{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:15:14Z","timestamp":1782882914615,"version":"3.54.5"},"reference-count":54,"publisher":"Royal Society of Chemistry (RSC)","issue":"57","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":345,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100007613","name":"Majmaah University","doi-asserted-by":"publisher","award":["R-2025-2174"],"award-info":[{"award-number":["R-2025-2174"]}],"id":[{"id":"10.13039\/501100007613","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["RICSP-25-3"],"award-info":[{"award-number":["RICSP-25-3"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>pH-responsive polymeric vesicles are promising nanocarriers for the controlled release of hydrophilic chemotherapeutic agents.<\/jats:p>","DOI":"10.1039\/d5ra06313b","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T09:17:36Z","timestamp":1765531056000},"page":"49545-49556","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["pH-Responsive polymeric vesicles prepared\n                    <i>via<\/i>\n                    polymerization-induced self-assembly for controlled 5-fluorouracil delivery"],"prefix":"10.1039","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9220-0620","authenticated-orcid":false,"given":"Laila M.","family":"Alhaidari","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science, University of Majmaah, Majmaah, 11952, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reema","family":"Altariqi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, University of Majmaah, Majmaah, 11952, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thana","family":"Alkhamis","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, University of Majmaah, Majmaah, 11952, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem","family":"Alanezi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, University of Majmaah, Majmaah, 11952, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada M.","family":"Merghani","sequence":"additional","affiliation":[{"name":"Central Research Laboratory, Vice Rectorate for Studies and Scientific Research, King Saud University, Riyadh, 12371, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5RA06313B\/cit1\/1","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.progpolymsci.2005.04.002","volume":"30","author":"Rodr\u00edguez-Hern\u00e1ndez","year":"2005","journal-title":"Prog. Polym. Sci."},{"key":"D5RA06313B\/cit2\/1","doi-asserted-by":"crossref","first-page":"5969","DOI":"10.1039\/c2cs35115c","volume":"41","author":"Mai","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"D5RA06313B\/cit3\/1","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1021\/acs.macromol.0c00371","volume":"53","author":"Wang","year":"2020","journal-title":"Macromolecules"},{"key":"D5RA06313B\/cit4\/1","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1039\/D0PY00296H","volume":"11","author":"Zhou","year":"2020","journal-title":"Polym. Chem."},{"key":"D5RA06313B\/cit5\/1","doi-asserted-by":"crossref","first-page":"8605","DOI":"10.1021\/acs.macromol.6b01966","volume":"49","author":"Wang","year":"2016","journal-title":"Macromolecules"},{"key":"D5RA06313B\/cit6\/1","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1039\/C9PY00498J","volume":"10","author":"Alzahrani","year":"2019","journal-title":"Polym. Chem."},{"key":"D5RA06313B\/cit7\/1","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1039\/b903040a","author":"Delaittre","year":"2009","journal-title":"Chem. Commun."},{"key":"D5RA06313B\/cit8\/1","doi-asserted-by":"crossref","first-page":"9243","DOI":"10.1021\/ma025626j","volume":"35","author":"Ferguson","year":"2002","journal-title":"Macromolecules"},{"key":"D5RA06313B\/cit9\/1","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1002\/anie.201001461","volume":"49","author":"Li","year":"2010","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5RA06313B\/cit10\/1","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1021\/acs.macromol.5b02602","volume":"49","author":"Canning","year":"2016","journal-title":"Macromolecules"},{"key":"D5RA06313B\/cit11\/1","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1021\/acsmacrolett.9b00464","volume":"8","author":"Penfold","year":"2019","journal-title":"ACS Macro Lett."