{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:34:42Z","timestamp":1791945282623,"version":"4.3.4"},"reference-count":66,"publisher":"Royal Society of Chemistry (RSC)","issue":"38","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":210,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/W524402\/1"],"award-info":[{"award-number":["EP\/W524402\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/Z534948\/1"],"award-info":[{"award-number":["EP\/Z534948\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>\n                    N\u2013CF\n                    <jats:sub>3<\/jats:sub>\n                    amides are an emerging class of functional groups in medicinal chemistry. This review summarises their properties, evaluates their suitability as drug targets, and critically discusses existing strategies for their synthesis.\n                  <\/jats:p>","DOI":"10.1039\/d5sc08413j","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:43:17Z","timestamp":1785418997000},"page":"18071-18087","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis and properties of\n                    <i>N<\/i>\n                    -(trifluoromethyl)amides"],"prefix":"10.1039","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8312-824X","authenticated-orcid":false,"given":"Miriam L.","family":"O'Duill","sequence":"first","affiliation":[{"name":"School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4311-1329","authenticated-orcid":false,"given":"Isabel L.","family":"Wood","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Brooks","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"McIvor","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5SC08413J\/cit1\/1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nature10702","volume":"480","author":"Pattabiraman","year":"2011","journal-title":"Nature"},{"key":"D5SC08413J\/cit2\/1","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1021\/jm200187y","volume":"54","author":"Roughley","year":"2011","journal-title":"J. Med. Chem."},{"key":"D5SC08413J\/cit3\/1","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.1021\/acs.jmedchem.5b01409","volume":"59","author":"Brown","year":"2016","journal-title":"J. Med. Chem."},{"key":"D5SC08413J\/cit4\/1","doi-asserted-by":"crossref","first-page":"12290","DOI":"10.1021\/acs.jmedchem.0c00530","volume":"63","author":"Kumari","year":"2020","journal-title":"J. Med. Chem."},{"key":"D5SC08413J\/cit5\/1","doi-asserted-by":"crossref","first-page":"8408","DOI":"10.1021\/acs.jmedchem.0c00754","volume":"63","author":"Ertl","year":"2020","journal-title":"J. Med. Chem."},{"key":"D5SC08413J\/cit6\/1","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1126\/science.1131943","volume":"317","author":"M\u00fcller","year":"2007","journal-title":"Science"},{"key":"D5SC08413J\/cit7\/1","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1039\/B711844A","volume":"37","author":"O'Hagan","year":"2008","journal-title":"Chem. Soc. Rev."},{"key":"D5SC08413J\/cit8\/1","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1039\/B610213C","volume":"37","author":"Purser","year":"2008","journal-title":"Chem. Soc. Rev."},{"key":"D5SC08413J\/cit9\/1","doi-asserted-by":"crossref","first-page":"8315","DOI":"10.1021\/acs.jmedchem.5b00258","volume":"58","author":"Gillis","year":"2015","journal-title":"J. Med. Chem."},{"key":"D5SC08413J\/cit10\/1","doi-asserted-by":"crossref","first-page":"5822","DOI":"10.1021\/acs.jmedchem.7b01788","volume":"61","author":"Meanwell","year":"2018","journal-title":"J. Med. Chem."},{"key":"D5SC08413J\/cit11\/1","doi-asserted-by":"crossref","first-page":"13076","DOI":"10.1021\/acs.jmedchem.0c01457","volume":"63","author":"Schiesser","year":"2020","journal-title":"J. Med. Chem."