{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:31:03Z","timestamp":1786368663668,"version":"build-2736575974"},"reference-count":35,"publisher":"Royal Society of Chemistry (RSC)","issue":"16","license":[{"start":{"date-parts":[[2027,7,2]],"date-time":"2027-07-02T00:00:00Z","timestamp":1814486400000},"content-version":"am","delay-in-days":547,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC2419100"],"award-info":[{"award-number":["2024YFC2419100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC2419104"],"award-info":[{"award-number":["2024YFC2419104"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871505"],"award-info":[{"award-number":["81871505"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61971026"],"award-info":[{"award-number":["61971026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Analyst"],"abstract":"<jats:p>A two-step centrifugal microfluidic platform integrates whole-blood incubation with automated chemiluminescence for semi-automated tuberculosis IGRA detection, providing a convenient \u201csample-to-result\u201d diagnostic solution.<\/jats:p>","DOI":"10.1039\/d6an00180g","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:18:53Z","timestamp":1783012733000},"page":"4777-4789","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A two-step centrifugal microfluidic platform for semi-automated IGRA detection of tuberculosis based on chemiluminescence"],"prefix":"10.1039","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7478-1317","authenticated-orcid":false,"given":"Tianwei","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Microfluidic Chip Development in Biomedical Engineering, College of Information Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7578-0406","authenticated-orcid":false,"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Microfluidic Chip Development in Biomedical Engineering, College of Information Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghua","family":"Dong","sequence":"additional","affiliation":[{"name":"Beijing Wantai Biological Pharmacy Enterprise Co., Ltd, Beijing 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Tan","sequence":"additional","affiliation":[{"name":"Institute for In Vitro Diagnostics Control, National Institutes for Food and Drug, Beijing 100050, China"},{"name":"School of Engineering, China Pharmaceutical University, Nanjing 211198, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Microfluidic Chip Development in Biomedical Engineering, College of Information Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Wantai Biological Pharmacy Enterprise Co., Ltd, Beijing 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Qiao","sequence":"additional","affiliation":[{"name":"Beijing Wantai Biological Pharmacy Enterprise Co., Ltd, Beijing 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxing","family":"Xing","sequence":"additional","affiliation":[{"name":"Institute of Microfluidic Chip Development in Biomedical Engineering, College of Information Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2437-1546","authenticated-orcid":false,"given":"Lulu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Microfluidic Chip Development in Biomedical Engineering, College of Information Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengxiang","family":"Ge","sequence":"additional","affiliation":[{"name":"National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen 361100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0179-5266","authenticated-orcid":false,"given":"Ningshao","family":"Xia","sequence":"additional","affiliation":[{"name":"National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen 361100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Shi","sequence":"additional","affiliation":[{"name":"Institute for In Vitro Diagnostics Control, National Institutes for Food and Drug, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1579-593X","authenticated-orcid":false,"given":"Xianbo","family":"Qiu","sequence":"additional","affiliation":[{"name":"Institute of Microfluidic Chip Development in Biomedical Engineering, College of Information Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6AN00180G\/cit1\/1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/crj.13569","volume":"17","author":"Santos","year":"2023","journal-title":"Clin. Respir. J."},{"key":"D6AN00180G\/cit2\/1","doi-asserted-by":"crossref","first-page":"109132","DOI":"10.1016\/j.clim.2022.109132","volume":"245","author":"Zhou","year":"2022","journal-title":"Clin. Immunol."},{"key":"D6AN00180G\/cit3\/1","doi-asserted-by":"crossref","first-page":"13529","DOI":"10.3390\/ijerph192013529","volume":"19","author":"Yoopetch","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"D6AN00180G\/cit4\/1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12995-021-00326-y","volume":"16","author":"Szturmowicz","year":"2021","journal-title":"J. Occup. Med. Toxicol."},{"key":"D6AN00180G\/cit5\/1","doi-asserted-by":"crossref","first-page":"e02443","DOI":"10.1128\/jcm.02443-21","volume":"60","author":"Dirix","year":"2022","journal-title":"J. Clin. Microbiol."},{"key":"D6AN00180G\/cit6\/1","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1186\/s12879-021-06855-5","volume":"21","author":"Lee","year":"2021","journal-title":"BMC Infect. Dis."},{"key":"D6AN00180G\/cit7\/1","first-page":"e01870","volume":"10","author":"Xu","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"D6AN00180G\/cit8\/1","first-page":"49","volume":"54","author":"Mazurek","year":"2005","journal-title":"MMWR Recomm. Rep."},{"key":"D6AN00180G\/cit9\/1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1183\/09031936.06.00016906","volume":"28","author":"Lee","year":"2006","journal-title":"Eur. Respir. J."