{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:17:09Z","timestamp":1782947829311,"version":"3.54.5"},"reference-count":62,"publisher":"Royal Society of Chemistry (RSC)","issue":"9","license":[{"start":{"date-parts":[[2027,4,7]],"date-time":"2027-04-07T00:00:00Z","timestamp":1807056000000},"content-version":"am","delay-in-days":461,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52073293"],"award-info":[{"award-number":["52073293"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52273160"],"award-info":[{"award-number":["52273160"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<jats:p>This study demonstrates that HACC is a promising candidate for regulating immune responses and mitigating allergic airway inflammation.<\/jats:p>","DOI":"10.1039\/d6bm00169f","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T15:14:17Z","timestamp":1775574857000},"page":"2472-2485","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Macrophage phenotype modulation\n                    <i>via<\/i>\n                    2-hydroxypropyltrimethyl ammonium chloride chitosan: a novel strategy for managing allergic rhinitis"],"prefix":"10.1039","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0238-414X","authenticated-orcid":false,"given":"Yi","family":"Peng","sequence":"first","affiliation":[{"name":"Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuida","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejia","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6722-0487","authenticated-orcid":false,"given":"Meng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Ju","sequence":"additional","affiliation":[{"name":"Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4607-2785","authenticated-orcid":false,"given":"Ye","family":"Tian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8495-5626","authenticated-orcid":false,"given":"Dongdong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6119-3227","authenticated-orcid":false,"given":"Zhongwei","family":"Niu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China"},{"name":"School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"1","key":"D6BM00169F\/cit1\/1","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s41572-020-00227-0","volume":"6","author":"Bousquet","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"10","key":"D6BM00169F\/cit2\/1","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1001\/jama.2024.0530","volume":"331","author":"Bernstein","year":"2024","journal-title":"J. Am. Med. Assoc."},{"issue":"3","key":"D6BM00169F\/cit3\/1","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1097\/ACI.0000000000001069","volume":"25","author":"Hamizan","year":"2025","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"issue":"3","key":"D6BM00169F\/cit4\/1","doi-asserted-by":"publisher","first-page":"e12130","DOI":"10.1002\/clt2.12130","volume":"12","author":"Savour\u00e9","year":"2022","journal-title":"Clin. Transl. Allergy"},{"issue":"8","key":"D6BM00169F\/cit5\/1","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1111\/all.12874","volume":"71","author":"Wang","year":"2016","journal-title":"Allergy"},{"issue":"6","key":"D6BM00169F\/cit6\/1","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1016\/j.jaip.2024.04.012","volume":"12","author":"Kim","year":"2024","journal-title":"J. Allergy Clin. Immunol.: Pract."},{"issue":"11","key":"D6BM00169F\/cit7\/1","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/s41577-021-00538-7","volume":"21","author":"Akdis","year":"2021","journal-title":"Nat. Rev. Immunol."},{"issue":"11","key":"D6BM00169F\/cit8\/1","doi-asserted-by":"publisher","first-page":"3383","DOI":"10.1111\/all.15044","volume":"76","author":"Zhang","year":"2021","journal-title":"Allergy"},{"issue":"3","key":"D6BM00169F\/cit9\/1","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1067\/mai.2000.104575","volume":"105","author":"Romagnani","year":"2000","journal-title":"J. Allergy Clin. Immunol."},{"issue":"2","key":"D6BM00169F\/cit10\/1","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S0091-6749(00)90068-X","volume":"105","author":"Christodoulopoulos","year":"2000","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5","key":"D6BM00169F\/cit11\/1","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1056\/NEJMcp1412282","volume":"372","author":"Wheatley","year":"2015","journal-title":"N. Engl. J. Med."},{"issue":"25","key":"D6BM00169F\/cit12\/1","doi-asserted-by":"publisher","first-page":"eaat1604","DOI":"10.1126\/sciimmunol.aat1604","volume":"3","author":"Lloyd","year":"2018","journal-title":"Sci. Immunol."},{"issue":"6","key":"D6BM00169F\/cit13\/1","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.jaci.2004.03.020","volume":"113","author":"Norman","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"issue":"6","key":"D6BM00169F\/cit14\/1","doi-asserted-by":"publisher","first-page":"604","DOI":"10.4168\/aair.2022.14.6.604","volume":"14","author":"Wang","year":"2022","journal-title":"Allergy, Asthma Immunol. Res."},{"issue":"10","key":"D6BM00169F\/cit15\/1","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/ni.1937","volume":"11","author":"Biswas","year":"2010","journal-title":"Nat. Immunol."