{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:05:06Z","timestamp":1784019906051,"version":"3.55.0"},"reference-count":48,"publisher":"Royal Society of Chemistry (RSC)","issue":"14","license":[{"start":{"date-parts":[[2027,6,15]],"date-time":"2027-06-15T00:00:00Z","timestamp":1813017600000},"content-version":"am","delay-in-days":530,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072707"],"award-info":[{"award-number":["82072707"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82503551"],"award-info":[{"award-number":["82503551"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302118"],"award-info":[{"award-number":["82302118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<jats:p>A biomimetic MXene nanoplatform enables tumor-targeted, oxygen self sufficient PTT\/PDT, triggering ICD and T cell immunity. Combined with \u03b1PD-1, it suppresses both primary and distant pancreatic tumors, overcoming immunotherapy resistance.<\/jats:p>","DOI":"10.1039\/d6bm00210b","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T07:43:02Z","timestamp":1781509382000},"page":"3885-3901","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomimetic MXene nanoplatform for tumor-specific synergistic phototherapy and immune reprogramming in pancreatic cancer"],"prefix":"10.1039","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5758-3642","authenticated-orcid":false,"given":"Tong","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Oncology, First Affiliated Hospital of Naval Medical University (Shanghai Changhai Hospital), Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4759-7364","authenticated-orcid":false,"given":"Xiaodong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Nanomedicine & Shanghai Key laboratory of Nautical Medicine and Translation of drugs and Medical Devices, Naval Medical University, Shanghai, 200433, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Oncology, First Affiliated Hospital of Naval Medical University (Shanghai Changhai Hospital), Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology, First Affiliated Hospital of Naval Medical University (Shanghai Changhai Hospital), Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Oncology, First Affiliated Hospital of Naval Medical University (Shanghai Changhai Hospital), Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Oncology, First Affiliated Hospital of Naval Medical University (Shanghai Changhai Hospital), Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology, First Affiliated Hospital of Naval Medical University (Shanghai Changhai Hospital), Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huawei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Oncology, First Affiliated Hospital of Naval Medical University (Shanghai Changhai Hospital), Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Oncology, First Affiliated Hospital of Naval Medical University (Shanghai Changhai Hospital), Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology, First Affiliated Hospital of Naval Medical University (Shanghai Changhai Hospital), Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Oncology, First Affiliated Hospital of Naval Medical University (Shanghai Changhai Hospital), Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nanomedicine & Shanghai Key laboratory of Nautical Medicine and Translation of drugs and Medical Devices, Naval Medical University, Shanghai, 200433, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianbao","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Oncology, First Affiliated Hospital of Naval Medical University (Shanghai Changhai Hospital), Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6BM00210B\/cit1\/1","doi-asserted-by":"crossref","first-page":"189183","DOI":"10.1016\/j.bbcan.2024.189183","volume":"1879","author":"Zhao","year":"2024","journal-title":"Biochim. Biophys. Acta, Rev. Cancer"},{"key":"D6BM00210B\/cit2\/1","doi-asserted-by":"crossref","first-page":"e2313670","DOI":"10.1002\/adma.202313670","volume":"36","author":"Geng","year":"2024","journal-title":"Adv. Mater."},{"key":"D6BM00210B\/cit3\/1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cytogfr.2023.06.006","volume":"71\u201372","author":"Bandi","year":"2023","journal-title":"Cytokine Growth Factor Rev."