{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T12:27:39Z","timestamp":1786451259868,"version":"build-2736575974"},"reference-count":36,"publisher":"Royal Society of Chemistry (RSC)","issue":"16","license":[{"start":{"date-parts":[[2027,7,3]],"date-time":"2027-07-03T00:00:00Z","timestamp":1814572800000},"content-version":"am","delay-in-days":548,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100008387","name":"Xi'an Science and Technology Bureau","doi-asserted-by":"publisher","award":["2025JH-YXYJYB-0119"],"award-info":[{"award-number":["2025JH-YXYJYB-0119"]}],"id":[{"id":"10.13039\/501100008387","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2025SF-YBXM-245"],"award-info":[{"award-number":["2025SF-YBXM-245"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<jats:p>\n                    FeOLDA network activates TRPV1 to induce Ca\n                    <jats:sup>2+<\/jats:sup>\n                    overload for ROS elevation and ER-stress-mediated apoptosis, and delivers Fe\n                    <jats:sup>2+<\/jats:sup>\n                    to trigger ferroptosis. Synergistic apoptosis\/ferroptosis induction provokes cell death for NSCLC therapy.\n                  <\/jats:p>","DOI":"10.1039\/d6bm00434b","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T02:43:18Z","timestamp":1783046598000},"page":"4336-4348","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["TRPV-1-targeted Fe-phenolate network provokes apoptosis and ferroptosis to treat non-small cell lung cancer"],"prefix":"10.1039","volume":"14","author":[{"given":"Ziyi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, P. R. China"},{"name":"Department of Biophysics, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Biophysics, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunbao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4048-2887","authenticated-orcid":false,"given":"Guanying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biophysics, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6BM00434B\/cit1\/1","first-page":"229","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"D6BM00434B\/cit2\/1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41572-024-00551-9","volume":"10","author":"Hendriks","year":"2024","journal-title":"Nat. Rev. Dis. Primers"},{"key":"D6BM00434B\/cit3\/1","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1200\/JCO.2017.76.8390","volume":"36","author":"Gridelli","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"D6BM00434B\/cit4\/1","doi-asserted-by":"crossref","first-page":"106939","DOI":"10.1016\/j.ejps.2024.106939","volume":"203","author":"Elmorsy","year":"2024","journal-title":"Eur. J. Pharm. Sci."},{"key":"D6BM00434B\/cit5\/1","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1021\/acs.chemrestox.9b00204","volume":"32","author":"Qi","year":"2019","journal-title":"Chem. Res. Toxicol."},{"key":"D6BM00434B\/cit6\/1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12943-022-01530-y","volume":"21","author":"Zhang","year":"2022","journal-title":"Mol. Cancer"},{"key":"D6BM00434B\/cit7\/1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/s41568-019-0149-1","volume":"19","author":"Friedmann Angeli","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"D6BM00434B\/cit8\/1","doi-asserted-by":"crossref","first-page":"13335","DOI":"10.3390\/ijms222413335","volume":"22","author":"Zou","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"D6BM00434B\/cit9\/1","first-page":"33","volume":"11","author":"Wu","year":"2025","journal-title":"Cell Death Discovery"},{"key":"D6BM00434B\/cit10\/1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/s41420-023-01407-z","volume":"9","author":"Xing","year":"2023","journal-title":"Cell Death Discovery"},{"key":"D6BM00434B\/cit11\/1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.22203\/eCM.v050a06","volume":"50","author":"Pang","year":"2025","journal-title":"Eur. Cells Mater."},{"key":"D6BM00434B\/cit12\/1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/s41392-021-00780-4","volume":"6","author":"Huang","year":"2021","journal-title":"Signal Transduction Targeted Ther."},{"key":"D6BM00434B\/cit13\/1","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/s41591-024-02903-0","volume":"30","author":"Singhal","year":"2024","journal-title":"Nat. Med."},{"key":"D6BM00434B\/cit14\/1","doi-asserted-by":"crossref","first-page":"112945","DOI":"10.1016\/j.celrep.2023.112945","volume":"42","author":"Yang","year":"2023","journal-title":"Cell Rep."