{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:04:47Z","timestamp":1784217887880,"version":"3.55.0"},"reference-count":71,"publisher":"Royal Society of Chemistry (RSC)","issue":"27","license":[{"start":{"date-parts":[[2027,6,29]],"date-time":"2027-06-29T00:00:00Z","timestamp":1814227200000},"content-version":"am","delay-in-days":544,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22104126"],"award-info":[{"award-number":["22104126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52303302"],"award-info":[{"award-number":["52303302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009377","name":"Education Department of Hunan Province","doi-asserted-by":"publisher","award":["22B0136"],"award-info":[{"award-number":["22B0136"]}],"id":[{"id":"10.13039\/100009377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009377","name":"Education Department of Hunan Province","doi-asserted-by":"publisher","award":["22B0177"],"award-info":[{"award-number":["22B0177"]}],"id":[{"id":"10.13039\/100009377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002767","name":"Department of Science and Technology of Hunan Province","doi-asserted-by":"publisher","award":["2021RC5007"],"award-info":[{"award-number":["2021RC5007"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002767","name":"Department of Science and Technology of Hunan Province","doi-asserted-by":"publisher","award":["2021RC5008"],"award-info":[{"award-number":["2021RC5008"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Anal. Methods"],"abstract":"<jats:p>This review examines recent advances in amino acid detection, highlighting two developments: wearable sensing platforms for diverse biofluids, and machine learning algorithms for processing complex signal responses in practical applications.<\/jats:p>","DOI":"10.1039\/d6ay00596a","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T06:02:58Z","timestamp":1782712978000},"page":"5667-5681","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Emerging trends in amino acid detection: wearable devices and machine learning-assisted signal processing"],"prefix":"10.1039","volume":"18","author":[{"given":"Hui","family":"Xu","sequence":"first","affiliation":[{"name":"Hunan Institute of Advanced Sensing and Information Technology, Xiangtan University, Xiangtan 411105, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lican","family":"He","sequence":"additional","affiliation":[{"name":"Hunan Institute of Advanced Sensing and Information Technology, Xiangtan University, Xiangtan 411105, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wei","sequence":"additional","affiliation":[{"name":"Hunan Institute of Advanced Sensing and Information Technology, Xiangtan University, Xiangtan 411105, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xiangtan Central Hospital, Xiangtan 411100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3074-6222","authenticated-orcid":false,"given":"Jian","family":"Shu","sequence":"additional","affiliation":[{"name":"Hunan Institute of Advanced Sensing and Information Technology, Xiangtan University, Xiangtan 411105, China"},{"name":"Hunan Provincial Key Laboratory of Smart Carbon Materials and Advanced Sensing, Xiangtan University, Xiangtan, 411105, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6AY00596A\/cit1\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00726-009-0269-0","volume":"37","author":"Wu","year":"2009","journal-title":"Amino acids"},{"key":"D6AY00596A\/cit2\/1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1039\/C1CS15159B","volume":"41","author":"Zhou","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"D6AY00596A\/cit3\/1","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/s41551-022-00916-z","volume":"6","author":"Wang","year":"2022","journal-title":"Nat. Biomed. Eng."