},{"key":"D5SC08413J\/cit12\/1","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.3390\/molecules30143009","volume":"30","author":"Nov\u00e1s","year":"2025","journal-title":"Molecules"},{"key":"D5SC08413J\/cit13\/1","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1007\/s00044-006-0020-2","volume":"15","author":"Sahu","year":"2007","journal-title":"Med. Chem. Res."},{"key":"D5SC08413J\/cit15\/1","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1021\/jacs.1c12467","volume":"144","author":"Liu","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"D5SC08413J\/cit17\/1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41586-019-1518-3","volume":"573","author":"Scattolin","year":"2019","journal-title":"Nature"},{"key":"D5SC08413J\/cit18\/1","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.6023\/cjoc202409003","volume":"45","author":"Lin","year":"2025","journal-title":"Chin. J. Org. Chem."},{"key":"D5SC08413J\/cit19\/1","doi-asserted-by":"crossref","first-page":"e202300011","DOI":"10.1002\/tcr.202300011","volume":"23","author":"Crousse","year":"2023","journal-title":"Chem. Rec."},{"key":"D5SC08413J\/cit20\/1","first-page":"554","volume":"2024","author":"Crousse","year":"2024","journal-title":"Sci. Synth."},{"key":"D5SC08413J\/cit21\/1","doi-asserted-by":"crossref","first-page":"4873","DOI":"10.1038\/s41467-025-60225-2","volume":"16","author":"Fu","year":"2025","journal-title":"Nat. Commun."},{"key":"D5SC08413J\/cit22\/1","doi-asserted-by":"publisher","DOI":"10.26434\/CHEMRXIV-2025-46Q0H","volume-title":"ChemRxiv","author":"Kub\u00ed\u010dkov\u00e1","year":"2025","unstructured":"A.Kub\u00ed\u010dkov\u00e1 ,  M.Dra\u010d\u00ednsk\u00fd ,  M.Stroka ,  L.Puzzini ,  A.Kur\u010dina ,  E.Andris ,  S.\u0160t\u011bp\u00e1nov\u00e1 ,  V.Ka\u0161i\u010dka ,  B.Klepet\u00e1\u0159ov\u00e1  and  P.Beier ,  ChemRxiv ,  2025 , preprint.,  10.26434\/CHEMRXIV-2025-46Q0H"},{"key":"D5SC08413J\/cit23\/1","doi-asserted-by":"crossref","first-page":"e1753273","DOI":"10.1002\/anie.1753273","volume":"65","author":"Huang","year":"2026","journal-title":"Angew. Chem., Int. Ed."},{"issue":"14","key":"D5SC08413J\/cit24\/1","doi-asserted-by":"crossref","first-page":"17319","DOI":"10.1021\/acs.jmedchem.6c01299","volume":"69","author":"Garonzi","year":"2026","journal-title":"J. Med. Chem."},{"key":"D5SC08413J\/cit25\/1","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.1021\/ja100996z","volume":"132","author":"Ho","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"D5SC08413J\/cit26\/1","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1021\/acs.joc.4c02710","volume":"90","author":"Li","year":"2025","journal-title":"J. Org. Chem."},{"key":"D5SC08413J\/cit27\/1","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.1021\/jacs.0c13317","volume":"143","author":"Yamashita","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"D5SC08413J\/cit28\/1","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1107\/S0567740872005801","volume":"28","author":"Blake","year":"1972","journal-title":"Acta Crystallogr."},{"key":"D5SC08413J\/cit29\/1","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1107\/S0567740878005270","volume":"34","author":"Leiserowitz","year":"1978","journal-title":"Acta Crystallogr."},{"key":"D5SC08413J\/cit30\/1","first-page":"1","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat. Commun."},{"key":"D5SC08413J\/cit31\/1","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1021\/ja01523a031","volume":"81","author":"Attaway","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"D5SC08413J\/cit32\/1","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1039\/j39670001241","author":"Haszeldine","year":"1967","journal-title":"J. Chem. Soc. C"},{"key":"D5SC08413J\/cit33\/1","first-page":"2502","volume":"28","author":"Yarovenko","year":"1958","journal-title":"Zh. Obshch. Khim."