{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:21:20Z","timestamp":1792790480168,"version":"4.5.0"},"reference-count":50,"publisher":"Royal Society of Chemistry (RSC)","issue":"9","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":40,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>\n                    This study investigated the green synthesis of magnesium oxide nanoparticles (MgO-NPs) using\n                    <jats:italic>Nigella sativa<\/jats:italic>\n                    (\n                    <jats:italic>N. Sativa<\/jats:italic>\n                    ) seed extract and evaluated their antioxidant and wound healing properties in diabetic rats.\n                  <\/jats:p>","DOI":"10.1039\/d5ra07329d","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T07:59:34Z","timestamp":1770710374000},"page":"8193-8205","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Green synthesis of magnesium oxide nanoparticles using\n                    <i>Nigella sativa<\/i>\n                    seed extract: characterization,\n                    <i>in vitro<\/i>\n                    antioxidant activities, and wound healing efficacy in streptozotocin-induced diabetic rats"],"prefix":"10.1039","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7796-9149","authenticated-orcid":false,"given":"Awatef","family":"Elwej","sequence":"first","affiliation":[{"name":"Laboratory of Toxicology and Environmental Health. LR17ES06, Sciences Faculty of Sfax, University of Sfax, Sfax, BP1171, 3000, Tunisia"},{"name":"Research Laboratory on Energy and Matter for Nuclear Science Development (LR16CNSTN02), National Center for Nuclear Sciences and Technologies, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abir","family":"Mhadhbi","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology and Environmental Health. LR17ES06, Sciences Faculty of Sfax, University of Sfax, Sfax, BP1171, 3000, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"Mohammed alzahrani","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Science, Al-Baha University, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassane","family":"oudadesse","sequence":"additional","affiliation":[{"name":"University of Rennes, CNRS, ISCR-UMR 6226, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamadi","family":"Fetoui","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology and Environmental Health. LR17ES06, Sciences Faculty of Sfax, University of Sfax, Sfax, BP1171, 3000, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naceur","family":"Mejri","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Nuclear Technology, National Center for Nuclear Sciences and Technologies, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Jebahi","sequence":"additional","affiliation":[{"name":"Research Laboratory on Energy and Matter for Nuclear Science Development (LR16CNSTN02), National Center for Nuclear Sciences and Technologies, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5RA07329D\/cit1\/1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3390\/molecules28020661","volume":"28","author":"Malik","year":"2023","journal-title":"Molecules"},{"key":"D5RA07329D\/cit2\/1","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.jconrel.2021.01.002","volume":"330","author":"Wang","year":"2021","journal-title":"J. Controlled Release"},{"key":"D5RA07329D\/cit3\/1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/978-981-16-1610-5_2","volume-title":"Nanotechnology Theranostics in Livestock Diseases and Management","author":"Kumar","year":"2024","unstructured":"A. Y. N.Kumar ,  A.Kurian ,  P. K.Yadav ,  R.Prasad  and  M.Ghosh , in  Nanotechnology Theranostics in Livestock Diseases and Management , ed.  M. Prasad ,  R. Kumar ,  M. Ghosh ,  S. M. Syed  and  S. Chakravarti ,  Springer Nature ,  Singapore ,  2024 ,  pp. 23\u201388"},{"key":"D5RA07329D\/cit4\/1","doi-asserted-by":"crossref","first-page":"7673","DOI":"10.1039\/D4NR05298F","volume":"17","author":"Mamidi","year":"2025","journal-title":"Nanoscale"},{"key":"D5RA07329D\/cit5\/1","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.3390\/pharmaceutics16121627","volume":"16","author":"Silina","year":"2024","journal-title":"Pharmaceutics"},{"issue":"1","key":"D5RA07329D\/cit6\/1","doi-asserted-by":"crossref","first-page":"1603276","DOI":"10.1002\/adma.201603276","volume":"29","author":"Tao","year":"2017","journal-title":"Adv. Mater."