{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:51:44Z","timestamp":1789689104150,"version":"4.0.1"},"reference-count":76,"publisher":"Royal Society of Chemistry (RSC)","issue":"22","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":126,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>A fluorescence polarisation binding assay for Tet(X), an emerging tetracycline antibiotic resistance mechanism, was developed. Application of the assay resulted in the discovery of inhibitors with novel binding modes.<\/jats:p>","DOI":"10.1039\/d5sc00964b","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T05:44:37Z","timestamp":1746596677000},"page":"9691-9704","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Binding assays enable discovery of Tet(X) inhibitors that combat tetracycline destructase resistance"],"prefix":"10.1039","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4416-4037","authenticated-orcid":false,"given":"Matthew J.","family":"Beech","sequence":"first","affiliation":[{"name":"Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, OX1 3TA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5717-2926","authenticated-orcid":false,"given":"Edmond C.","family":"Toma","sequence":"additional","affiliation":[{"name":"Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, OX1 3TA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8286-2856","authenticated-orcid":false,"given":"Helen G.","family":"Smith","sequence":"additional","affiliation":[{"name":"Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, OX1 3TA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5462-7026","authenticated-orcid":false,"given":"Maria M.","family":"Trush","sequence":"additional","affiliation":[{"name":"Department of Biology and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, OX1 3RE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jit H. J.","family":"Ang","sequence":"additional","affiliation":[{"name":"Experimental Drug Development Centre (EDDC), Agency for Science, Technology and Research (A*STAR), 10, Biopolis Road, Singapore 138670, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei Y.","family":"Wong","sequence":"additional","affiliation":[{"name":"Experimental Drug Development Centre (EDDC), Agency for Science, Technology and Research (A*STAR), 10, Biopolis Road, Singapore 138670, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung H. J.","family":"Wong","sequence":"additional","affiliation":[{"name":"Experimental Drug Development Centre (EDDC), Agency for Science, Technology and Research (A*STAR), 10, Biopolis Road, Singapore 138670, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5770-5376","authenticated-orcid":false,"given":"Hafiz S.","family":"Ali","sequence":"additional","affiliation":[{"name":"Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, OX1 3TA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakia","family":"Butt","sequence":"additional","affiliation":[{"name":"Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, OX1 3TA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viha","family":"Goel","sequence":"additional","affiliation":[{"name":"Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, OX1 3TA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6062-8209","authenticated-orcid":false,"given":"Fernanda","family":"Duarte","sequence":"additional","affiliation":[{"name":"Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, OX1 3TA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5578-6790","authenticated-orcid":false,"given":"Alistair J. M.","family":"Farley","sequence":"additional","affiliation":[{"name":"Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, OX1 3TA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4315-4096","authenticated-orcid":false,"given":"Timothy R.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Biology and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, OX1 3RE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0290-6565","authenticated-orcid":false,"given":"Christopher J.","family":"Schofield","sequence":"additional","affiliation":[{"name":"Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, OX1 3TA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5SC00964B\/cit1\/1","doi-asserted-by":"crossref","first-page":"e893","DOI":"10.1016\/S2542-5196(21)00280-1","volume":"5","author":"Browne","year":"2021","journal-title":"Lancet Planet. Health"},{"key":"D5SC00964B\/cit2\/1","volume-title":"WHO Model List of Essential Medicines \u2013 23rd List WHO\/MHP\/HPS\/EML\/2023.02","year":"2023","unstructured":"WHO Model List of Essential Medicines \u2013 23rd List WHO\/MHP\/HPS\/EML\/2023.02 ,  World Health Organization ,  Geneva ,  2023"},{"key":"D5SC00964B\/cit3\/1","doi-asserted-by":"crossref","first-page":"e1315497","DOI":"10.1155\/2017\/1315497","volume":"2017","author":"Granados-Chinchilla","year":"2017","journal-title":"J. Anal. Methods Chem."