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Rev."},{"key":"D6AN00294C\/cit91\/1","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1093\/cid\/ciae234","volume":"79","author":"Peri","year":"2024","journal-title":"Clin. Infect. Dis"},{"key":"D6AN00294C\/cit92\/1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/cid\/ciw649","volume":"64","author":"Timbrook","year":"2017","journal-title":"Clin. Infect. Dis"},{"key":"D6AN00294C\/cit93\/1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.mimet.2017.05.004","volume":"139","author":"Buchanan","year":"2017","journal-title":"J. Microbiol. Methods"},{"key":"D6AN00294C\/cit94\/1","doi-asserted-by":"crossref","first-page":"001465","DOI":"10.1099\/jmm.0.001465","volume":"70","author":"Hoj","year":"2021","journal-title":"J. Med. Microbiol."},{"key":"D6AN00294C\/cit95\/1","doi-asserted-by":"crossref","first-page":"e2209607119","DOI":"10.1073\/pnas.2209607119","volume":"119","author":"Ganguli","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. 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