{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T01:29:36Z","timestamp":1792286976208,"version":"4.4.0"},"reference-count":50,"publisher":"Royal Society of Chemistry (RSC)","issue":"10","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100013317","name":"Shanxi Provincial Key Research and Development Project","doi-asserted-by":"publisher","award":["2021ZDLSF04-03"],"award-info":[{"award-number":["2021ZDLSF04-03"]}],"id":[{"id":"10.13039\/501100013317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82505119"],"award-info":[{"award-number":["82505119"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304859"],"award-info":[{"award-number":["82304859"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515110678"],"award-info":[{"award-number":["2022A1515110678"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["20241168"],"award-info":[{"award-number":["20241168"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["20231206"],"award-info":[{"award-number":["20231206"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2021A03907"],"award-info":[{"award-number":["CI2021A03907"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["A2024479"],"award-info":[{"award-number":["A2024479"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFC3507700"],"award-info":[{"award-number":["2025YFC3507700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>\n                    The polyphenols from the TP fraction of\n                    <jats:italic>I. serra<\/jats:italic>\n                    exhibited potent hepatoprotective effects against\n                    <jats:italic>t<\/jats:italic>\n                    -BHP-induced hepatotoxicity both\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1039\/d5ra08382f","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:28:14Z","timestamp":1770820094000},"page":"8487-8498","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bioactive polyphenols from\n                    <i>Isodon serra<\/i>\n                    with antioxidant and hepatoprotective activities\n                    <i>in vitro<\/i>\n                    and\n                    <i>in vivo<\/i>"],"prefix":"10.1039","volume":"16","author":[{"given":"Siqin","family":"Li","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China"},{"name":"Department of Pharmacy, Shaoguan First People's Hospital, Affiliated Hospital of Shaoguan University, Shaoguan 512000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziying","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lv","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixiong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Yang","sequence":"additional","affiliation":[{"name":"China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyao","family":"Du","sequence":"additional","affiliation":[{"name":"Hebei University of Traditional Chinese Medicine, Shijiazhuang 050200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Hong","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangdong Pharmaceutical University, Guang Dong 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9476-3401","authenticated-orcid":false,"given":"Xin","family":"He","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5631-4946","authenticated-orcid":false,"given":"Ji","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5RA08382F\/cit1\/1","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.ajpath.2023.06.002","volume":"193","author":"Banerjee","year":"2023","journal-title":"Am. J. Pathol."},{"key":"D5RA08382F\/cit2\/1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3390\/antiox13030312","volume":"13","author":"Hong","year":"2024","journal-title":"Antioxidants"},{"key":"D5RA08382F\/cit3\/1","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.3390\/antiox9121279","volume":"9","author":"Ramos-Tovar","year":"2020","journal-title":"Antioxidants"},{"key":"D5RA08382F\/cit4\/1","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/B978-0-12-803951-9.00011-2","volume-title":"The Liver","author":"Hassan","year":"2018","unstructured":"H. A.Hassan , in  The Liver , ed  V. B. Patel ,  R. Rajendram  and  V. R. Preedy ,  Academic Press ,  Boston ,  2018 ,  10.1016\/B978-0-12-803951-9.00011-2 ,  pp. 121\u2013130"},{"key":"D5RA08382F\/cit5\/1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/B978-0-323-91250-1.00006-9","volume":"75","author":"Bhuyan","year":"2022","journal-title":"Stud. Nat. Prod. Chem."