{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:07:22Z","timestamp":1787004442628,"version":"build-2736575974"},"reference-count":38,"publisher":"Royal Society of Chemistry (RSC)","issue":"12","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000146","name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems","doi-asserted-by":"publisher","award":["2045887-CBET"],"award-info":[{"award-number":["2045887-CBET"]}],"id":[{"id":"10.13039\/100000146","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>\n                    The reverse\/reductive tricarboxylic acid (rTCA) cycle is a highly conserved CO\n                    <jats:sub>2<\/jats:sub>\n                    fixation pathway and candidate for prebiotic carbon fixation. The kinetic viability of prebiotic hypotheses are studied here using reaction exploration algorithms.\n                  <\/jats:p>","DOI":"10.1039\/d5sc05872d","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T11:39:51Z","timestamp":1770205191000},"page":"6197-6207","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Kinetics overcome thermodynamics in primitive analogs of the reverse tricarboxylic acid cycle"],"prefix":"10.1039","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7384-4005","authenticated-orcid":false,"given":"Vignesh","family":"Sathyaseelan","sequence":"first","affiliation":[{"name":"Davidson School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47906, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5326-4988","authenticated-orcid":false,"given":"John","family":"Morgan","sequence":"additional","affiliation":[{"name":"Davidson School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47906, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7039-4039","authenticated-orcid":false,"given":"Brett M.","family":"Savoie","sequence":"additional","affiliation":[{"name":"Davidson School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47906, USA"},{"name":"Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"6375","key":"D5SC05872D\/cit1\/1","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1126\/science.aao3407","volume":"359","author":"Nunoura","year":"2018","journal-title":"Science"},{"issue":"7856","key":"D5SC05872D\/cit2\/1","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/s41586-021-03456-9","volume":"592","author":"Steffens","year":"2021","journal-title":"Nature"},{"issue":"15","key":"D5SC05872D\/cit3\/1","doi-asserted-by":"crossref","first-page":"7708","DOI":"10.1021\/acs.chemrev.0c00191","volume":"120","author":"Muchowska","year":"2020","journal-title":"Chem. 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