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B"],"abstract":"<jats:p>\n                    We developed a buoyant plasmonic Au\/microbubble (MB) substrate functionalized with copper ions (Cu\n                    <jats:sup>2+<\/jats:sup>\n                    ) and 4-mercaptobenzoic acid (4-MBA) to establish a SERS-based sensing platform for detecting amyloid-\u03b2 (A\u03b2) proteins.\n                  <\/jats:p>","DOI":"10.1039\/d5tb00632e","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T21:40:46Z","timestamp":1750714846000},"page":"8883-8896","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A buoyant plasmonic microbubble-based SERS sensing platform for amyloid-beta protein detection in Alzheimer's disease"],"prefix":"10.1039","volume":"13","author":[{"given":"Willis Kwun Hei","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong 999077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong 999077, China"},{"name":"The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariza","family":"Zhorabe","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Hong Kong 999077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxiang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong 999077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutian","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong 999077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong 999077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5477-902X","authenticated-orcid":false,"given":"Changqing","family":"Yi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Sensing Technology and Biomedical Instruments (Guangdong Province), School of Biomedical Engineering, Sun Yat-Sen University, Guangzhou 510000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Automotive Engineering, Royal Melbourne Institute of Technology, Melbourne, VIC 3000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3863-8187","authenticated-orcid":false,"given":"Mo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong 999077, China"},{"name":"The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen 518000, China"},{"name":"Research Center for Nanoscience and Nanotechnology, The Hong Kong Polytechnic University, Kowloon, Hong Kong 999077, China"},{"name":"Joint Research Center of Biosensing and Precision Theranostics, The Hong Kong Polytechnic University, Kowloon, Hong Kong 999077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5TB00632E\/cit1\/1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jalz.2016.02.002","volume":"12","author":"Dubois","year":"2016","journal-title":"Alzheimer's Dementia"},{"key":"D5TB00632E\/cit2\/1","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1021\/acs.chemrev.8b00138","volume":"119","author":"Savelieff","year":"2019","journal-title":"Chem. 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