},{"key":"D5RA08382F\/cit6\/1","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.3390\/ijms25052600","volume":"25","author":"Andr\u00e9s","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"D5RA08382F\/cit7\/1","doi-asserted-by":"crossref","first-page":"7531","DOI":"10.1007\/s00210-024-03172-x","volume":"397","author":"Zare Mehrjerdi","year":"2024","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"D5RA08382F\/cit8\/1","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.3390\/molecules23123212","volume":"23","author":"Fuccelli","year":"2018","journal-title":"Molecules"},{"key":"D5RA08382F\/cit9\/1","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1021\/acs.jnatprod.9b01281","volume":"83","author":"Xing","year":"2020","journal-title":"J. Nat. Prod."},{"key":"D5RA08382F\/cit10\/1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.4062\/biomolther.2020.003","volume":"28","author":"Bae","year":"2020","journal-title":"J. Biomol. Res. Therapeut."},{"key":"D5RA08382F\/cit11\/1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.phytochem.2016.05.014","volume":"130","author":"Wan","year":"2016","journal-title":"Phytochemistry"},{"key":"D5RA08382F\/cit12\/1","doi-asserted-by":"crossref","first-page":"720","DOI":"10.2174\/138620711796504352","volume":"14","author":"Lin","year":"2011","journal-title":"Combinatorial Chemistry & High Throughput Screening"},{"key":"D5RA08382F\/cit13\/1","first-page":"354","volume":"13","author":"Hassanpour","year":"2023","journal-title":"Avicenna J. Phytomed."},{"key":"D5RA08382F\/cit14\/1","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.foodchem.2005.07.015","volume":"98","author":"S\u00e1nchez-Moreno","year":"2006","journal-title":"Food Chem."},{"key":"D5RA08382F\/cit15\/1","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/1750-3841.13605","volume":"82","author":"Zhang","year":"2017","journal-title":"J. Food Sci."},{"key":"D5RA08382F\/cit16\/1","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.bcp.2003.09.026","volume":"67","author":"Piret","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"D5RA08382F\/cit17\/1","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/0031-9422(96)00242-7","volume":"42","author":"Kraut","year":"1996","journal-title":"Phytochemistry"},{"key":"D5RA08382F\/cit18\/1","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/mrc.1260310717","volume":"31","author":"Pieters","year":"1993","journal-title":"Magn. Reson. Chem."},{"key":"D5RA08382F\/cit19\/1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0031-9422(00)00309-5","volume":"55","author":"Lu","year":"2000","journal-title":"Phytochemistry"},{"key":"D5RA08382F\/cit20\/1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1080\/10286020.2010.484805","volume":"12","author":"Feng","year":"2010","journal-title":"J. Asian Nat. Prod. Res."},{"key":"D5RA08382F\/cit21\/1","doi-asserted-by":"crossref","first-page":"11986","DOI":"10.1021\/acs.jafc.9b05605","volume":"67","author":"Wu","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"D5RA08382F\/cit22\/1","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/s11418-007-0182-3","volume":"61","author":"Sadhu","year":"2007","journal-title":"J. Nat. Med."},{"key":"D5RA08382F\/cit23\/1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1021\/np50117a007","volume":"58","author":"Kashiwada","year":"1995","journal-title":"J. Nat. Prod."},{"key":"D5RA08382F\/cit24\/1","first-page":"207","author":"GhangTai","year":"2010","journal-title":"Nat. Prod. Sci."},{"key":"D5RA08382F\/cit25\/1","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1021\/jf050024v","volume":"53","author":"Le Claire","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"D5RA08382F\/cit26\/1","first-page":"5","volume":"9","author":"Liu","year":"2010","journal-title":"J. Dali Univ."},{"key":"D5RA08382F\/cit27\/1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jfutfo.2023.07.002","volume":"4","author":"Lang","year":"2024","journal-title":"J. Future Foods"},{"key":"D5RA08382F\/cit28\/1","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.3390\/ma17112575","volume":"17","author":"\u015awiderski","year":"2024","journal-title":"Materials"},{"key":"D5RA08382F\/cit29\/1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.sajb.2018.04.005","volume":"120","author":"Tufa","year":"2019","journal-title":"J. S. Afr. Bot."