},{"key":"D5RA07329D\/cit7\/1","doi-asserted-by":"crossref","first-page":"111967","DOI":"10.1016\/j.envres.2021.111967","volume":"204","author":"Ahmed","year":"2022","journal-title":"Environ. Res."},{"key":"D5RA07329D\/cit8\/1","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1007\/s13399-023-04827-0","volume":"15","author":"El-Khawaga","year":"2025","journal-title":"Biomass Convers. Biorefin."},{"key":"D5RA07329D\/cit9\/1","doi-asserted-by":"crossref","first-page":"103019","DOI":"10.1016\/j.algal.2023.103019","volume":"71","author":"Alishah Aratboni","year":"2023","journal-title":"Algal Res."},{"key":"D5RA07329D\/cit10\/1","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1038\/s41598-024-54449-3","volume":"14","author":"Alburae","year":"2024","journal-title":"Sci. Rep."},{"key":"D5RA07329D\/cit11\/1","doi-asserted-by":"crossref","first-page":"116316","DOI":"10.1016\/j.envres.2023.116316","volume":"231","author":"Gupta","year":"2023","journal-title":"Environ. Res."},{"key":"D5RA07329D\/cit12\/1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/cbf.3816","volume":"41","author":"Hosseinzadeh","year":"2023","journal-title":"Cell Biochem. Funct."},{"key":"D5RA07329D\/cit13\/1","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.3390\/ph17121711","volume":"17","author":"Karnwal","year":"2024","journal-title":"Pharmaceuticals"},{"key":"D5RA07329D\/cit14\/1","doi-asserted-by":"crossref","first-page":"136909","DOI":"10.1016\/j.molstruc.2023.136909","volume":"1297","author":"Raimi","year":"2024","journal-title":"J. Mol. Struct."},{"key":"D5RA07329D\/cit15\/1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.12688\/f1000research.132106.1","volume":"12","author":"Palanisamy","year":"2023","journal-title":"F1000Research"},{"key":"D5RA07329D\/cit16\/1","doi-asserted-by":"crossref","first-page":"101212","DOI":"10.1016\/j.nanoso.2024.101212","volume":"38","author":"Waseem","year":"2024","journal-title":"Nano-Struct. Nano-Objects"},{"key":"D5RA07329D\/cit17\/1","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1021\/jf9913458","volume":"48","author":"Pulido","year":"2000","journal-title":"J. Agric. Food Chem."},{"key":"D5RA07329D\/cit18\/1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/(SICI)1097-0010(199802)76:2<270::AID-JSFA945>3.0.CO;2-9","volume":"76","author":"S\u00e1nchez-Moreno","year":"1998","journal-title":"J. Sci. Food Agric."},{"key":"D5RA07329D\/cit19\/1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/s41596-023-00899-4","volume":"19","author":"Yampolsky","year":"2024","journal-title":"Nat. Protoc."},{"key":"D5RA07329D\/cit20\/1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/bdrc.21024","volume":"96","author":"Yates","year":"2012","journal-title":"Birth Defects Research Part C: Embryo Today: Reviews"},{"key":"D5RA07329D\/cit21\/1","first-page":"421","volume-title":"Methods in Enzymology","volume":"186","author":"Draper","year":"1990","unstructured":"H. H.Draper  and  M.Hadley , in  Methods in Enzymology ,  Academic Press ,  1990 , vol.  186 ,  pp. 421\u2013431"},{"key":"D5RA07329D\/cit22\/1","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1007\/s12011-020-02352-z","volume":"199","author":"Turkyilmaz","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"D5RA07329D\/cit23\/1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"D5RA07329D\/cit24\/1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000136485","volume":"11","author":"Jollow","year":"2008","journal-title":"Pharmacology"},{"key":"D5RA07329D\/cit25\/1","first-page":"121","volume-title":"Methods in Enzymology","volume":"105","author":"Aebi","year":"1984","unstructured":"H.Aebi , in  Methods in Enzymology ,  Academic Press ,  1984 , vol.  105 ,  pp. 121\u2013126"},{"key":"D5RA07329D\/cit26\/1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0003-2697(71)90370-8","volume":"44","author":"Beauchamp","year":"1971","journal-title":"Anal. Biochem."},{"key":"D5RA07329D\/cit27\/1","first-page":"114","volume-title":"Methods in Enzymology","volume":"105","author":"Floh\u00e9","year":"1984","unstructured":"L.Floh\u00e9  and  W. A.G\u00fcnzler , in  Methods in Enzymology ,  Academic Press ,  1984 , vol.  105 ,  pp. 114\u2013120"},{"key":"D5RA07329D\/cit28\/1","doi-asserted-by":"crossref","first-page":"117932","DOI":"10.1007\/s11356-023-30411-0","volume":"30","author":"Koley","year":"2023","journal-title":"Environ. Sci. Pollut. Res."},{"key":"D5RA07329D\/cit29\/1","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1007\/s12298-023-01391-9","volume":"29","author":"Gautam","year":"2023","journal-title":"Physiol. Mol. Biol. Plants"},{"key":"D5RA07329D\/cit30\/1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13045-023-01512-7","volume":"16","author":"Liu","year":"2023","journal-title":"J. Hematol. Oncol."