{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:43:52Z","timestamp":1783017832615,"version":"3.54.6"},"reference-count":48,"publisher":"Royal Society of Chemistry (RSC)","issue":"3","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21306172"],"award-info":[{"award-number":["21306172"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008327","name":"Zhejiang University of Technology","doi-asserted-by":"publisher","award":["116004029"],"award-info":[{"award-number":["116004029"]}],"id":[{"id":"10.13039\/501100008327","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016693","name":"Science and Technology Research","doi-asserted-by":"publisher","award":["2014C32094"],"award-info":[{"award-number":["2014C32094"]}],"id":[{"id":"10.13039\/100016693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>\n                    An efficient continuous-flow biocatalytic synthesis of\n                    <jats:italic>N<\/jats:italic>\n                    -alkylated pyrazoles was established, with 25 derivatives prepared to verify applicability and supply pharmaceutical parameters.\n                  <\/jats:p>","DOI":"10.1039\/d5ra08312e","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T09:52:42Z","timestamp":1768384362000},"page":"2850-2857","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biocatalyzed aza-michael addition\n                    <i>via<\/i>\n                    continuous flow technology: a game-changer for the facile synthesis of\n                    <i>N-<\/i>\n                    alkylated pyrazole derivatives"],"prefix":"10.1039","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6767-2248","authenticated-orcid":false,"given":"Li-Hua","family":"Du","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Science, ZheJiang University of Technology, Hangzhou 310014, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-Lin","family":"Yan","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Science, ZheJiang University of Technology, Hangzhou 310014, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao-Miao","family":"Xue","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Science, ZheJiang University of Technology, Hangzhou 310014, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Science, ZheJiang University of Technology, Hangzhou 310014, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8310-7034","authenticated-orcid":false,"given":"Xi-Ping","family":"Luo","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Key Laboratory of Chemical Utilization of Forestry Biomass, Zhejiang A&F University, Hangzhou, Zhejiang, 311300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5RA08312E\/cit1\/1","doi-asserted-by":"crossref","first-page":"11622","DOI":"10.1021\/acs.jmedchem.4c01122","volume":"67","author":"Marshall","year":"2024","journal-title":"J. Med. Chem."},{"key":"D5RA08312E\/cit2\/1","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1039\/D4GC05685J","volume":"27","author":"Wei","year":"2025","journal-title":"Green Chem."},{"key":"D5RA08312E\/cit3\/1","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1039\/D2CC00002D","volume":"58","author":"Ghosh","year":"2022","journal-title":"Chem. Commun."},{"key":"D5RA08312E\/cit4\/1","doi-asserted-by":"crossref","first-page":"117081","DOI":"10.1016\/j.ejmech.2024.117081","volume":"282","author":"Rehman","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"D5RA08312E\/cit5\/1","doi-asserted-by":"crossref","first-page":"e2400081","DOI":"10.1002\/ardp.202400081","volume":"357","author":"Ramirez-Prada","year":"2024","journal-title":"Arch. Pharm."},{"key":"D5RA08312E\/cit6\/1","doi-asserted-by":"crossref","first-page":"9769","DOI":"10.1021\/acs.jmedchem.7b01236","volume":"60","author":"Bezencon","year":"2017","journal-title":"J. Med. Chem."},{"key":"D5RA08312E\/cit7\/1","doi-asserted-by":"crossref","first-page":"1380523","DOI":"10.3389\/fchem.2024.1380523","volume":"12","author":"Ahmed","year":"2024","journal-title":"Front. Chem."