},{"key":"D6AY00596A\/cit4\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0378-4347(96)00057-6","volume":"682","author":"Fekkes","year":"1996","journal-title":"Journal of Chromatography B: Biomedical Sciences and Applications"},{"key":"D6AY00596A\/cit5\/1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s11306-018-1374-4","volume":"14","author":"Casado","year":"2018","journal-title":"Metabolomics"},{"key":"D6AY00596A\/cit6\/1","doi-asserted-by":"crossref","first-page":"e0206488","DOI":"10.1371\/journal.pone.0206488","volume":"13","author":"Huang","year":"2018","journal-title":"PLoS One"},{"key":"D6AY00596A\/cit7\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmsacl.2023.07.001","volume":"30","author":"Junger","year":"2023","journal-title":"J. Mass Spectrom. Adv. Clin. Lab"},{"key":"D6AY00596A\/cit8\/1","doi-asserted-by":"crossref","first-page":"130708","DOI":"10.1016\/j.snb.2021.130708","volume":"348","author":"Chu","year":"2021","journal-title":"Sens. Actuators, B"},{"key":"D6AY00596A\/cit9\/1","doi-asserted-by":"crossref","first-page":"104396","DOI":"10.1016\/j.tifs.2024.104396","volume":"146","author":"Wang","year":"2024","journal-title":"Trends Food Sci. Technol."},{"key":"D6AY00596A\/cit10\/1","doi-asserted-by":"crossref","first-page":"148456","DOI":"10.1016\/j.foodchem.2026.148456","volume":"508","author":"Qiang","year":"2026","journal-title":"Food Chem."},{"key":"D6AY00596A\/cit11\/1","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1080\/10408347.2023.2205500","volume":"54","author":"Geng","year":"2024","journal-title":"Crit. Rev. Anal. Chem."},{"issue":"39","key":"D6AY00596A\/cit12\/1","doi-asserted-by":"crossref","first-page":"2405212","DOI":"10.1002\/adfm.202405212","volume":"34","author":"Ouyang","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"D6AY00596A\/cit13\/1","doi-asserted-by":"crossref","first-page":"2504059","DOI":"10.1002\/smll.202504059","volume":"21","author":"Li","year":"2025","journal-title":"Small"},{"key":"D6AY00596A\/cit14\/1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/978-981-97-5473-1_13","volume-title":"Biosensors for Personalized Healthcare","author":"Panicker","year":"2024","unstructured":"L. R.Panicker ,  M. R.Keerthanaa  and  R. A.Sukumaran ,  et al. Biosensors for Personalized Healthcare ,  2024 ,  pp. 359\u2013374"},{"key":"D6AY00596A\/cit15\/1","doi-asserted-by":"crossref","first-page":"23198","DOI":"10.1038\/s41598-025-05051-8","volume":"15","author":"Spano","year":"2025","journal-title":"Sci. Rep."},{"key":"D6AY00596A\/cit16\/1","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/s41467-024-44751-z","volume":"15","author":"Zhong","year":"2024","journal-title":"Nat. Commun."},{"key":"D6AY00596A\/cit17\/1","doi-asserted-by":"crossref","first-page":"118357","DOI":"10.1016\/j.trac.2025.118357","author":"Wu","year":"2025","journal-title":"TrAC, Trends Anal. Chem."},{"key":"D6AY00596A\/cit18\/1","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.1021\/acsomega.3c07660","volume":"9","author":"Jarosi\u0144ska","year":"2024","journal-title":"ACS Omega"},{"key":"D6AY00596A\/cit19\/1","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.1021\/acssensors.4c01582","volume":"9","author":"Bhaiyya","year":"2024","journal-title":"ACS Sens."},{"key":"D6AY00596A\/cit20\/1","doi-asserted-by":"crossref","first-page":"118162","DOI":"10.1016\/j.trac.2025.118162","volume":"185","author":"Tang","year":"2025","journal-title":"TrAC, Trends Anal. Chem."},{"key":"D6AY00596A\/cit21\/1","doi-asserted-by":"crossref","first-page":"118469","DOI":"10.1016\/j.trac.2025.118469","volume":"193","author":"Li","year":"2025","journal-title":"TrAC, Trends Anal. Chem."},{"key":"D6AY00596A\/cit22\/1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s13206-025-00229-8","volume":"19","author":"Lee","year":"2025","journal-title":"BioChip J."},{"issue":"11","key":"D6AY00596A\/cit23\/1","doi-asserted-by":"crossref","first-page":"2300040","DOI":"10.1002\/sscp.202300040","volume":"6","author":"Kaur","year":"2023","journal-title":"Sep. Sci. plus"},{"key":"D6AY00596A\/cit24\/1","doi-asserted-by":"crossref","first-page":"117510","DOI":"10.1016\/j.trac.2023.117510","volume":"171","author":"Erdem","year":"2024","journal-title":"TrAC, Trends Anal. Chem."},{"issue":"34","key":"D6AY00596A\/cit25\/1","doi-asserted-by":"crossref","first-page":"2504796","DOI":"10.1002\/adma.202504796","volume":"37","author":"Akka\u015f","year":"2025","journal-title":"Adv. Mater."},{"key":"D6AY00596A\/cit26\/1","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1007\/s41664-025-00381-y","volume":"9","author":"Huang","year":"2025","journal-title":"J. Anal. Test."