{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:03:32Z","timestamp":1791475412042,"version":"4.3.4"},"reference-count":69,"publisher":"Royal Society of Chemistry (RSC)","issue":"1","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>The study focused on the development of new quinazoline hybrid antimalarials, emphasising the significance of the molecular hybridisation approach and identifying potent hit molecules for the development of new antimalarials.<\/jats:p>","DOI":"10.1039\/d5ra08515b","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T10:40:12Z","timestamp":1767350412000},"page":"617-641","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Development of substituted 2-(4-(sulfonyl)piperazin-1-yl)quinazoline molecular hybrids as a new class of antimalarials"],"prefix":"10.1039","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4992-096X","authenticated-orcid":false,"given":"Hari","family":"Madhav","sequence":"first","affiliation":[{"name":"Drug Design and Synthesis Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi-110025, India"},{"name":"International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi-110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Panda","sequence":"additional","affiliation":[{"name":"International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi-110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipanwita","family":"Datta","sequence":"additional","affiliation":[{"name":"International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi-110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kashfa","family":"Shaheen","sequence":"additional","affiliation":[{"name":"Drug Design and Synthesis Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi-110025, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi-110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azhar Tariq","family":"Khan","sequence":"additional","affiliation":[{"name":"Drug Design and Synthesis Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi-110025, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souvik","family":"Bhattacharjee","sequence":"additional","affiliation":[{"name":"Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi-110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhiraj","family":"Kumar","sequence":"additional","affiliation":[{"name":"International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi-110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawan","family":"Malhotra","sequence":"additional","affiliation":[{"name":"International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi-110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9779-2056","authenticated-orcid":false,"given":"Nasimul","family":"Hoda","sequence":"additional","affiliation":[{"name":"Drug Design and Synthesis Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi-110025, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5RA08515B\/cit1\/1","doi-asserted-by":"crossref","DOI":"10.30875\/9789287076717","volume-title":"World Malaria Report 2024: Addressing Inequity in the Global Malaria Response","author":"World Health Organisation","year":"2024","unstructured":"World Health Organisation ,  World Malaria Report 2024: Addressing Inequity in the Global Malaria Response ,  Geneva ,  2024"},{"key":"D5RA08515B\/cit2\/1","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1111\/bcp.14474","volume":"88","author":"Hanboonkunupakarn","year":"2022","journal-title":"Br. J. Clin. Pharmacol."},{"key":"D5RA08515B\/cit3\/1","doi-asserted-by":"publisher","first-page":"112955","DOI":"10.1016\/j.ejmech.2020.112955","volume":"210","author":"Madhav","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"D5RA08515B\/cit4\/1","doi-asserted-by":"publisher","first-page":"2678","DOI":"10.1038\/s41467-022-30133-w","volume":"13","author":"Jagannathan","year":"2022","journal-title":"Nat. Commun."},{"key":"D5RA08515B\/cit5\/1","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1016\/S0140-6736(20)30552-3","volume":"395","author":"van der Pluijm","year":"2020","journal-title":"Lancet"},{"key":"D5RA08515B\/cit6\/1","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1016\/S1473-3099(21)00692-7","volume":"22","author":"Peto","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"D5RA08515B\/cit7\/1","doi-asserted-by":"publisher","first-page":"105359","DOI":"10.1016\/j.bioorg.2021.105359","volume":"117","author":"Ashton","year":"2021","journal-title":"Bioorg. Chem."