{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:36:31Z","timestamp":1787726191508,"version":"build-2784847793"},"reference-count":56,"publisher":"Royal Society of Chemistry (RSC)","issue":"3","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["VI.Veni.232.338"],"award-info":[{"award-number":["VI.Veni.232.338"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>\n                    Radiation-generated organochloride-peroxyl radicals trigger the uncaging of boronic acid prodrugs. Amine catalysis further enhances yields and enables efficient\n                    <jats:italic>in vitro<\/jats:italic>\n                    activation of a gemcitabine prodrug at clinical radiation doses.\n                  <\/jats:p>","DOI":"10.1039\/d5sc03191e","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T10:00:58Z","timestamp":1763978458000},"page":"1752-1760","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Organochloride mediated prodrug activation induced by ionizing radiation"],"prefix":"10.1039","volume":"17","author":[{"given":"Juncheng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, Netherlands"},{"name":"Department of Radiation Science and Technology, Delft University of Technology, Mekelweg 15, 2629 JB Delft, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, Netherlands"},{"name":"Department of Radiation Science and Technology, Delft University of Technology, Mekelweg 15, 2629 JB Delft, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1639-5890","authenticated-orcid":false,"given":"Mark A. R.","family":"de Geus","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia G.","family":"Denkova","sequence":"additional","affiliation":[{"name":"Department of Radiation Science and Technology, Delft University of Technology, Mekelweg 15, 2629 JB Delft, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2626-6371","authenticated-orcid":false,"given":"Rienk","family":"Eelkema","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5SC03191E\/cit1\/1","doi-asserted-by":"crossref","first-page":"1900177","DOI":"10.1002\/adtp.201900177","volume":"3","author":"Denkova","year":"2020","journal-title":"Adv. Therap."},{"key":"D5SC03191E\/cit2\/1","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1002\/cmdc.201900324","volume":"14","author":"Matsushita","year":"2019","journal-title":"ChemMedChem"},{"key":"D5SC03191E\/cit3\/1","doi-asserted-by":"crossref","first-page":"103158","DOI":"10.1016\/j.bioorg.2019.103158","volume":"91","author":"Skarbek","year":"2019","journal-title":"Bioorg. Chem."},{"key":"D5SC03191E\/cit4\/1","first-page":"dju403","volume":"107","author":"Lee","year":"2015","journal-title":"J. Natl. Cancer Inst."},{"key":"D5SC03191E\/cit5\/1","doi-asserted-by":"crossref","first-page":"8112","DOI":"10.1038\/s41467-023-43805-y","volume":"14","author":"Long","year":"2023","journal-title":"Nat. Commun."},{"key":"D5SC03191E\/cit6\/1","doi-asserted-by":"crossref","first-page":"8323","DOI":"10.1039\/D3CC01398G","volume":"59","author":"Cao","year":"2023","journal-title":"Chem. Commun."},{"key":"D5SC03191E\/cit7\/1","doi-asserted-by":"crossref","first-page":"e202306100","DOI":"10.1002\/anie.202306100","volume":"62","author":"Liu","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5SC03191E\/cit8\/1","doi-asserted-by":"crossref","first-page":"7737","DOI":"10.1039\/D2CS00889K","volume":"52","author":"Fu","year":"2023","journal-title":"Chem. Soc. Rev."},{"key":"D5SC03191E\/cit9\/1","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1021\/acscentsci.5c00875","volume":"11","author":"Wang","year":"2025","journal-title":"ACS Cent. Sci."},{"key":"D5SC03191E\/cit10\/1","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.3390\/biom13071041","volume":"13","author":"Wardman","year":"2023","journal-title":"Biomolecules"},{"key":"D5SC03191E\/cit11\/1","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1016\/j.bmcl.2011.12.106","volume":"22","author":"Tanabe","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D5SC03191E\/cit12\/1","doi-asserted-by":"crossref","first-page":"21546","DOI":"10.1002\/anie.202005612","volume":"59","author":"Fu","year":"2020","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5SC03191E\/cit13\/1","doi-asserted-by":"crossref","first-page":"9458","DOI":"10.1021\/jacs.2c02521","volume":"144","author":"Ding","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"D5SC03191E\/cit14\/1","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1038\/s41557-024-01501-4","volume":"16","author":"Fu","year":"2024","journal-title":"Nat. Chem."