{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:43:32Z","timestamp":1793108612319,"version":"4.5.0"},"reference-count":50,"publisher":"Royal Society of Chemistry (RSC)","issue":"21","license":[{"start":{"date-parts":[[2027,9,15]],"date-time":"2027-09-15T00:00:00Z","timestamp":1820966400000},"content-version":"am","delay-in-days":622,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR36505\/NNT\/28\/1818\/2022"],"award-info":[{"award-number":["BT\/PR36505\/NNT\/28\/1818\/2022"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020918","name":"Indian National Academy of Engineering","doi-asserted-by":"publisher","award":["INAE\/121\/AKF\/37"],"award-info":[{"award-number":["INAE\/121\/AKF\/37"]}],"id":[{"id":"10.13039\/100020918","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Anusandhan National Research Foundation","doi-asserted-by":"publisher","award":["CRG\/2020\/005244"],"award-info":[{"award-number":["CRG\/2020\/005244"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<jats:p>\n                    Schematic of an\n                    <jats:italic>in situ<\/jats:italic>\n                    -forming injectable GelVS hydrogel for localized co-delivery of RES and SAL, enabling sustained release and targeting bulk breast cancer cells and stem cell-enriched mammospheres for improved\n                    <jats:italic>in vivo<\/jats:italic>\n                    antitumour efficacy.\n                  <\/jats:p>","DOI":"10.1039\/d6bm00435k","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:30:26Z","timestamp":1789461026000},"page":"5667-5685","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting tumor heterogeneity using an injectable gelatin hydrogel for the dual elimination of cancer cells and cancer stem cells"],"prefix":"10.1039","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4831-2949","authenticated-orcid":false,"given":"Jeyashree","family":"Kumarasekar","sequence":"first","affiliation":[{"name":"Engineering Nanomaterials and Regenerative Medicine Lab, Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi, Telangana, 502284, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhiram","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Birla Institute of Technology & Science, Pilani, Hyderabad Campus, Telangana, 500078, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar Pranav","family":"Narayan","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Birla Institute of Technology & Science, Pilani, Hyderabad Campus, Telangana, 500078, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2313-4912","authenticated-orcid":false,"given":"Jyotsnendu","family":"Giri","sequence":"additional","affiliation":[{"name":"Engineering Nanomaterials and Regenerative Medicine Lab, Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi, Telangana, 502284, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"6","key":"D6BM00435K\/cit1\/1","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1080\/15384047.2016.1190488","volume":"17","author":"Wang","year":"2016","journal-title":"Cancer Biol. Ther."},{"issue":"10","key":"D6BM00435K\/cit2\/1","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1007\/s10495-017-1394-y","volume":"22","author":"Dewangan","year":"2017","journal-title":"Apoptosis"},{"issue":"1","key":"D6BM00435K\/cit3\/1","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1146\/annurev.bi.62.070193.002125","volume":"62","author":"Gottesman","year":"1993","journal-title":"Annu. Rev. Biochem."},{"issue":"1","key":"D6BM00435K\/cit4\/1","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1186\/s12935-024-03558-0","volume":"24","author":"Mengistu","year":"2024","journal-title":"Cancer Cell Int."},{"key":"D6BM00435K\/cit5\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/950658","volume":"2012","author":"Naujokat","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"issue":"2","key":"D6BM00435K\/cit6\/1","doi-asserted-by":"publisher","first-page":"217","DOI":"10.3390\/ijtm3020016","volume":"3","author":"Soni","year":"2023","journal-title":"Int. J. Transl. Med."},{"issue":"7","key":"D6BM00435K\/cit7\/1","doi-asserted-by":"publisher","first-page":"e69086","DOI":"10.1371\/journal.pone.0069086","volume":"8","author":"Ojo","year":"2013","journal-title":"PLoS One"},{"issue":"12","key":"D6BM00435K\/cit8\/1","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.2460\/javma.230.12.1822","volume":"230","author":"Aleman","year":"2007","journal-title":"J. Am. Vet. Med. Assoc."