},{"issue":"4","key":"D6BM00169F\/cit16\/1","doi-asserted-by":"publisher","first-page":"793","DOI":"10.3390\/polym15040793","volume":"15","author":"Piekarska","year":"2023","journal-title":"Polymers"},{"key":"D6BM00169F\/cit17\/1","doi-asserted-by":"publisher","first-page":"103267","DOI":"10.1016\/j.cis.2024.103267","volume":"332","author":"Zhang","year":"2024","journal-title":"Adv. Colloid Interface Sci."},{"issue":"1","key":"D6BM00169F\/cit18\/1","doi-asserted-by":"publisher","first-page":"130517","DOI":"10.1016\/j.bbagen.2023.130517","volume":"1868","author":"Prabakaran","year":"2024","journal-title":"Biochim. Biophys. Acta, Gen. Subj."},{"issue":"7","key":"D6BM00169F\/cit19\/1","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1023\/a:1012160102740","volume":"14","author":"Schipper","year":"1997","journal-title":"Pharm. Res."},{"issue":"26","key":"D6BM00169F\/cit20\/1","doi-asserted-by":"publisher","first-page":"6164","DOI":"10.1016\/j.biomaterials.2011.03.056","volume":"32","author":"Yeh","year":"2011","journal-title":"Biomaterials"},{"issue":"1\u20132","key":"D6BM00169F\/cit21\/1","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.ijpharm.2010.08.020","volume":"400","author":"Vllasaliu","year":"2010","journal-title":"Int. J. Pharm."},{"key":"D6BM00169F\/cit22\/1","doi-asserted-by":"publisher","first-page":"152131","DOI":"10.1016\/j.cej.2024.152131","volume":"491","author":"Zhu","year":"2024","journal-title":"Chem. Eng. J."},{"key":"D6BM00169F\/cit23\/1","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.carbpol.2018.10.101","volume":"205","author":"Yang","year":"2019","journal-title":"Carbohydr. Polym."},{"issue":"5","key":"D6BM00169F\/cit24\/1","doi-asserted-by":"publisher","first-page":"2056","DOI":"10.1021\/acs.nanolett.2c03809","volume":"23","author":"Ou","year":"2023","journal-title":"Nano Lett."},{"issue":"8","key":"D6BM00169F\/cit25\/1","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1113\/EP087751","volume":"104","author":"Cui","year":"2019","journal-title":"Exp. Physiol."},{"issue":"2","key":"D6BM00169F\/cit26\/1","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3390\/md20020086","volume":"20","author":"Cui","year":"2022","journal-title":"Mar. Drugs"},{"key":"D6BM00169F\/cit27\/1","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1016\/j.ijbiomac.2019.11.019","volume":"154","author":"Wang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"D6BM00169F\/cit28\/1","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.ijbiomac.2017.05.132","volume":"103","author":"Tan","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"D6BM00169F\/cit29\/1","doi-asserted-by":"publisher","first-page":"118050","DOI":"10.1016\/j.carbpol.2021.118050","volume":"264","author":"Li","year":"2021","journal-title":"Carbohydr. Polym."},{"issue":"2","key":"D6BM00169F\/cit30\/1","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/S0378-5173(99)00442-1","volume":"198","author":"Washington","year":"2000","journal-title":"Int. J. Pharm."},{"issue":"1","key":"D6BM00169F\/cit31\/1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1046\/j.1365-2273.1999.00223.x","volume":"24","author":"England","year":"1999","journal-title":"Clin. Otolaryngol. Allied Sci."},{"key":"D6BM00169F\/cit32\/1","doi-asserted-by":"publisher","first-page":"217772","DOI":"10.1016\/j.canlet.2025.217772","volume":"625","author":"Bai","year":"2025","journal-title":"Cancer Lett."},{"key":"D6BM00169F\/cit33\/1","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1186\/s13075-022-02938-z","volume":"24","author":"Wu","year":"2022","journal-title":"Arthritis Res. Ther."},{"issue":"2","key":"D6BM00169F\/cit34\/1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1189\/jlb.0602325","volume":"73","author":"Mosser","year":"2003","journal-title":"J. Leukocyte Biol."},{"key":"D6BM00169F\/cit35\/1","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.3389\/fimmu.2019.01084","volume":"10","author":"Orecchioni","year":"2019","journal-title":"Front. Immunol."},{"issue":"1","key":"D6BM00169F\/cit36\/1","doi-asserted-by":"publisher","first-page":"816460","DOI":"10.1155\/2015\/816460","volume":"2015","author":"R\u0151szer","year":"2015","journal-title":"Mediators Inflammation"},{"issue":"25","key":"D6BM00169F\/cit37\/1","doi-asserted-by":"publisher","first-page":"4054","DOI":"10.1182\/blood-2013-05-501494","volume":"122","author":"Zajac","year":"2013","journal-title":"Blood"},{"key":"D6BM00169F\/cit38\/1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.12703\/P6-13","volume":"6","author":"Martinez","year":"2014","journal-title":"F1000prime Rep."},{"issue":"5","key":"D6BM00169F\/cit39\/1","doi-asserted-by":"publisher","first-page":"2379","DOI":"10.3390\/molecules28052379","volume":"28","author":"Deng","year":"2023","journal-title":"Molecules"},{"key":"D6BM00169F\/cit40\/1","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nature11986","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"issue":"1","key":"D6BM00169F\/cit41\/1","doi-asserted-by":"publisher","first-page":"605","DOI":"10.4049\/jimmunol.0901698","volume":"185","author":"Rodr\u00edguez-Prados","year":"2010","journal-title":"J. Immunol."