{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:20:38Z","timestamp":1783448438653,"version":"3.55.0"},"reference-count":63,"publisher":"Royal Society of Chemistry (RSC)","issue":"28","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":173,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20H00416"],"award-info":[{"award-number":["20H00416"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25H00924"],"award-info":[{"award-number":["25H00924"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23H04564"],"award-info":[{"award-number":["23H04564"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25H01597"],"award-info":[{"award-number":["25H01597"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21J01340"],"award-info":[{"award-number":["21J01340"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"The Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22ama121001"],"award-info":[{"award-number":["JP22ama121001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004595","name":"Universiti Sains Malaysia","doi-asserted-by":"publisher","award":["000723"],"award-info":[{"award-number":["000723"]}],"id":[{"id":"10.13039\/501100004595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>\n                    Spiroacetal rearrangement of reveromycin significantly reduces its biological potency. This study developed novel reveromycins with improved stability\n                    <jats:italic>via<\/jats:italic>\n                    P450 engineering and synthetic biological approaches.\n                  <\/jats:p>","DOI":"10.1039\/d5sc01355k","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T04:07:13Z","timestamp":1750651633000},"page":"13106-13114","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Biosynthesis of reveromycin derivatives by altering the regioselectivity of cytochrome P450revI"],"prefix":"10.1039","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8979-1771","authenticated-orcid":false,"given":"Ya Fen","family":"Yong","sequence":"first","affiliation":[{"name":"Natural Product Biosynthesis Research Unit, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan"},{"name":"Institute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Liu","sequence":"additional","affiliation":[{"name":"Natural Product Biosynthesis Research Unit, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan"},{"name":"Science Center for Future Foods, Jiangnan University, Lihu Ave. 1800, Wuxi, Jiangsu 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9210-6176","authenticated-orcid":false,"given":"Katsuyuki","family":"Sakai","sequence":"additional","affiliation":[{"name":"Natural Product Biosynthesis Research Unit, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0960-353X","authenticated-orcid":false,"given":"Keisuke","family":"Fujiyama","sequence":"additional","affiliation":[{"name":"Natural Product Biosynthesis Research Unit, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Takagi","sequence":"additional","affiliation":[{"name":"Natural Product Biosynthesis Research Unit, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4224-6944","authenticated-orcid":false,"given":"Yushi","family":"Futamura","sequence":"additional","affiliation":[{"name":"Chemical Resource Development Research Unit and Drug Discovery Chemical Bank Unit, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan"},{"name":"Institute of Microbial Chemistry, Shinagawa, Tokyo 141-0021, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Chemical Resource Development Research Unit and Drug Discovery Chemical Bank Unit, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3606-4925","authenticated-orcid":false,"given":"Hiroyuki","family":"Osada","sequence":"additional","affiliation":[{"name":"Chemical Resource Development Research Unit and Drug Discovery Chemical Bank Unit, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan"},{"name":"Institute of Microbial Chemistry, Shinagawa, Tokyo 141-0021, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6259-9029","authenticated-orcid":false,"given":"Eugene Boon Beng","family":"Ong","sequence":"additional","affiliation":[{"name":"Institute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1684-9298","authenticated-orcid":false,"given":"Shunji","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Natural Product Biosynthesis Research Unit, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5SC01355K\/cit1\/1","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"key":"D5SC01355K\/cit2\/1","doi-asserted-by":"crossref","first-page":"11882","DOI":"10.1039\/D1SC02725E","volume":"12","author":"Gro\u00df","year":"2021","journal-title":"Chem. Sci."},{"key":"D5SC01355K\/cit3\/1","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1021\/acs.jafc.0c05475","volume":"69","author":"Peng","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"D5SC01355K\/cit4\/1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ejmech.2016.02.020","volume":"112","author":"Zou","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"D5SC01355K\/cit5\/1","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1039\/D4NP00009A","volume":"41","author":"Ancajas","year":"2024","journal-title":"Nat. Prod. Rep."},{"key":"D5SC01355K\/cit6\/1","doi-asserted-by":"crossref","first-page":"9357","DOI":"10.1039\/C6RA28613E","volume":"7","author":"Menezes","year":"2017","journal-title":"RSC Adv."