{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:07:28Z","timestamp":1793156848322,"version":"4.5.0"},"reference-count":85,"publisher":"Royal Society of Chemistry (RSC)","issue":"3","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004242","name":"Princess Nourah Bint Abdulrahman University","doi-asserted-by":"publisher","award":["PNURSP2026R488"],"award-info":[{"award-number":["PNURSP2026R488"]}],"id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>Breast cancer remains a leading cause of mortality in women, underscoring the need for multitarget therapeutic agents.<\/jats:p>","DOI":"10.1039\/d5ra07680c","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T15:47:56Z","timestamp":1768232876000},"page":"2528-2554","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Design, synthesis, and multi-target anticancer evaluation of 1,3-thiazolodin-4-one analogues against breast cancer: mechanistic insights into estrogen metabolism, inflammation, angiogenesis, and oxidative stress"],"prefix":"10.1039","volume":"16","author":[{"given":"Manar A.","family":"El-Zend","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim M.","family":"El-Deen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Fathy Mohamed","family":"Reyad","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar Zuhair","family":"Alshawwa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal Abdullah","family":"Alrashidi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7342-6200","authenticated-orcid":false,"given":"Essa M.","family":"Saied","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt"},{"name":"Institute for Chemistry, Humboldt Universit\u00e4t zu Berlin, 12489 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5RA07680C\/cit1\/1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"Sung","year":"2021","journal-title":"Ca-Cancer J. Clin."},{"key":"D5RA07680C\/cit2\/1","first-page":"e1291","volume":"5","author":"Vaidya","year":"2022","journal-title":"Cancer Rep."},{"key":"D5RA07680C\/cit3\/1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41392-024-02108-4","volume":"10","author":"Xiong","year":"2025","journal-title":"Signal Transduction Targeted Ther."},{"key":"D5RA07680C\/cit4\/1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s10495-022-01780-7","volume":"28","author":"Kaloni","year":"2023","journal-title":"Apoptosis"},{"key":"D5RA07680C\/cit5\/1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41392-025-02176-0","volume":"10","author":"Vogler","year":"2025","journal-title":"Signal Transduction Targeted Ther."},{"key":"D5RA07680C\/cit6\/1","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.3390\/biomedicines10061313","volume":"10","author":"Manna","year":"2022","journal-title":"Biomedicines"},{"key":"D5RA07680C\/cit7\/1","doi-asserted-by":"crossref","first-page":"5351","DOI":"10.3390\/molecules25225351","volume":"25","author":"Caciolla","year":"2020","journal-title":"Molecules"},{"key":"D5RA07680C\/cit8\/1","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.3390\/molecules26102852","volume":"26","author":"Foster","year":"2021","journal-title":"Molecules"},{"key":"D5RA07680C\/cit9\/1","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.3390\/cimb46050282","volume":"46","author":"Bel\u2019skaya","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"D5RA07680C\/cit10\/1","doi-asserted-by":"crossref","first-page":"115036","DOI":"10.1016\/j.biopha.2023.115036","volume":"165","author":"Zhou","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"D5RA07680C\/cit11\/1","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41419-024-06939-5","volume":"15","author":"An","year":"2024","journal-title":"Cell Death Dis."},{"key":"D5RA07680C\/cit12\/1","doi-asserted-by":"crossref","first-page":"e1596","DOI":"10.1002\/wsbm.1596","volume":"15","author":"Sahu","year":"2023","journal-title":"WIREs Mech. Dis."},{"key":"D5RA07680C\/cit13\/1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41698-025-00990-x","volume":"9","author":"Xu","year":"2025","journal-title":"npj Precis. Oncol."},{"key":"D5RA07680C\/cit14\/1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/s41392-023-01460-1","volume":"8","author":"Liu","year":"2023","journal-title":"Signal Transduction Targeted Ther."