},{"key":"D6BM00210B\/cit4\/1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/EXP.20210003","volume":"1","author":"Liu","year":"2021","journal-title":"Exploration"},{"issue":"25","key":"D6BM00210B\/cit5\/1","doi-asserted-by":"crossref","first-page":"6119","DOI":"10.1016\/j.cell.2021.11.017","volume":"184","author":"Raghavan","year":"2021","journal-title":"Cell"},{"key":"D6BM00210B\/cit6\/1","doi-asserted-by":"crossref","first-page":"217699","DOI":"10.1016\/j.canlet.2025.217699","volume":"622","author":"Br\u00e4utigam","year":"2025","journal-title":"Cancer Lett."},{"key":"D6BM00210B\/cit7\/1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12943-023-01813-y","volume":"22","author":"Gautam","year":"2023","journal-title":"Mol. Cancer"},{"key":"D6BM00210B\/cit8\/1","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.3390\/pharmaceutics14102033","volume":"14","author":"Hou","year":"2022","journal-title":"Pharmaceutics"},{"key":"D6BM00210B\/cit9\/1","first-page":"257","volume":"1","author":"Li","year":"2025","journal-title":"Med. Res."},{"key":"D6BM00210B\/cit10\/1","doi-asserted-by":"crossref","first-page":"122369","DOI":"10.1016\/j.biomaterials.2023.122369","volume":"303","author":"Long","year":"2023","journal-title":"Biomaterials"},{"key":"D6BM00210B\/cit11\/1","doi-asserted-by":"crossref","first-page":"137652","DOI":"10.1016\/j.jcis.2025.137652","author":"Gan","year":"2025","journal-title":"J. Colloid Interface Sci."},{"key":"D6BM00210B\/cit12\/1","doi-asserted-by":"crossref","first-page":"7546","DOI":"10.7150\/thno.56482","volume":"11","author":"Huang","year":"2021","journal-title":"Theranostics"},{"key":"D6BM00210B\/cit13\/1","doi-asserted-by":"crossref","first-page":"1800678","DOI":"10.1002\/smll.201800678","volume":"14","author":"Sweeney","year":"2018","journal-title":"Small"},{"key":"D6BM00210B\/cit14\/1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/imr.13301","volume":"321","author":"Janssens","year":"2024","journal-title":"Immunol. Rev."},{"key":"D6BM00210B\/cit15\/1","doi-asserted-by":"crossref","first-page":"2205701","DOI":"10.1002\/adma.202205701","volume":"34","author":"Zhang","year":"2022","journal-title":"Adv. Mater."},{"key":"D6BM00210B\/cit16\/1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.7150\/thno.67300","volume":"12","author":"Ji","year":"2022","journal-title":"Theranostics"},{"key":"D6BM00210B\/cit17\/1","first-page":"490","volume":"36","author":"Hu","year":"2024","journal-title":"Bioact. Mater."},{"key":"D6BM00210B\/cit18\/1","doi-asserted-by":"crossref","first-page":"0015","DOI":"10.34133\/bmef.0015","volume":"4","author":"Jin","year":"2023","journal-title":"BME Front."},{"key":"D6BM00210B\/cit19\/1","doi-asserted-by":"crossref","first-page":"8065","DOI":"10.1039\/D0CS00215A","volume":"49","author":"Xie","year":"2020","journal-title":"Chem. Soc. Rev."},{"key":"D6BM00210B\/cit20\/1","doi-asserted-by":"crossref","first-page":"26769","DOI":"10.1002\/anie.202111767","volume":"60","author":"Yan","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6BM00210B\/cit21\/1","doi-asserted-by":"crossref","first-page":"121476","DOI":"10.1016\/j.biomaterials.2022.121476","volume":"283","author":"Li","year":"2022","journal-title":"Biomaterials"},{"key":"D6BM00210B\/cit22\/1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.biomaterials.2016.03.037","volume":"93","author":"Hu","year":"2016","journal-title":"Biomaterials"},{"key":"D6BM00210B\/cit23\/1","doi-asserted-by":"crossref","first-page":"11446","DOI":"10.1021\/acsnano.8b06478","volume":"12","author":"Liang","year":"2018","journal-title":"ACS Nano"},{"key":"D6BM00210B\/cit24\/1","doi-asserted-by":"crossref","first-page":"e202202614","DOI":"10.1002\/anie.202202614","volume":"61","author":"Yan","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6BM00210B\/cit25\/1","doi-asserted-by":"crossref","first-page":"2401655","DOI":"10.1002\/smll.202401655","volume":"20","author":"Zhu","year":"2024","journal-title":"Small"},{"key":"D6BM00210B\/cit26\/1","doi-asserted-by":"crossref","first-page":"e2302559","DOI":"10.1002\/adma.202302559","volume":"35","author":"Gao","year":"2023","journal-title":"Adv. Mater."},{"key":"D6BM00210B\/cit27\/1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s40820-020-00561-8","volume":"13","author":"Yang","year":"2021","journal-title":"Nano-Micro Lett."},{"key":"D6BM00210B\/cit28\/1","doi-asserted-by":"crossref","first-page":"2416161","DOI":"10.1002\/adma.202416161","volume":"37","author":"Song","year":"2025","journal-title":"Adv. Mater."