},{"key":"D5RA06313B\/cit12\/1","doi-asserted-by":"crossref","first-page":"4192","DOI":"10.1039\/D2SC00762B","volume":"13","author":"Wan","year":"2022","journal-title":"Chem. Sci."},{"key":"D5RA06313B\/cit13\/1","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.31635\/ccschem.020.202000470","volume":"3","author":"Cornel","year":"2021","journal-title":"CCS Chem."},{"key":"D5RA06313B\/cit14\/1","doi-asserted-by":"crossref","first-page":"e202308372","DOI":"10.1002\/anie.202308372","volume":"62","author":"Gy\u00f6rgy","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5RA06313B\/cit15\/1","doi-asserted-by":"crossref","first-page":"5559","DOI":"10.1021\/ma9804951","volume":"31","author":"Chiefari","year":"1998","journal-title":"Macromolecules"},{"key":"D5RA06313B\/cit16\/1","doi-asserted-by":"crossref","first-page":"7433","DOI":"10.1021\/acs.macromol.7b00767","volume":"50","author":"Perrier","year":"2017","journal-title":"Macromolecules"},{"key":"D5RA06313B\/cit17\/1","doi-asserted-by":"crossref","first-page":"5459","DOI":"10.1021\/acs.macromol.5b00342","volume":"48","author":"Hill","year":"2015","journal-title":"Macromolecules"},{"key":"D5RA06313B\/cit18\/1","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1126\/science.284.5417.1143","volume":"284","author":"Discher","year":"1999","journal-title":"Science"},{"key":"D5RA06313B\/cit19\/1","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1039\/c1py00061f","volume":"2","author":"Brinkhuis","year":"2011","journal-title":"Polym. Chem."},{"key":"D5RA06313B\/cit20\/1","doi-asserted-by":"crossref","first-page":"22028","DOI":"10.1039\/c2jm34546c","volume":"22","author":"Thambi","year":"2012","journal-title":"J. Mater. Chem."},{"key":"D5RA06313B\/cit21\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/marc.201600528","volume":"38","author":"Pei","year":"2017","journal-title":"Macromol. Rapid Commun."},{"key":"D5RA06313B\/cit22\/1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1021\/acs.biomac.6b01704","volume":"18","author":"Hu","year":"2017","journal-title":"Biomacromolecules"},{"key":"D5RA06313B\/cit23\/1","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1039\/C7SC04788F","volume":"9","author":"Mable","year":"2018","journal-title":"Chem. Sci."},{"key":"D5RA06313B\/cit24\/1","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1021\/acs.macromol.8b02081","volume":"52","author":"Chen","year":"2019","journal-title":"Macromolecules"},{"key":"D5RA06313B\/cit25\/1","doi-asserted-by":"crossref","first-page":"42711","DOI":"10.1021\/acsomega.2c04036","volume":"7","author":"Luk\u00e1\u0161 Petrova","year":"2022","journal-title":"ACS Omega"},{"key":"D5RA06313B\/cit26\/1","doi-asserted-by":"crossref","first-page":"29042","DOI":"10.1039\/D1RA05555K","volume":"11","author":"Zhang","year":"2021","journal-title":"RSC Adv."},{"key":"D5RA06313B\/cit27\/1","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1021\/acs.biomac.7b00931","volume":"18","author":"Yildirim","year":"2017","journal-title":"Biomacromolecules"},{"key":"D5RA06313B\/cit28\/1","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1039\/C4SC03334E","volume":"6","author":"Figg","year":"2015","journal-title":"Chem. Sci."},{"key":"D5RA06313B\/cit29\/1","doi-asserted-by":"crossref","first-page":"9741","DOI":"10.1021\/ja3024059","volume":"134","author":"Blanazs","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"D5RA06313B\/cit30\/1","doi-asserted-by":"crossref","first-page":"4688","DOI":"10.1021\/acsnano.0c09166","volume":"15","author":"Fan","year":"2021","journal-title":"ACS Nano"},{"key":"D5RA06313B\/cit31\/1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1021\/acsmacrolett.5b00928","volume":"5","author":"Shi","year":"2016","journal-title":"ACS Macro Lett."},{"key":"D5RA06313B\/cit32\/1","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1021\/mp100253e","volume":"7","author":"Gao","year":"2010","journal-title":"Mol. Pharm."},{"key":"D5RA06313B\/cit33\/1","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1021\/bm500919z","volume":"15","author":"Car","year":"2014","journal-title":"Biomacromolecules"},{"key":"D5RA06313B\/cit34\/1","doi-asserted-by":"crossref","first-page":"4192","DOI":"10.1021\/acs.biomac.4c00282","volume":"25","author":"J\u00e4ger","year":"2024","journal-title":"Biomacromolecules"},{"key":"D5RA06313B\/cit35\/1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1039\/b717431d","volume":"139","author":"Lomas","year":"2008","journal-title":"Faraday Discuss."