},{"key":"D5SC08413J\/cit35\/1","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1021\/ja00881a017","volume":"84","author":"Fawcett","year":"1962","journal-title":"J. Am. Chem. Soc."},{"key":"D5SC08413J\/cit37\/1","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1007\/BF00923664","volume":"26","author":"Til\u2019kunova","year":"1977","journal-title":"Russ. Chem. Bull."},{"key":"D5SC08413J\/cit38\/1","first-page":"2519","volume":"27","author":"Til\u2019kunova","year":"1978","journal-title":"Russ. Chem. Bull."},{"key":"D5SC08413J\/cit39\/1","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1002\/cber.19791120623","volume":"112","author":"Lutz","year":"1979","journal-title":"Chem. Ber."},{"key":"D5SC08413J\/cit40\/1","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1002\/cber.19861190404","volume":"119","author":"J\u00e4ger","year":"1986","journal-title":"Chem. Ber."},{"key":"D5SC08413J\/cit41\/1","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/ange.19870990932","volume":"99","author":"Lentz","year":"1987","journal-title":"Angew. Chem."},{"key":"D5SC08413J\/cit42\/1","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.jfluchem.2011.06.012","volume":"132","author":"Desmarteau","year":"2011","journal-title":"J. Fluorine Chem."},{"key":"D5SC08413J\/cit44\/1","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1039\/B701677H","volume":"38","author":"Valeur","year":"2009","journal-title":"Chem. Soc. Rev."},{"key":"D5SC08413J\/cit45\/1","doi-asserted-by":"crossref","first-page":"e00453","DOI":"10.1002\/ajoc.202500453","volume":"14","author":"Li","year":"2025","journal-title":"Asian J. Org. Chem."},{"key":"D5SC08413J\/cit46\/1","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1021\/acs.orglett.7b00908","volume":"19","author":"Van der Werf","year":"2017","journal-title":"Org. Lett."},{"key":"D5SC08413J\/cit47\/1","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1021\/jo502638y","volume":"80","author":"Mamone","year":"2015","journal-title":"J. Org. Chem."},{"key":"D5SC08413J\/cit48\/1","doi-asserted-by":"crossref","first-page":"10351","DOI":"10.1039\/D1CC04538E","volume":"57","author":"Cao","year":"2021","journal-title":"Chem. Commun."},{"key":"D5SC08413J\/cit49\/1","doi-asserted-by":"crossref","first-page":"13959","DOI":"10.1021\/acs.joc.4c01118","volume":"89","author":"Li","year":"2024","journal-title":"J. Org. Chem."},{"key":"D5SC08413J\/cit51\/1","doi-asserted-by":"crossref","first-page":"110356","DOI":"10.1016\/j.jfluchem.2024.110356","volume":"280","author":"Song","year":"2024","journal-title":"J. Fluorine Chem."},{"key":"D5SC08413J\/cit52\/1","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1016\/j.chempr.2021.07.005","volume":"7","author":"Liu","year":"2021","journal-title":"Chem"},{"key":"D5SC08413J\/cit53\/1","volume-title":"US Pat.","author":"Niyaz","unstructured":"N. M.Niyaz ,  R.Hunter ,  T. C.Johnson ,  T. K.Trullinger ,  A. V.Brown  and  K.Bryan ,  US Pat. , US8455649B2, 2009"},{"key":"D5SC08413J\/cit54\/1","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.1021\/ja00947a021","volume":"87","author":"Sheppard","year":"1965","journal-title":"J. Am. Chem. Soc."},{"key":"D5SC08413J\/cit55\/1","doi-asserted-by":"crossref","first-page":"8578","DOI":"10.1021\/jo901560b","volume":"74","author":"Hagooly","year":"2009","journal-title":"J. Org. Chem."},{"key":"D5SC08413J\/cit56\/1","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1002\/chem.202000116","volume":"26","author":"Turksoy","year":"2020","journal-title":"Chem.\u2013Eur. J."},{"key":"D5SC08413J\/cit57\/1","doi-asserted-by":"crossref","first-page":"11908","DOI":"10.1002\/anie.202004321","volume":"59","author":"Bouayad-Gervais","year":"2020","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5SC08413J\/cit58\/1","doi-asserted-by":"crossref","first-page":"6100","DOI":"10.1021\/jacs.2c02004","volume":"144","author":"Bouayad-Gervais","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"D5SC08413J\/cit59\/1","doi-asserted-by":"crossref","first-page":"e202201435","DOI":"10.1002\/chem.202201435","volume":"28","author":"Turksoy","year":"2022","journal-title":"Chem.