},{"key":"D5RA07680C\/cit15\/1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s10456-023-09876-7","volume":"26","author":"Dudley","year":"2023","journal-title":"Angiogenesis"},{"key":"D5RA07680C\/cit16\/1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/s12964-024-01607-9","volume":"22","author":"Doostmohammadi","year":"2024","journal-title":"Cell Commun. Signaling"},{"key":"D5RA07680C\/cit17\/1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s43440-025-00715-8","volume":"77","author":"Ryszkiewicz","year":"2025","journal-title":"Pharmacol. Rep."},{"key":"D5RA07680C\/cit18\/1","doi-asserted-by":"crossref","first-page":"e202200618","DOI":"10.1002\/cmdc.202200618","volume":"18","author":"Seboletswe","year":"2023","journal-title":"ChemMedChem"},{"key":"D5RA07680C\/cit19\/1","doi-asserted-by":"crossref","first-page":"13135","DOI":"10.3390\/ijms232113135","volume":"23","author":"Roszczenko","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"D5RA07680C\/cit20\/1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.bioorg.2017.10.014","volume":"75","author":"Kaur Manjal","year":"2017","journal-title":"Bioorg. Chem."},{"key":"D5RA07680C\/cit21\/1","doi-asserted-by":"crossref","first-page":"101828","DOI":"10.1016\/j.rechem.2024.101828","volume":"11","author":"Szostek","year":"2024","journal-title":"Results Chem."},{"key":"D5RA07680C\/cit22\/1","doi-asserted-by":"crossref","first-page":"104827","DOI":"10.1016\/j.bioorg.2021.104827","volume":"111","author":"Abd El-Karim","year":"2021","journal-title":"Bioorg. Chem."},{"key":"D5RA07680C\/cit23\/1","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.bioorg.2019.03.076","volume":"87","author":"Afifi","year":"2019","journal-title":"Bioorg. Chem."},{"key":"D5RA07680C\/cit24\/1","doi-asserted-by":"crossref","first-page":"6079","DOI":"10.1007\/s11164-017-2978-4","volume":"43","author":"Pogaku","year":"2017","journal-title":"Res. Chem. Intermed."},{"key":"D5RA07680C\/cit25\/1","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3390\/molecules27030769","volume":"27","author":"Oubella","year":"2022","journal-title":"Molecules"},{"key":"D5RA07680C\/cit26\/1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.bioorg.2018.06.013","volume":"80","author":"Tageldin","year":"2018","journal-title":"Bioorg. Chem."},{"key":"D5RA07680C\/cit27\/1","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1007\/s00706-018-2292-x","volume":"149","author":"Asghari","year":"2018","journal-title":"Monatsh. Chem."},{"key":"D5RA07680C\/cit28\/1","doi-asserted-by":"crossref","first-page":"104366","DOI":"10.1016\/j.bioorg.2020.104366","volume":"105","author":"Yousef","year":"2020","journal-title":"Bioorg. Chem."},{"key":"D5RA07680C\/cit29\/1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1021\/acs.jmedchem.3c01802","volume":"67","author":"Chen","year":"2024","journal-title":"J. Med. Chem."},{"key":"D5RA07680C\/cit30\/1","doi-asserted-by":"crossref","first-page":"e202413562","DOI":"10.1002\/anie.202413562","volume":"63","author":"Kirmpaki","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5RA07680C\/cit31\/1","doi-asserted-by":"crossref","first-page":"8171","DOI":"10.3390\/ijms22158171","volume":"22","author":"Saied","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"D5RA07680C\/cit32\/1","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1016\/j.bmc.2018.06.031","volume":"26","author":"Saied","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"D5RA07680C\/cit33\/1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s13065-023-01063-5","volume":"17","author":"Alzamami","year":"2023","journal-title":"BMC Chem."},{"key":"D5RA07680C\/cit34\/1","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.3390\/ph15121576","volume":"15","author":"Khirallah","year":"2022","journal-title":"Pharmaceuticals"},{"key":"D5RA07680C\/cit35\/1","doi-asserted-by":"crossref","first-page":"e202109967","DOI":"10.1002\/anie.202109967","volume":"61","author":"Healey","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5RA07680C\/cit36\/1","doi-asserted-by":"crossref","first-page":"135631","DOI":"10.1016\/j.ijbiomac.2024.135631","volume":"280","author":"Peng","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"D5RA07680C\/cit37\/1","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1007\/s10904-014-0060-x","volume":"24","author":"Refat","year":"2014","journal-title":"J. Inorg. Organomet. Polym. Mater."},{"key":"D5RA07680C\/cit38\/1","doi-asserted-by":"crossref","first-page":"106496","DOI":"10.1016\/j.bioorg.2023.106496","volume":"135","author":"Amin","year":"2023","journal-title":"Bioorg. Chem."