},{"key":"D6AY00596A\/cit27\/1","doi-asserted-by":"crossref","first-page":"122869","DOI":"10.1016\/j.talanta.2021.122869","volume":"237","author":"Fiore","year":"2022","journal-title":"Talanta"},{"key":"D6AY00596A\/cit28\/1","doi-asserted-by":"crossref","first-page":"117926","DOI":"10.1016\/j.bios.2025.117926","volume":"289","author":"Stakelyt\u0117","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"D6AY00596A\/cit29\/1","doi-asserted-by":"crossref","first-page":"113764","DOI":"10.1016\/j.bios.2021.113764","volume":"197","author":"Parrilla","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"D6AY00596A\/cit30\/1","doi-asserted-by":"crossref","first-page":"7953","DOI":"10.1021\/acs.chemrev.1c00759","volume":"123","author":"Li","year":"2023","journal-title":"Chem. Rev."},{"key":"D6AY00596A\/cit31\/1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s44222-025-00276-8","volume":"3","author":"Lee","year":"2025","journal-title":"Nat. Rev. Bioeng."},{"key":"D6AY00596A\/cit32\/1","first-page":"202503019","author":"Hussain","year":"2025","journal-title":"Scierxiv"},{"key":"D6AY00596A\/cit33\/1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.20517\/ss.2025.45","volume":"5","author":"Ibrahim","year":"2025","journal-title":"Soft Sci."},{"key":"D6AY00596A\/cit34\/1","doi-asserted-by":"crossref","first-page":"147369","DOI":"10.1016\/j.electacta.2025.147369","volume":"541","author":"Tang","year":"2025","journal-title":"Electrochim. Acta"},{"key":"D6AY00596A\/cit35\/1","doi-asserted-by":"crossref","first-page":"341948","DOI":"10.1016\/j.aca.2023.341948","volume":"1283","author":"Xu","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"D6AY00596A\/cit36\/1","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1039\/D4LC00734D","volume":"25","author":"Cho","year":"2025","journal-title":"Lab Chip"},{"key":"D6AY00596A\/cit37\/1","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1039\/D3LC00210A","volume":"23","author":"Friedel","year":"2023","journal-title":"Lab Chip"},{"key":"D6AY00596A\/cit38\/1","doi-asserted-by":"crossref","first-page":"11856","DOI":"10.1021\/acs.analchem.2c02317","volume":"94","author":"Wang","year":"2022","journal-title":"Anal. Chem."},{"key":"D6AY00596A\/cit39\/1","doi-asserted-by":"crossref","first-page":"20073","DOI":"10.1021\/acsnano.3c05638","volume":"17","author":"Huang","year":"2023","journal-title":"ACS Nano"},{"key":"D6AY00596A\/cit40\/1","first-page":"e03698","author":"Quan","year":"2025","journal-title":"Adv. Healthcare Mater."},{"key":"D6AY00596A\/cit41\/1","doi-asserted-by":"crossref","first-page":"2417520","DOI":"10.1002\/adma.202417520","volume":"37","author":"Bocan","year":"2025","journal-title":"Adv. Mater."},{"key":"D6AY00596A\/cit42\/1","first-page":"5","volume":"11","author":"Jung","year":"2024","journal-title":"Commun. Mater."},{"key":"D6AY00596A\/cit43\/1","first-page":"1","author":"Masood","year":"2024","journal-title":"CAAI Trans. Intell. Technol."},{"issue":"3","key":"D6AY00596A\/cit44\/1","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.32604\/cmc.2025.063643","volume":"83","author":"Alqudah","year":"2025","journal-title":"Comput., Mater. & Continua"},{"issue":"3","key":"D6AY00596A\/cit45\/1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3390\/a18030156","volume":"18","author":"Chow","year":"2025","journal-title":"Algorithms"},{"key":"D6AY00596A\/cit46\/1","doi-asserted-by":"crossref","first-page":"69902","DOI":"10.1039\/C6RA09773A","volume":"6","author":"Akta\u015f","year":"2016","journal-title":"RSC Adv."},{"key":"D6AY00596A\/cit47\/1","doi-asserted-by":"crossref","first-page":"117089","DOI":"10.1016\/j.trac.2023.117089","volume":"164","author":"Desagani","year":"2023","journal-title":"TrAC, Trends Anal. Chem."},{"key":"D6AY00596A\/cit48\/1","doi-asserted-by":"crossref","first-page":"113356","DOI":"10.1016\/j.microc.2025.113356","volume":"212","author":"Sierra-Padilla","year":"2025","journal-title":"Microchem. J."},{"key":"D6AY00596A\/cit49\/1","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41377-023-01271-7","volume":"12","author":"Shi","year":"2023","journal-title":"Light: Sci. Appl."},{"key":"D6AY00596A\/cit50\/1","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.1021\/acs.jcim.4c00077","volume":"64","author":"Berger","year":"2024","journal-title":"J. Chem. Inf. Model."