},{"key":"D5SC00964B\/cit4\/1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1128\/MMBR.65.2.232-260.2001","volume":"65","author":"Chopra","year":"2001","journal-title":"Microbiol. Mol. Biol."},{"key":"D5SC00964B\/cit5\/1","doi-asserted-by":"crossref","first-page":"a025387","DOI":"10.1101\/cshperspect.a025387","volume":"6","author":"Grossman","year":"2016","journal-title":"Cold Spring Harbor Perspect. Med."},{"key":"D5SC00964B\/cit6\/1","doi-asserted-by":"crossref","first-page":"5401","DOI":"10.1073\/pnas.1501775112","volume":"112","author":"Arenz","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D5SC00964B\/cit7\/1","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1038\/s41594-023-01047-y","volume":"30","author":"Paternoga","year":"2023","journal-title":"Nat. Struct. Mol. Biol."},{"key":"D5SC00964B\/cit8\/1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/s12915-021-01199-7","volume":"19","author":"Cheng","year":"2021","journal-title":"BMC Biol."},{"key":"D5SC00964B\/cit9\/1","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1128\/AAC.47.12.3675-3681.2003","volume":"47","author":"Connell","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"D5SC00964B\/cit10\/1","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.2146\/ajhp050487","volume":"63","author":"Kasbekar","year":"2006","journal-title":"Am. J. Health-Syst. Pharm."},{"key":"D5SC00964B\/cit11\/1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s40265-020-01257-4","volume":"80","author":"Zhanel","year":"2020","journal-title":"Drugs"},{"key":"D5SC00964B\/cit12\/1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s40265-016-0545-8","volume":"76","author":"Zhanel","year":"2016","journal-title":"Drugs"},{"key":"D5SC00964B\/cit13\/1","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.1073\/pnas.1216691110","volume":"110","author":"Jenner","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"D5SC00964B\/cit14\/1","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/S1473-3099(11)70177-3","volume":"11","author":"Tasina","year":"2011","journal-title":"Lancet Infect. Dis."},{"key":"D5SC00964B\/cit15\/1","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1128\/AAC.06187-11","volume":"56","author":"Grossman","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"D5SC00964B\/cit16\/1","doi-asserted-by":"crossref","first-page":"52346","DOI":"10.1074\/jbc.M409573200","volume":"279","author":"Yang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"D5SC00964B\/cit17\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-022-04154-6","volume":"6","author":"Kumar","year":"2023","journal-title":"Commun. Biol."},{"key":"D5SC00964B\/cit18\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-024-06023-w","volume":"7","author":"Blake","year":"2024","journal-title":"Commun. Biol."},{"key":"D5SC00964B\/cit19\/1","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.chembiol.2015.05.017","volume":"22","author":"Forsberg","year":"2015","journal-title":"Chem. Biol."},{"key":"D5SC00964B\/cit20\/1","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nchembio.2376","volume":"13","author":"Park","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"D5SC00964B\/cit21\/1","doi-asserted-by":"crossref","first-page":"11829","DOI":"10.1021\/bi0506066","volume":"44","author":"Moore","year":"2005","journal-title":"Biochemistry"},{"key":"D5SC00964B\/cit22\/1","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/s41564-019-0496-4","volume":"4","author":"Sun","year":"2019","journal-title":"Nat. Microbiol."},{"key":"D5SC00964B\/cit23\/1","doi-asserted-by":"crossref","first-page":"147613","DOI":"10.1016\/j.scitotenv.2021.147613","volume":"787","author":"Mohsin","year":"2021","journal-title":"Sci. Total Environ."},{"key":"D5SC00964B\/cit24\/1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01326-19","volume":"64","author":"Wang","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"D5SC00964B\/cit25\/1","doi-asserted-by":"crossref","first-page":"e01081","DOI":"10.1128\/spectrum.01081-21","volume":"10","author":"Zhai","year":"2022","journal-title":"Microbiol. Spectrum"},{"key":"D5SC00964B\/cit26\/1","first-page":"e02283","volume":"10","author":"Dong","year":"2022","journal-title":"Microbiol. Spectrum"},{"key":"D5SC00964B\/cit27\/1","first-page":"e00196","volume":"10","author":"Lu","year":"2022","journal-title":"Microbiol. Spectrum"},{"key":"D5SC00964B\/cit28\/1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1031688","volume":"13","author":"Shafiq","year":"2022","journal-title":"Front. Microbiol."