{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:57:58Z","timestamp":1790686678307,"version":"4.1.0"},"reference-count":64,"publisher":"Royal Society of Chemistry (RSC)","issue":"19","license":[{"start":{"date-parts":[[2027,8,3]],"date-time":"2027-08-03T00:00:00Z","timestamp":1817251200000},"content-version":"am","delay-in-days":579,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["2021-10784\/CMB-BMS"],"award-info":[{"award-number":["2021-10784\/CMB-BMS"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["211610122720"],"award-info":[{"award-number":["211610122720"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<jats:p>The anticancer mechanism of DOX\/MET co-loaded GA\u2013GT nanohydrogel in MCF-7 cells, showing enhanced intracellular drug delivery, PI3K\/AKT\/mTOR inhibition, suppression of TNT-mediated intercellular communication, and subsequent induction of apoptosis and inhibition of cell migration.<\/jats:p>","DOI":"10.1039\/d6bm00697c","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T12:03:29Z","timestamp":1785758609000},"page":"5170-5185","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual delivery of metformin and doxorubicin\n                    <i>via<\/i>\n                    the gum acacia\u2013gelatin nanohydrogel disrupts tunnelling nanotube-mediated breast cancer progression"],"prefix":"10.1039","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8931-6818","authenticated-orcid":false,"given":"Soumya Ranjan","family":"Jena","sequence":"first","affiliation":[{"name":"Redox Biology & Proteomics Laboratory, Department of Zoology, Ravenshaw University, Cuttack 753003, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9968-6900","authenticated-orcid":false,"given":"Anwesha","family":"Pradhan","sequence":"additional","affiliation":[{"name":"Redox Biology & Proteomics Laboratory, Department of Zoology, Ravenshaw University, Cuttack 753003, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6599-6456","authenticated-orcid":false,"given":"Ganeswar","family":"Dalei","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Odisha University of Technology and Research, Bhubaneswar 751029, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7503-1168","authenticated-orcid":false,"given":"Subhraseema","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Odisha University of Technology and Research, Bhubaneswar 751029, Odisha, India"},{"name":"Department of Chemistry, Ravenshaw University, Cuttack 753003, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2969-0071","authenticated-orcid":false,"given":"Luna","family":"Samanta","sequence":"additional","affiliation":[{"name":"Redox Biology & Proteomics Laboratory, Department of Zoology, Ravenshaw University, Cuttack 753003, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6BM00697C\/cit1\/1","doi-asserted-by":"publisher","first-page":"145212","DOI":"10.1016\/j.cej.2023.145212","volume":"473","author":"Li","year":"2023","journal-title":"Chem. Eng. J."},{"key":"D6BM00697C\/cit2\/1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1159\/000447579","volume":"91","author":"Patil","year":"2016","journal-title":"Oncology"},{"key":"D6BM00697C\/cit3\/1","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1021\/acsabm.9b00218","volume":"2","author":"Li","year":"2019","journal-title":"ACS Appl. Bio Mater."},{"key":"D6BM00697C\/cit4\/1","doi-asserted-by":"publisher","first-page":"111435","DOI":"10.1016\/j.eurpolymj.2022.111435","volume":"176","author":"Karimi","year":"2022","journal-title":"Eur. Polym. J."},{"key":"D6BM00697C\/cit5\/1","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.jconrel.2014.05.012","volume":"190","author":"Jhaveri","year":"2014","journal-title":"J. Controlled Release"},{"key":"D6BM00697C\/cit6\/1","doi-asserted-by":"publisher","first-page":"7004","DOI":"10.3390\/molecules28207004","volume":"28","author":"Han","year":"2023","journal-title":"Molecules"},{"key":"D6BM00697C\/cit7\/1","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S1470-2045(23)00587-9","volume":"25","author":"Pfister","year":"2024","journal-title":"Lancet Oncol."