},{"key":"D5RA06313B\/cit36\/1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nrc1074","volume":"3","author":"Longley","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"D5RA06313B\/cit37\/1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1021\/bc00034a019","volume":"6","author":"Putnam","year":"1995","journal-title":"Bioconjugate Chem."},{"key":"D5RA06313B\/cit38\/1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0168-3659(95)00141-7","volume":"39","author":"Nichifor","year":"1996","journal-title":"J. Controlled Release"},{"key":"D5RA06313B\/cit39\/1","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.3390\/polym15071778","volume":"15","author":"Alhaidari","year":"2023","journal-title":"Polymers"},{"key":"D5RA06313B\/cit40\/1","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jconrel.2010.11.018","volume":"150","author":"Thomas","year":"2011","journal-title":"J. Controlled Release"},{"key":"D5RA06313B\/cit41\/1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0378-5173(93)90356-K","volume":"99","author":"Fresta","year":"1993","journal-title":"Int. J. Pharm."},{"key":"D5RA06313B\/cit42\/1","doi-asserted-by":"crossref","first-page":"45405","DOI":"10.1021\/acsomega.3c04457","volume":"8","author":"Khalid","year":"2023","journal-title":"ACS Omega"},{"key":"D5RA06313B\/cit43\/1","doi-asserted-by":"crossref","first-page":"6977","DOI":"10.1021\/ma9906837","volume":"32","author":"Mayadunne","year":"1999","journal-title":"Macromolecules"},{"key":"D5RA06313B\/cit44\/1","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1039\/C3CS60290G","volume":"43","author":"Keddie","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"D5RA06313B\/cit45\/1","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1039\/D0PY00455C","volume":"11","author":"Liu","year":"2012","journal-title":"Polym. Chem."},{"key":"D5RA06313B\/cit46\/1","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.1016\/j.polymer.2010.08.056","volume":"51","author":"Huang","year":"2010","journal-title":"Polymer"},{"key":"D5RA06313B\/cit47\/1","doi-asserted-by":"crossref","first-page":"16581","DOI":"10.1021\/ja206301a","volume":"133","author":"Blanazs","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"D5RA06313B\/cit48\/1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/marc.201300730","volume":"35","author":"Karagoz","year":"2014","journal-title":"Macromol. Rapid Commun."},{"key":"D5RA06313B\/cit49\/1","doi-asserted-by":"crossref","first-page":"16098","DOI":"10.1021\/jacs.5b10415","volume":"137","author":"Mable","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"D5RA06313B\/cit50\/1","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1002\/pol.20230579","volume":"61","author":"Hochreiner","year":"2023","journal-title":"J. Polym. Sci."},{"key":"D5RA06313B\/cit51\/1","doi-asserted-by":"crossref","first-page":"24716","DOI":"10.1002\/anie.202108928","volume":"60","author":"Sobotta","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5RA06313B\/cit52\/1","doi-asserted-by":"crossref","first-page":"30221","DOI":"10.1021\/acsami.0c09054","volume":"12","author":"Cao","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D5RA06313B\/cit53\/1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0168-3659(01)00248-6","volume":"73","author":"Huang","year":"2001","journal-title":"J. Controlled Release"},{"key":"D5RA06313B\/cit54\/1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ejps.2009.11.010","volume":"39","author":"Misra","year":"2010","journal-title":"Eur. J. Pharm. Sci."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/RA\/D5RA06313B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:08:09Z","timestamp":1782878889000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/15\/57\/49545-49556\/908389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":54,"journal-issue":{"issue":"57","published-print":{"date-parts":[[2025,12,8]]}},"URL":"https:\/\/doi.org\/10.1039\/d5ra06313b","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}