{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:50:08Z","timestamp":1787064608964,"version":"build-2736575974"},"reference-count":144,"publisher":"Royal Society of Chemistry (RSC)","issue":"4","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100007787","name":"National Research Centre","doi-asserted-by":"publisher","award":["13010102"],"award-info":[{"award-number":["13010102"]}],"id":[{"id":"10.13039\/100007787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>New phosphazine and triazole derivatives were synthesized and evaluated as potential anti-Alzheimer's agents. The compounds modulate ROS\/JNK and Wnt\/\u03b2-catenin pathways, showing promising neuroprotective activities.<\/jats:p>","DOI":"10.1039\/d5ra07584j","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T08:57:57Z","timestamp":1768381077000},"page":"3077-3100","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Design and synthesis of new phosphazine and triazole derivatives for treatment of Alzheimer's disease: modulating ROS\/JNK and Wnt\/\u03b2-catenin signaling pathways"],"prefix":"10.1039","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9489-2342","authenticated-orcid":false,"given":"Rania S.","family":"Salah","sequence":"first","affiliation":[{"name":"Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Bohouth St., Dokki, 12622, Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naglaa F.","family":"El-Sayed","sequence":"additional","affiliation":[{"name":"Organometallic and Organometalloid Chemistry Department, National Research Centre, 33ElBohouth St. (Former El Tahrir) Dokki, 12622, Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa","family":"El-Hussieny","sequence":"additional","affiliation":[{"name":"Organometallic and Organometalloid Chemistry Department, National Research Centre, 33ElBohouth St. (Former El Tahrir) Dokki, 12622, Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaimaa T.","family":"Mansour","sequence":"additional","affiliation":[{"name":"Organometallic and Organometalloid Chemistry Department, National Research Centre, 33ElBohouth St. (Former El Tahrir) Dokki, 12622, Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8379-5704","authenticated-orcid":false,"given":"Mohamed","family":"Othman","sequence":"additional","affiliation":[{"name":"Normandie Univ., UNILEHAVRE, FR 3038 CNRS, URCOM, 76600, Le Havre, France"},{"name":"UR 3221, INC3M CNRS-FR 3038 UFR ST, BP: 1123, 25 Rue Philipe Lebon, 76063, Le Havre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3227-8683","authenticated-orcid":false,"given":"Marwa A.","family":"Fouad","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., Cairo, 11562, Egypt"},{"name":"Pharmaceutical Chemistry Department, School of Pharmacy, Newgiza University, Newgiza, Km 22 Cairo-Alexandria Desert Road, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7474-1678","authenticated-orcid":false,"given":"Huda R. M.","family":"Rashdan","sequence":"additional","affiliation":[{"name":"Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 ElBohouth St. (Former El Tahrir) Dokki, 12622, Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4832-5766","authenticated-orcid":false,"given":"Ewies F.","family":"Ewies","sequence":"additional","affiliation":[{"name":"Organometallic and Organometalloid Chemistry Department, National Research Centre, 33ElBohouth St. (Former El Tahrir) Dokki, 12622, Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba S. A.","family":"Gharib","sequence":"additional","affiliation":[{"name":"Behaviour and Management of Animal, Poultry and Aquatics Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Zagazig, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5505-217X","authenticated-orcid":false,"given":"Ghada H.","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Bohouth St., Dokki, 12622, Giza, Egypt"},{"name":"Stem Cells Lab, Centre of Excellence for Advanced Sciences, National