{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T08:02:33Z","timestamp":1785225753792,"version":"3.55.0"},"reference-count":30,"publisher":"Royal Society of Chemistry (RSC)","issue":"15","license":[{"start":{"date-parts":[[2027,6,19]],"date-time":"2027-06-19T00:00:00Z","timestamp":1813363200000},"content-version":"am","delay-in-days":534,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1100500"],"award-info":[{"award-number":["2021YFA1100500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92159202"],"award-info":[{"award-number":["92159202"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52273153"],"award-info":[{"award-number":["52273153"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2024C03051"],"award-info":[{"award-number":["2024C03051"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<jats:p>Schematic illustration of intratumorally delivered PQDMA@CEL NPs, triggering HCC ferroptosis and degrading lipids, and further remodeling immunosuppressive microenvironment and enhancing anti-tumor efficacy in Hepa1-6 bilateral tumor models.<\/jats:p>","DOI":"10.1039\/d6bm00447d","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:23:41Z","timestamp":1781879021000},"page":"3982-3994","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An esterase-activated celastrol delivery system suppressed steatosis-related hepatocellular carcinoma progression"],"prefix":"10.1039","volume":"14","author":[{"given":"Zile","family":"Shao","sequence":"first","affiliation":[{"name":"The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou First People's Hospital, Hangzhou 310053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangla","family":"Xie","sequence":"additional","affiliation":[{"name":"Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidan","family":"Shen","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyang","family":"Sun","sequence":"additional","affiliation":[{"name":"The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou First People's Hospital, Hangzhou 310053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hangzhou Normal University, Hangzhou 311121, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasha","family":"Qiu","sequence":"additional","affiliation":[{"name":"The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou First People's Hospital, Hangzhou 310053, China"},{"name":"Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2761-2811","authenticated-orcid":false,"given":"Xiao","family":"Xu","sequence":"additional","affiliation":[{"name":"The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou First People's Hospital, Hangzhou 310053, China"},{"name":"Zhejiang University School of Medicine, Hangzhou 310058, China"},{"name":"Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6BM00447D\/cit1\/1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41572-020-00240-3","volume":"7","author":"Llovet","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"D6BM00447D\/cit2\/1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1136\/gutjnl-2021-324915","volume":"72","author":"Vitale","year":"2023","journal-title":"Gut"},{"key":"D6BM00447D\/cit3\/1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s44178-025-00173-5","volume":"4","author":"Liu","year":"2025","journal-title":"Holistic Integr. Oncol."},{"key":"D6BM00447D\/cit4\/1","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1186\/s12967-025-07177-9","volume":"23","author":"Chen","year":"2025","journal-title":"J. Transl. Med."},{"key":"D6BM00447D\/cit5\/1","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.jhep.2022.06.012","volume":"77","author":"Peiseler","year":"2022","journal-title":"J. Hepatol."},{"key":"D6BM00447D\/cit6\/1","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.apsb.2021.09.019","volume":"12","author":"Du","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"D6BM00447D\/cit7\/1","doi-asserted-by":"crossref","first-page":"157450","DOI":"10.1016\/j.phymed.2025.157450","volume":"148","author":"Xue","year":"2025","journal-title":"Phytomedicine"},{"key":"D6BM00447D\/cit8\/1","doi-asserted-by":"crossref","first-page":"102135","DOI":"10.1016\/j.mtbio.2025.102135","volume":"34","author":"Bai","year":"2025","journal-title":"Mater. Today. Bio"},{"key":"D6BM00447D\/cit9\/1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41392-024-01963-5","volume":"9","author":"Shan","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"D6BM00447D\/cit10\/1","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/S0140-6736(25)00403-9","volume":"405","author":"Yau","year":"2025","journal-title":"Lancet"},{"key":"D6BM00447D\/cit11\/1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s44178-024-00143-3","volume":"3","author":"Feng","year":"2024","journal-title":"Holistic Integr. Oncol."