},{"key":"D5SC00964B\/cit29\/1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1128\/AAC.01727-13","volume":"58","author":"Deng","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"D5SC00964B\/cit30\/1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ijantimicag.2013.04.014","volume":"42","author":"Leski","year":"2013","journal-title":"Int. J. Antimicrob. Agents"},{"key":"D5SC00964B\/cit31\/1","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.3390\/antibiotics10101239","volume":"10","author":"Hsieh","year":"2021","journal-title":"Antibiotics"},{"key":"D5SC00964B\/cit32\/1","doi-asserted-by":"crossref","first-page":"2400019","DOI":"10.2807\/1560-7917.ES.2024.29.28.2400019","volume":"29","author":"Talsma","year":"2024","journal-title":"Eurosurveillance"},{"key":"D5SC00964B\/cit33\/1","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1021\/acsinfecdis.8b00349","volume":"5","author":"Markley","year":"2019","journal-title":"ACS Infect. Dis."},{"key":"D5SC00964B\/cit34\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-020-0966-5","volume":"3","author":"Gasparrini","year":"2020","journal-title":"Commun. Biol."},{"key":"D5SC00964B\/cit35\/1","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1016\/j.jmb.2019.04.002","volume":"431","author":"Tooke","year":"2019","journal-title":"J. Mol. Biol."},{"key":"D5SC00964B\/cit36\/1","doi-asserted-by":"crossref","first-page":"a025247","DOI":"10.1101\/cshperspect.a025247","volume":"6","author":"Bush","year":"2016","journal-title":"Cold Spring Harbor Perspect. Med."},{"key":"D5SC00964B\/cit37\/1","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1021\/acs.jmedchem.2c01629","volume":"66","author":"Williford","year":"2023","journal-title":"J. Med. Chem."},{"key":"D5SC00964B\/cit38\/1","doi-asserted-by":"crossref","first-page":"103943","DOI":"10.1016\/j.ebiom.2022.103943","volume":"78","author":"Xu","year":"2022","journal-title":"eBioMedicine"},{"key":"D5SC00964B\/cit39\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s44280-023-00030-y","volume":"2","author":"Xu","year":"2024","journal-title":"One Health Adv."},{"key":"D5SC00964B\/cit40\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-019-0734-6","volume":"3","author":"Liu","year":"2020","journal-title":"Commun. Biol."},{"key":"D5SC00964B\/cit41\/1","first-page":"e01578","volume":"10","author":"Deng","year":"2022","journal-title":"Microbiol. Spectrum"},{"key":"D5SC00964B\/cit42\/1","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1107\/S0907444913013802","volume":"69","author":"Volkers","year":"2013","journal-title":"Acta Crystallogr., Sect. D:Biol. Crystallogr."},{"key":"D5SC00964B\/cit43\/1","doi-asserted-by":"crossref","first-page":"6558","DOI":"10.1016\/j.bmcl.2007.09.077","volume":"17","author":"Chen","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D5SC00964B\/cit44\/1","doi-asserted-by":"crossref","DOI":"10.1002\/9781119007104","volume-title":"Handbook of Fluorescent Dyes and Probes","author":"Sabnis","year":"2015","unstructured":"R. W.Sabnis ,  Handbook of Fluorescent Dyes and Probes ,  Wiley ,  New Jersey ,  2015"},{"key":"D5SC00964B\/cit45\/1","doi-asserted-by":"crossref","first-page":"022001","DOI":"10.1088\/2050-6120\/4\/2\/022001","volume":"4","author":"Hall","year":"2016","journal-title":"Methods Appl. Fluoresc."},{"key":"D5SC00964B\/cit46\/1","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.febslet.2011.03.012","volume":"585","author":"Volkers","year":"2011","journal-title":"FEBS Lett."},{"key":"D5SC00964B\/cit47\/1","doi-asserted-by":"crossref","first-page":"969769","DOI":"10.3389\/fmicb.2022.969769","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Microbiol."},{"key":"D5SC00964B\/cit48\/1","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1111\/j.1476-5381.2010.01127.x","volume":"162","author":"Hughes","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"D5SC00964B\/cit49\/1","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/s42003-021-02743-5","volume":"4","author":"Liu","year":"2021","journal-title":"Commun. Biol."},{"key":"D5SC00964B\/cit50\/1","doi-asserted-by":"crossref","first-page":"17913","DOI":"10.1021\/ja806629e","volume":"130","author":"Sun","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"D5SC00964B\/cit51\/1","doi-asserted-by":"crossref","first-page":"5838","DOI":"10.1021\/jo030047d","volume":"68","author":"Nelson","year":"2003","journal-title":"J. Org. Chem."},{"key":"D5SC00964B\/cit52\/1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1021\/jm00055a008","volume":"36","author":"Nelson","year":"1993","journal-title":"J. Med. Chem."},{"key":"D5SC00964B\/cit53\/1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.dnarep.2010.11.007","volume":"10","author":"Cooper","year":"2011","journal-title":"DNA Repair"},{"key":"D5SC00964B\/cit54\/1","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1016\/j.apsb.2021.02.023","volume":"11","author":"Sun","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"D5SC00964B\/cit55\/1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1107\/S2059798316018210","volume":"73","author":"Liebschner","year":"2017","journal-title":"Acta Crystallogr., Sect. D: Struct. Biol."