},{"key":"D6BM00697C\/cit8\/1","doi-asserted-by":"publisher","first-page":"2415227","DOI":"10.1002\/advs.202415227","volume":"12","author":"Huang","year":"2025","journal-title":"Adv. Sci."},{"key":"D6BM00697C\/cit9\/1","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1186\/S12885-016-2551-3","volume":"16","author":"Martinez","year":"2016","journal-title":"BMC Cancer"},{"key":"D6BM00697C\/cit10\/1","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.ctrv.2017.01.005","volume":"54","author":"Peng","year":"2017","journal-title":"Cancer Treat. Rev."},{"key":"D6BM00697C\/cit11\/1","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/j.cmet.2014.09.018","volume":"20","author":"Foretz","year":"2014","journal-title":"Cell Metab."},{"key":"D6BM00697C\/cit12\/1","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.18632\/oncotarget.23160","volume":"9","author":"Li","year":"2018","journal-title":"Oncotarget"},{"key":"D6BM00697C\/cit13\/1","doi-asserted-by":"publisher","first-page":"101946","DOI":"10.1016\/j.tranon.2024.101946","volume":"45","author":"Jalali","year":"2024","journal-title":"Transl. Oncol."},{"key":"D6BM00697C\/cit14\/1","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.3390\/pharmaceutics15082064","volume":"15","author":"Mondal","year":"2023","journal-title":"Pharmaceutics"},{"key":"D6BM00697C\/cit15\/1","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1080\/21691401.2024.2436350","volume":"52","author":"Hsu","year":"2024","journal-title":"Artif. Cells, Nanomed., Biotechnol."},{"key":"D6BM00697C\/cit16\/1","doi-asserted-by":"publisher","first-page":"82","DOI":"10.22203\/eCM.v053a07","volume":"53","author":"Deng","year":"2025","journal-title":"Eur. Cells Mater."},{"key":"D6BM00697C\/cit17\/1","doi-asserted-by":"publisher","first-page":"eadk2444","DOI":"10.1126\/sciadv.adk2444","volume":"10","author":"Liu","year":"2024","journal-title":"Sci. Adv."},{"key":"D6BM00697C\/cit18\/1","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1080\/10717544.2021.1898703","volume":"28","author":"Song","year":"2021","journal-title":"Drug Delivery"},{"key":"D6BM00697C\/cit19\/1","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s11095-018-2404-7","volume":"35","author":"Shafiei-Irannejad","year":"2018","journal-title":"Pharm. Res."},{"key":"D6BM00697C\/cit20\/1","doi-asserted-by":"publisher","first-page":"145412","DOI":"10.1016\/j.ijbiomac.2025.145412","volume":"319","author":"Zahid","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"D6BM00697C\/cit21\/1","doi-asserted-by":"publisher","first-page":"129914","DOI":"10.1016\/j.ijbiomac.2024.129914","volume":"262","author":"Kumari","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"D6BM00697C\/cit22\/1","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1039\/D4MA00992D","volume":"6","author":"UrRehman","year":"2025","journal-title":"Mater. Adv."},{"key":"D6BM00697C\/cit23\/1","doi-asserted-by":"publisher","first-page":"e39073","DOI":"10.1016\/j.heliyon.2024.e39073","volume":"10","author":"Pajoum","year":"2024","journal-title":"Heliyon"},{"key":"D6BM00697C\/cit24\/1","doi-asserted-by":"publisher","first-page":"025021","DOI":"10.1088\/2057-1976\/aafc14","volume":"5","author":"Alwaan","year":"2019","journal-title":"Biomed. Phys. Eng. Exp."},{"key":"D6BM00697C\/cit25\/1","doi-asserted-by":"publisher","first-page":"5011","DOI":"10.1007\/s00289-018-2642-1","volume":"76","author":"Fasiku","year":"2019","journal-title":"Polym. Bull."},{"key":"D6BM00697C\/cit26\/1","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1007\/S10311-021-01184-0","volume":"19","author":"Rigueto","year":"2021","journal-title":"Chem. Lett."