},{"key":"D6BM00210B\/cit29\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.canlet.2020.04.018","volume":"484","author":"Yamasaki","year":"2020","journal-title":"Cancer Lett."},{"key":"D6BM00210B\/cit30\/1","doi-asserted-by":"crossref","first-page":"6591","DOI":"10.21873\/anticanres.13026","volume":"38","author":"Aslan","year":"2018","journal-title":"Anticancer Res."},{"key":"D6BM00210B\/cit31\/1","doi-asserted-by":"crossref","first-page":"216636","DOI":"10.1016\/j.canlet.2024.216636","volume":"585","author":"Wei","year":"2024","journal-title":"Cancer Lett."},{"key":"D6BM00210B\/cit32\/1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.53388\/BMEC2026011","volume":"5","author":"Li","year":"2026","journal-title":"Biomed. Eng. Commun."},{"key":"D6BM00210B\/cit33\/1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1039\/D5BM01202C","volume":"14","author":"Ambigaibalan","year":"2026","journal-title":"Biomater. Sci."},{"key":"D6BM00210B\/cit34\/1","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1021\/acsaenm.5c00041","volume":"3","author":"Ambigaibalan","year":"2025","journal-title":"ACS Appl. Eng. Mater."},{"key":"D6BM00210B\/cit35\/1","doi-asserted-by":"crossref","first-page":"106810","DOI":"10.1016\/j.jddst.2025.106810","volume":"107","author":"Dharshini","year":"2025","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"D6BM00210B\/cit36\/1","doi-asserted-by":"crossref","first-page":"114142","DOI":"10.1016\/j.jconrel.2025.114142","volume":"386","author":"Guo","year":"2025","journal-title":"J. Controlled Release"},{"key":"D6BM00210B\/cit37\/1","doi-asserted-by":"crossref","first-page":"2200389","DOI":"10.1002\/adma.202200389","volume":"34","author":"Hou","year":"2022","journal-title":"Adv. Mater."},{"key":"D6BM00210B\/cit38\/1","doi-asserted-by":"crossref","first-page":"5895","DOI":"10.1021\/acs.nanolett.6b02786","volume":"16","author":"Zhu","year":"2016","journal-title":"Nano Lett."},{"key":"D6BM00210B\/cit39\/1","doi-asserted-by":"crossref","first-page":"159311","DOI":"10.1016\/j.cej.2025.159311","volume":"505","author":"Wang","year":"2025","journal-title":"Chem. Eng. J."},{"key":"D6BM00210B\/cit40\/1","doi-asserted-by":"crossref","first-page":"215712","DOI":"10.1016\/j.ccr.2024.215712","volume":"506","author":"Pan","year":"2024","journal-title":"Coord. Chem. Rev."},{"key":"D6BM00210B\/cit41\/1","doi-asserted-by":"crossref","first-page":"20230061","DOI":"10.1002\/EXP.20230061","volume":"3","author":"Yang","year":"2023","journal-title":"Exploration"},{"key":"D6BM00210B\/cit42\/1","doi-asserted-by":"crossref","first-page":"109578","DOI":"10.1016\/j.cclet.2024.109578","volume":"35","author":"Wang","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"D6BM00210B\/cit43\/1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jconrel.2023.10.032","volume":"364","author":"Sun","year":"2023","journal-title":"J. Controlled Release"},{"key":"D6BM00210B\/cit44\/1","doi-asserted-by":"crossref","first-page":"e70117","DOI":"10.1002\/imt2.70117","volume":"5","author":"Ji","year":"2026","journal-title":"iMeta"},{"key":"D6BM00210B\/cit45\/1","first-page":"257","volume":"1","author":"Li","year":"2025","journal-title":"Med Res."},{"key":"D6BM00210B\/cit46\/1","doi-asserted-by":"crossref","first-page":"0574","DOI":"10.34133\/research.0574","volume":"8","author":"Wang","year":"2025","journal-title":"Research"},{"key":"D6BM00210B\/cit47\/1","doi-asserted-by":"crossref","first-page":"e70027","DOI":"10.1002\/inm3.70027","volume":"00","author":"Wang","year":"2026","journal-title":"iNew Med."},{"key":"D6BM00210B\/cit48\/1","doi-asserted-by":"crossref","first-page":"100001","DOI":"10.1016\/j.nbe.2025.100001","volume":"18","author":"Xu","year":"2026","journal-title":"Nano Biomed. Eng."}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/BM\/article-pdf\/doi\/10.1039\/D6BM00210B\/0\/D6BM00210B.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T08:16:39Z","timestamp":1784016999000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/BM\/article-lookup\/doi\/10.1039\/D6BM00210B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":48,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2026,7,14]]}},"URL":"https:\/\/doi.org\/10.1039\/d6bm00210b","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}