Research Centre, 33 El-Bohouth St., Dokki, 12622, Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"4","key":"D5RA07584J\/cit1\/1","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/alz.12638","volume":"18","author":"Alzheimer\u2019s disease facts and figures","year":"2022","journal-title":"Alzheimer\u2019s Dementia"},{"key":"D5RA07584J\/cit2\/1","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/461895a","volume":"461","author":"Mucke","year":"2009","journal-title":"Nature"},{"key":"D5RA07584J\/cit3\/1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3233\/JAD-2010-1221","volume":"19","author":"Murphy","year":"2010","journal-title":"J. Alzheim. Dis."},{"key":"D5RA07584J\/cit4\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.54646\/bijnn.2025.22","volume":"3","author":"Ehsanifar","year":"2025","journal-title":"BOHR Int. J. Neurology Neurosci."},{"key":"D5RA07584J\/cit5\/1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0361-9230(01)00459-2","volume":"55","author":"Flaten","year":"2001","journal-title":"Brain Res. Bull."},{"key":"D5RA07584J\/cit6\/1","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1080\/00207450390232292","volume":"113","author":"Miu","year":"2003","journal-title":"Int. J. Neurosci."},{"key":"D5RA07584J\/cit7\/1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1191\/0748233706th242oa","volume":"22","author":"Kaur","year":"2006","journal-title":"Toxicol. Ind. Health"},{"key":"D5RA07584J\/cit8\/1","doi-asserted-by":"crossref","first-page":"S209","DOI":"10.3233\/JAD-161103","volume":"60","author":"Prema","year":"2017","journal-title":"J. Alzheim. Dis."},{"key":"D5RA07584J\/cit9\/1","doi-asserted-by":"crossref","first-page":"127352","DOI":"10.1016\/j.jtemb.2023.127352","volume":"82","author":"AbdEl-Raouf","year":"2024","journal-title":"J. Trace Elem. Med. Biol."},{"key":"D5RA07584J\/cit10\/1","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.redox.2017.10.014","volume":"14","author":"Cheignon","year":"2018","journal-title":"Redox Biol."},{"key":"D5RA07584J\/cit11\/1","doi-asserted-by":"crossref","first-page":"4350965","DOI":"10.1155\/2016\/4350965","volume":"2016","author":"Zhang","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"D5RA07584J\/cit12\/1","first-page":"153","volume":"22","author":"Pearson","year":"2001","journal-title":"Endocr. Rev."},{"key":"D5RA07584J\/cit13\/1","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.4103\/1673-5374.237110","volume":"13","author":"Gu","year":"2018","journal-title":"Neural Regen. Res."},{"key":"D5RA07584J\/cit14\/1","doi-asserted-by":"crossref","first-page":"e24361","DOI":"10.1371\/journal.pone.0024361","volume":"6","author":"Tare","year":"2011","journal-title":"PLoS One"},{"key":"D5RA07584J\/cit15\/1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1159\/000067426","volume":"11","author":"Zhu","year":"2002","journal-title":"Neurosignals"},{"key":"D5RA07584J\/cit16\/1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1104\/pp.106.079160","volume":"141","author":"Pitzschke","year":"2006","journal-title":"Plant Physiol."},{"key":"D5RA07584J\/cit17\/1","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.2337\/db13-1513","volume":"63","author":"Ren","year":"2014","journal-title":"Diabetes"},{"key":"D5RA07584J\/cit18\/1","doi-asserted-by":"crossref","first-page":"25310","DOI":"10.18632\/oncotarget.15813","volume":"8","author":"Yang","year":"2017","journal-title":"Oncotarget"},{"key":"D5RA07584J\/cit19\/1","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1111\/jnc.13128","volume":"134","author":"Akhter","year":"2015","journal-title":"J. Neurochem."},{"key":"D5RA07584J\/cit20\/1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10989-022-10457-3","volume":"28","author":"Naseri","year":"2022","journal-title":"Int. J. Pept. Res. Ther."