{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:56:52Z","timestamp":1782892612040,"version":"3.54.5"},"reference-count":37,"publisher":"Royal Society of Chemistry (RSC)","issue":"3","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["328170591"],"award-info":[{"award-number":["328170591"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["390761711 (EXC-2082\/1)"],"award-info":[{"award-number":["390761711 (EXC-2082\/1)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["397252409"],"award-info":[{"award-number":["397252409"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["417223351"],"award-info":[{"award-number":["417223351"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["511488495 (SFB-1638\/1"],"award-info":[{"award-number":["511488495 (SFB-1638\/1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["P15)"],"award-info":[{"award-number":["P15)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["101076997 (Starting Grant ENSYNC)"],"award-info":[{"award-number":["101076997 (Starting Grant ENSYNC)"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Soft Matter"],"abstract":"<jats:p>RT-DC is applied to GUVs and accurately matched with numerical simulation data to extract the area expansion modulus, building the basis for contact-free, high-throughput mechanics phenotyping and sorting of vesicles.<\/jats:p>","DOI":"10.1039\/d5sm01140j","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T09:40:54Z","timestamp":1765532454000},"page":"625-635","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High-throughput mechanical characterization of giant unilamellar vesicles by real-time deformability cytometry"],"prefix":"10.1039","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7126-8032","authenticated-orcid":false,"given":"Maximilian","family":"Kloppe","sequence":"first","affiliation":[{"name":"Institute of Numerical Mathematics and Optimization, TU Bergakademie Freiberg, Akademiestr. 6, 09599 Freiberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan J.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Heidelberg University, Center for Molecular Biology of Heidelberg University (ZMBH), Berliner Str. 45, D-69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2705-0983","authenticated-orcid":false,"given":"Tobias","family":"Abele","sequence":"additional","affiliation":[{"name":"Heidelberg University, Center for Molecular Biology of Heidelberg University (ZMBH), Berliner Str. 45, D-69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2115-3551","authenticated-orcid":false,"given":"Kerstin","family":"G\u00f6pfrich","sequence":"additional","affiliation":[{"name":"Heidelberg University, Center for Molecular Biology of Heidelberg University (ZMBH), Berliner Str. 45, D-69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5258-0006","authenticated-orcid":false,"given":"Sebastian","family":"Aland","sequence":"additional","affiliation":[{"name":"Institute of Numerical Mathematics and Optimization, TU Bergakademie Freiberg, Akademiestr. 6, 09599 Freiberg, Germany"},{"name":"Faculty of Computer Science\/Mathematics, HTW Dresden, Friedrich-List-Platz 1, 01069 Dresden, Germany"},{"name":"Center for Systems Biology Dresden, Pfotenhauerstr. 108, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"6","key":"D5SM01140J\/cit1\/1","doi-asserted-by":"crossref","first-page":"2106709","DOI":"10.1002\/adma.202106709","volume":"34","author":"Abele","year":"2022","journal-title":"Adv. Mater."},{"issue":"1","key":"D5SM01140J\/cit2\/1","first-page":"2125342","volume":"8","author":"Aleksanyan","year":"2023","journal-title":"Adv. Phys.: X"},{"issue":"1","key":"D5SM01140J\/cit3\/1","doi-asserted-by":"crossref","first-page":"14040","DOI":"10.1038\/s41598-020-70562-5","volume":"10","author":"Ali Doosti","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"D5SM01140J\/cit4\/1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.addr.2012.09.037","volume":"65","author":"Allen","year":"2013","journal-title":"Adv. Drug Delivery Rev."