},{"issue":"8","key":"D6BM00435K\/cit9\/1","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.3390\/pharmaceutics13081120","volume":"13","author":"Tefas","year":"2021","journal-title":"Pharmaceutics"},{"issue":"8","key":"D6BM00435K\/cit10\/1","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.1021\/mp5002312","volume":"11","author":"Zhao","year":"2014","journal-title":"Mol. Pharm."},{"key":"D6BM00435K\/cit11\/1","doi-asserted-by":"publisher","first-page":"109211","DOI":"10.1016\/j.jnutbio.2022.109211","volume":"112","author":"Xie","year":"2023","journal-title":"J. Nutr. Biochem."},{"key":"D6BM00435K\/cit12\/1","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.3389\/fphar.2019.01614","volume":"10","author":"Choudhari","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"8","key":"D6BM00435K\/cit13\/1","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.3390\/nu15081896","volume":"15","author":"Rudzi\u0144ska","year":"2023","journal-title":"Nutrients"},{"issue":"1","key":"D6BM00435K\/cit14\/1","doi-asserted-by":"publisher","first-page":"2951697","DOI":"10.1155\/2021\/2951697","volume":"2021","author":"Hu","year":"2021","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"D6BM00435K\/cit15\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3897\/pharmacia.71.e122169","volume":"71","author":"Ben Haj Yahia","year":"2024","journal-title":"Pharmacia"},{"issue":"11\u201312","key":"D6BM00435K\/cit16\/1","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/s10495-021-01689-7","volume":"26","author":"Fu","year":"2021","journal-title":"Apoptosis"},{"issue":"1","key":"D6BM00435K\/cit17\/1","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1007\/s12672-025-02471-w","volume":"16","author":"Hedayati","year":"2025","journal-title":"Discov. Oncol."},{"issue":"3","key":"D6BM00435K\/cit18\/1","doi-asserted-by":"publisher","first-page":"e1353","DOI":"10.1002\/cnr2.1353","volume":"4","author":"Annaji","year":"2021","journal-title":"Cancer Rep."},{"key":"D6BM00435K\/cit19\/1","doi-asserted-by":"publisher","first-page":"100386","DOI":"10.1016\/j.mtbio.2022.100386","volume":"16","author":"Shin","year":"2022","journal-title":"Mater. Today. Bio"},{"key":"D6BM00435K\/cit20\/1","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.2147\/DDDT.S467835","volume":"18","author":"Jiang","year":"2024","journal-title":"Drug Des., Dev. Ther."},{"issue":"4","key":"D6BM00435K\/cit21\/1","doi-asserted-by":"publisher","first-page":"e327","DOI":"10.1002\/mco2.327","volume":"4","author":"Xuan","year":"2023","journal-title":"MedComm"},{"issue":"1","key":"D6BM00435K\/cit22\/1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s40164-025-00602-1","volume":"14","author":"Cheng","year":"2025","journal-title":"Exp. Hematol. Oncol."},{"issue":"5","key":"D6BM00435K\/cit23\/1","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1016\/j.drudis.2022.02.005","volume":"27","author":"Kaur","year":"2022","journal-title":"Drug Discovery Today"},{"issue":"2","key":"D6BM00435K\/cit24\/1","doi-asserted-by":"publisher","first-page":"226","DOI":"10.18502\/ijph.v51i2.8677","volume":"51","author":"Yousefi Rizi","year":"2022","journal-title":"Iran. J. Public Health"},{"key":"D6BM00435K\/cit25\/1","doi-asserted-by":"publisher","first-page":"120316","DOI":"10.1016\/j.ijpharm.2021.120316","volume":"598","author":"Norouzi","year":"2021","journal-title":"Int. J. Pharm."},{"key":"D6BM00435K\/cit26\/1","doi-asserted-by":"publisher","first-page":"133590","DOI":"10.1016\/j.ijbiomac.2024.133590","volume":"274","author":"Zhang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"D6BM00435K\/cit27\/1","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.3390\/polym15041026","volume":"15","author":"Andreazza","year":"2023","journal-title":"Polymers"},{"issue":"11","key":"D6BM00435K\/cit28\/1","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.1007\/s10529-015-1907-0","volume":"37","author":"Su","year":"2015","journal-title":"Biotechnol. Lett."