{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:57:06Z","timestamp":1782885426365,"version":"3.54.5"},"reference-count":51,"publisher":"Royal Society of Chemistry (RSC)","issue":"42","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":265,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21834003"],"award-info":[{"award-number":["21834003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008048","name":"Nanjing University","doi-asserted-by":"publisher","award":["ZYJH004"],"award-info":[{"award-number":["ZYJH004"]}],"id":[{"id":"10.13039\/501100008048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011400","name":"State Key Laboratory of Analytical Chemistry for Life Science","doi-asserted-by":"publisher","award":["5431ZZXM2404"],"award-info":[{"award-number":["5431ZZXM2404"]}],"id":[{"id":"10.13039\/501100011400","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>A tri-specific molecularly imprinted polymer-based lysosome-targeted chimera was developed for synergistic anti-inflammatory therapy, effectively reducing the level of IL-6, TNF-\u03b1, and downstream p-STAT3\/NF-\u03baB p65, thereby alleviating cytokine storm.<\/jats:p>","DOI":"10.1039\/d5sc04757a","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T09:20:53Z","timestamp":1758619253000},"page":"20002-20011","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tri-specific molecularly imprinted lysosomal nanodegrader enables synergistic therapy of cytokine storm"],"prefix":"10.1039","volume":"16","author":[{"given":"Jingran","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanchen","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8440-2554","authenticated-orcid":false,"given":"Zhen","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5SC04757A\/cit1\/1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s40425-018-0343-9","volume":"6","author":"Shimabukuro-Vornhagen","year":"2018","journal-title":"J. Immunother. Cancer"},{"key":"D5SC04757A\/cit2\/1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nrmicro.2016.81","volume":"14","author":"de Wit","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"D5SC04757A\/cit3\/1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"D5SC04757A\/cit4\/1","doi-asserted-by":"crossref","first-page":"100777","DOI":"10.1016\/j.cpsurg.2020.100777","volume":"57","author":"Mowery","year":"2020","journal-title":"Curr. Probl. Surg."},{"key":"D5SC04757A\/cit5\/1","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1038\/ncomms4987","volume":"5","author":"Touzot","year":"2014","journal-title":"Nat. Commun."},{"key":"D5SC04757A\/cit6\/1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nrd2070","volume":"5","author":"O'Neill","year":"2006","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D5SC04757A\/cit7\/1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/s41584-020-0419-z","volume":"16","author":"Choy","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"D5SC04757A\/cit8\/1","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.immuni.2020.04.003","volume":"52","author":"Hirano","year":"2020","journal-title":"Immunity"},{"key":"D5SC04757A\/cit9\/1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41577-022-00792-3","volume":"23","author":"van Loo","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"D5SC04757A\/cit10\/1","doi-asserted-by":"crossref","first-page":"6870","DOI":"10.4049\/jimmunol.175.10.6870","volume":"175","author":"Faulkner","year":"2005","journal-title":"J. Immunol."},{"key":"D5SC04757A\/cit11\/1","doi-asserted-by":"crossref","first-page":"156287","DOI":"10.1016\/j.cyto.2023.156287","volume":"169","author":"Dharra","year":"2023","journal-title":"Cytokine"},{"key":"D5SC04757A\/cit12\/1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.4161\/mabs.2.3.11782","volume":"2","author":"Brennan","year":"2010","journal-title":"mAbs"},{"key":"D5SC04757A\/cit13\/1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/antib11010017","volume":"11","author":"Baldo","year":"2022","journal-title":"Antibodies"},{"key":"D5SC04757A\/cit14\/1","doi-asserted-by":"crossref","first-page":"105982","DOI":"10.1016\/j.ijantimicag.2020.105982","volume":"55","author":"Zhao","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"D5SC04757A\/cit15\/1","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(20)30628-0","volume":"395","author":"Mehta","year":"2020","journal-title":"Lancet"},{"key":"D5SC04757A\/cit16\/1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41584-020-0372-x","volume":"16","author":"Schrezenmeier","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"D5SC04757A\/cit17\/1","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.jaccas.2020.02.014","volume":"2","author":"Mulkareddy","year":"2020","journal-title":"JACC Case Rep."},{"key":"D5SC04757A\/cit18\/1","doi-asserted-by":"crossref","first-page":"e2100012","DOI":"10.1002\/adma.202100012","volume":"33","author":"Meng","year":"2021","journal-title":"Adv. Mater."},{"key":"D5SC04757A\/cit19\/1","doi-asserted-by":"crossref","first-page":"376","DOI":"10.31635\/ccschem.020.202000165","volume":"2","author":"Zhang","year":"2020","journal-title":"CCS Chem."},{"key":"D5SC04757A\/cit20\/1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.chembiol.2024.01.002","volume":"31","author":"Su","year":"2024","journal-title":"Cell Chem. Biol."},{"key":"D5SC04757A\/cit21\/1","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/s41589-021-00770-1","volume":"17","author":"Ahn","year":"2021","journal-title":"Nat. Chem. Biol."