},{"key":"D6BM00434B\/cit15\/1","doi-asserted-by":"crossref","first-page":"7482","DOI":"10.1021\/acsnano.1c00894","volume":"15","author":"Liu","year":"2021","journal-title":"ACS Nano"},{"key":"D6BM00434B\/cit16\/1","doi-asserted-by":"crossref","first-page":"2108263","DOI":"10.1002\/adma.202108263","volume":"34","author":"Zhao","year":"2022","journal-title":"Adv. Mater."},{"key":"D6BM00434B\/cit17\/1","doi-asserted-by":"crossref","first-page":"e19431","DOI":"10.1002\/advs.202519431","volume":"13","author":"Zhao","year":"2026","journal-title":"Adv. Sci."},{"key":"D6BM00434B\/cit18\/1","doi-asserted-by":"crossref","first-page":"6066","DOI":"10.1021\/acsabm.5c00634","volume":"8","author":"Wang","year":"2025","journal-title":"ACS Appl. Bio Mater."},{"key":"D6BM00434B\/cit19\/1","doi-asserted-by":"crossref","first-page":"12181","DOI":"10.1021\/acsnano.8b05860","volume":"12","author":"Liu","year":"2018","journal-title":"ACS Nano"},{"key":"D6BM00434B\/cit20\/1","doi-asserted-by":"crossref","first-page":"1704877","DOI":"10.1002\/adma.201704877","volume":"30","author":"Dai","year":"2018","journal-title":"Adv. Mater."},{"key":"D6BM00434B\/cit21\/1","doi-asserted-by":"crossref","first-page":"8141","DOI":"10.1021\/acs.nanolett.0c03127","volume":"20","author":"Chen","year":"2020","journal-title":"Nano Lett."},{"key":"D6BM00434B\/cit22\/1","doi-asserted-by":"crossref","first-page":"102135","DOI":"10.1016\/j.mtbio.2025.102135","volume":"34","author":"Bai","year":"2025","journal-title":"Mater. Today Bio"},{"key":"D6BM00434B\/cit23\/1","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.apsb.2021.11.001","volume":"12","author":"Zhong","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"D6BM00434B\/cit24\/1","doi-asserted-by":"crossref","first-page":"137192","DOI":"10.1016\/j.ijbiomac.2024.137192","volume":"282","author":"Yu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"D6BM00434B\/cit25\/1","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s13402-023-00894-7","volume":"47","author":"Wang","year":"2024","journal-title":"Cell. Oncol."},{"key":"D6BM00434B\/cit26\/1","doi-asserted-by":"crossref","first-page":"773654","DOI":"10.3389\/fonc.2022.773654","volume":"12","author":"Li","year":"2022","journal-title":"Front. Oncol."},{"key":"D6BM00434B\/cit27\/1","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1002\/mco2.139","volume":"3","author":"Gao","year":"2022","journal-title":"MedComm"},{"key":"D6BM00434B\/cit28\/1","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1111\/1759-7714.13042","volume":"10","author":"Zhu","year":"2019","journal-title":"Thorac. Cancer"},{"key":"D6BM00434B\/cit29\/1","doi-asserted-by":"crossref","first-page":"13633","DOI":"10.1074\/jbc.M211231200","volume":"278","author":"Chu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"D6BM00434B\/cit30\/1","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"D6BM00434B\/cit31\/1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1021\/ac50118a003","volume":"10","author":"Smith","year":"1938","journal-title":"Ind. Eng. Chem., Anal. Ed."},{"key":"D6BM00434B\/cit32\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0304-3940(91)90496-G","volume":"134","author":"Urban","year":"1991","journal-title":"Neurosci. Lett."},{"key":"D6BM00434B\/cit33\/1","doi-asserted-by":"crossref","first-page":"39776","DOI":"10.1074\/jbc.M112.382986","volume":"287","author":"Prantner","year":"2012","journal-title":"J. Biol. Chem."},{"key":"D6BM00434B\/cit34\/1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.bbrc.2015.02.004","volume":"460","author":"Krebs","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"D6BM00434B\/cit35\/1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nrm3270","volume":"13","author":"Hetz","year":"2012","journal-title":"Nat. Rev. Mol.Cell Biol."},{"key":"D6BM00434B\/cit36\/1","doi-asserted-by":"publisher","DOI":"10.1520\/F0756-17","volume-title":"Standard Practice for Assessment of Hemolytic Properties of Materials","volume":"13.01","author":"ASTM F756-17","year":"2025","unstructured":"ASTM F756-17 ,  Standard Practice for Assessment of Hemolytic Properties of Materials . Book of Standards. Vol.  13.01 ,  2025 .  10.1520\/F0756-17"}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/BM\/article-pdf\/doi\/10.1039\/D6BM00434B\/0\/D6BM00434B.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T11:28:30Z","timestamp":1786447710000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/BM\/article-lookup\/doi\/10.1039\/D6BM00434B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":36,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,8,11]]}},"URL":"https:\/\/doi.org\/10.1039\/d6bm00434b","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}