},{"key":"D5SC00964B\/cit56\/1","doi-asserted-by":"crossref","first-page":"4230","DOI":"10.3390\/molecules26144230","volume":"26","author":"Santi","year":"2021","journal-title":"Molecules"},{"key":"D5SC00964B\/cit57\/1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0301-2115(98)00278-4","volume":"85","author":"Hochner-Celnikier","year":"1999","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"D5SC00964B\/cit58\/1","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1517\/13543784.16.5.705","volume":"16","author":"Crockett","year":"2007","journal-title":"Expert Opin. Investig. Drugs"},{"key":"D5SC00964B\/cit59\/1","doi-asserted-by":"crossref","first-page":"7086","DOI":"10.1128\/AAC.01474-16","volume":"60","author":"Tsiang","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"D5SC00964B\/cit60\/1","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1046\/j.1365-2036.2001.01094.x","volume":"15","author":"M\u00fcller-Lissner","year":"2001","journal-title":"Aliment. Pharmacol."},{"key":"D5SC00964B\/cit61\/1","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.2174\/138945006778226552","volume":"7","author":"Mitchell","year":"2006","journal-title":"Curr. Drug Targets"},{"key":"D5SC00964B\/cit62\/1","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.3389\/fmicb.2018.01058","volume":"9","author":"Markley","year":"2018","journal-title":"Front. Microbiol."},{"key":"D5SC00964B\/cit63\/1","doi-asserted-by":"crossref","first-page":"W530","DOI":"10.1093\/nar\/gkab294","volume":"49","author":"Adasme","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"D5SC00964B\/cit64\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jac\/dkg301","volume":"52","author":"Odds","year":"2003","journal-title":"J. Antimicrob. Chemother."},{"key":"D5SC00964B\/cit65\/1","doi-asserted-by":"crossref","first-page":"e0189950","DOI":"10.1371\/journal.pone.0189950","volume":"13","author":"Nehme","year":"2018","journal-title":"PLoS One"},{"key":"D5SC00964B\/cit66\/1","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/ja.2017.65","volume":"70","author":"Lacriola","year":"2017","journal-title":"J. Antibiot."},{"key":"D5SC00964B\/cit67\/1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41564-019-0357-1","volume":"4","author":"Farha","year":"2019","journal-title":"Nat. Microbiol."},{"key":"D5SC00964B\/cit68\/1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1126\/science.adk7368","volume":"384","author":"Noto Guillen","year":"2024","journal-title":"Science"},{"key":"D5SC00964B\/cit69\/1","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1002\/prot.23052","volume":"79","author":"Walkiewicz","year":"2011","journal-title":"Proteins"},{"key":"D5SC00964B\/cit70\/1","doi-asserted-by":"crossref","first-page":"16928","DOI":"10.1039\/D4SC04937C","volume":"15","author":"Smith","year":"2024","journal-title":"Chem. Sci."},{"key":"D5SC00964B\/cit71\/1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1107\/S2059798320003198","volume":"76","author":"Beilsten-Edmands","year":"2020","journal-title":"Acta Crystallogr., Sect. D:Biol. Crystallogr."},{"key":"D5SC00964B\/cit72\/1","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1107\/S2059798319011471","volume":"75","author":"Liebschner","year":"2019","journal-title":"Acta Crystallogr., Sect. D: Struct. Biol."},{"key":"D5SC00964B\/cit73\/1","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr., Sect. D:Biol. Crystallogr."},{"key":"D5SC00964B\/cit74\/1","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing","author":"Lewis","year":"2025","unstructured":"J. S.Lewis ,  A. J.Mathers ,  A. M.Bobenchik ,  A. L.Bryson ,  S.Campeau ,  S. K.Cullen ,  T.Dingle ,  G.Esparza ,  R. M.Humphries ,  T. J.Kirn ,  J.Lutgring ,  N.Narayanan ,  E.Palavecino ,  V. M.Pierce ,  A. N.Schuetz ,  S.Sharp ,  P. J.Simner ,  P. D.Tamma  and  M. P.Weinstein ,  Performance Standards for Antimicrobial Susceptibility Testing ,  Clinical and Laboratory Standards Institute ,  Malvern , 35th edn,  2025"},{"key":"D5SC00964B\/cit75\/1","doi-asserted-by":"crossref","first-page":"5421","DOI":"10.1046\/j.1432-1327.2000.01606.x","volume":"267","author":"O'Brien","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"D5SC00964B\/cit76\/1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1093\/infdis\/137.2.122","volume":"137","author":"Berenbaum","year":"1978","journal-title":"J. Infect. Dis."}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/SC\/D5SC00964B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:57:46Z","timestamp":1783533466000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/sc\/article\/16\/22\/9691-9704\/909987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":76,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2025,6,4]]}},"URL":"https:\/\/doi.org\/10.1039\/d5sc00964b","relation":{},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}