},{"key":"D6BM00169F\/cit42\/1","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s40364-022-00376-2","volume":"10","author":"Okabe","year":"2022","journal-title":"Biomarker Res."},{"issue":"3","key":"D6BM00169F\/cit43\/1","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.yexmp.2009.01.003","volume":"86","author":"Yalcin","year":"2009","journal-title":"Exp. Mol. Pathol."},{"issue":"4","key":"D6BM00169F\/cit44\/1","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/S0092-8674(04)00451-9","volume":"117","author":"Amsen","year":"2004","journal-title":"Cell"},{"issue":"1","key":"D6BM00169F\/cit45\/1","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.jaci.2021.05.044","volume":"149","author":"Gauthier","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"D6BM00169F\/cit46\/1","doi-asserted-by":"publisher","first-page":"292376","DOI":"10.1155\/2014\/292376","volume":"2014","author":"Aldinucci","year":"2014","journal-title":"Mediators Inflammation"},{"issue":"1","key":"D6BM00169F\/cit47\/1","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.jaci.2023.02.028","volume":"152","author":"Gauthier","year":"2023","journal-title":"J. Allergy Clin. Immunol."},{"key":"D6BM00169F\/cit48\/1","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12967-020-02251-w","volume":"18","author":"Abdelaziz","year":"2020","journal-title":"J. Transl. Med."},{"issue":"6","key":"D6BM00169F\/cit49\/1","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1159\/000529436","volume":"184","author":"Lou","year":"2023","journal-title":"Int. Arch. Allergy Immunol."},{"issue":"7","key":"D6BM00169F\/cit50\/1","doi-asserted-by":"publisher","first-page":"2689","DOI":"10.1007\/s00436-013-3436-x","volume":"112","author":"Zhao","year":"2013","journal-title":"Parasitol. Res."},{"issue":"12","key":"D6BM00169F\/cit51\/1","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1038\/ni.3023","volume":"15","author":"Sutherland","year":"2014","journal-title":"Nat. Immunol."},{"issue":"1","key":"D6BM00169F\/cit52\/1","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.chest.2019.04.101","volume":"156","author":"Kato","year":"2019","journal-title":"Chest"},{"issue":"2","key":"D6BM00169F\/cit53\/1","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.jaci.2015.08.044","volume":"137","author":"Holt","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"issue":"11","key":"D6BM00169F\/cit54\/1","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1111\/all.13852","volume":"74","author":"Lou","year":"2019","journal-title":"Allergy"},{"key":"D6BM00169F\/cit55\/1","doi-asserted-by":"publisher","first-page":"105","DOI":"10.3390\/md15040105","volume":"15","author":"Lee","year":"2017","journal-title":"Mar. Drugs"},{"issue":"4","key":"D6BM00169F\/cit56\/1","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/s0092-8674(00)80240-8","volume":"89","author":"Zheng","year":"1997","journal-title":"Cell"},{"issue":"1","key":"D6BM00169F\/cit57\/1","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1146\/annurev-immunol-030409-101212","volume":"28","author":"Zhu","year":"2010","journal-title":"Annu. Rev. Immunol."},{"issue":"2","key":"D6BM00169F\/cit58\/1","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.jtbi.2004.06.013","volume":"231","author":"Yates","year":"2004","journal-title":"J. Theor. Biol."},{"issue":"1","key":"D6BM00169F\/cit59\/1","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/all.16326","volume":"80","author":"Conrad","year":"2025","journal-title":"Allergy"},{"issue":"5","key":"D6BM00169F\/cit60\/1","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1016\/j.jaci.2021.03.015","volume":"147","author":"Bartemes","year":"2021","journal-title":"J.\nAllergy Clin. Immunol."},{"key":"D6BM00169F\/cit61\/1","doi-asserted-by":"publisher","first-page":"5610","DOI":"10.1038\/s41467-025-60920-0","volume":"16","author":"Zhou","year":"2025","journal-title":"Nat. Commun."},{"key":"D6BM00169F\/cit62\/1","doi-asserted-by":"publisher","first-page":"138478","DOI":"10.1016\/j.ijbiomac.2024.138478","volume":"286","author":"Pan","year":"2025","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/BM\/D6BM00169F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T22:11:01Z","timestamp":1782943861000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/14\/9\/2472-2485\/1229028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":62,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,5,5]]}},"URL":"https:\/\/doi.org\/10.1039\/d6bm00169f","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D6BM00169F\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6BM00169F\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6BM00169F\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6BM00169F\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6BM00169F\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6BM00169F\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6BM00169F\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}