},{"key":"D5RA07584J\/cit21\/1","doi-asserted-by":"crossref","first-page":"114550","DOI":"10.1016\/j.intimp.2025.114550","volume":"155","author":"Sun","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"D5RA07584J\/cit22\/1","first-page":"156","volume":"7","author":"Atef","year":"2023","journal-title":"Rec. Pharm. Biomed. Sci."},{"key":"D5RA07584J\/cit23\/1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13041-019-0525-5","volume":"12","author":"Jia","year":"2019","journal-title":"Mol. Brain"},{"key":"D5RA07584J\/cit24\/1","first-page":"46","volume":"7","author":"Llorens-Mar\u00edtin","year":"2014","journal-title":"Front. Mol. Neurosci."},{"key":"D5RA07584J\/cit25\/1","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1007\/s12035-018-1103-z","volume":"56","author":"Folke","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"D5RA07584J\/cit26\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13024-018-0295-z","volume":"13","author":"Zhu","year":"2018","journal-title":"Mol. Neurodegener."},{"key":"D5RA07584J\/cit27\/1","doi-asserted-by":"crossref","first-page":"6197","DOI":"10.1523\/JNEUROSCI.2124-22.2023","volume":"43","author":"Yao","year":"2023","journal-title":"J. Neurosci."},{"key":"D5RA07584J\/cit28\/1","doi-asserted-by":"crossref","first-page":"14980","DOI":"10.1038\/s41598-020-72168-3","volume":"10","author":"Zuliani","year":"2020","journal-title":"Sci. Rep."},{"key":"D5RA07584J\/cit29\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40035-017-0093-5","volume":"6","author":"Das","year":"2017","journal-title":"Transl. Neurodegener."},{"key":"D5RA07584J\/cit30\/1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00401-013-1152-3","volume":"126","author":"Kandalepas","year":"2013","journal-title":"Acta Neuropathol."},{"key":"D5RA07584J\/cit31\/1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40035-016-0061-5","volume":"5","author":"Yan","year":"2016","journal-title":"Transl. Neurodegener."},{"key":"D5RA07584J\/cit32\/1","doi-asserted-by":"crossref","first-page":"7101","DOI":"10.1039\/C5RA25446A","volume":"6","author":"Demkowicz","year":"2016","journal-title":"RSC Adv."},{"key":"D5RA07584J\/cit33\/1","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1093\/brain\/awy132","volume":"141","author":"Hampel","year":"2018","journal-title":"Brain"},{"key":"D5RA07584J\/cit34\/1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s12272-013-0036-3","volume":"36","author":"Anand","year":"2013","journal-title":"Arch Pharm. Res."},{"key":"D5RA07584J\/cit35\/1","first-page":"1","author":"Arora","year":"2025","journal-title":"Mol. Diversity"},{"key":"D5RA07584J\/cit36\/1","doi-asserted-by":"crossref","first-page":"103499","DOI":"10.1016\/j.bioorg.2019.103499","volume":"95","author":"El-Sayed","year":"2020","journal-title":"Bioorg. Chem."},{"key":"D5RA07584J\/cit37\/1","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1080\/14756366.2018.1499627","volume":"33","author":"Markowicz-Piasecka","year":"2018","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D5RA07584J\/cit38\/1","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.ejmech.2019.07.059","volume":"180","author":"Xu","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"D5RA07584J\/cit39\/1","doi-asserted-by":"crossref","first-page":"2166040","DOI":"10.1080\/14756366.2023.2166040","volume":"38","author":"El-Hussieny","year":"2023","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D5RA07584J\/cit40\/1","doi-asserted-by":"crossref","first-page":"e202301834","DOI":"10.1002\/slct.202301834","volume":"8","author":"Reddy Dodlapati","year":"2023","journal-title":"ChemistrySelect"},{"key":"D5RA07584J\/cit41\/1","first-page":"29","volume":"49","author":"Jalani","year":"2017","journal-title":"Synthesis"},{"key":"D5RA07584J\/cit42\/1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1039\/dt9750000016","author":"Goldwhite","year":"1975","journal-title":"J. Chem. Soc., Dalton Trans."},{"key":"D5RA07584J\/cit43\/1","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1021\/jo00878a013","volume":"41","author":"Albright","year":"1976","journal-title":"J. Org. Chem."