},{"key":"D5SC01355K\/cit7\/1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1126\/science.1155165","volume":"320","author":"White","year":"2008","journal-title":"Science"},{"key":"D5SC01355K\/cit8\/1","doi-asserted-by":"crossref","first-page":"112646","DOI":"10.1016\/j.ejmech.2020.112646","volume":"205","author":"Phang","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"D5SC01355K\/cit9\/1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.7164\/antibiotics.44.259","volume":"44","author":"Osada","year":"1991","journal-title":"J. Antibiot."},{"key":"D5SC01355K\/cit10\/1","first-page":"689","volume":"88","author":"Komaki","year":"2024","journal-title":"Biosci., Biotechnol., Biochem."},{"key":"D5SC01355K\/cit11\/1","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.7164\/antibiotics.45.1409","volume":"45","author":"Takahashi","year":"1992","journal-title":"J. Antibiot."},{"key":"D5SC01355K\/cit12\/1","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.7164\/antibiotics.45.1420","volume":"45","author":"Koshino","year":"1992","journal-title":"J. Antibiot."},{"key":"D5SC01355K\/cit13\/1","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1039\/C0OB00654H","volume":"9","author":"Fremlin","year":"2011","journal-title":"Org. Biomol. Chem."},{"issue":"16","key":"D5SC01355K\/cit14\/1","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1039\/c39940001877","author":"Ubukata","year":"1994","journal-title":"J. Chem. Soc., Chem. Commun."},{"key":"D5SC01355K\/cit15\/1","doi-asserted-by":"crossref","first-page":"4729","DOI":"10.1073\/pnas.0505663103","volume":"103","author":"Woo","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D5SC01355K\/cit16\/1","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1177\/0022034512451026","volume":"91","author":"Tanaka","year":"2012","journal-title":"J. Dent. Res."},{"key":"D5SC01355K\/cit17\/1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.ajodo.2013.04.016","volume":"144","author":"Yabumoto","year":"2013","journal-title":"Am. J. Orthod."},{"key":"D5SC01355K\/cit18\/1","doi-asserted-by":"crossref","first-page":"16510","DOI":"10.1038\/srep16510","volume":"5","author":"Mizuno","year":"2015","journal-title":"Sci. Rep."},{"key":"D5SC01355K\/cit19\/1","doi-asserted-by":"crossref","first-page":"15541","DOI":"10.1073\/pnas.0805354105","volume":"105","author":"Yano","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D5SC01355K\/cit20\/1","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.3324\/haematol.2019.244418","volume":"106","author":"Keiichiro","year":"2021","journal-title":"Haematologica"},{"key":"D5SC01355K\/cit21\/1","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.7164\/antibiotics.45.1414","volume":"45","author":"Takahashi","year":"1992","journal-title":"J. Antibiot."},{"key":"D5SC01355K\/cit22\/1","first-page":"550","volume":"8","author":"Lyu","year":"2017","journal-title":"Front. Microbiol."},{"key":"D5SC01355K\/cit23\/1","doi-asserted-by":"crossref","first-page":"28810","DOI":"10.1074\/jbc.M203827200","volume":"277","author":"Miyamoto","year":"2002","journal-title":"J. Biol. Chem."},{"key":"D5SC01355K\/cit24\/1","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1038\/s41467-021-21902-0","volume":"12","author":"Chen","year":"2021","journal-title":"Nat. Commun."},{"key":"D5SC01355K\/cit25\/1","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1016\/S0960-894X(02)00782-5","volume":"12","author":"Shimizu","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D5SC01355K\/cit26\/1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1021\/ol991290v","volume":"2","author":"Drouet","year":"2000","journal-title":"Org. Lett."},{"key":"D5SC01355K\/cit27\/1","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1021\/ol0060634","volume":"2","author":"Shimizu","year":"2000","journal-title":"Org. Lett."},{"key":"D5SC01355K\/cit28\/1","doi-asserted-by":"crossref","first-page":"6755","DOI":"10.1016\/S0040-4039(96)01460-8","volume":"37","author":"Shimizu","year":"1996","journal-title":"Tetrahedron Lett."},{"key":"D5SC01355K\/cit29\/1","doi-asserted-by":"crossref","first-page":"8591","DOI":"10.1016\/S0040-4039(00)01494-5","volume":"41","author":"El Sous","year":"2000","journal-title":"Tetrahedron Lett."},{"key":"D5SC01355K\/cit30\/1","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1055\/s-0030-1258308","volume":"2010","author":"El Sous","year":"2010","journal-title":"Synthesis"},{"key":"D5SC01355K\/cit31\/1","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1021\/jo962316o","volume":"62","author":"McRae","year":"1997","journal-title":"J. Org. Chem."},{"key":"D5SC01355K\/cit32\/1","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1021\/jo001646c","volume":"66","author":"Cuzzupe","year":"2001","journal-title":"J. Org. Chem."},{"key":"D5SC01355K\/cit33\/1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nchembio.583","volume":"7","author":"Takahashi","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"D5SC01355K\/cit34\/1","doi-asserted-by":"crossref","first-page":"32446","DOI":"10.1074\/jbc.M114.598391","volume":"289","author":"Takahashi","year":"2014","journal-title":"J. Biol. Chem."},{"key":"D5SC01355K\/cit35\/1","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1021\/ol048811l","volume":"6","author":"El Sous","year":"2004","journal-title":"Org. Lett."},{"key":"D5SC01355K\/cit36\/1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0021-9258(17)49939-X","volume":"295","author":"Li","year":"2020","journal-title":"J. Biol. Chem."