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Rep."},{"key":"D6BM00766J\/cit181\/1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.18063\/ijb.775","volume":"9","author":"Galarraga","year":"2023","journal-title":"Int. J. Bioprint."},{"key":"D6BM00766J\/cit182\/1","doi-asserted-by":"crossref","first-page":"100492","DOI":"10.1016\/j.ocarto.2024.100492","volume":"6","author":"van der Weiden","year":"2024","journal-title":"Osteoarthr. Cartil. Open."},{"key":"D6BM00766J\/cit183\/1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.joca.2014.01.004","volume":"22","author":"Filardo","year":"2014","journal-title":"Osteoarthr. Cartil."},{"key":"D6BM00766J\/cit184\/1","doi-asserted-by":"crossref","first-page":"e2103457118","DOI":"10.1073\/pnas.2103457118","volume":"118","author":"Gao","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D6BM00766J\/cit185\/1","first-page":"440","volume":"41","author":"Zhang","year":"2024","journal-title":"Bioact. 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