},{"key":"D5RA07584J\/cit44\/1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0040-4020(01)92417-2","volume":"37","author":"Gololobov","year":"1981","journal-title":"Tetrahedron"},{"key":"D5RA07584J\/cit45\/1","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1515\/znb-2015-0187","volume":"71","author":"El-Sayed","year":"2016","journal-title":"Z. Naturforsch., B"},{"key":"D5RA07584J\/cit46\/1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.21608\/jmals.2021.210630","volume":"3","author":"Abdel-Aal","year":"2021","journal-title":"J. Med. Life Sci."},{"key":"D5RA07584J\/cit47\/1","doi-asserted-by":"crossref","first-page":"4926151","DOI":"10.1155\/2023\/4926151","volume":"2023","author":"Beigom Hejaziyan","year":"2023","journal-title":"Evid. base Compl. Alternative Med."},{"key":"D5RA07584J\/cit48\/1","doi-asserted-by":"crossref","first-page":"149573","DOI":"10.1016\/j.brainres.2025.149573","volume":"1855","author":"Abdel-Aal","year":"2025","journal-title":"Brain Res."},{"key":"D5RA07584J\/cit49\/1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4236\/jbbs.2018.84012","volume":"8","author":"Zghari","year":"2018","journal-title":"J. Behav. Brain Sci."},{"key":"D5RA07584J\/cit50\/1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1080\/01616412.2018.1441776","volume":"40","author":"Abulfadl","year":"2018","journal-title":"Neurol. Res."},{"key":"D5RA07584J\/cit51\/1","doi-asserted-by":"crossref","first-page":"598617","DOI":"10.3389\/fnins.2020.598617","volume":"14","author":"Amanzadeh Jajin","year":"2021","journal-title":"Front. Neurosci."},{"key":"D5RA07584J\/cit52\/1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.pathophys.2017.06.001","volume":"24","author":"Falode","year":"2017","journal-title":"Pathophysiology"},{"key":"D5RA07584J\/cit53\/1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.9734\/jammr\/2021\/v33i330822","volume":"33","author":"Abdel-Atty","year":"2021","journal-title":"Med. Med. Res."},{"key":"D5RA07584J\/cit54\/1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.bbrc.2023.06.063","volume":"674","author":"Shourkabi","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"12","key":"D5RA07584J\/cit55\/1","doi-asserted-by":"crossref","first-page":"e22545","DOI":"10.1016\/j.heliyon.2023.e22545","volume":"9","author":"Hawiset","year":"2023","journal-title":"Heliyon"},{"key":"D5RA07584J\/cit56\/1","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.1021\/acschemneuro.9b00286","volume":"10","author":"Gothwal","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"D5RA07584J\/cit57\/1","first-page":"1609","volume":"13","author":"Khalil","year":"2023","journal-title":"J. Adv. Vet. Res."},{"key":"D5RA07584J\/cit58\/1","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1093\/jpp\/rgad048","volume":"75","author":"Abuelezz","year":"2023","journal-title":"J. Pharm. Pharmacol."},{"key":"D5RA07584J\/cit59\/1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-1-4939-8994-2_10","volume-title":"Pre-clinical Models: Techniques and Protocols","author":"Kraeuter","year":"2019","unstructured":"A.-K.Kraeuter ,  P. C.Guest  and  Z.Sarnyai ,  Pre-clinical Models: Techniques and Protocols ,  2019 ,  pp. 105\u2013111"},{"key":"D5RA07584J\/cit60\/1","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1007\/s12035-016-9762-0","volume":"54","author":"Alawdi","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"D5RA07584J\/cit61\/1","first-page":"723","volume":"46","author":"Ismail","year":"2023","journal-title":"Egypt. J. Histol."},{"key":"D5RA07584J\/cit62\/1","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1007\/s10787-023-01287-w","volume":"31","author":"Awad","year":"2023","journal-title":"Inflammopharmacology"},{"key":"D5RA07584J\/cit63\/1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.12980\/jad.6.201704012","volume":"6","author":"Bais","year":"2017","journal-title":"J. Acute Dis."