},{"key":"D5RA08515B\/cit8\/1","doi-asserted-by":"publisher","first-page":"112996","DOI":"10.1016\/j.ejmech.2020.112996","volume":"212","author":"Malasala","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"D5RA08515B\/cit9\/1","doi-asserted-by":"publisher","first-page":"20386","DOI":"10.1039\/D1NJ03749H","volume":"45","author":"Al Neyadi","year":"2021","journal-title":"New J. Chem."},{"key":"D5RA08515B\/cit10\/1","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1039\/C7MD00097A","volume":"8","author":"Shagufta","year":"2017","journal-title":"Medchemcomm"},{"key":"D5RA08515B\/cit11\/1","doi-asserted-by":"publisher","first-page":"116018","DOI":"10.1016\/j.bmc.2021.116018","volume":"33","author":"Mizukawa","year":"2021","journal-title":"Bioorg. Med. Chem."},{"issue":"9","key":"D5RA08515B\/cit12\/1","doi-asserted-by":"publisher","first-page":"4413","DOI":"10.1021\/acsabm.2c00562","volume":"5","author":"Dutta","year":"2022","journal-title":"ACS Appl. Bio Mater."},{"key":"D5RA08515B\/cit13\/1","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1021\/acs.jmedchem.6b01673","volume":"60","author":"Gilson","year":"2017","journal-title":"J. Med. Chem."},{"key":"D5RA08515B\/cit14\/1","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.ejmech.2018.10.041","volume":"161","author":"Bouchut","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"D5RA08515B\/cit15\/1","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.1021\/acsomega.7b00310","volume":"2","author":"Fr\u00f6hlich","year":"2017","journal-title":"ACS Omega"},{"key":"D5RA08515B\/cit16\/1","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.dcmed.2021.12.004","volume":"4","author":"Shntaif","year":"2021","journal-title":"Digit. Chinese Med."},{"key":"D5RA08515B\/cit17\/1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ejmech.2018.05.034","volume":"155","author":"Peerzada","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"D5RA08515B\/cit18\/1","doi-asserted-by":"publisher","first-page":"4295","DOI":"10.1016\/j.bmc.2011.05.056","volume":"19","author":"de Oliveira","year":"2011","journal-title":"Bioorg. Med. Chem."},{"issue":"5","key":"D5RA08515B\/cit19\/1","doi-asserted-by":"publisher","first-page":"e202103908","DOI":"10.1002\/slct.202103908","volume":"7","author":"Ezugwu","year":"2022","journal-title":"ChemistrySelect"},{"key":"D5RA08515B\/cit20\/1","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1080\/14756366.2018.1477137","volume":"33","author":"Sabt","year":"2018","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D5RA08515B\/cit21\/1","doi-asserted-by":"publisher","first-page":"6828","DOI":"10.1128\/AAC.03644-14","volume":"58","author":"Papadopoulou","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"D5RA08515B\/cit22\/1","doi-asserted-by":"publisher","first-page":"31854","DOI":"10.1021\/acsomega.1c04552","volume":"6","author":"Pingaew","year":"2021","journal-title":"ACS Omega"},{"key":"D5RA08515B\/cit23\/1","doi-asserted-by":"publisher","first-page":"4485","DOI":"10.3390\/molecules25194485","volume":"25","author":"Karpina","year":"2020","journal-title":"Molecules"},{"key":"D5RA08515B\/cit24\/1","doi-asserted-by":"publisher","first-page":"489","DOI":"10.2165\/11203790-000000000-00000","volume":"70","author":"Dhillon","year":"2010","journal-title":"Drugs"},{"key":"D5RA08515B\/cit25\/1","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.ejmech.2018.11.018","volume":"163","author":"Xing","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"D5RA08515B\/cit26\/1","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.apsb.2020.06.003","volume":"11","author":"Chang","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"D5RA08515B\/cit27\/1","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.ejmech.2015.10.005","volume":"105","author":"Jiang","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"D5RA08515B\/cit28\/1","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1007\/s11030-021-10190-x","volume":"26","author":"Patil","year":"2022","journal-title":"Mol. Divers."