{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:50:42Z","timestamp":1784775042241,"version":"3.55.0"},"reference-count":38,"publisher":"Royal Society of Chemistry (RSC)","issue":"42","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"am","delay-in-days":645,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22201058"],"award-info":[{"award-number":["22201058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22275046"],"award-info":[{"award-number":["22275046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52473127"],"award-info":[{"award-number":["52473127"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0908500"],"award-info":[{"award-number":["2020YFA0908500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["J. Mater. Chem. B"],"abstract":"<jats:p>Herein, we design a series of PEG-based artificial proton channels with ON\/OFF switchable transport behaviors and apply in cancer treatment.<\/jats:p>","DOI":"10.1039\/d5tb01835h","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T09:31:18Z","timestamp":1759915878000},"page":"13658-13665","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Photo-regulated supramolecular artificial proton channels induce cancer cell apoptosis"],"prefix":"10.1039","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7346-6724","authenticated-orcid":false,"given":"Tianlong","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyue","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canhong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangkun","family":"Xing","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayun","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangjiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengfei","family":"Yan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1608-7908","authenticated-orcid":false,"given":"Junqiu","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5TB01835H\/cit1\/1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/s41586-018-0003-8","volume":"556","author":"Abe","year":"2018","journal-title":"Nature"},{"key":"D5TB01835H\/cit2\/1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1056\/NEJM199809173391207","volume":"339","author":"Hood","year":"1998","journal-title":"New. Engl. J. Med."},{"key":"D5TB01835H\/cit3\/1","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1126\/science.228.4701.867","volume":"228","author":"Aldrich","year":"1985","journal-title":"Science"},{"key":"D5TB01835H\/cit4\/1","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1172\/JCI26011","volume":"115","author":"Kass","year":"2005","journal-title":"J. Clin. Invest."},{"key":"D5TB01835H\/cit5\/1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/00019052-200304000-00009","volume":"16","author":"Mulley","year":"2003","journal-title":"Curr. Opin. Neurol."},{"key":"D5TB01835H\/cit6\/1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.tips.2021.03.005","volume":"42","author":"Burg","year":"2021","journal-title":"Trends Pharmacol. Sci."},{"key":"D5TB01835H\/cit7\/1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.chest.2018.04.036","volume":"154","author":"Gentzsch","year":"2018","journal-title":"Chest"},{"key":"D5TB01835H\/cit8\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12916-015-0545-7","volume":"14","author":"Lambertini","year":"2016","journal-title":"BMC Med."},{"key":"D5TB01835H\/cit9\/1","doi-asserted-by":"crossref","first-page":"15653","DOI":"10.1021\/jacs.1c05750","volume":"143","author":"Wang","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"D5TB01835H\/cit10\/1","doi-asserted-by":"crossref","first-page":"2400432","DOI":"10.1002\/adfm.202400432","volume":"34","author":"Wu","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"D5TB01835H\/cit11\/1","doi-asserted-by":"crossref","first-page":"8817","DOI":"10.1021\/jacs.8b04657","volume":"140","author":"Ren","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"D5TB01835H\/cit12\/1","doi-asserted-by":"crossref","first-page":"12564","DOI":"10.1002\/anie.201106857","volume":"50","author":"Si","year":"2011","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5TB01835H\/cit13\/1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41565-019-0586-8","volume":"15","author":"Song","year":"2020","journal-title":"Nat. Nanotechnol."},{"key":"D5TB01835H\/cit14\/1","doi-asserted-by":"crossref","first-page":"23213","DOI":"10.1002\/anie.202009219","volume":"59","author":"Strilets","year":"2020","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5TB01835H\/cit15\/1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/s41586-019-1881-0","volume":"577","author":"Jiang","year":"2020","journal-title":"Nature"},{"key":"D5TB01835H\/cit16\/1","doi-asserted-by":"crossref","first-page":"e202500986","DOI":"10.1002\/anie.202500986","volume":"64","author":"Li","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5TB01835H\/cit17\/1","doi-asserted-by":"crossref","first-page":"e202408558","DOI":"10.1002\/anie.202408558","volume":"63","author":"Lin","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5TB01835H\/cit18\/1","doi-asserted-by":"crossref","first-page":"10462","DOI":"10.1021\/acs.nanolett.1c03858","volume":"21","author":"Yan","year":"2021","journal-title":"Nano Lett."