},{"key":"D5RA07584J\/cit64\/1","doi-asserted-by":"crossref","first-page":"31646","DOI":"10.1039\/C8RA05356A","volume":"8","author":"Xing","year":"2018","journal-title":"RSC Adv."},{"key":"D5RA07584J\/cit65\/1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.9758\/cpn.2018.16.2.153","volume":"16","author":"Chogtu","year":"2018","journal-title":"Clin. Psychopharmacol. Neurosci."},{"key":"D5RA07584J\/cit66\/1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.brainresbull.2020.08.001","volume":"164","author":"Akhtar","year":"2020","journal-title":"Brain Res. Bull."},{"key":"D5RA07584J\/cit67\/1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2174\/1570159X11311030006","volume":"11","author":"Colovic","year":"2013","journal-title":"Curr. Neuropharmacol."},{"key":"D5RA07584J\/cit68\/1","doi-asserted-by":"crossref","first-page":"110623","DOI":"10.1016\/j.cbi.2023.110623","volume":"382","author":"Li","year":"2023","journal-title":"Chem.-Biol. Interact."},{"key":"D5RA07584J\/cit69\/1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.2174\/0118715249278489231128042135","volume":"24","author":"Egbujor","year":"2024","journal-title":"Cent. Nerv. Syst. Agents Med. Chem."},{"key":"D5RA07584J\/cit70\/1","first-page":"117990","volume":"116","author":"Elbatrawy","year":"2025","journal-title":"ACS Omega"},{"key":"D5RA07584J\/cit71\/1","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.3390\/molecules25143190","volume":"25","author":"Zribi","year":"2020","journal-title":"Molecules"},{"key":"D5RA07584J\/cit72\/1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1080\/07391102.2023.2280765","volume":"43","author":"Jana","year":"2025","journal-title":"J. Biomol. Struct. Dyn."},{"key":"D5RA07584J\/cit73\/1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00775-021-01866-8","volume":"26","author":"Kaur","year":"2021","journal-title":"J. Biol. Inorg. Chem."},{"key":"D5RA07584J\/cit74\/1","doi-asserted-by":"crossref","first-page":"107729","DOI":"10.1016\/j.intimp.2021.107729","volume":"96","author":"Ali","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"D5RA07584J\/cit75\/1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1080\/13880209.2021.1883678","volume":"59","author":"Lu","year":"2021","journal-title":"Pharm. Biol."},{"key":"D5RA07584J\/cit76\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/07391102.2024.2435641","author":"Nabi","year":"2024","journal-title":"J. Biomol. Struct. Dyn."},{"key":"D5RA07584J\/cit77\/1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2147\/IJN.S39232","author":"Ismail","year":"2013","journal-title":"Int. J. Nanomed."},{"key":"D5RA07584J\/cit78\/1","doi-asserted-by":"crossref","first-page":"134487","DOI":"10.1016\/j.molstruc.2022.134487","volume":"1274","author":"Gupta","year":"2023","journal-title":"J. Mol. Struct."},{"key":"D5RA07584J\/cit79\/1","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.bioorg.2019.03.058","volume":"87","author":"Kaur","year":"2019","journal-title":"Bioorg. Chem."},{"key":"D5RA07584J\/cit80\/1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.bioorg.2018.11.038","volume":"84","author":"Yazdani","year":"2019","journal-title":"Bioorg. Chem."},{"key":"D5RA07584J\/cit81\/1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.bioorg.2018.10.065","volume":"83","author":"Rastegari","year":"2019","journal-title":"Bioorg. Chem."},{"key":"D5RA07584J\/cit82\/1","doi-asserted-by":"crossref","first-page":"104795","DOI":"10.1016\/j.nbd.2020.104795","volume":"138","author":"Butterfield","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"D5RA07584J\/cit83\/1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3389\/fnagi.2018.00244","volume":"10","author":"Singh","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"D5RA07584J\/cit84\/1","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1096\/fj.02-0012fje","volume":"16","author":"Pratic\u00f2","year":"2002","journal-title":"Faseb. J."