},{"key":"D5RA07329D\/cit31\/1","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1021\/acs.biomac.6b00398","volume":"17","author":"Wu","year":"2016","journal-title":"Biomacromolecules"},{"key":"D5RA07329D\/cit32\/1","doi-asserted-by":"crossref","first-page":"130835","DOI":"10.1016\/j.ijbiomac.2024.130835","volume":"265","author":"Fahaduddin","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"D5RA07329D\/cit33\/1","doi-asserted-by":"crossref","first-page":"697","DOI":"10.4239\/wjd.v5.i5.697","volume":"5","author":"Agrawal","year":"2014","journal-title":"World J. Diabetes"},{"key":"D5RA07329D\/cit34\/1","doi-asserted-by":"crossref","first-page":"e27749","DOI":"10.1016\/j.heliyon.2024.e27749","volume":"10","author":"Saberi","year":"2024","journal-title":"Heliyon"},{"key":"D5RA07329D\/cit35\/1","doi-asserted-by":"crossref","first-page":"117084","DOI":"10.1016\/j.biopha.2024.117084","volume":"178","author":"Chen","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"D5RA07329D\/cit36\/1","doi-asserted-by":"crossref","first-page":"131843","DOI":"10.1016\/j.ijbiomac.2024.131843","volume":"268","author":"Li","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"D5RA07329D\/cit37\/1","doi-asserted-by":"crossref","first-page":"114004","DOI":"10.1016\/j.biopha.2022.114004","volume":"157","author":"Wang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"D5RA07329D\/cit38\/1","doi-asserted-by":"crossref","first-page":"8308050","DOI":"10.1155\/2021\/8308050","volume":"2021","author":"Tiji","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"D5RA07329D\/cit39\/1","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.3390\/molecules30091913","volume":"30","author":"Nizi\u0144ski","year":"2025","journal-title":"Molecules"},{"key":"D5RA07329D\/cit40\/1","doi-asserted-by":"crossref","first-page":"492","DOI":"10.3390\/md17090492","volume":"17","author":"Cheng-S\u00e1nchez","year":"2019","journal-title":"Mar. Drugs"},{"key":"D5RA07329D\/cit41\/1","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1080\/1061186X.2024.2445744","volume":"33","author":"Khazaei","year":"2025","journal-title":"J. Drug Targeting"},{"key":"D5RA07329D\/cit42\/1","doi-asserted-by":"crossref","first-page":"9039","DOI":"10.3390\/cimb45110567","volume":"45","author":"Kmail","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"key":"D5RA07329D\/cit43\/1","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.30574\/wjarr.2025.26.3.1709","volume":"26","author":"Priya L","year":"2025","journal-title":"World J. Adv. Res. Rev."},{"key":"D5RA07329D\/cit44\/1","doi-asserted-by":"crossref","first-page":"103688","DOI":"10.1016\/j.bcab.2025.103688","volume":"67","author":"Y\u0131ld\u0131r\u0131m","year":"2025","journal-title":"Biocatal. Agric. Biotechnol."},{"key":"D5RA07329D\/cit45\/1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.actbio.2021.10.008","volume":"137","author":"Huang","year":"2022","journal-title":"Acta Biomater."},{"key":"D5RA07329D\/cit46\/1","doi-asserted-by":"crossref","first-page":"6783","DOI":"10.1038\/s41467-024-50769-0","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat. Commun."},{"key":"D5RA07329D\/cit47\/1","doi-asserted-by":"crossref","first-page":"6423","DOI":"10.2147\/IJN.S514000","volume":"20","author":"Chen","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"D5RA07329D\/cit48\/1","doi-asserted-by":"crossref","first-page":"24477","DOI":"10.1021\/acsomega.0c02946","volume":"5","author":"Liu","year":"2020","journal-title":"ACS Omega"},{"key":"D5RA07329D\/cit49\/1","doi-asserted-by":"crossref","first-page":"101631","DOI":"10.1016\/j.mtbio.2025.101631","volume":"31","author":"Liu","year":"2025","journal-title":"Mater. Today Bio"},{"key":"D5RA07329D\/cit50\/1","doi-asserted-by":"crossref","first-page":"e202400739","DOI":"10.1002\/slct.202400739","volume":"9","author":"Koolabadi","year":"2024","journal-title":"ChemistrySelect"}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/RA\/D5RA07329D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:24:41Z","timestamp":1782926681000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/16\/9\/8193-8205\/908776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":50,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,2,5]]}},"URL":"https:\/\/doi.org\/10.1039\/d5ra07329d","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}