},{"key":"D6AN00180G\/cit10\/1","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1001\/jama.286.14.1740","volume":"286","author":"Mazurek","year":"2001","journal-title":"J. Am. Med. Assoc."},{"key":"D6AN00180G\/cit11\/1","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1039\/D4LC00779D","volume":"25","author":"Yuan","year":"2025","journal-title":"Lab Chip"},{"key":"D6AN00180G\/cit12\/1","doi-asserted-by":"crossref","first-page":"113589","DOI":"10.1016\/j.microc.2025.113589","volume":"213","author":"Du","year":"2025","journal-title":"Microchem. J."},{"key":"D6AN00180G\/cit13\/1","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1039\/D4LC00979G","volume":"25","author":"Oksuz","year":"2025","journal-title":"Lab Chip"},{"key":"D6AN00180G\/cit14\/1","doi-asserted-by":"crossref","first-page":"133048","DOI":"10.1016\/j.snb.2022.133048","volume":"376","author":"Shi","year":"2023","journal-title":"Sens. Actuators, B"},{"key":"D6AN00180G\/cit15\/1","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1007\/s00542-015-2408-8","volume":"21","author":"Kuo","year":"2015","journal-title":"Microsyst. Technol."},{"key":"D6AN00180G\/cit16\/1","doi-asserted-by":"crossref","first-page":"12521","DOI":"10.1021\/acs.analchem.3c02564","volume":"95","author":"Qian","year":"2023","journal-title":"Anal. Chem."},{"key":"D6AN00180G\/cit17\/1","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.3390\/mi14122257","volume":"14","author":"Hou","year":"2023","journal-title":"Micromachines"},{"key":"D6AN00180G\/cit18\/1","doi-asserted-by":"crossref","first-page":"139051","DOI":"10.1016\/j.snb.2025.139051","volume":"448","author":"Zhou","year":"2026","journal-title":"Sens. Actuators, B"},{"key":"D6AN00180G\/cit19\/1","doi-asserted-by":"crossref","first-page":"138319","DOI":"10.1016\/j.snb.2025.138319","volume":"444","author":"Zhang","year":"2025","journal-title":"Sens. Actuators, B"},{"key":"D6AN00180G\/cit20\/1","doi-asserted-by":"crossref","first-page":"144808","DOI":"10.1016\/j.cej.2023.144808","volume":"472","author":"Van Nguyen","year":"2023","journal-title":"Chem. Eng. J."},{"key":"D6AN00180G\/cit21\/1","doi-asserted-by":"crossref","first-page":"13827","DOI":"10.1039\/D4RA02656J","volume":"14","author":"Okamoto","year":"2024","journal-title":"RSC Adv."},{"key":"D6AN00180G\/cit22\/1","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S1473-3099(04)01206-X","volume":"4","author":"Pai","year":"2004","journal-title":"Lancet Infect. Dis."},{"key":"D6AN00180G\/cit23\/1","author":"Steigert","year":"2006","unstructured":"J.Steigert ,  T.Brenner ,  M.Grumann ,  L.Riegger ,  R.Zengerle  and  J.Ducree , 19th IEEE International Conference on Micro Electro Mechanical Systems,  2006"},{"key":"D6AN00180G\/cit24\/1","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/B978-012124546-7\/50407-1","volume-title":"Handbook of Cell Signaling","author":"Walter","year":"2003","unstructured":"M. R.Walter , in  Handbook of Cell Signaling ,  Elsevier ,  2003 , pp.  271\u2013273 .  10.1016\/B978-012124546-7\/50407-1"},{"key":"D6AN00180G\/cit25\/1","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.1007\/s00216-021-03512-3","volume":"413","author":"Ch\u00e1vez Ramos","year":"2021","journal-title":"Anal. Bioanal. Chem."},{"key":"D6AN00180G\/cit26\/1","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1039\/B604145K","volume":"6","author":"Haeberle","year":"2006","journal-title":"Lab Chip"},{"key":"D6AN00180G\/cit27\/1","doi-asserted-by":"crossref","first-page":"6556","DOI":"10.1021\/bi00442a005","volume":"28","author":"Mulkerrin","year":"1989","journal-title":"Biochemistry"},{"key":"D6AN00180G\/cit28\/1","doi-asserted-by":"crossref","first-page":"012013","DOI":"10.1088\/1742-6596\/757\/1\/012013","volume":"757","author":"Kinahan","year":"2016","journal-title":"J. Phys. Conf. Ser."},{"key":"D6AN00180G\/cit29\/1","doi-asserted-by":"crossref","first-page":"5456","DOI":"10.1039\/D3AN00862B","volume":"148","author":"Khodadadi","year":"2023","journal-title":"Analyst"},{"key":"D6AN00180G\/cit30\/1","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.3390\/mi13081218","volume":"13","author":"Lee","year":"2022","journal-title":"Micromachines"},{"key":"D6AN00180G\/cit31\/1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3390\/mi7020022","volume":"7","author":"Smith","year":"2016","journal-title":"Micromachines"},{"key":"D6AN00180G\/cit32\/1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1039\/b418253g","volume":"5","author":"Grumann","year":"2005","journal-title":"Lab Chip"},{"key":"D6AN00180G\/cit33\/1","doi-asserted-by":"crossref","first-page":"125319","DOI":"10.1016\/j.talanta.2023.125319","volume":"268","author":"Dong","year":"2024","journal-title":"Talanta"},{"key":"D6AN00180G\/cit34\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2334-8-35","volume":"8","author":"Baba","year":"2008","journal-title":"BMC Infect. Dis."},{"key":"D6AN00180G\/cit35\/1","doi-asserted-by":"crossref","first-page":"1131840","DOI":"10.3389\/fbioe.2023.1131840","volume":"11","author":"Yuan","year":"2023","journal-title":"Front. Bioeng. Biotechnol."}],"container-title":["The Analyst"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/AN\/article-pdf\/doi\/10.1039\/D6AN00180G\/0\/D6AN00180G.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:59:06Z","timestamp":1786366746000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/AN\/article-lookup\/doi\/10.1039\/D6AN00180G"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":35,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,8,10]]}},"URL":"https:\/\/doi.org\/10.1039\/d6an00180g","relation":{},"ISSN":["0003-2654","1364-5528"],"issn-type":[{"value":"0003-2654","type":"print"},{"value":"1364-5528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}