{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T22:01:59Z","timestamp":1782943319835,"version":"3.54.5"},"reference-count":33,"publisher":"Royal Society of Chemistry (RSC)","issue":"15","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":67,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>Hydrated \u03b1- and \u03b2-forms were obtained from aqueous solvents, whereas the anhydrous \u03b3-form was first identified from organic solvents. The proposed dimensionless plotting method represents a promising and effective approach for polymorph screening.<\/jats:p>","DOI":"10.1039\/d5ra07845h","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T15:06:21Z","timestamp":1773068781000},"page":"13021-13031","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of nucleation on solvate and polymorph control \u2013 evaporative crystallization of taltirelin"],"prefix":"10.1039","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7933-4294","authenticated-orcid":false,"given":"Dang Le Tri","family":"Nguyen","sequence":"first","affiliation":[{"name":"Crystallization Process & Engineering Center, Hanbat National University, Yusung 34158, Daejeon, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungsuk","family":"Kim","sequence":"additional","affiliation":[{"name":"Ehe. Zentrum f\u00fcr Ingenieurwissenschaften, Nat Fak I, Martin-Luther-Universit\u00e4t Halle-Wittenberg, D-06099 Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0759-2953","authenticated-orcid":false,"given":"Kwang-Joo","family":"Kim","sequence":"additional","affiliation":[{"name":"Crystallization Process & Engineering Center, Hanbat National University, Yusung 34158, Daejeon, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Ehe. Zentrum f\u00fcr Ingenieurwissenschaften, Nat Fak I, Martin-Luther-Universit\u00e4t Halle-Wittenberg, D-06099 Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5RA07845H\/cit1\/1","volume-title":"Polymorphism in Pharmaceutical Solids","author":"Brittain","year":"1999","unstructured":"H. G.Brittain ,  Polymorphism in Pharmaceutical Solids ,  Marcel Dekker ,  1999"},{"key":"D5RA07845H\/cit2\/1","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1002\/1521-4079(200112)36:12<1315::AID-CRAT1315>3.0.CO;2-R","volume":"36","author":"Bechtloff","year":"2001","journal-title":"Cryst. Res. Technol."},{"key":"D5RA07845H\/cit3\/1","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1016\/j.cherd.2010.02.005","volume":"88","author":"Guo","year":"2010","journal-title":"Chem. Eng. Res. Des."},{"key":"D5RA07845H\/cit4\/1","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1205\/cerd.82.12.1567.58038","volume":"82","author":"Ulrich","year":"2004","journal-title":"Chem. Eng. Res. Des."},{"key":"D5RA07845H\/cit5\/1","doi-asserted-by":"crossref","first-page":"2100176","DOI":"10.1002\/crat.202100176","volume":"57","author":"Kim","year":"2022","journal-title":"Cryst. Res. Technol."},{"key":"D5RA07845H\/cit6\/1","doi-asserted-by":"crossref","first-page":"7052","DOI":"10.1021\/acs.iecr.2c00244","volume":"61","author":"Kim","year":"2022","journal-title":"Ind. Eng. Chem. Res."},{"key":"D5RA07845H\/cit7\/1","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1021\/cg0497795","volume":"4","author":"Kitamura","year":"2004","journal-title":"Cryst. Growth Des."},{"key":"D5RA07845H\/cit8\/1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.drudis.2007.11.006","volume":"13","author":"Linas","year":"2008","journal-title":"Drug Discov Today"},{"key":"D5RA07845H\/cit9\/1","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1016\/S0022-0248(01)02284-9","volume":"237","author":"Ulrich","year":"2002","journal-title":"J. Cryst. Growth"},{"key":"D5RA07845H\/cit10\/1","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/ceat.200300003","volume":"26","author":"Ulrich","year":"2003","journal-title":"Chem. Eng. Technol."},{"key":"D5RA07845H\/cit11\/1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S1385-8947(99)00115-1","volume":"75","author":"Maruyama","year":"1999","journal-title":"Chem. Eng. J."},{"key":"D5RA07845H\/cit12\/1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0022-0248(99)00903-3","volume":"212","author":"Maruyama","year":"2000","journal-title":"J. Cryst. Growth"},{"key":"D5RA07845H\/cit13\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1385-8947(00)00193-5","volume":"81","author":"Maruyama","year":"2001","journal-title":"Chem. Eng. J."