},{"key":"D5RA07584J\/cit85\/1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.neuroscience.2016.02.055","volume":"324","author":"Sharma","year":"2016","journal-title":"Neuroscience"},{"key":"D5RA07584J\/cit86\/1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.freeradbiomed.2003.11.017","volume":"36","author":"Exley","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"D5RA07584J\/cit87\/1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jinorgbio.2012.09.008","volume":"117","author":"Ruip\u00e9rez","year":"2012","journal-title":"J. Inorg. Biochem."},{"key":"D5RA07584J\/cit88\/1","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1042\/BCJ20200754","volume":"478","author":"Gupta","year":"2021","journal-title":"Biochem. J."},{"key":"D5RA07584J\/cit89\/1","doi-asserted-by":"crossref","first-page":"127999","DOI":"10.1016\/j.bmcl.2021.127999","volume":"42","author":"Dalvi","year":"2021","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D5RA07584J\/cit90\/1","doi-asserted-by":"crossref","first-page":"e2400406","DOI":"10.1002\/ardp.202400406","volume":"357","author":"Ko\u00e7ak Aslan","year":"2024","journal-title":"Arch. Pharmazie"},{"key":"D5RA07584J\/cit91\/1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/01616412.2024.2430998","volume":"47","author":"Soukhaklari","year":"2025","journal-title":"Neurol. Res."},{"key":"D5RA07584J\/cit92\/1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/alz.12370","volume":"18","author":"Zhao","year":"2022","journal-title":"Alzheimer's Dementia"},{"key":"D5RA07584J\/cit93\/1","doi-asserted-by":"crossref","first-page":"136942","DOI":"10.1016\/j.scitotenv.2020.136942","volume":"715","author":"Zhang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"D5RA07584J\/cit94\/1","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1039\/C6FO01817C","volume":"8","author":"Cheng","year":"2017","journal-title":"Food Funct."},{"key":"D5RA07584J\/cit95\/1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1021\/cn100109k","volume":"2","author":"Chambers","year":"2011","journal-title":"ACS Chem. Neurosci."},{"key":"D5RA07584J\/cit96\/1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2174\/092986712803414213","volume":"19","author":"Zhou","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"D5RA07584J\/cit97\/1","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.neurobiolaging.2014.10.007","volume":"36","author":"Feng","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"D5RA07584J\/cit98\/1","doi-asserted-by":"crossref","first-page":"BSR20180849","DOI":"10.1042\/BSR20180849","volume":"38","author":"Wu","year":"2018","journal-title":"Biosci. Rep."},{"key":"D5RA07584J\/cit99\/1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.17116\/patol20218303156","volume":"83","author":"Salkov","year":"2021","journal-title":"Arkh. Patol."},{"key":"D5RA07584J\/cit100\/1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.taap.2011.11.015","volume":"258","author":"Liu","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"D5RA07584J\/cit101\/1","doi-asserted-by":"crossref","first-page":"10812","DOI":"10.1074\/jbc.M113.519355","volume":"289","author":"Akhter","year":"2014","journal-title":"J. Biol. Chem."},{"key":"D5RA07584J\/cit102\/1","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.freeradbiomed.2005.10.056","volume":"40","author":"Shen","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"D5RA07584J\/cit103\/1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2174\/1389200215666140908101958","volume":"15","author":"Pokuri","year":"2014","journal-title":"Curr. Drug Metabol."},{"key":"D5RA07584J\/cit104\/1","doi-asserted-by":"crossref","first-page":"112114","DOI":"10.1016\/j.ejmech.2020.112114","volume":"190","author":"Liao","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"D5RA07584J\/cit105\/1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41392-018-0018-5","volume":"3","author":"Chen","year":"2018","journal-title":"Signal Transduct. Targeted Ther."