},{"key":"D5SM01140J\/cit5\/1","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1039\/D2SM01515C","volume":"19","author":"B\u00fcy\u00fckurganci","year":"2023","journal-title":"Soft Matter"},{"issue":"2","key":"D5SM01140J\/cit6\/1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1145\/992200.992206","volume":"30","author":"Davis","year":"2004","journal-title":"ACM Trans. Math. Softw."},{"key":"D5SM01140J\/cit7\/1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev-biophys-052118-115342","volume":"48","author":"Dimova","year":"2019","journal-title":"Ann. Rev. Biophys."},{"key":"D5SM01140J\/cit8\/1","first-page":"235","volume-title":"Handbook of Electroporation","author":"Dimova","year":"2016","unstructured":"R.Dimova ,  K. A.Riske  and  M.Damijan ,  Electrodeformation, electroporation, and electrofusion of giant unilamellar vesicles ,  Handbook of Electroporation  ( 2016 ),  pp. 235\u2013252"},{"issue":"2","key":"D5SM01140J\/cit9\/1","doi-asserted-by":"crossref","first-page":"151428","DOI":"10.1016\/j.ejcb.2024.151428","volume":"103","author":"Fink","year":"2024","journal-title":"Eur. J. Cell Biol."},{"key":"D5SM01140J\/cit10\/1","doi-asserted-by":"crossref","first-page":"605a","DOI":"10.1016\/j.bpj.2019.11.3267","volume":"118","author":"Fregin","year":"2020","journal-title":"Biophys. J."},{"key":"D5SM01140J\/cit11\/1","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.1704.00572","volume-title":"arXiv","author":"Herold","year":"2017","unstructured":"C.Herold ,  Mapping of deformation to apparent young's modulus in real-time deformability cytometry ,  arXiv ,  2017 , preprint, arXiv:1704.00572 10.48550\/arXiv.1704.00572"},{"key":"D5SM01140J\/cit12\/1","doi-asserted-by":"crossref","first-page":"117090","DOI":"10.1016\/j.cma.2024.117090","volume":"428","author":"Kloppe","year":"2024","journal-title":"Comput. Methods Appl. Mech. Eng."},{"issue":"1","key":"D5SM01140J\/cit13\/1","doi-asserted-by":"crossref","first-page":"2101020","DOI":"10.1002\/adbi.202101020","volume":"6","author":"Lipowsky","year":"2022","journal-title":"Adv. Biol."},{"issue":"36","key":"D5SM01140J\/cit14\/1","doi-asserted-by":"crossref","first-page":"7521","DOI":"10.1039\/C6SM01349J","volume":"12","author":"Lu","year":"2016","journal-title":"Soft Matter"},{"issue":"7","key":"D5SM01140J\/cit15\/1","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1021\/bi00122a017","volume":"31","author":"McIntosh","year":"1992","journal-title":"Biochemistry"},{"issue":"10","key":"D5SM01140J\/cit16\/1","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/j.bpj.2015.09.006","volume":"109","author":"Mietke","year":"2015","journal-title":"Biophys. J."},{"issue":"11","key":"D5SM01140J\/cit17\/1","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1021\/acsbiomaterials.6b00558","volume":"3","author":"Mokbel","year":"2017","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"10","key":"D5SM01140J\/cit18\/1","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.1529\/biophysj.107.116228","volume":"93","author":"Montes","year":"2007","journal-title":"Biophys. J."},{"key":"D5SM01140J\/cit19\/1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BFb0067700","volume-title":"Numerical Analysis","author":"Mor\u00e9","year":"1978","unstructured":"J. J.Mor\u00e9 ,  The Levenberg-Marquardt algorithm: implementation and theory , in  Numerical Analysis , ed.  G. A. Watson ,  Springer Berlin ,  Heidelberg ,  1978 ,  pp. 105\u2013116"},{"issue":"2","key":"D5SM01140J\/cit20\/1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1039\/D2LC00636G","volume":"23","author":"Nawaz","year":"2023","journal-title":"Lab Chip"},{"issue":"6","key":"D5SM01140J\/cit21\/1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/s41592-020-0831-y","volume":"17","author":"Nawaz","year":"2020","journal-title":"Nat. Methods"},{"issue":"4","key":"D5SM01140J\/cit22\/1","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.bpj.2021.01.006","volume":"120","author":"Ngassam","year":"2021","journal-title":"Biophys. J."