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Immunol."},{"key":"D5TB01024A\/cit103\/1","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.it.2019.09.005","volume":"40","author":"Xue","year":"2019","journal-title":"Trends Immunol."},{"key":"D5TB01024A\/cit104\/1","doi-asserted-by":"crossref","first-page":"45300","DOI":"10.1021\/acsami.1c14082","volume":"13","author":"Nandi","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D5TB01024A\/cit105\/1","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nature07725","volume":"458","author":"Hornung","year":"2009","journal-title":"Nature"},{"key":"D5TB01024A\/cit106\/1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.immuni.2007.10.002","volume":"27","author":"Kanneganti","year":"2007","journal-title":"Immunity"},{"key":"D5TB01024A\/cit107\/1","doi-asserted-by":"crossref","first-page":"5411","DOI":"10.1021\/jacs.1c12924","volume":"144","author":"Ngai","year":"2022","journal-title":"J. Am. Chem. 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