},{"key":"D5RA07680C\/cit39\/1","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.ejmech.2009.10.044","volume":"45","author":"Kamel","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"D5RA07680C\/cit40\/1","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.3390\/molecules23061420","volume":"23","author":"El-Naggar","year":"2018","journal-title":"Molecules"},{"key":"D5RA07680C\/cit41\/1","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s11030-020-10087-1","volume":"25","author":"T\u00fcre","year":"2021","journal-title":"Mol. Diversity"},{"key":"D5RA07680C\/cit42\/1","doi-asserted-by":"crossref","first-page":"103035","DOI":"10.1016\/j.bioorg.2019.103035","volume":"89","author":"Abbas","year":"2019","journal-title":"Bioorg. Chem."},{"key":"D5RA07680C\/cit43\/1","doi-asserted-by":"crossref","first-page":"105184","DOI":"10.1016\/j.bioorg.2021.105184","volume":"115","author":"Oubella","year":"2021","journal-title":"Bioorg. Chem."},{"issue":"3","key":"D5RA07680C\/cit44\/1","doi-asserted-by":"crossref","first-page":"103670","DOI":"10.1016\/j.arabjc.2021.103670","volume":"15","author":"Altass","year":"2022","journal-title":"Arabian J. Chem."},{"key":"D5RA07680C\/cit45\/1","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1016\/j.bmc.2018.05.022","volume":"26","author":"Batran","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"D5RA07680C\/cit46\/1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00345","volume":"11","author":"Duncan","year":"2020","journal-title":"Front. Endocrinol."},{"key":"D5RA07680C\/cit47\/1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.bioorg.2018.06.036","volume":"80","author":"Omar","year":"2018","journal-title":"Bioorg. Chem."},{"key":"D5RA07680C\/cit48\/1","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.3390\/molecules27041326","volume":"27","author":"Baliyan","year":"2022","journal-title":"Molecules"},{"key":"D5RA07680C\/cit49\/1","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1007\/s00706-018-2292-x","volume":"149","author":"Asghari","year":"2018","journal-title":"Monatsh. Chem."},{"key":"D5RA07680C\/cit50\/1","doi-asserted-by":"crossref","first-page":"5537","DOI":"10.1128\/AAC.03457-14","volume":"58","author":"Banhart","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"D5RA07680C\/cit51\/1","doi-asserted-by":"crossref","first-page":"1231030","DOI":"10.3389\/fchem.2023.1231030","volume":"11","author":"Radwan","year":"2023","journal-title":"Front. Chem."},{"key":"D5RA07680C\/cit52\/1","doi-asserted-by":"crossref","first-page":"e202104333","DOI":"10.1002\/slct.202104333","volume":"7","author":"Mohammed","year":"2022","journal-title":"ChemistrySelect"},{"key":"D5RA07680C\/cit53\/1","doi-asserted-by":"crossref","first-page":"33080","DOI":"10.1039\/D3RA06189B","volume":"13","author":"Salem","year":"2023","journal-title":"RSC Adv."},{"key":"D5RA07680C\/cit54\/1","doi-asserted-by":"crossref","first-page":"e2100580","DOI":"10.1002\/cbdv.202100580","volume":"18","author":"Mohammed","year":"2021","journal-title":"Chem. Biodiversity"},{"key":"D5RA07680C\/cit55\/1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s13065-023-01063-5","volume":"17","author":"Alzamami","year":"2023","journal-title":"BMC Chem."},{"key":"D5RA07680C\/cit56\/1","doi-asserted-by":"crossref","first-page":"19400","DOI":"10.1039\/D4RA02131B","volume":"14","author":"Alzahrani","year":"2024","journal-title":"RSC Adv."},{"key":"D5RA07680C\/cit57\/1","doi-asserted-by":"crossref","first-page":"24769","DOI":"10.1039\/D5RA02512E","volume":"15","author":"Ali Almasmoum","year":"2025","journal-title":"RSC Adv."},{"key":"D5RA07680C\/cit58\/1","doi-asserted-by":"crossref","first-page":"103495","DOI":"10.1016\/j.bioorg.2019.103495","volume":"95","author":"Grienke","year":"2020","journal-title":"Bioorg. Chem."},{"key":"D5RA07680C\/cit59\/1","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.3390\/molecules27041326","volume":"27","author":"Baliyan","year":"2022","journal-title":"Molecules"},{"key":"D5RA07680C\/cit60\/1","doi-asserted-by":"crossref","first-page":"19400","DOI":"10.1039\/D4RA02131B","volume":"14","author":"Alzahrani","year":"2024","journal-title":"RSC Adv."},{"key":"D5RA07680C\/cit61\/1","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.3390\/biom14081018","volume":"14","author":"Labib","year":"2024","journal-title":"Biomolecules"},{"key":"D5RA07680C\/cit62\/1","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.4155\/fmc-2023-0375","volume":"16","author":"Salem","year":"2024","journal-title":"Future Med. Chem."