},{"key":"D6BM00447D\/cit12\/1","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1016\/j.apsb.2024.04.010","volume":"14","author":"Wang","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"D6BM00447D\/cit13\/1","doi-asserted-by":"crossref","first-page":"62693","DOI":"10.1021\/acsami.4c14169","volume":"16","author":"Shen","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D6BM00447D\/cit14\/1","doi-asserted-by":"crossref","first-page":"123260","DOI":"10.1016\/j.biomaterials.2025.123260","volume":"320","author":"Qiu","year":"2025","journal-title":"Biomaterials"},{"key":"D6BM00447D\/cit15\/1","doi-asserted-by":"crossref","first-page":"120604","DOI":"10.1016\/j.biomaterials.2020.120604","volume":"269","author":"Qiu","year":"2021","journal-title":"Biomaterials"},{"key":"D6BM00447D\/cit16\/1","doi-asserted-by":"crossref","first-page":"155380","DOI":"10.1016\/j.phymed.2024.155380","volume":"128","author":"Shen","year":"2024","journal-title":"Phytomedicine"},{"key":"D6BM00447D\/cit17\/1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41591-019-0358-x","volume":"25","author":"Feng","year":"2019","journal-title":"Nat. Med."},{"key":"D6BM00447D\/cit18\/1","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.2337\/db18-1167","volume":"68","author":"Saito","year":"2019","journal-title":"Diabetes"},{"key":"D6BM00447D\/cit19\/1","doi-asserted-by":"crossref","first-page":"49272","DOI":"10.1021\/acsami.5c11296","volume":"17","author":"Xiong","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D6BM00447D\/cit20\/1","doi-asserted-by":"crossref","first-page":"e00854","DOI":"10.1002\/advs.202500854","volume":"12","author":"Xu","year":"2025","journal-title":"Adv. Sci."},{"key":"D6BM00447D\/cit21\/1","doi-asserted-by":"crossref","first-page":"157275","DOI":"10.1016\/j.phymed.2025.157275","volume":"148","author":"Li","year":"2025","journal-title":"Phytomedicine"},{"key":"D6BM00447D\/cit22\/1","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1016\/j.apsb.2025.03.017","volume":"15","author":"Zhang","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"D6BM00447D\/cit23\/1","doi-asserted-by":"crossref","first-page":"120439","DOI":"10.1016\/j.carbpol.2022.120439","volume":"303","author":"Zhang","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"D6BM00447D\/cit24\/1","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.1021\/acs.nanolett.2c00901","volume":"22","author":"Sun","year":"2022","journal-title":"Nano Lett."},{"key":"D6BM00447D\/cit25\/1","doi-asserted-by":"crossref","first-page":"e469","DOI":"10.1097\/TP.0000000000005412","volume":"109","author":"Xie","year":"2025","journal-title":"Transplantation"},{"key":"D6BM00447D\/cit26\/1","doi-asserted-by":"crossref","first-page":"e2303614","DOI":"10.1002\/adma.202303614","volume":"35","author":"Zhang","year":"2023","journal-title":"Adv. Mater."},{"key":"D6BM00447D\/cit27\/1","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1021\/acsami.7b14496","volume":"10","author":"Xu","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D6BM00447D\/cit28\/1","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1038\/s41423-024-01199-x","volume":"21","author":"Wang","year":"2024","journal-title":"Cell. Mol. Immunol."},{"key":"D6BM00447D\/cit29\/1","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.7150\/ijbs.91751","volume":"20","author":"Liu","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"D6BM00447D\/cit30\/1","doi-asserted-by":"crossref","first-page":"101222","DOI":"10.1016\/j.neo.2025.101222","volume":"69","author":"Yehezkel","year":"2025","journal-title":"Neoplasia"}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/BM\/article-pdf\/doi\/10.1039\/D6BM00447D\/0\/D6BM00447D.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:43:07Z","timestamp":1785224587000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/BM\/article-lookup\/doi\/10.1039\/D6BM00447D"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":30,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2026,7,28]]}},"URL":"https:\/\/doi.org\/10.1039\/d6bm00447d","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D6BM00447D\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6BM00447D\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6BM00447D\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6BM00447D\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6BM00447D\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6BM00447D\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}