},{"key":"D5RA08515B\/cit29\/1","doi-asserted-by":"publisher","first-page":"132407","DOI":"10.1016\/j.molstruc.2022.132407","volume":"1255","author":"Raveesha","year":"2022","journal-title":"J. Mol. Struct."},{"key":"D5RA08515B\/cit30\/1","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/ja.2010.161","volume":"64","author":"Shan","year":"2011","journal-title":"J. Antibiot."},{"key":"D5RA08515B\/cit31\/1","doi-asserted-by":"publisher","first-page":"2746","DOI":"10.1021\/jm501929n","volume":"58","author":"Lawrence","year":"2015","journal-title":"J. Med. Chem."},{"key":"D5RA08515B\/cit32\/1","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1080\/14756366.2021.2015344","volume":"37","author":"Elbadawi","year":"2022","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D5RA08515B\/cit33\/1","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1007\/s00044-014-1194-7","volume":"24","author":"Balam","year":"2015","journal-title":"Med. Chem. Res."},{"key":"D5RA08515B\/cit34\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/07391102.2023.2188959","author":"Jameel","year":"2023","journal-title":"J. Biomol. Struct. Dyn."},{"key":"D5RA08515B\/cit35\/1","doi-asserted-by":"publisher","first-page":"7876","DOI":"10.3390\/molecules28237876","volume":"28","author":"Hu","year":"2023","journal-title":"Molecules"},{"key":"D5RA08515B\/cit36\/1","doi-asserted-by":"publisher","first-page":"M1173","DOI":"10.3390\/M1173","volume":"2020","author":"Raveesha","year":"2020","journal-title":"Molbank"},{"key":"D5RA08515B\/cit37\/1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00249-17","volume":"61","author":"Agarwal","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"D5RA08515B\/cit38\/1","doi-asserted-by":"publisher","first-page":"2421","DOI":"10.3390\/molecules26092421","volume":"26","author":"Johnson","year":"2021","journal-title":"Molecules"},{"key":"D5RA08515B\/cit39\/1","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1093\/nar\/gki317","volume":"33","author":"Mignon","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"D5RA08515B\/cit40\/1","doi-asserted-by":"publisher","first-page":"4384","DOI":"10.1073\/pnas.0307720101","volume":"101","author":"Sijwali","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D5RA08515B\/cit41\/1","doi-asserted-by":"publisher","first-page":"4968","DOI":"10.1128\/AAC.00882-09","volume":"53","author":"Moura","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"D5RA08515B\/cit42\/1","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.pt.2022.02.010","volume":"38","author":"Matz","year":"2022","journal-title":"Trends Parasitol."},{"key":"D5RA08515B\/cit43\/1","doi-asserted-by":"publisher","first-page":"e1000053","DOI":"10.1371\/journal.ppat.1000053","volume":"4","author":"Jani","year":"2008","journal-title":"PLoS Pathog."},{"key":"D5RA08515B\/cit44\/1","doi-asserted-by":"publisher","first-page":"3010","DOI":"10.2174\/0929867327666200730215316","volume":"28","author":"Ettari","year":"2021","journal-title":"Curr. Med. Chem."},{"key":"D5RA08515B\/cit45\/1","doi-asserted-by":"publisher","first-page":"14910","DOI":"10.1074\/jbc.M109680200","volume":"277","author":"Sijwali","year":"2002","journal-title":"J. Biol. Chem."},{"key":"D5RA08515B\/cit46\/1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3389\/fmicb.2019.00394","volume":"10","author":"Mishra","year":"2019","journal-title":"Front. Microbiol."},{"key":"D5RA08515B\/cit47\/1","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1038\/s42003-024-06774-6","volume":"7","author":"Lin","year":"2024","journal-title":"Commun. Biol."},{"key":"D5RA08515B\/cit48\/1","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.chembiol.2024.03.002","volume":"31","author":"Wirjanata","year":"2024","journal-title":"Cell Chem. Biol."