},{"key":"D5RA08312E\/cit8\/1","doi-asserted-by":"crossref","first-page":"e202400015","DOI":"10.1002\/cbdv.202400015","volume":"21","author":"Dabhade","year":"2024","journal-title":"Chem. Biodiversity"},{"key":"D5RA08312E\/cit9\/1","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.3390\/molecules26051202","volume":"26","author":"Li","year":"2021","journal-title":"Molecules"},{"key":"D5RA08312E\/cit10\/1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nrd3652","volume":"11","author":"Mesa","year":"2012","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D5RA08312E\/cit11\/1","doi-asserted-by":"crossref","first-page":"e202400880","DOI":"10.1002\/cbdv.202400880","volume":"21","author":"Hosamani","year":"2024","journal-title":"Chem. Biodiversity"},{"key":"D5RA08312E\/cit12\/1","doi-asserted-by":"crossref","first-page":"24528","DOI":"10.1021\/acs.jafc.5c08390","volume":"73","author":"Li","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"D5RA08312E\/cit13\/1","doi-asserted-by":"crossref","first-page":"8358","DOI":"10.1021\/acs.jafc.1c01189","volume":"69","author":"Xia","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"D5RA08312E\/cit14\/1","doi-asserted-by":"crossref","first-page":"12698","DOI":"10.1039\/D4RA08527B","volume":"15","author":"Swietczak","year":"2025","journal-title":"RSC Adv."},{"key":"D5RA08312E\/cit15\/1","doi-asserted-by":"crossref","first-page":"19693","DOI":"10.1039\/D0RA02394A","volume":"10","author":"Tigreros","year":"2020","journal-title":"RSC Adv."},{"key":"D5RA08312E\/cit16\/1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.molcatb.2015.05.020","volume":"121","author":"Mane","year":"2015","journal-title":"J. Mol. Catal. B: Enzym."},{"key":"D5RA08312E\/cit17\/1","doi-asserted-by":"crossref","first-page":"8069","DOI":"10.1021\/acscatal.5c01747","volume":"15","author":"Liang","year":"2025","journal-title":"ACS Catal."},{"key":"D5RA08312E\/cit18\/1","doi-asserted-by":"crossref","first-page":"7292","DOI":"10.1021\/acscatal.9b01748","volume":"9","author":"Fu","year":"2019","journal-title":"ACS Catal."},{"key":"D5RA08312E\/cit19\/1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1002\/adsc.202101312","volume":"364","author":"Dasgupta","year":"2021","journal-title":"Adv. Synth. Catal."},{"key":"D5RA08312E\/cit20\/1","doi-asserted-by":"crossref","first-page":"9930","DOI":"10.1002\/anie.201704175","volume":"56","author":"Liu","year":"2017","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"D5RA08312E\/cit21\/1","doi-asserted-by":"crossref","first-page":"7587","DOI":"10.1021\/jacs.8b02865","volume":"140","author":"Kou","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"D5RA08312E\/cit22\/1","doi-asserted-by":"crossref","first-page":"7229","DOI":"10.1021\/acs.joc.1c00569","volume":"86","author":"Golovanov","year":"2021","journal-title":"J. Org. Chem."},{"key":"D5RA08312E\/cit23\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3390\/molecules23010003","volume":"23","author":"Pozgan","year":"2017","journal-title":"Molecules"},{"key":"D5RA08312E\/cit24\/1","doi-asserted-by":"crossref","first-page":"4048","DOI":"10.1021\/acs.joc.6b00341","volume":"81","author":"Kim","year":"2016","journal-title":"J. Org. Chem."},{"key":"D5RA08312E\/cit25\/1","first-page":"134","author":"Zhang","year":"2023","journal-title":"Tetrahedron"},{"key":"D5RA08312E\/cit26\/1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1021\/acs.orglett.4c03808","volume":"27","author":"Cheng","year":"2025","journal-title":"Org. Lett."},{"key":"D5RA08312E\/cit27\/1","doi-asserted-by":"crossref","first-page":"6495","DOI":"10.1002\/ejoc.201500940","volume":"2015","author":"Lee","year":"2015","journal-title":"Eur. J. Org Chem."},{"key":"D5RA08312E\/cit28\/1","doi-asserted-by":"crossref","first-page":"8313","DOI":"10.1039\/D2OB01634F","volume":"20","author":"Yoon","year":"2022","journal-title":"Org. Biomol. Chem."},{"key":"D5RA08312E\/cit29\/1","doi-asserted-by":"crossref","first-page":"5459","DOI":"10.1021\/acs.chemrev.2c00767","volume":"123","author":"Emmanuel","year":"2023","journal-title":"Chem. Rev."