},{"key":"D5RA07584J\/cit106\/1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3389\/fnins.2018.00255","volume":"12","author":"Fujikake","year":"2018","journal-title":"Front. Neurosci."},{"key":"D5RA07584J\/cit107\/1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1080\/01616412.2022.2132727","volume":"45","author":"Makhdoomi","year":"2023","journal-title":"Neurol. Res."},{"key":"D5RA07584J\/cit108\/1","doi-asserted-by":"crossref","first-page":"763866","DOI":"10.3389\/fphar.2021.763866","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol"},{"key":"D5RA07584J\/cit109\/1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.7555\/JBR.36.20220145","volume":"37","author":"Yuan","year":"2022","journal-title":"J. Biomed. Res."},{"key":"D5RA07584J\/cit110\/1","doi-asserted-by":"crossref","first-page":"e12801","DOI":"10.1111\/acel.12801","volume":"17","author":"Cheng","year":"2018","journal-title":"Aging Cell"},{"key":"D5RA07584J\/cit111\/1","first-page":"2947","author":"Hsieh","year":"2016","journal-title":"Drug Des. Dev. Ther."},{"key":"D5RA07584J\/cit112\/1","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.18632\/aging.102830","volume":"12","author":"Vall\u00e9e","year":"2020","journal-title":"Aging"},{"key":"D5RA07584J\/cit113\/1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s12017-018-8486-x","volume":"20","author":"Vall\u00e9e","year":"2018","journal-title":"NeuroMolecular Med."},{"key":"D5RA07584J\/cit114\/1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3389\/fncel.2013.00097","volume":"7","author":"Silva-Alvarez","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"D5RA07584J\/cit115\/1","doi-asserted-by":"crossref","first-page":"S547","DOI":"10.3233\/JAD-179934","volume":"64","author":"Bhat","year":"2018","journal-title":"J. Alzheim. Dis."},{"key":"D5RA07584J\/cit116\/1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.21608\/aijpms.2022.107355.1097","volume":"2","author":"Omran","year":"2022","journal-title":"Azhar Int. J. Pharm. Med. Sci."},{"key":"D5RA07584J\/cit117\/1","doi-asserted-by":"crossref","first-page":"1208252","DOI":"10.3389\/fphar.2023.1208252","volume":"14","author":"Abu-Elfotuh","year":"2023","journal-title":"Front. Pharmacol."},{"key":"D5RA07584J\/cit118\/1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1021\/acschemneuro.5b00262","volume":"7","author":"Dunning","year":"2016","journal-title":"ACS Chem. Neurosci."},{"key":"D5RA07584J\/cit119\/1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s41983-023-00751-2","volume":"59","author":"Limantoro","year":"2023","journal-title":"Egypt. J. Neurol. Psychiat. Neurosurg."},{"key":"D5RA07584J\/cit120\/1","doi-asserted-by":"crossref","first-page":"118664","DOI":"10.1016\/j.bbamcr.2020.118664","volume":"1867","author":"Lauretti","year":"2020","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"key":"D5RA07584J\/cit121\/1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.biopsych.2020.02.001","volume":"89","author":"Hampel","year":"2021","journal-title":"Biol. Psychiatry"},{"key":"D5RA07584J\/cit122\/1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s13311-021-01172-w","volume":"19","author":"Heilman","year":"2022","journal-title":"Neurotherapeutics"},{"key":"D5RA07584J\/cit123\/1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.14336\/AD.2017.0903","volume":"9","author":"Morroni","year":"2018","journal-title":"Aging Dis."},{"key":"D5RA07584J\/cit124\/1","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1007\/s11064-014-1317-z","volume":"39","author":"Wang","year":"2014","journal-title":"Neurochem. Res."},{"key":"D5RA07584J\/cit125\/1","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.3390\/ph15081008","volume":"15","author":"Hamdan","year":"2022","journal-title":"Pharmaceuticals"},{"key":"D5RA07584J\/cit126\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40035-018-0106-z","volume":"7","author":"Li","year":"2018","journal-title":"Transl. Neurodegener."