},{"key":"D5RA08515B\/cit49\/1","doi-asserted-by":"publisher","first-page":"128394","DOI":"10.1016\/j.bmcl.2021.128394","volume":"52","author":"Eagon","year":"2021","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D5RA08515B\/cit50\/1","doi-asserted-by":"publisher","first-page":"127683","DOI":"10.1016\/j.bmcl.2020.127683","volume":"32","author":"Kahlon","year":"2021","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D5RA08515B\/cit51\/1","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1021\/acs.jcim.0c00057","volume":"60","author":"Guterres","year":"2020","journal-title":"J. Chem. Inf. Model."},{"key":"D5RA08515B\/cit52\/1","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1021\/acs.jcim.9b00843","volume":"60","author":"Fusani","year":"2020","journal-title":"J. Chem. Inf. Model."},{"key":"D5RA08515B\/cit53\/1","doi-asserted-by":"publisher","first-page":"115354","DOI":"10.1016\/j.ejmech.2023.115354","volume":"254","author":"Madhav","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"D5RA08515B\/cit54\/1","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1007\/s00018-009-0014-6","volume":"66","author":"Teilum","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"D5RA08515B\/cit55\/1","doi-asserted-by":"publisher","first-page":"21606","DOI":"10.1021\/jacs.2c08885","volume":"144","author":"Fatima","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"D5RA08515B\/cit56\/1","doi-asserted-by":"publisher","first-page":"5538","DOI":"10.1038\/s41467-024-49858-x","volume":"15","author":"Song","year":"2024","journal-title":"Nat. Commun."},{"key":"D5RA08515B\/cit57\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/1178228","volume":"2022","author":"Fatriansyah","year":"2022","journal-title":"J. Trop. Med."},{"key":"D5RA08515B\/cit58\/1","doi-asserted-by":"publisher","first-page":"118901","DOI":"10.1016\/j.molliq.2022.118901","volume":"354","author":"Ghahremanian","year":"2022","journal-title":"J. Mol. Liq."},{"key":"D5RA08515B\/cit59\/1","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/s42003-022-03416-7","volume":"5","author":"Yasuda","year":"2022","journal-title":"Commun. Biol."},{"key":"D5RA08515B\/cit60\/1","doi-asserted-by":"publisher","first-page":"195025","DOI":"10.1016\/j.bbagrm.2024.195025","volume":"1867","author":"Yu","year":"2024","journal-title":"Biochim. Biophys. Acta - Gene Regul. Mech."},{"key":"D5RA08515B\/cit61\/1","doi-asserted-by":"publisher","first-page":"7192","DOI":"10.3390\/molecules26237192","volume":"26","author":"De Vita","year":"2021","journal-title":"Molecules"},{"key":"D5RA08515B\/cit62\/1","doi-asserted-by":"publisher","first-page":"113224","DOI":"10.1016\/j.ejmech.2021.113224","volume":"215","author":"Manzoor","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"D5RA08515B\/cit63\/1","doi-asserted-by":"publisher","first-page":"103086","DOI":"10.1016\/j.bioorg.2019.103086","volume":"90","author":"Hu","year":"2019","journal-title":"Bioorg. Chem."},{"key":"D5RA08515B\/cit64\/1","doi-asserted-by":"publisher","first-page":"104514","DOI":"10.1016\/j.bioorg.2020.104514","author":"Singh","year":"2020","journal-title":"Bioorg. Chem."},{"key":"D5RA08515B\/cit65\/1","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1128\/AAC.48.5.1803-1806.2004","volume":"48","author":"Smilkstein","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"D5RA08515B\/cit66\/1","doi-asserted-by":"publisher","first-page":"115055","DOI":"10.1016\/j.ejmech.2022.115055","volume":"248","author":"Pal","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"D5RA08515B\/cit67\/1","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1021\/ci800324m","volume":"49","author":"Halgren","year":"2009","journal-title":"J. Chem. Inf. Model."},{"key":"D5RA08515B\/cit68\/1","doi-asserted-by":"publisher","first-page":"6177","DOI":"10.1021\/jm051256o","volume":"49","author":"Friesner","year":"2006","journal-title":"J. Med. Chem."},{"key":"D5RA08515B\/cit69\/1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41598-023-50992-7","volume":"14","author":"Pandya","year":"2024","journal-title":"Sci. Rep."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/RA\/D5RA08515B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:55:44Z","timestamp":1782881744000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/16\/1\/617-641\/909159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12,22]]}},"URL":"https:\/\/doi.org\/10.1039\/d5ra08515b","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}