{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:07:18Z","timestamp":1787004438285,"version":"build-2736575974"},"reference-count":26,"publisher":"Royal Society of Chemistry (RSC)","issue":"9","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":78,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000771","name":"Prostate Cancer UK","doi-asserted-by":"publisher","award":["RIA21-ST2-011"],"award-info":[{"award-number":["RIA21-ST2-011"]}],"id":[{"id":"10.13039\/501100000771","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Analyst"],"abstract":"<jats:p>A spatially invariant version of the Minimum Noise Fraction denoising algorithm (iMNF) that removes the spatial-order dependency of standard MNF, keeping biochemical fidelity across unstructured datasets or datasets analysed in a patch-wise manner*.<\/jats:p>","DOI":"10.1039\/d6an00152a","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T11:00:47Z","timestamp":1774004447000},"page":"2624-2637","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A spatially invariant noise model for minimum noise fraction (MNF) denoising of hyperspectral datasets: applications to large-scale infrared spectroscopic pathology"],"prefix":"10.1039","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4766-5339","authenticated-orcid":false,"given":"Dougal","family":"Ferguson","sequence":"first","affiliation":[{"name":"Photon Science Institute, University of Manchester, Oxford Road, Manchester, M13 9PL, UK"},{"name":"Department of Chemical Engineering, School of Engineering, University of Manchester, Oxford Road, Manchester, M13 9PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4034-3764","authenticated-orcid":false,"given":"Peter","family":"Gardner","sequence":"additional","affiliation":[{"name":"Photon Science Institute, University of Manchester, Oxford Road, Manchester, M13 9PL, UK"},{"name":"Department of Chemical Engineering, School of Engineering, University of Manchester, Oxford Road, Manchester, M13 9PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6AN00152A\/cit1\/1","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1039\/C5CS00846H","volume":"45","author":"Pilling","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"D6AN00152A\/cit2\/1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1109\/36.3001","volume":"26","author":"Green","year":"1988","journal-title":"IEEE Trans. Geosci. Remote Sens."},{"key":"D6AN00152A\/cit3\/1","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1139\/e05-064","volume":"42","author":"Harris","year":"2005","journal-title":"Can. J. Earth Sci."},{"key":"D6AN00152A\/cit4\/1","author":"Frassy","unstructured":"F.Frassy ,  G.Dalla Via ,  P.Maianti ,  A.Marchesi ,  F. R.Nodari  and  M.Gianinetto , 2013 5th Workshop on Hyperspectral Image and Signal Processing: Evolution in Remote Sensing (WHISPERS), IEEE, 2013, pp. 1\u20134"},{"key":"D6AN00152A\/cit5\/1","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1080\/07038992.2022.2116307","volume":"48","author":"Chen","year":"2022","journal-title":"Can. J. Remote Sens."},{"key":"D6AN00152A\/cit6\/1","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1039\/c0an00350f","volume":"135","author":"Reddy","year":"2010","journal-title":"Analyst"},{"key":"D6AN00152A\/cit7\/1","doi-asserted-by":"crossref","first-page":"14351","DOI":"10.1038\/s41598-018-32713-7","volume":"8","author":"Koziol","year":"2018","journal-title":"Sci. Rep."