cit5\/1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s13659-024-00482-8","volume":"14","author":"Su","year":"2024","journal-title":"Nat. Prod. Bioprospect."},{"key":"D5RA04691B\/cit6\/1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.fct.2015.02.020","volume":"80","author":"Xiang","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"D5RA04691B\/cit7\/1","doi-asserted-by":"crossref","first-page":"18521","DOI":"10.18632\/oncotarget.7848","volume":"7","author":"Xiang","year":"2016","journal-title":"Oncotarget"},{"key":"D5RA04691B\/cit8\/1","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1002\/pca.3346","volume":"35","author":"Huang","year":"2024","journal-title":"Phytochem. Anal."},{"key":"D5RA04691B\/cit9\/1","first-page":"1261","volume-title":"Acta Botanica Boreali-Occidentalia Sinica","author":"Yang","year":"2007","unstructured":"Z.Yang ,  B.Li ,  X.Tian  and  B.Liang ,  Acta Botanica Boreali-Occidentalia Sinica ,  2007 ,  pp. 1261\u20131264"},{"key":"D5RA04691B\/cit10\/1","first-page":"183","volume":"34","author":"Ren","year":"2009","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"D5RA04691B\/cit11\/1","doi-asserted-by":"crossref","first-page":"728","DOI":"10.3390\/molecules16010728","volume":"16","author":"Xiang","year":"2011","journal-title":"Molecules"},{"key":"D5RA04691B\/cit12\/1","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1016\/j.phytochem.2005.02.002","volume":"66","author":"Slade","year":"2005","journal-title":"Phytochemistry"},{"key":"D5RA04691B\/cit13\/1","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.jep.2014.06.008","volume":"155","author":"Bobach","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"D5RA04691B\/cit14\/1","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1248\/cpb.35.611","volume":"35","author":"Hasimoto","year":"1987","journal-title":"Chem. Pharm. Bull."},{"key":"D5RA04691B\/cit15\/1","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1271\/bbb.63.430","volume":"63","author":"Okushio","year":"1999","journal-title":"Biosci., Biotechnol., Biochem."},{"key":"D5RA04691B\/cit16\/1","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1055\/s-2006-961546","volume":"58","author":"Hoffmann-Bohm","year":"1992","journal-title":"Planta Med."},{"key":"D5RA04691B\/cit17\/1","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1055\/s-2005-864189","volume":"71","author":"Lee","year":"2005","journal-title":"Planta Med."},{"key":"D5RA04691B\/cit18\/1","first-page":"533","volume":"40","author":"Xu","year":"2009","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"D5RA04691B\/cit19\/1","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1007\/s12272-001-2100-7","volume":"31","author":"Kim","year":"2008","journal-title":"Arch. Pharmacal Res."},{"key":"D5RA04691B\/cit20\/1","first-page":"524","volume":"20","author":"Wei","year":"2010","journal-title":"Chin. J. Med. Chem."},{"key":"D5RA04691B\/cit21\/1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10600-009-9352-8","volume":"45","author":"Dai","year":"2009","journal-title":"Chem. Nat. Compd."},{"key":"D5RA04691B\/cit22\/1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/14786410410001704732","volume":"19","author":"Pathak","year":"2005","journal-title":"Nat. Prod. Res."},{"key":"D5RA04691B\/cit23\/1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jep.2004.09.036","volume":"96","author":"Wang","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"D5RA04691B\/cit24\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0308-8146(98)00245-3","volume":"65","author":"Lu","year":"1999","journal-title":"Food Chem."},{"key":"D5RA04691B\/cit25\/1","first-page":"15","author":"Ju","year":"2000","journal-title":"China J. Pharm."},{"key":"D5RA04691B\/cit26\/1","first-page":"1685","volume":"5","author":"Xiang","year":"2011","journal-title":"J. Med. Plants Res."},{"key":"D5RA04691B\/cit27\/1","first-page":"1610","volume":"35","author":"Xiang","year":"2012","journal-title":"J. Chin. Med. Mater."},{"key":"D5RA04691B\/cit28\/1","doi-asserted-by":"crossref","first-page":"717","DOI":"10.2174\/0929867053202241","volume":"12","author":"Botta","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"D5RA04691B\/cit29\/1","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jfca.2008.02.008","volume":"21","author":"Dhalwal","year":"2008","journal-title":"J. Food Compos. Anal."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/RA\/D5RA04691B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T22:02:35Z","timestamp":1782943355000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/15\/47\/40021-40029\/907679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":29,"journal-issue":{"issue":"47","published-print":{"date-parts":[[2025,10,20]]}},"URL":"https:\/\/doi.org\/10.1039\/d5ra04691b","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}