},{"key":"D5RA08312E\/cit30\/1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/anie.202006648","volume":"60","author":"Wu","year":"2021","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"D5RA08312E\/cit31\/1","doi-asserted-by":"crossref","first-page":"11248","DOI":"10.1039\/D5GC02458G","volume":"27","author":"Zhang","year":"2025","journal-title":"Green Chem."},{"key":"D5RA08312E\/cit32\/1","doi-asserted-by":"crossref","first-page":"30396","DOI":"10.1039\/D4RA04824E","volume":"14","author":"Fernandes","year":"2024","journal-title":"RSC Adv."},{"key":"D5RA08312E\/cit33\/1","first-page":"146","volume":"466","author":"Zhang","year":"2019","journal-title":"Mol. Catal."},{"key":"D5RA08312E\/cit34\/1","doi-asserted-by":"crossref","first-page":"2001648","DOI":"10.1002\/adfm.202001648","volume":"30","author":"Liang","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"D5RA08312E\/cit35\/1","doi-asserted-by":"crossref","first-page":"12713","DOI":"10.1038\/s41598-022-16291-3","volume":"12","author":"Bavandi","year":"2022","journal-title":"Sci. Rep."},{"key":"D5RA08312E\/cit36\/1","doi-asserted-by":"crossref","first-page":"10953","DOI":"10.1039\/D4RA00097H","volume":"14","author":"Zhang","year":"2024","journal-title":"RSC Adv."},{"key":"D5RA08312E\/cit37\/1","first-page":"1347","author":"Yu","year":"2025","journal-title":"J. Mol. Struct."},{"key":"D5RA08312E\/cit38\/1","doi-asserted-by":"crossref","first-page":"129723","DOI":"10.1016\/j.seppur.2024.129723","volume":"355","author":"Minh Nguyet Bui","year":"2025","journal-title":"Sep. Purif. Technol."},{"key":"D5RA08312E\/cit39\/1","doi-asserted-by":"crossref","first-page":"27479","DOI":"10.1021\/acsami.9b07268","volume":"11","author":"Roberts","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D5RA08312E\/cit40\/1","doi-asserted-by":"crossref","first-page":"148570","DOI":"10.1016\/j.cej.2024.148570","volume":"481","author":"Vo","year":"2024","journal-title":"Chem. Eng. J."},{"key":"D5RA08312E\/cit41\/1","doi-asserted-by":"crossref","first-page":"121056","DOI":"10.1016\/j.ces.2024.121056","volume":"304","author":"Li","year":"2025","journal-title":"Chem. Eng. Sci."},{"key":"D5RA08312E\/cit42\/1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2025.07.010","author":"Bai","year":"2025","journal-title":"J. Adv. Res."},{"key":"D5RA08312E\/cit43\/1","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1021\/acs.oprd.3c00405","volume":"28","author":"Tang","year":"2024","journal-title":"Org. Process Res. Dev."},{"key":"D5RA08312E\/cit44\/1","doi-asserted-by":"crossref","first-page":"133440","DOI":"10.1016\/j.foodchem.2022.133440","volume":"393","author":"Xu","year":"2022","journal-title":"Food Chem."},{"key":"D5RA08312E\/cit45\/1","doi-asserted-by":"crossref","first-page":"e202402007","DOI":"10.1002\/cssc.202402007","volume":"18","author":"Patti","year":"2025","journal-title":"ChemSusChem"},{"key":"D5RA08312E\/cit46\/1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1039\/D0RE00483A","volume":"6","author":"Ben\u00edtez-Mateos","year":"2021","journal-title":"React. Chem. Eng."},{"key":"D5RA08312E\/cit47\/1","doi-asserted-by":"crossref","first-page":"e202102709","DOI":"10.1002\/cssc.202102709","volume":"15","author":"Alcantara","year":"2022","journal-title":"ChemSusChem"},{"key":"D5RA08312E\/cit48\/1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s41981-023-00286-w","volume":"14","author":"Donzella","year":"2023","journal-title":"J. Flow Chem."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/RA\/D5RA08312E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:40:11Z","timestamp":1783014011000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/16\/3\/2850-2857\/909101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,1,7]]}},"URL":"https:\/\/doi.org\/10.1039\/d5ra08312e","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5RA08312E\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5RA08312E\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5RA08312E\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5RA08312E\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5RA08312E\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5RA08312E\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}