},{"key":"D5SC01355K\/cit37\/1","doi-asserted-by":"crossref","first-page":"18695","DOI":"10.1021\/ja3073462","volume":"134","author":"Zhang","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"D5SC01355K\/cit38\/1","doi-asserted-by":"crossref","first-page":"8659","DOI":"10.1002\/anie.201310892","volume":"53","author":"Roiban","year":"2014","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5SC01355K\/cit39\/1","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1021\/acscatal.2c04906","volume":"13","author":"Zhang","year":"2023","journal-title":"ACS Catal."},{"key":"D5SC01355K\/cit40\/1","doi-asserted-by":"crossref","first-page":"24562","DOI":"10.1074\/jbc.M110.131904","volume":"285","author":"Cryle","year":"2010","journal-title":"J. Biol. Chem."},{"key":"D5SC01355K\/cit41\/1","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1021\/cb400555e","volume":"8","author":"Uhlmann","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"D5SC01355K\/cit42\/1","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1021\/cr9600316","volume":"97","author":"Staunton","year":"1997","journal-title":"Chem. Rev."},{"key":"D5SC01355K\/cit43\/1","first-page":"950","volume":"15","author":"Anzai","year":"2008","journal-title":"Cell Chem. Biol."},{"key":"D5SC01355K\/cit44\/1","first-page":"661","volume":"5","author":"Xue","year":"1998","journal-title":"Cell Chem. Biol."},{"key":"D5SC01355K\/cit45\/1","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1128\/AEM.72.4.2514-2519.2006","volume":"72","author":"Volokhan","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"key":"D5SC01355K\/cit46\/1","doi-asserted-by":"crossref","first-page":"36711","DOI":"10.1074\/jbc.M109.064683","volume":"284","author":"Zhao","year":"2009","journal-title":"J. Biol. Chem."},{"key":"D5SC01355K\/cit47\/1","first-page":"1633","volume":"22","author":"Huang","year":"2015","journal-title":"Cell Chem. Biol."},{"key":"D5SC01355K\/cit48\/1","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1002\/cbic.201000117","volume":"11","author":"Daum","year":"2010","journal-title":"ChemBioChem"},{"key":"D5SC01355K\/cit49\/1","doi-asserted-by":"crossref","first-page":"9559","DOI":"10.1039\/C8CC03165G","volume":"54","author":"Milan","year":"2018","journal-title":"Chem. Commun."},{"key":"D5SC01355K\/cit50\/1","doi-asserted-by":"crossref","first-page":"18161","DOI":"10.1021\/jacs.3c03422","volume":"145","author":"Stout","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"D5SC01355K\/cit51\/1","doi-asserted-by":"crossref","first-page":"e202303879","DOI":"10.1002\/anie.202303879","volume":"62","author":"Calv\u00f3-Tusell","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5SC01355K\/cit52\/1","doi-asserted-by":"crossref","first-page":"15673","DOI":"10.1021\/acscatal.3c04440","volume":"13","author":"Luo","year":"2023","journal-title":"ACS Catal."},{"key":"D5SC01355K\/cit53\/1","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1021\/acscatal.3c06137","volume":"14","author":"Chen","year":"2024","journal-title":"ACS Catal."},{"key":"D5SC01355K\/cit54\/1","doi-asserted-by":"crossref","first-page":"6307","DOI":"10.1039\/D1SC00317H","volume":"12","author":"Zhao","year":"2021","journal-title":"Chem. Sci."},{"key":"D5SC01355K\/cit55\/1","doi-asserted-by":"crossref","first-page":"8989","DOI":"10.1021\/jacs.9b02931","volume":"141","author":"Brandenberg","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"D5SC01355K\/cit56\/1","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1021\/acscatal.8b00389","volume":"8","author":"Acevedo-Rocha","year":"2018","journal-title":"ACS Catal."},{"key":"D5SC01355K\/cit57\/1","doi-asserted-by":"crossref","first-page":"e202204290","DOI":"10.1002\/anie.202204290","volume":"61","author":"Zhang","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5SC01355K\/cit58\/1","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1038\/s41467-023-37288-0","volume":"14","author":"Pan","year":"2023","journal-title":"Nat. Commun."},{"key":"D5SC01355K\/cit59\/1","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1002\/bit.28491","volume":"120","author":"Li","year":"2023","journal-title":"Biotechnol. Bioeng."},{"key":"D5SC01355K\/cit60\/1","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.copbio.2011.02.008","volume":"22","author":"Jung","year":"2011","journal-title":"Curr. Opin. Biotechnol."},{"key":"D5SC01355K\/cit61\/1","doi-asserted-by":"crossref","first-page":"31659","DOI":"10.1074\/jbc.M505261200","volume":"280","author":"Nagano","year":"2005","journal-title":"J. Biol. Chem."},{"key":"D5SC01355K\/cit62\/1","doi-asserted-by":"crossref","first-page":"eadc9249","DOI":"10.1126\/scitranslmed.adc9249","volume":"15","author":"Istvan","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"D5SC01355K\/cit63\/1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1172\/JCI113863","volume":"83","author":"Teti","year":"1989","journal-title":"J. Clin. Invest."}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/SC\/D5SC01355K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:11:16Z","timestamp":1783447876000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/sc\/article\/16\/28\/13106-13114\/910072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":63,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2025,7,16]]}},"URL":"https:\/\/doi.org\/10.1039\/d5sc01355k","relation":{},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}