},{"key":"D5RA07845H\/cit14\/1","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1002\/ceat.201400725","volume":"38","author":"Dang","year":"2015","journal-title":"Chem. Eng. Technol."},{"key":"D5RA07845H\/cit15\/1","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1002\/ceat.201600043","volume":"39","author":"Dang","year":"2016","journal-title":"Chem. Eng. Technol."},{"issue":"3","key":"D5RA07845H\/cit16\/1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1252\/jcej.17we080","volume":"51","author":"Dang","year":"2018","journal-title":"Chem. Eng. Japan"},{"issue":"10","key":"D5RA07845H\/cit17\/1","doi-asserted-by":"crossref","first-page":"e70111","DOI":"10.1002\/ceat.70111","volume":"48","author":"Dang","year":"2025","journal-title":"Chem. Eng. Technol."},{"key":"D5RA07845H\/cit18\/1","volume-title":"Crystallization","author":"Mullin","year":"2001","unstructured":"J. W.Mullin ,  Crystallization ,  Elsevier Science ,  2001"},{"key":"D5RA07845H\/cit19\/1","doi-asserted-by":"crossref","DOI":"10.1201\/9780203908280","volume-title":"Crystallization Technology Handbook","author":"Mersmann","year":"2001","unstructured":"A.Mersmann ,  Crystallization Technology Handbook ,  Taylor & Francis ,  2001"},{"key":"D5RA07845H\/cit20\/1","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1002\/ceat.201200718","volume":"36","author":"Hellst\u00e9n","year":"2013","journal-title":"Chem. Eng. Technol."},{"key":"D5RA07845H\/cit21\/1","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1002\/chem.201705356","volume":"24","author":"Tohnai","year":"2018","journal-title":"Chem.\u2013Eur. J."},{"key":"D5RA07845H\/cit22\/1","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1016\/j.jcrysgro.2009.02.004","volume":"311","author":"Qu","year":"2009","journal-title":"J. Cryst. Growth"},{"key":"D5RA07845H\/cit23\/1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/ceat.200900572","volume":"33","author":"Tian","year":"2010","journal-title":"Chem. Eng. Technol."},{"key":"D5RA07845H\/cit24\/1","first-page":"479","volume":"4","author":"Desai","year":"2014","journal-title":"Am. J. Pharm. Tech. Res."},{"key":"D5RA07845H\/cit25\/1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/ceat.202100260","volume":"45","author":"Kim","year":"2022","journal-title":"Chem. Eng. Technol."},{"key":"D5RA07845H\/cit26\/1","doi-asserted-by":"crossref","first-page":"14609","DOI":"10.1021\/acs.iecr.2c02135","volume":"61","author":"Kim","year":"2022","journal-title":"Ind. Eng. Chem. Res."},{"key":"D5RA07845H\/cit27\/1","doi-asserted-by":"crossref","first-page":"11151","DOI":"10.1021\/ie4007968","volume":"52","author":"Jim","year":"2013","journal-title":"Ind. Eng. Chem. Res."},{"key":"D5RA07845H\/cit28\/1","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/crat.200410443","volume":"40","author":"Lu","year":"2005","journal-title":"Cryst. Res. and Technol."},{"key":"D5RA07845H\/cit29\/1","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1002\/ceat.201100717","volume":"35","author":"Jim","year":"2012","journal-title":"Chem. Eng. Technol."},{"key":"D5RA07845H\/cit30\/1","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1002\/jps.20868","volume":"96","author":"Lu","year":"2007","journal-title":"J. Pharm. Sci."},{"key":"D5RA07845H\/cit31\/1","first-page":"812","volume":"74","author":"Mersmann","year":"1996","journal-title":"Chem. Eng. Res. Des."},{"key":"D5RA07845H\/cit32\/1","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/S0009-2509(00)00450-4","volume":"56","author":"Kim","year":"2001","journal-title":"Chem. Eng. Sci."},{"key":"D5RA07845H\/cit33\/1","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1002\/aic.14745","volume":"61","author":"Kim","year":"2015","journal-title":"AIChE"}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/RA\/D5RA07845H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:30:50Z","timestamp":1782941450000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/16\/15\/13021-13031\/1228445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":33,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2026,3,9]]}},"URL":"https:\/\/doi.org\/10.1039\/d5ra07845h","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}