},{"key":"D5RA07680C\/cit63\/1","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.2147\/DDDT.S463626","volume":"18","author":"Alzahrani","year":"2024","journal-title":"Drug Des., Dev. Ther."},{"issue":"3","key":"D5RA07680C\/cit64\/1","doi-asserted-by":"publisher","DOI":"10.1142\/S2737416523500655","volume":"23","author":"Chopade","year":"2024","journal-title":"J. Comput. Biophys. Chem."},{"key":"D5RA07680C\/cit65\/1","doi-asserted-by":"crossref","first-page":"428","DOI":"10.4049\/jimmunol.79.5.428","volume":"79","author":"McLimans","year":"1957","journal-title":"J. Immunol."},{"key":"D5RA07680C\/cit66\/1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.9734\/ajacr\/2022\/v12i3223","author":"Zakir","year":"2022","journal-title":"Asian J. Appl. Chem. Res."},{"key":"D5RA07680C\/cit67\/1","doi-asserted-by":"crossref","first-page":"20143","DOI":"10.1039\/D5RA01014D","volume":"15","author":"Behery","year":"2025","journal-title":"RSC Adv."},{"key":"D5RA07680C\/cit68\/1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0041-0101(86)90199-6","volume":"24","author":"Meier","year":"1986","journal-title":"Toxicon"},{"key":"D5RA07680C\/cit69\/1","first-page":"2973","volume":"36","author":"Crump","year":"1976","journal-title":"Cancer Res."},{"key":"D5RA07680C\/cit70\/1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1681\/ASN.2005020217","volume":"17","author":"Zhang","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"D5RA07680C\/cit71\/1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3390\/mps5050081","volume":"5","author":"Hartmann","year":"2022","journal-title":"Methods Protoc."},{"key":"D5RA07680C\/cit72\/1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1378249","volume":"15","author":"Elshaer","year":"2024","journal-title":"Front. Pharmacol."},{"key":"D5RA07680C\/cit73\/1","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0006-291X(72)80218-3","volume":"46","author":"Nishikimi","year":"1972","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"D5RA07680C\/cit74\/1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/BF02148042","volume":"19","author":"Beutler","year":"1963","journal-title":"Experientia"},{"key":"D5RA07680C\/cit75\/1","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.3390\/ph14121222","volume":"14","author":"Mohamed","year":"2021","journal-title":"Pharmaceuticals"},{"key":"D5RA07680C\/cit76\/1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"D5RA07680C\/cit77\/1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12951-021-00796-6","volume":"19","author":"Di Bella","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"D5RA07680C\/cit78\/1","first-page":"541","volume":"9","author":"Zhou","year":"2022","journal-title":"Bioact. Mater."},{"key":"D5RA07680C\/cit79\/1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3390\/pharmaceutics14030529","volume":"14","author":"Mohamed","year":"2022","journal-title":"Pharmaceutics"},{"key":"D5RA07680C\/cit80\/1","doi-asserted-by":"crossref","first-page":"832","DOI":"10.3390\/ph15070832","volume":"15","author":"Mohamed","year":"2022","journal-title":"Pharmaceuticals"},{"key":"D5RA07680C\/cit81\/1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2023.1268126","volume":"17","author":"Mohamed","year":"2023","journal-title":"Front. Cell. Neurosci."},{"key":"D5RA07680C\/cit82\/1","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1681\/ASN.2010010010","volume":"21","author":"Tervaert","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"D5RA07680C\/cit83\/1","doi-asserted-by":"crossref","first-page":"2241665","DOI":"10.1080\/10717544.2023.2241665","volume":"30","author":"Fathy Elhabal","year":"2023","journal-title":"Drug Delivery"},{"key":"D5RA07680C\/cit84\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/ddr.22008","volume":"84","author":"Hassan","year":"2023","journal-title":"Drug Dev. Res."},{"key":"D5RA07680C\/cit85\/1","doi-asserted-by":"crossref","first-page":"1231030","DOI":"10.3389\/fchem.2023.1231030","volume":"11","author":"Radwan","year":"2023","journal-title":"Front. Chem."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/RA\/D5RA07680C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T22:06:59Z","timestamp":1782943619000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/16\/3\/2528-2554\/908895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":85,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,1,7]]}},"URL":"https:\/\/doi.org\/10.1039\/d5ra07680c","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}