\u2013Eur. J."},{"key":"D5SC08413J\/cit60\/1","doi-asserted-by":"crossref","first-page":"13029","DOI":"10.1021\/jacs.1c07780","volume":"143","author":"Nielsen","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"D5SC08413J\/cit61\/1","doi-asserted-by":"crossref","first-page":"e202213829","DOI":"10.1002\/anie.202213829","volume":"61","author":"Zivkovic","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5SC08413J\/cit62\/1","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1021\/acs.orglett.5c00355","volume":"27","author":"Turksoy","year":"2025","journal-title":"Org. Lett."},{"key":"D5SC08413J\/cit63\/1","first-page":"1","volume":"2026","author":"Chen","year":"2026","journal-title":"Nat. Synth."},{"key":"D5SC08413J\/cit64\/1","doi-asserted-by":"crossref","first-page":"15237","DOI":"10.1021\/acs.joc.3c01740","volume":"88","author":"Tao","year":"2023","journal-title":"J. Org. Chem."},{"key":"D5SC08413J\/cit65\/1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1021\/cr9408991","volume":"97","author":"Prakash","year":"1997","journal-title":"Chem. Rev."},{"key":"D5SC08413J\/cit67\/1","doi-asserted-by":"crossref","first-page":"e202304205","DOI":"10.1002\/chem.202304205","volume":"30","author":"Templ","year":"2024","journal-title":"Chem.\u2013Eur. J."},{"key":"D5SC08413J\/cit68\/1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1039\/JR9510000060","author":"Banus","year":"1951","journal-title":"J. Chem. Soc."},{"key":"D5SC08413J\/cit69\/1","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1002\/cjoc.202000132","volume":"38","author":"Zhang","year":"2020","journal-title":"Chin. J. Chem."},{"key":"D5SC08413J\/cit71\/1","doi-asserted-by":"crossref","first-page":"e202300039","DOI":"10.1002\/asia.202300039","volume":"18","author":"Liu","year":"2023","journal-title":"Chem.\u2013Asian J."},{"key":"D5SC08413J\/cit72\/1","doi-asserted-by":"crossref","first-page":"5637","DOI":"10.1021\/ja01602a046","volume":"78","author":"Young","year":"1956","journal-title":"J. Am. Chem. Soc."},{"key":"D5SC08413J\/cit73\/1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0022-1139(01)00545-0","volume":"113","author":"Ignat\u2019ev","year":"2002","journal-title":"J. Fluorine Chem."},{"key":"D5SC08413J\/cit74\/1","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1021\/acs.orglett.8b01510","volume":"20","author":"Xu","year":"2018","journal-title":"Org. Lett."}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/SC\/article-pdf\/doi\/10.1039\/D5SC08413J\/0\/D5SC08413J.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:03:45Z","timestamp":1791374625000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/SC\/article-lookup\/doi\/10.1039\/D5SC08413J"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":66,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2026,10,7]]}},"URL":"https:\/\/doi.org\/10.1039\/d5sc08413j","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5SC08413J\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5SC08413J\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5SC08413J\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5SC08413J\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5SC08413J\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5SC08413J\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5SC08413J\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5SC08413J\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5SC08413J\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5SC08413J\/v3\/response1","asserted-by":"object"}]},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}