},{"key":"D6BM00697C\/cit27\/1","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.ijbiomac.2022.07.087","volume":"218","author":"Mushtaq","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"D6BM00697C\/cit28\/1","doi-asserted-by":"publisher","first-page":"125640","DOI":"10.1016\/j.ijbiomac.2023.125640","volume":"246","author":"Ziaei","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"D6BM00697C\/cit29\/1","doi-asserted-by":"publisher","first-page":"e50578","DOI":"10.1002\/app.50578","volume":"138","author":"Derakhshankhah","year":"2021","journal-title":"J. Appl. Polym. Sci."},{"key":"D6BM00697C\/cit30\/1","doi-asserted-by":"publisher","first-page":"012007","DOI":"10.1088\/1757-899X\/1183\/1\/012007","volume":"1183","author":"Jagtap","year":"2021","journal-title":"IOP Conf. Ser. Mater. Sci. Eng."},{"key":"D6BM00697C\/cit31\/1","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.ijbiomac.2013.12.017","volume":"64","author":"Luo","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"key":"D6BM00697C\/cit32\/1","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1016\/j.drudis.2017.07.009","volume":"22","author":"Meka","year":"2017","journal-title":"Drug Discovery Today"},{"key":"D6BM00697C\/cit33\/1","doi-asserted-by":"publisher","first-page":"672","DOI":"10.3390\/polym11040672","volume":"11","author":"Ishihara","year":"2019","journal-title":"Polymers"},{"key":"D6BM00697C\/cit34\/1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.cis.2016.12.004","volume":"244","author":"Das","year":"2017","journal-title":"Adv. Colloid Interface Sci."},{"key":"D6BM00697C\/cit35\/1","doi-asserted-by":"publisher","first-page":"115068","DOI":"10.1016\/j.carbpol.2019.115068","volume":"223","author":"de Oliveira","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"D6BM00697C\/cit36\/1","doi-asserted-by":"publisher","first-page":"5413","DOI":"10.1021\/acs.molpharmaceut.4c00563","volume":"21","author":"Chen","year":"2024","journal-title":"Mol. Pharm."},{"key":"D6BM00697C\/cit37\/1","doi-asserted-by":"publisher","first-page":"109624","DOI":"10.1016\/j.abb.2023.109624","volume":"742","author":"Mahadik","year":"2023","journal-title":"Arch. Biochem. Biophys."},{"key":"D6BM00697C\/cit38\/1","doi-asserted-by":"publisher","first-page":"204","DOI":"10.3390\/cells13030204","volume":"13","author":"Boyineni","year":"2024","journal-title":"Cells"},{"key":"D6BM00697C\/cit39\/1","doi-asserted-by":"publisher","first-page":"274","DOI":"10.3390\/cancers13020274","volume":"13","author":"Cole","year":"2021","journal-title":"Cancer"},{"key":"D6BM00697C\/cit40\/1","doi-asserted-by":"publisher","first-page":"e01532","DOI":"10.1016\/j.susmat.2025.e01532","volume":"45","author":"Jena","year":"2025","journal-title":"Sustainable Mater. Technol."},{"key":"D6BM00697C\/cit41\/1","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.colsurfb.2017.02.006","volume":"153","author":"Li","year":"2017","journal-title":"Colloids Surf., B"},{"key":"D6BM00697C\/cit42\/1","doi-asserted-by":"publisher","first-page":"5440","DOI":"10.1016\/j.biomaterials.2006.06.011","volume":"27","author":"Serra","year":"2006","journal-title":"Biomaterials"},{"key":"D6BM00697C\/cit43\/1","doi-asserted-by":"publisher","first-page":"189028","DOI":"10.1016\/j.bbcan.2023.189028","volume":"1878","author":"Melwani","year":"2023","journal-title":"Biochim. Biophys. Acta. Rev. Cancer"},{"key":"D6BM00697C\/cit44\/1","doi-asserted-by":"publisher","first-page":"102219","DOI":"10.1016\/j.jksus.2021.102219","volume":"34","author":"Alghutyami","year":"2022","journal-title":"J. King Saud Univ., Sci."},{"key":"D6BM00697C\/cit45\/1","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.saa.2013.09.061","volume":"117","author":"Staroszczyk","year":"2014","journal-title":"Spectrochim. Acta, Part A"},{"key":"D6BM00697C\/cit46\/1","doi-asserted-by":"publisher","first-page":"13209","DOI":"10.1038\/s41598-022-17386-7","volume":"12","author":"Kiey","year":"2022","journal-title":"Sci. Rep."