},{"key":"D6BM00435K\/cit29\/1","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.biomaterials.2015.08.045","volume":"73","author":"Yue","year":"2015","journal-title":"Biomaterials"},{"key":"D6BM00435K\/cit30\/1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1515\/bnm-2014-0008","volume":"15","author":"Qin","year":"2014","journal-title":"BioNanoMaterials"},{"key":"D6BM00435K\/cit31\/1","doi-asserted-by":"publisher","first-page":"117486","DOI":"10.1016\/j.biopha.2024.117486","volume":"180","author":"Li","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"D6BM00435K\/cit32\/1","doi-asserted-by":"publisher","first-page":"138200","DOI":"10.1016\/j.ijbiomac.2024.138200","volume":"285","author":"Chauhan","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"D6BM00435K\/cit33\/1","unstructured":"Protein based hydrogel and process for the preparing the same"},{"issue":"8","key":"D6BM00435K\/cit34\/1","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.1039\/D5TB02316E","volume":"14","author":"Jeyashree","year":"2026","journal-title":"J. Mater. Chem. B"},{"key":"D6BM00435K\/cit35\/1","doi-asserted-by":"publisher","first-page":"111775","DOI":"10.1016\/j.colsurfb.2021.111775","volume":"204","author":"Basu","year":"2021","journal-title":"Colloids Surf., B"},{"issue":"24","key":"D6BM00435K\/cit36\/1","doi-asserted-by":"publisher","first-page":"7072","DOI":"10.1039\/D4TB02836H","volume":"13","author":"Rajendran","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"D6BM00435K\/cit37\/1","unstructured":"FITC Annexin V Apoptosis Detection Kit with 7-AAD"},{"issue":"2","key":"D6BM00435K\/cit38\/1","doi-asserted-by":"publisher","first-page":"119","DOI":"10.18502\/bccr.v13i2.10031","volume":"13","author":"Valizadeh","year":"2022","journal-title":"Basic Clin. Cancer Res."},{"issue":"4","key":"D6BM00435K\/cit39\/1","doi-asserted-by":"publisher","first-page":"294","DOI":"10.4162\/nrp.2012.6.4.294","volume":"6","author":"Lee","year":"2012","journal-title":"Nutr. Res. Pract."},{"issue":"4","key":"D6BM00435K\/cit40\/1","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1006\/bbrc.2002.6554","volume":"291","author":"Bove","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"D6BM00435K\/cit41\/1","doi-asserted-by":"publisher","first-page":"914118","DOI":"10.3389\/fnut.2022.914118","volume":"9","author":"Yilmaz","year":"2022","journal-title":"Front. Nutr."},{"issue":"14","key":"D6BM00435K\/cit42\/1","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.3390\/polym14142777","volume":"14","author":"Derkach","year":"2022","journal-title":"Polymers"},{"issue":"10","key":"D6BM00435K\/cit43\/1","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1007\/s10495-017-1394-y","volume":"22","author":"Dewangan","year":"2017","journal-title":"Apoptosis"},{"issue":"6","key":"D6BM00435K\/cit44\/1","doi-asserted-by":"publisher","first-page":"829","DOI":"10.3978\/j.issn.2072-1439.2014.03.38","volume":"6","author":"Wang","year":"2014","journal-title":"J. Thorac. Dis."},{"issue":"10","key":"D6BM00435K\/cit45\/1","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1101\/gad.1061803","volume":"17","author":"Dontu","year":"2003","journal-title":"Genes Dev."},{"issue":"12","key":"D6BM00435K\/cit46\/1","doi-asserted-by":"publisher","first-page":"5399","DOI":"10.1021\/acsabm.3c00644","volume":"6","author":"Hasan","year":"2023","journal-title":"ACS Appl. Bio Mater."},{"key":"D6BM00435K\/cit47\/1","doi-asserted-by":"publisher","first-page":"347","DOI":"10.3389\/fonc.2018.00347","volume":"8","author":"Bahmad","year":"2018","journal-title":"Front. Oncol."},{"key":"D6BM00435K\/cit48\/1","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.jconrel.2021.10.029","volume":"340","author":"Shang","year":"2021","journal-title":"J. Controlled Release"},{"key":"D6BM00435K\/cit49\/1","doi-asserted-by":"publisher","first-page":"122497","DOI":"10.1016\/j.biomaterials.2024.122497","volume":"306","author":"Wang","year":"2024","journal-title":"Biomaterials"},{"issue":"5","key":"D6BM00435K\/cit50\/1","doi-asserted-by":"publisher","first-page":"100851","DOI":"10.1016\/j.ajps.2023.100851","volume":"18","author":"Gao","year":"2023","journal-title":"Asian J. Pharm. Sci."}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/BM\/article-pdf\/doi\/10.1039\/D6BM00435K\/0\/D6BM00435K.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:12:25Z","timestamp":1793106745000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/BM\/article-lookup\/doi\/10.1039\/D6BM00435K"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":50,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2026,10,27]]}},"URL":"https:\/\/doi.org\/10.1039\/d6bm00435k","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}