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Sci."],"abstract":"<jats:p>\n                    The stereo-determining nucleophilic attack transition state from the intimate ion pair has significant S\n                    <jats:sub>N<\/jats:sub>\n                    2 character with dynamically coupled nitrogen\u2013carbon bond formation and leaving group ejection.\n                  <\/jats:p>","DOI":"10.1039\/d5sc05616k","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T07:34:09Z","timestamp":1760600049000},"page":"21554-21561","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dynamics-based transition states reveal solvent cage effect and S\n                    <sub>N<\/sub>\n                    2 transition state motion in Lewis acid catalyzed stereoselective tertiary alcohol nucleophilic substitution reactions"],"prefix":"10.1039","volume":"16","author":[{"given":"Anthony J.","family":"Schaefer","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, 84604, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor","family":"Mallavia","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, 84604, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5689-9762","authenticated-orcid":false,"given":"Daniel H.","family":"Ess","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, 84604, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5SC05616K\/cit1\/1","volume-title":"Advanced Organic Chemistry: Part A: Structure and Mechanisms","author":"Carey","year":"2007","unstructured":"For a general review of these experiments and mechanism model see,  F. 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