},{"key":"D5TB01835H\/cit19\/1","doi-asserted-by":"crossref","first-page":"e202200259","DOI":"10.1002\/anie.202200259","volume":"61","author":"Shen","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5TB01835H\/cit20\/1","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/s41565-021-00915-2","volume":"16","author":"Roy","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"D5TB01835H\/cit21\/1","doi-asserted-by":"crossref","first-page":"4852","DOI":"10.1063\/1.477096","volume":"109","author":"Tawa","year":"1998","journal-title":"J. Chem. Phys."},{"key":"D5TB01835H\/cit22\/1","doi-asserted-by":"crossref","first-page":"11534","DOI":"10.1021\/jp012536s","volume":"105","author":"Zhan","year":"2001","journal-title":"J. Phys. Chem. A"},{"key":"D5TB01835H\/cit23\/1","doi-asserted-by":"crossref","first-page":"e202314666","DOI":"10.1002\/anie.202314666","volume":"63","author":"Zhong","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5TB01835H\/cit24\/1","doi-asserted-by":"crossref","first-page":"9737","DOI":"10.1021\/jacs.3c01451","volume":"145","author":"Mondal","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"D5TB01835H\/cit25\/1","doi-asserted-by":"crossref","first-page":"e202217859","DOI":"10.1002\/anie.202217859","volume":"62","author":"Xin","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5TB01835H\/cit26\/1","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1126\/science.168.3935.1091","volume":"168","author":"Ohnishi","year":"1970","journal-title":"Science"},{"key":"D5TB01835H\/cit27\/1","doi-asserted-by":"crossref","first-page":"4180","DOI":"10.1021\/ja012026b","volume":"124","author":"Matsumori","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"D5TB01835H\/cit28\/1","doi-asserted-by":"crossref","first-page":"7436","DOI":"10.1021\/bi00148a002","volume":"31","author":"Zeidel","year":"1992","journal-title":"Biochemistry"},{"key":"D5TB01835H\/cit29\/1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0006-3495(81)84805-9","volume":"35","author":"Dani","year":"1981","journal-title":"Biophys. J."},{"key":"D5TB01835H\/cit30\/1","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0006-3495(97)78115-3","volume":"73","author":"Matsuzaki","year":"1997","journal-title":"Biophys. J."},{"key":"D5TB01835H\/cit31\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01870590","volume":"71","author":"Nagle","year":"1983","journal-title":"J. Membr. Biol."},{"key":"D5TB01835H\/cit32\/1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/0009-2614(95)00905-J","volume":"244","author":"Agmon","year":"1995","journal-title":"Chem. Phys. Lett."},{"key":"D5TB01835H\/cit33\/1","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1021\/ar500109h","volume":"47","author":"Harada","year":"2014","journal-title":"Acc. Chem. Res."},{"key":"D5TB01835H\/cit34\/1","doi-asserted-by":"crossref","first-page":"10769","DOI":"10.1021\/jacs.0c02134","volume":"142","author":"Shen","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"D5TB01835H\/cit35\/1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0014-5793(97)00669-8","volume":"411","author":"Salvioli","year":"1997","journal-title":"FEBS Lett."},{"key":"D5TB01835H\/cit36\/1","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/S0891-5849(99)00107-0","volume":"27","author":"Wang","year":"1999","journal-title":"Free Radical. Biol. Med."},{"key":"D5TB01835H\/cit37\/1","doi-asserted-by":"crossref","first-page":"e2312352","DOI":"10.1002\/adma.202312352","volume":"36","author":"Li","year":"2024","journal-title":"Adv. Mater."},{"key":"D5TB01835H\/cit38\/1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0091-679X(08)61717-3","volume":"41","author":"Traganos","year":"1994","journal-title":"Methods Cell Biol."}],"container-title":["Journal of Materials Chemistry B"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/TB\/D5TB01835H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:56:25Z","timestamp":1783014985000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/tb\/article\/13\/42\/13658-13665\/315898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":38,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2025,10,29]]}},"URL":"https:\/\/doi.org\/10.1039\/d5tb01835h","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5TB01835H\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5TB01835H\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5TB01835H\/v2\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5TB01835H\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5TB01835H\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5TB01835H\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5TB01835H\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5TB01835H\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5TB01835H\/v2\/review1","asserted-by":"object"}]},"ISSN":["2050-750X","2050-7518"],"issn-type":[{"value":"2050-750X","type":"print"},{"value":"2050-7518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}