},{"key":"D5SC03191E\/cit15\/1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/s41557-021-00711-4","volume":"13","author":"Geng","year":"2021","journal-title":"Nat. Chem."},{"key":"D5SC03191E\/cit16\/1","doi-asserted-by":"crossref","first-page":"e202205014","DOI":"10.1002\/anie.202205014","volume":"61","author":"Guo","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5SC03191E\/cit17\/1","doi-asserted-by":"crossref","first-page":"5164","DOI":"10.1016\/j.bmc.2012.07.008","volume":"20","author":"Tanabe","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"D5SC03191E\/cit18\/1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41572-019-0064-5","volume":"5","author":"De Ruysscher","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"key":"D5SC03191E\/cit19\/1","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1021\/acs.accounts.9b00338","volume":"52","author":"Gnaim","year":"2019","journal-title":"Acc. Chem. Res."},{"key":"D5SC03191E\/cit20\/1","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1021\/tx300164j","volume":"25","author":"Zielonka","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"D5SC03191E\/cit21\/1","doi-asserted-by":"crossref","first-page":"7968","DOI":"10.1039\/c1cc12526e","volume":"47","author":"Jourden","year":"2011","journal-title":"Chem. Commun."},{"key":"D5SC03191E\/cit22\/1","doi-asserted-by":"crossref","first-page":"24043","DOI":"10.1002\/anie.202110041","volume":"60","author":"Maslah","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5SC03191E\/cit23\/1","doi-asserted-by":"crossref","first-page":"e202403880","DOI":"10.1002\/anie.202403880","volume":"63","author":"Kondengadan","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5SC03191E\/cit24\/1","doi-asserted-by":"crossref","first-page":"10082","DOI":"10.1021\/jacs.3c00254","volume":"145","author":"Liu","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"D5SC03191E\/cit25\/1","doi-asserted-by":"crossref","first-page":"e202310920","DOI":"10.1002\/anie.202310920","volume":"62","author":"Liang","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5SC03191E\/cit26\/1","doi-asserted-by":"crossref","first-page":"10651","DOI":"10.1021\/jacs.3c00801","volume":"145","author":"Nakamura","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"D5SC03191E\/cit27\/1","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.31635\/ccschem.024.202303794","volume":"6","author":"Liu","year":"2024","journal-title":"CCS Chem."},{"key":"D5SC03191E\/cit28\/1","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1021\/acsapm.5c00054","volume":"7","author":"Liu","year":"2025","journal-title":"ACS Appl. Polym. Mater."},{"key":"D5SC03191E\/cit29\/1","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.tetlet.2017.01.051","volume":"58","author":"Gupta","year":"2017","journal-title":"Tetrahedron Lett."},{"key":"D5SC03191E\/cit30\/1","doi-asserted-by":"crossref","first-page":"24698","DOI":"10.1021\/jacs.3c08012","volume":"145","author":"Yan","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"D5SC03191E\/cit31\/1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1021\/acs.jmedchem.1c01493","volume":"65","author":"Zhou","year":"2022","journal-title":"J. Med. Chem."},{"key":"D5SC03191E\/cit32\/1","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1021\/ol301463c","volume":"14","author":"Zhu","year":"2012","journal-title":"Org. Lett."},{"key":"D5SC03191E\/cit33\/1","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1002\/adsc.201400305","volume":"356","author":"Zhu","year":"2014","journal-title":"Adv. Synth. Catal."},{"key":"D5SC03191E\/cit34\/1","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1039\/c3cy00963g","volume":"4","author":"Gopiraman","year":"2014","journal-title":"Catal. Sci. Technol."},{"key":"D5SC03191E\/cit35\/1","doi-asserted-by":"crossref","first-page":"10100","DOI":"10.1021\/jacs.5b05848","volume":"137","author":"Sandford","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"D5SC03191E\/cit36\/1","doi-asserted-by":"crossref","first-page":"7492","DOI":"10.1002\/anie.201500088","volume":"54","author":"Alouane","year":"2015","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5SC03191E\/cit37\/1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/713611034","volume":"33","author":"Weber","year":"2003","journal-title":"Crit. Rev. Toxicol."