},{"key":"D6BM00697C\/cit47\/1","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.colsurfb.2015.05.027","volume":"132","author":"Li","year":"2015","journal-title":"Colloids Surf., B"},{"key":"D6BM00697C\/cit48\/1","doi-asserted-by":"publisher","first-page":"103544","DOI":"10.1016\/j.jddst.2022.103544","volume":"74","author":"Moghadam","year":"2022","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"D6BM00697C\/cit49\/1","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.3390\/cells11152277","volume":"11","author":"Ferrer","year":"2022","journal-title":"Cells"},{"key":"D6BM00697C\/cit50\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12989-024-00562-0","volume":"21","author":"Lin","year":"2024","journal-title":"Part. Fibre Toxicol."},{"key":"D6BM00697C\/cit51\/1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s13046-018-0731-5","volume":"37","author":"Wang","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"D6BM00697C\/cit52\/1","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nrc3215","volume":"12","author":"Pollak","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"D6BM00697C\/cit53\/1","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.3892\/or.2014.3356","volume":"32","author":"Feng","year":"2014","journal-title":"Oncol. Rep."},{"key":"D6BM00697C\/cit54\/1","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1016\/j.ejca.2010.07.034","volume":"46","author":"Jalving","year":"2010","journal-title":"Eur. J. Cancer"},{"key":"D6BM00697C\/cit55\/1","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1124\/pr.56.2.6","volume":"56","author":"Minotti","year":"2004","journal-title":"Pharmacol. Rev."},{"key":"D6BM00697C\/cit56\/1","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.chembiol.2010.04.012","volume":"17","author":"Pommier","year":"2010","journal-title":"Chem. Biol."},{"key":"D6BM00697C\/cit57\/1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.bbrc.2019.03.004","volume":"512","author":"Shi","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"D6BM00697C\/cit58\/1","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1158\/1535-7163.MCT-14-0723","volume":"14","author":"Zhuang","year":"2015","journal-title":"Mol. Cancer Ther."},{"key":"D6BM00697C\/cit59\/1","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.actbio.2022.07.055","volume":"151","author":"Zhang","year":"2022","journal-title":"Acta Biomater."},{"key":"D6BM00697C\/cit60\/1","doi-asserted-by":"publisher","first-page":"9484","DOI":"10.1038\/s41598-018-27649-x","volume":"8","author":"Desir","year":"2018","journal-title":"Sci. Rep."},{"key":"D6BM00697C\/cit61\/1","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/1479-5876-11-94","volume":"11","author":"Pasquier","year":"2013","journal-title":"J. Transl. Med."},{"key":"D6BM00697C\/cit62\/1","doi-asserted-by":"publisher","first-page":"399","DOI":"10.4161\/cib.20569","volume":"5","author":"Lou","year":"2012","journal-title":"Integr. Biol."},{"key":"D6BM00697C\/cit63\/1","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3389\/fnmol.2017.00333","volume":"10","author":"Ariazi","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"D6BM00697C\/cit64\/1","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s12943-017-0701-0","volume":"16","author":"Chen","year":"2017","journal-title":"Mol. Cancer"}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/BM\/article-pdf\/doi\/10.1039\/D6BM00697C\/0\/D6BM00697C.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:19:36Z","timestamp":1790684376000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/BM\/article-lookup\/doi\/10.1039\/D6BM00697C"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":64,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026,9,29]]}},"URL":"https:\/\/doi.org\/10.1039\/d6bm00697c","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D6BM00697C\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6BM00697C\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6BM00697C\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6BM00697C\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6BM00697C\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6BM00697C\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}