},{"key":"D6AY00596A\/cit51\/1","doi-asserted-by":"crossref","first-page":"124187","DOI":"10.1016\/j.talanta.2022.124187","volume":"254","author":"Hubli","year":"2023","journal-title":"Talanta"},{"key":"D6AY00596A\/cit52\/1","doi-asserted-by":"crossref","first-page":"122293","DOI":"10.1016\/j.saa.2022.122293","volume":"290","author":"Wang","year":"2023","journal-title":"Spectrochim. Acta, Part A"},{"key":"D6AY00596A\/cit53\/1","doi-asserted-by":"crossref","first-page":"pyaf016","DOI":"10.1093\/ijnp\/pyaf016","volume":"28","author":"Sugiki","year":"2025","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"D6AY00596A\/cit54\/1","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.3390\/app14052118","volume":"14","author":"Huang","year":"2024","journal-title":"Appl. Sci."},{"key":"D6AY00596A\/cit55\/1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3390\/bioengineering11050482","volume":"11","author":"Srivastava","year":"2024","journal-title":"Bioengineering"},{"key":"D6AY00596A\/cit56\/1","doi-asserted-by":"crossref","first-page":"8665","DOI":"10.1007\/s11468-025-02810-1","volume":"20","author":"Ould","year":"2025","journal-title":"Plasmonics"},{"key":"D6AY00596A\/cit57\/1","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1021\/jf052570u","volume":"54","author":"Kovalenko","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"D6AY00596A\/cit58\/1","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.jpba.2009.06.040","volume":"50","author":"Lin","year":"2009","journal-title":"J. Pharm. Biomed. Anal."},{"key":"D6AY00596A\/cit59\/1","doi-asserted-by":"crossref","first-page":"e0210084","DOI":"10.1371\/journal.pone.0210084","volume":"14","author":"Yang","year":"2019","journal-title":"PLoS One"},{"key":"D6AY00596A\/cit60\/1","doi-asserted-by":"crossref","first-page":"1588072","DOI":"10.3389\/fimmu.2025.1588072","volume":"16","author":"Zhu","year":"2025","journal-title":"Front. Immunol."},{"key":"D6AY00596A\/cit61\/1","doi-asserted-by":"crossref","first-page":"102811","DOI":"10.1016\/j.pdpdt.2022.102811","volume":"38","author":"Dawuti","year":"2022","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"D6AY00596A\/cit62\/1","doi-asserted-by":"crossref","first-page":"1345099","DOI":"10.3389\/fphar.2024.1345099","volume":"15","author":"Yan","year":"2024","journal-title":"Front. Pharmacol"},{"key":"D6AY00596A\/cit63\/1","doi-asserted-by":"crossref","first-page":"5436","DOI":"10.1038\/s41598-020-62338-8","volume":"10","author":"Seifert","year":"2020","journal-title":"Sci. Rep."},{"key":"D6AY00596A\/cit64\/1","doi-asserted-by":"crossref","first-page":"116457","DOI":"10.1016\/j.jpba.2024.116457","volume":"252","author":"Zhang","year":"2025","journal-title":"J. Pharm. Biomed. Anal."},{"key":"D6AY00596A\/cit65\/1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1186\/s12871-023-02317-4","volume":"23","author":"She","year":"2023","journal-title":"BMC Anesthesiol."},{"key":"D6AY00596A\/cit66\/1","doi-asserted-by":"crossref","first-page":"117523","DOI":"10.1016\/j.cca.2023.117523","volume":"548","author":"Sun","year":"2023","journal-title":"Clin. Chim. Acta"},{"key":"D6AY00596A\/cit67\/1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12911-023-02171-x","volume":"23","author":"Guan","year":"2023","journal-title":"BMC Med. Inf. Decis. Making"},{"key":"D6AY00596A\/cit68\/1","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/s44222-023-00094-w","volume":"1","author":"Chen","year":"2023","journal-title":"Nat. Rev. Bioeng."},{"key":"D6AY00596A\/cit69\/1","doi-asserted-by":"crossref","first-page":"987","DOI":"10.3390\/metabo13090987","volume":"13","author":"Mujalli","year":"2023","journal-title":"Metabolites"},{"key":"D6AY00596A\/cit70\/1","doi-asserted-by":"crossref","first-page":"e37964","DOI":"10.1016\/j.heliyon.2024.e37964","volume":"10","author":"Nashruddin","year":"2024","journal-title":"Heliyon"},{"key":"D6AY00596A\/cit71\/1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3390\/bios15080487","volume":"15","author":"Liu","year":"2025","journal-title":"Biosensors"}],"container-title":["Analytical Methods"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/AY\/article-pdf\/doi\/10.1039\/D6AY00596A\/0\/D6AY00596A.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T15:16:01Z","timestamp":1784214961000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/AY\/article-lookup\/doi\/10.1039\/D6AY00596A"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":71,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2026,7,16]]}},"URL":"https:\/\/doi.org\/10.1039\/d6ay00596a","relation":{},"ISSN":["1759-9660","1759-9679"],"issn-type":[{"value":"1759-9660","type":"print"},{"value":"1759-9679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}