},{"key":"D5SC03191E\/cit38\/1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1063\/1.555805","volume":"17","author":"Buxton","year":"1988","journal-title":"J. Phys. Chem. Ref. Data"},{"key":"D5SC03191E\/cit39\/1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1063\/1.555978","volume":"25","author":"Neta","year":"1996","journal-title":"J. Phys. Chem. Ref. Data"},{"key":"D5SC03191E\/cit40\/1","doi-asserted-by":"crossref","first-page":"9352","DOI":"10.1021\/jp0207578","volume":"106","author":"Hiroki","year":"2002","journal-title":"J. Phys. Chem. A"},{"key":"D5SC03191E\/cit41\/1","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1021\/acs.chemrestox.3c00140","volume":"36","author":"Pierzcha\u0142a","year":"2023","journal-title":"Chem. Res. Toxicol."},{"key":"D5SC03191E\/cit42\/1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0009-2797(83)90041-8","volume":"45","author":"Monig","year":"1983","journal-title":"Chem.-Biol. Interactions"},{"key":"D5SC03191E\/cit43\/1","doi-asserted-by":"publisher","DOI":"10.26434\/chemrxiv-2025-cq53z","author":"Liu","year":"2025","journal-title":"ChemRxiv"},{"key":"D5SC03191E\/cit44\/1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nrc704","volume":"2","author":"Harris","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"D5SC03191E\/cit45\/1","doi-asserted-by":"crossref","first-page":"20130676","DOI":"10.1259\/bjr.20130676","volume":"87","author":"McKeown","year":"2014","journal-title":"Brit. J. Radiol."},{"key":"D5SC03191E\/cit46\/1","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1093\/annonc\/mdl117","volume":"17","author":"Mornex","year":"2006","journal-title":"Ann. Oncol."},{"key":"D5SC03191E\/cit47\/1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1634\/theoncologist.10-1-34","volume":"10","author":"Pauwels","year":"2005","journal-title":"Oncologist"},{"key":"D5SC03191E\/cit48\/1","doi-asserted-by":"crossref","first-page":"466","DOI":"10.3390\/genes13030466","volume":"13","author":"Pandit","year":"2022","journal-title":"Genes"},{"key":"D5SC03191E\/cit49\/1","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1016\/B978-0-323-07307-3.10123-5","volume-title":"Pediatric Critical Care","author":"Heard","year":"2011","unstructured":"C. M. B.Heard  and  J. E.Fletcher , in  Pediatric Critical Care ,  B. P. Fuhrman  and  J. J. Zimmerman ,  Mosby, Saint Louis , 4th edn,  2011 ,  pp. 1654\u20131681 ,  10.1016\/B978-0-323-07307-3.10123-5"},{"key":"D5SC03191E\/cit50\/1","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.3390\/nu15143091","volume":"15","author":"Lee","year":"2023","journal-title":"Nutrients"},{"key":"D5SC03191E\/cit51\/1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3390\/encyclopedia5010038","volume":"5","author":"Jay-Gerin","year":"2025","journal-title":"Encyclopedia"},{"key":"D5SC03191E\/cit52\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jbiotec.2010.01.012","volume":"148","author":"Hirschhaeuser","year":"2010","journal-title":"J. Biotechnol."},{"key":"D5SC03191E\/cit53\/1","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1021\/jacs.2c12493","volume":"145","author":"Wallabregue","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"D5SC03191E\/cit54\/1","doi-asserted-by":"crossref","first-page":"e1006469","DOI":"10.1371\/journal.pcbi.1006469","volume":"14","author":"Mao","year":"2018","journal-title":"PLoS Comput. Biol."},{"key":"D5SC03191E\/cit55\/1","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1177\/1087057106292763","volume":"11","author":"Ivascu","year":"2006","journal-title":"J. Biomol. Screen"},{"key":"D5SC03191E\/cit56\/1","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.1158\/0008-5472.CAN-04-2184","volume":"65","author":"Leek","year":"2005","journal-title":"Cancer Res."}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/SC\/D5SC03191E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:02:39Z","timestamp":1782968559000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/sc\/article\/17\/3\/1752-1760\/910489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,1,21]]}},"URL":"https:\/\/doi.org\/10.1039\/d5sc03191e","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5SC03191E\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5SC03191E\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5SC03191E\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5SC03191E\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5SC03191E\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5SC03191E\/v2\/review1","asserted-by":"object"}]},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}