},{"key":"D5RA07584J\/cit127\/1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41398-020-0709-x","volume":"10","author":"Ray","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"D5RA07584J\/cit128\/1","doi-asserted-by":"crossref","first-page":"1459025","DOI":"10.3389\/fnagi.2024.1459025","volume":"16","author":"Pan","year":"2024","journal-title":"Front. Aging Neurosci."},{"key":"D5RA07584J\/cit129\/1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41413-024-00342-8","volume":"12","author":"Hu","year":"2024","journal-title":"Bone Res."},{"key":"D5RA07584J\/cit130\/1","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.csbj.2020.06.013","volume":"18","author":"Duong","year":"2020","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"D5RA07584J\/cit131\/1","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/nsb1203-980","volume":"10","author":"Berman","year":"2003","journal-title":"Nat. Struct. Mol. Biol."},{"key":"D5RA07584J\/cit132\/1","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.csbj.2020.06.013","volume":"18","author":"Duong","year":"2020","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"D5RA07584J\/cit133\/1","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S1074-5521(03)00159-5","volume":"10","author":"Scapin","year":"2003","journal-title":"Chem. Biol."},{"key":"D5RA07584J\/cit134\/1","doi-asserted-by":"crossref","first-page":"114917","DOI":"10.1016\/j.ejmech.2022.114917","volume":"245","author":"Jun","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"D5RA07584J\/cit135\/1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jmgm.2019.05.015","volume":"91","author":"Tuffaha","year":"2019","journal-title":"J. Mol. Graph. Model."},{"key":"D5RA07584J\/cit136\/1","doi-asserted-by":"crossref","first-page":"W469","DOI":"10.1093\/nar\/gkae254","volume":"52","author":"Myung","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"D5RA07584J\/cit137\/1","doi-asserted-by":"crossref","first-page":"12434","DOI":"10.1021\/ja051685b","volume":"127","author":"Thomas","year":"2005","journal-title":"J. Am. Chem. Soc."},{"issue":"4","key":"D5RA07584J\/cit138\/1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/15376516.2021.1995557","volume":"32","author":"Ogidigo","year":"2022","journal-title":"Toxicol. Mech. Methods"},{"key":"D5RA07584J\/cit140\/1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","volume":"11","author":"Morris","year":"1984","journal-title":"J. Neurosci. Methods"},{"key":"D5RA07584J\/cit141\/1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3390\/brainsci14050427","volume":"14","author":"Bekci","year":"2024","journal-title":"Brain Sci."},{"key":"D5RA07584J\/cit142\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13195-024-01655-w","volume":"17","author":"Zhang","year":"2025","journal-title":"Alzheimers Res. Ther."},{"key":"D5RA07584J\/cit143\/1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/17425247.2023.2153831","volume":"20","author":"George","year":"2023","journal-title":"Expet Opin. Drug Deliv."},{"key":"D5RA07584J\/cit144\/1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"Livak","year":"2001","journal-title":"methods"},{"key":"D5RA07584J\/cit145\/1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s004180000149","volume":"113","author":"Kawamoto","year":"2000","journal-title":"Histochem. Cell Biol."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/RA\/D5RA07584J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:08:06Z","timestamp":1782886086000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/16\/4\/3077-3100\/908867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":144,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,1,13]]}},"URL":"https:\/\/doi.org\/10.1039\/d5ra07584j","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}