},{"key":"D5SC04757A\/cit22\/1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41586-020-2545-9","volume":"584","author":"Banik","year":"2020","journal-title":"Nature"},{"key":"D5SC04757A\/cit23\/1","doi-asserted-by":"crossref","first-page":"e202218106","DOI":"10.1002\/anie.202218106","volume":"62","author":"Wu","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5SC04757A\/cit24\/1","doi-asserted-by":"crossref","first-page":"24272","DOI":"10.1021\/jacs.3c08886","volume":"145","author":"Zhang","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"D5SC04757A\/cit25\/1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41587-022-01456-2","volume":"41","author":"Pance","year":"2023","journal-title":"Nat. Biotechnol."},{"key":"D5SC04757A\/cit26\/1","first-page":"341","volume":"11","author":"Wullf","year":"1972","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5SC04757A\/cit27\/1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/19267","volume":"398","author":"Shi","year":"1999","journal-title":"Nature"},{"key":"D5SC04757A\/cit28\/1","doi-asserted-by":"crossref","first-page":"6644","DOI":"10.1021\/ja102148f","volume":"132","author":"Hoshino","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"D5SC04757A\/cit29\/1","doi-asserted-by":"crossref","first-page":"7451","DOI":"10.1002\/anie.201207950","volume":"52","author":"Li","year":"2013","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5SC04757A\/cit30\/1","doi-asserted-by":"crossref","first-page":"18214","DOI":"10.1021\/acsnano.1c07166","volume":"15","author":"Lu","year":"2021","journal-title":"ACS Nano"},{"key":"D5SC04757A\/cit31\/1","doi-asserted-by":"crossref","first-page":"44098","DOI":"10.1021\/acsami.2c11091","volume":"14","author":"Lu","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D5SC04757A\/cit32\/1","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.1002\/anie.202005309","volume":"60","author":"Xu","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5SC04757A\/cit33\/1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/s41586-022-04439-0","volume":"603","author":"Seung","year":"2022","journal-title":"Nature"},{"key":"D5SC04757A\/cit34\/1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s43018-019-0004-z","volume":"1","author":"Wu","year":"2020","journal-title":"Nat. Cancer"},{"key":"D5SC04757A\/cit35\/1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/d41573-020-00164-3","volume":"19","author":"Mullard","year":"2020","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D5SC04757A\/cit36\/1","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S2213-2600(17)30188-1","volume":"5","author":"Matthay","year":"2017","journal-title":"Lancet Respir. Med."},{"key":"D5SC04757A\/cit37\/1","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1016\/S0140-6736(16)00578-X","volume":"388","author":"Sweeney","year":"2016","journal-title":"Lancet"},{"key":"D5SC04757A\/cit38\/1","doi-asserted-by":"crossref","first-page":"e2101713","DOI":"10.1002\/advs.202101713","volume":"8","author":"Guo","year":"2021","journal-title":"Adv. Sci."},{"key":"D5SC04757A\/cit39\/1","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/cdd.2016.162","volume":"24","author":"Jiang","year":"2017","journal-title":"Cell Death Differ."},{"key":"D5SC04757A\/cit40\/1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/intimm\/dxaa078","volume":"33","author":"Hirano","year":"2021","journal-title":"Int. Immunol."},{"key":"D5SC04757A\/cit41\/1","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1093\/emboj\/21.5.1054","volume":"21","author":"Brown","year":"2002","journal-title":"EMBO J."},{"key":"D5SC04757A\/cit42\/1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0014-4886(81)90090-X","volume":"71","author":"Stauber","year":"1981","journal-title":"Exp. Neurol."},{"key":"D5SC04757A\/cit43\/1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s12931-021-01792-y","volume":"22","author":"Yang","year":"2021","journal-title":"Respir. Res."},{"key":"D5SC04757A\/cit44\/1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1165\/rcmb.2009-0210ST","volume":"44","author":"Matute-Bello","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"D5SC04757A\/cit45\/1","doi-asserted-by":"crossref","first-page":"2008960","DOI":"10.1002\/adfm.202008960","volume":"31","author":"Yang","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"D5SC04757A\/cit46\/1","doi-asserted-by":"crossref","first-page":"e2104051","DOI":"10.1002\/advs.202104051","volume":"9","author":"Sun","year":"2022","journal-title":"Adv. Sci."},{"key":"D5SC04757A\/cit47\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2007.03.025","volume":"337","author":"Costantino","year":"2007","journal-title":"Int. J. Pharm."},{"key":"D5SC04757A\/cit48\/1","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.3390\/ph17091180","volume":"17","author":"Safarov","year":"2024","journal-title":"Pharmaceuticals"},{"key":"D5SC04757A\/cit49\/1","doi-asserted-by":"crossref","first-page":"5392","DOI":"10.1021\/acsnano.4c13463","volume":"19","author":"Guan","year":"2025","journal-title":"ACS Nano"},{"key":"D5SC04757A\/cit50\/1","doi-asserted-by":"crossref","first-page":"23553","DOI":"10.1021\/acsnano.4c07416","volume":"18","author":"Lu","year":"2024","journal-title":"ACS Nano"},{"key":"D5SC04757A\/cit51\/1","doi-asserted-by":"crossref","first-page":"e202301202","DOI":"10.1002\/anie.202301202","volume":"62","author":"Guan","year":"2023","journal-title":"Angew. Chem., Int. Ed."}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/SC\/D5SC04757A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:41:45Z","timestamp":1782880905000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/sc\/article\/16\/42\/20002-20011\/910827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":51,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2025,10,29]]}},"URL":"https:\/\/doi.org\/10.1039\/d5sc04757a","relation":{},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}