},{"key":"D5RA08382F\/cit30\/1","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.saa.2019.04.025","volume":"219","author":"Spagnol","year":"2019","journal-title":"Spectrochim. Acta, Part A Mol. Biomol. Spectrosc."},{"key":"D5RA08382F\/cit31\/1","doi-asserted-by":"crossref","first-page":"113169","DOI":"10.1016\/j.jep.2020.113169","volume":"262","author":"Trifan","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"D5RA08382F\/cit32\/1","doi-asserted-by":"crossref","first-page":"14497","DOI":"10.3390\/ijms232214497","volume":"23","author":"Ami\u0107","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"D5RA08382F\/cit33\/1","doi-asserted-by":"crossref","first-page":"24071","DOI":"10.1021\/acsomega.4c02931","volume":"9","author":"Quy Huong","year":"2024","journal-title":"ACS Omega"},{"key":"D5RA08382F\/cit34\/1","doi-asserted-by":"crossref","first-page":"117084","DOI":"10.1016\/j.biopha.2024.117084","volume":"178","author":"Chen","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"D5RA08382F\/cit35\/1","first-page":"517350","volume":"2015","author":"Choi","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med"},{"key":"D5RA08382F\/cit36\/1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.ijbiomac.2022.03.134","volume":"208","author":"Wu","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"D5RA08382F\/cit37\/1","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s11033-024-09771-4","volume":"51","author":"Xiao","year":"2024","journal-title":"Mol. Biol. Rep."},{"key":"D5RA08382F\/cit38\/1","doi-asserted-by":"crossref","first-page":"4485","DOI":"10.1039\/D0FO00575D","volume":"11","author":"Guo","year":"2020","journal-title":"Food Funct."},{"key":"D5RA08382F\/cit39\/1","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.cellsig.2010.06.004","volume":"22","author":"Kim","year":"2010","journal-title":"Cell. Signal."},{"key":"D5RA08382F\/cit40\/1","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0968-0896(98)00063-7","volume":"6","author":"Ito","year":"1998","journal-title":"Bioorg. Med. Chem."},{"key":"D5RA08382F\/cit41\/1","doi-asserted-by":"crossref","first-page":"5979","DOI":"10.3390\/molecules28165979","volume":"28","author":"Cordiano","year":"2023","journal-title":"Molecules"},{"key":"D5RA08382F\/cit42\/1","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.3390\/molecules29122733","volume":"29","author":"Li","year":"2024","journal-title":"Molecules"},{"key":"D5RA08382F\/cit43\/1","doi-asserted-by":"crossref","first-page":"153209","DOI":"10.1016\/j.phymed.2020.153209","volume":"69","author":"Li","year":"2020","journal-title":"Phytomedicine"},{"key":"D5RA08382F\/cit44\/1","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1021\/jf104640k","volume":"59","author":"Zou","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"D5RA08382F\/cit45\/1","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.3390\/antiox11061189","volume":"11","author":"Muema","year":"2022","journal-title":"Antioxidants"},{"key":"D5RA08382F\/cit46\/1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3390\/antiox8080296","volume":"8","author":"Xu","year":"2019","journal-title":"Antioxidants"},{"key":"D5RA08382F\/cit47\/1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.phytochem.2015.11.014","volume":"122","author":"Wang","year":"2016","journal-title":"Phytochemistry"},{"key":"D5RA08382F\/cit48\/1","doi-asserted-by":"crossref","first-page":"153479","DOI":"10.1016\/j.phymed.2021.153479","volume":"83","author":"Feng","year":"2021","journal-title":"Phytomedicine"},{"key":"D5RA08382F\/cit49\/1","doi-asserted-by":"crossref","first-page":"e3000410","DOI":"10.1371\/journal.pbio.3000410","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol."},{"key":"D5RA08382F\/cit50\/1","doi-asserted-by":"crossref","first-page":"154726","DOI":"10.1016\/j.phymed.2023.154726","volume":"113","author":"Li","year":"2023","journal-title":"Phytomedicine"}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/RA\/D5RA08382F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:15:56Z","timestamp":1782969356000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/16\/10\/8487-8498\/909120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":50,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,2,11]]}},"URL":"https:\/\/doi.org\/10.1039\/d5ra08382f","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}