},{"key":"D6AN00152A\/cit8\/1","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1039\/D5AN00046G","volume":"150","author":"Ferguson","year":"2025","journal-title":"Analyst"},{"key":"D6AN00152A\/cit9\/1","author":"Wrobel","unstructured":"T. P.Wrobel ,  J. T.Kwak ,  A.Kadjacsy-Balla  and  R.Bhargava , Medical Imaging 2016: Digital Pathology, SPIE, 2016, vol. 9791, pp. 347\u2013353"},{"key":"D6AN00152A\/cit10\/1","author":"Mittal","unstructured":"S.Mittal ,  T. P.Wrobel ,  L. S.Leslie ,  A.Kadjacsy-Balla  and  R.Bhargava , Medical Imaging 2016: Digital Pathology, SPIE, 2016, vol. 9791, pp. 310\u2013317"},{"key":"D6AN00152A\/cit11\/1","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1039\/C8AN01782D","volume":"144","author":"Mittal","year":"2019","journal-title":"Analyst"},{"key":"D6AN00152A\/cit12\/1","doi-asserted-by":"crossref","first-page":"100006","DOI":"10.1016\/j.clispe.2021.100006","volume":"3","author":"Mittal","year":"2021","journal-title":"Clinical Spectroscopy"},{"key":"D6AN00152A\/cit13\/1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.aca.2018.11.032","volume":"1051","author":"Koziol","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"D6AN00152A\/cit14\/1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.aca.2019.07.045","volume":"1085","author":"Raczkowska","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"D6AN00152A\/cit15\/1","doi-asserted-by":"crossref","first-page":"e0127238","DOI":"10.1371\/journal.pone.0127238","volume":"10","author":"Leslie","year":"2015","journal-title":"PLoS One"},{"key":"D6AN00152A\/cit16\/1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1080\/07038992.2016.1160772","volume":"42","author":"Luo","year":"2016","journal-title":"Can. J. Remote Sens."},{"key":"D6AN00152A\/cit17\/1","author":"Switzer","unstructured":"P.Switzer , Technical report, Dept. of Statistics, Stanford University"},{"key":"D6AN00152A\/cit18\/1","author":"Gao","unstructured":"L.Gao ,  B.Zhang ,  Z.Chen  and  L.Lei , 2011 3rd Workshop on Hyperspectral Image and Signal Processing: Evolution in Remote Sensing (WHISPERS), IEEE, 2011, pp. 1\u20134"},{"key":"D6AN00152A\/cit19\/1","doi-asserted-by":"crossref","first-page":"e0205219","DOI":"10.1371\/journal.pone.0205219","volume":"14","author":"Gupta","year":"2019","journal-title":"PLoS One"},{"key":"D6AN00152A\/cit20\/1","doi-asserted-by":"crossref","first-page":"105042","DOI":"10.1016\/j.chemolab.2023.105042","volume":"244","author":"Liberda-Matyja","year":"2024","journal-title":"Chemom. Intell. Lab. Syst."},{"key":"D6AN00152A\/cit21\/1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5c04765","author":"O\u2019Leary","year":"2026","journal-title":"Anal. Chem."},{"key":"D6AN00152A\/cit22\/1","doi-asserted-by":"crossref","first-page":"5439","DOI":"10.1093\/nar\/gkr175","volume":"39","author":"Whelan","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"D6AN00152A\/cit23\/1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1080\/05704920701829043","volume":"43","author":"Movasaghi","year":"2008","journal-title":"Appl. Spectrosc. Rev."},{"key":"D6AN00152A\/cit24\/1","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1039\/D5AN00126A","volume":"150","author":"Gladwell","year":"2025","journal-title":"Analyst"},{"key":"D6AN00152A\/cit26\/1","doi-asserted-by":"publisher","DOI":"10.5281\/zenodo.18132289","author":"Ferguson","year":"2026","journal-title":"Zenodo"},{"key":"D6AN00152A\/cit27\/1","author":"O'Leary","year":"2026","unstructured":"L.O'Leary ,  D.Ferguson ,  C. A.Hart ,  M.Brown ,  N.Clarke ,  A.Sachdeva ,  P.Gardner ,  H.Yin  and  P.Oliveira , PCUK2023 FTIR Prostate TMA Dataset Zenodo,  2026"}],"container-title":["The Analyst"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/AN\/D6AN00152A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:25:24Z","timestamp":1782887124000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/an\/article\/151\/9\/2624-2637\/1235024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,5,5]]}},"URL":"https:\/\/doi.org\/10.1039\/d6an00152a","relation":{},"ISSN":["0003-2654","1364-5528"],"issn-type":[{"value":"0003-2654","type":"print"},{"value":"1364-5528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}