},{"key":"D5SM01140J\/cit23\/1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nmeth.3281","volume":"12","author":"Otto","year":"2015","journal-title":"Nat. Methods"},{"key":"D5SM01140J\/cit24\/1","author":"Praetorius","unstructured":"S.Praetorius , The adaptive multi-dimensional simulation toolbox (AMDiS), a discretization module on top of the Dune framework,  https:\/\/gitlab.com\/amdis\/amdis"},{"issue":"1","key":"D5SM01140J\/cit25\/1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0006-3495(00)76295-3","volume":"79","author":"Rawicz","year":"2000","journal-title":"Biophys. J."},{"issue":"12","key":"D5SM01140J\/cit26\/1","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.1529\/biophysj.107.121731","volume":"94","author":"Rawicz","year":"2008","journal-title":"Biophys. J."},{"issue":"5","key":"D5SM01140J\/cit27\/1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nmeth.4639","volume":"15","author":"Rosendahl","year":"2018","journal-title":"Nat. Methods"},{"issue":"33","key":"D5SM01140J\/cit28\/1","doi-asserted-by":"crossref","first-page":"10463","DOI":"10.1021\/la401969t","volume":"29","author":"Sch\u00e4fer","year":"2013","journal-title":"Langmuir"},{"key":"D5SM01140J\/cit29\/1","doi-asserted-by":"crossref","first-page":"4487","DOI":"10.1039\/C5SM00191A","volume":"11","author":"Sch\u00e4fer","year":"2015","journal-title":"Soft Matter"},{"issue":"5","key":"D5SM01140J\/cit30\/1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3109\/09687688.2012.700490","volume":"29","author":"Sezgin","year":"2012","journal-title":"Mol. Membr. Biol."},{"issue":"12","key":"D5SM01140J\/cit31\/1","doi-asserted-by":"crossref","first-page":"2300416","DOI":"10.1002\/smtd.202300416","volume":"7","author":"Van de Cauter","year":"2023","journal-title":"Small Methods"},{"key":"D5SM01140J\/cit32\/1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00791-006-0048-3","volume":"10","author":"Vey","year":"2007","journal-title":"Comput. Visualization Sci."},{"issue":"1","key":"D5SM01140J\/cit33\/1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.18388\/abp.2009_2514","volume":"56","author":"Weso\u0142owska","year":"2009","journal-title":"Acta Biochim. Pol."},{"key":"D5SM01140J\/cit34\/1","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s10444-015-9405-4","volume":"41","author":"Witkowski","year":"2015","journal-title":"Adv. Comput. Math."},{"key":"D5SM01140J\/cit35\/1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/B978-0-323-85740-6.00010-8","volume-title":"Modeling of Mass Transport Processes in Biological Media","author":"Wittwer","year":"2022","unstructured":"L. D.Wittwer ,  F.Reichel  and  S.Aland ,  Numerical simulation of deformability cytometry: transport of a biological cell through a microfluidic channel , in  Modeling of Mass Transport Processes in Biological Media , ed.  S. Becker ,  A. V. Kuznetsov ,  F. de Monte ,  G. Pontrelli , and  D. Zhao ,  Academic Press ,  2022 , ch. 3,  pp. 33\u201356"},{"key":"D5SM01140J\/cit36\/1","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1039\/D2SM01418A","volume":"19","author":"Wittwer","year":"2023","journal-title":"Soft Matter"},{"key":"D5SM01140J\/cit37\/1","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.csbj.2022.12.025","volume":"21","author":"Wubshet","year":"2023","journal-title":"Comput. Struct. Biotechnol. J."}],"container-title":["Soft Matter"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/SM\/D5SM01140J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:05:05Z","timestamp":1782885905000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/sm\/article\/22\/3\/625-635\/913015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,1,21]]}},"URL":"https:\/\/doi.org\/10.1039\/d5sm01140j","relation":{},"ISSN":["1744-683X","1744-6848"],"issn-type":[{"value":"1744-683X","type":"print"},{"value":"1744-6848","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}