{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T16:42:05Z","timestamp":1789922525831,"version":"4.0.1"},"reference-count":294,"publisher":"Royal Society of Chemistry (RSC)","issue":"8","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":155,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG66986"],"award-info":[{"award-number":["AG66986"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Chem. Biol."],"abstract":"<jats:p>\u03b3-Secretase is an intricate intramembrane aspartyl protease that cleaves within the transmembrane domain of \u223c150 substrates, plays critical roles in biology and disease, and is considered the \u2018proteasome of the membrane\u2019.<\/jats:p>","DOI":"10.1039\/d6cb00022c","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T15:42:52Z","timestamp":1780674172000},"page":"1456-1481","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The \u03b3-secretase complex: from discovery to a therapeutic target"],"prefix":"10.1039","volume":"7","author":[{"given":"Shweta R.","family":"Malvankar","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry, School of Pharmacy, The University of Kansas, 1567 Irving Hill Road, GLH 2215, Lawrence, KS 66045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5721-9092","authenticated-orcid":false,"given":"Michael S.","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, School of Pharmacy, The University of Kansas, 1567 Irving Hill Road, GLH 2215, Lawrence, KS 66045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"5687","key":"D6CB00022C\/cit1\/1","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1126\/science.1096187","volume":"305","author":"Wolfe","year":"2004","journal-title":"Science"},{"issue":"5","key":"D6CB00022C\/cit2\/1","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.bpj.2014.12.045","volume":"108","author":"Kamp","year":"2015","journal-title":"Biophys. J."},{"issue":"4","key":"D6CB00022C\/cit3\/1","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1515\/hsz-2016-0269","volume":"398","author":"Langosch","year":"2017","journal-title":"Biol. Chem."},{"issue":"6","key":"D6CB00022C\/cit4\/1","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1016\/j.cell.2013.10.053","volume":"155","author":"Dickey","year":"2013","journal-title":"Cell"},{"issue":"17","key":"D6CB00022C\/cit5\/1","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.15252\/embj.201488149","volume":"33","author":"Arutyunova","year":"2014","journal-title":"EMBO J."},{"issue":"4","key":"D6CB00022C\/cit6\/1","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/S0092-8674(00)80675-3","volume":"100","author":"Brown","year":"2000","journal-title":"Cell"},{"issue":"2","key":"D6CB00022C\/cit7\/1","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.semcdb.2008.11.006","volume":"20","author":"Ha","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"issue":"2","key":"D6CB00022C\/cit8\/1","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.semcdb.2008.11.004","volume":"20","author":"Sannerud","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"issue":"7245","key":"D6CB00022C\/cit9\/1","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/nature08146","volume":"459","author":"Erez","year":"2009","journal-title":"Nature"},{"issue":"21","key":"D6CB00022C\/cit10\/1","doi-asserted-by":"publisher","first-page":"13969","DOI":"10.1074\/jbc.R800039200","volume":"284","author":"Wolfe","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"12","key":"D6CB00022C\/cit11\/1","doi-asserted-by":"publisher","first-page":"2797","DOI":"10.1016\/j.bbamem.2013.07.001","volume":"1828","author":"Urban","year":"2013","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"issue":"7","key":"D6CB00022C\/cit12\/1","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1111\/febs.12199","volume":"280","author":"Strisovsky","year":"2013","journal-title":"FEBS J."},{"issue":"1","key":"D6CB00022C\/cit13\/1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S1097-2765(00)80006-4","volume":"1","author":"Rawson","year":"1997","journal-title":"Mol. Cell"},{"issue":"2","key":"D6CB00022C\/cit14\/1","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/S0092-8674(01)00525-6","volume":"107","author":"Urban","year":"2001","journal-title":"Cell"},{"issue":"16","key":"D6CB00022C\/cit15\/1","doi-asserted-by":"publisher","first-page":"jcs217745","DOI":"10.1242\/jcs.217745","volume":"132","author":"K\u00fchnle","year":"2019","journal-title":"J. Cell Sci."},{"issue":"1","key":"D6CB00022C\/cit16\/1","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1146\/annurev-cellbio-100913-012944","volume":"30","author":"Freeman","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"7479","key":"D6CB00022C\/cit17\/1","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/nature12754","volume":"504","author":"Manolaridis","year":"2013","journal-title":"Nature"},{"issue":"12","key":"D6CB00022C\/cit18\/1","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.1016\/j.bbamem.2013.03.032","volume":"1828","author":"Kroos","year":"2013","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"issue":"26","key":"D6CB00022C\/cit19\/1","doi-asserted-by":"publisher","first-page":"7931","DOI":"10.1021\/bi060799c","volume":"45","author":"Wolfe","year":"2006","journal-title":"Biochemistry"},{"key":"D6CB00022C\/cit20\/1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.semcdb.2020.01.005","volume":"105","author":"Wolfe","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"issue":"1","key":"D6CB00022C\/cit21\/1","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1146\/annurev.cb.10.110194.002105","volume":"10","author":"Selkoe","year":"1994","journal-title":"Annu. Rev. Cell Biol."},{"issue":"6","key":"D6CB00022C\/cit22\/1","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1016\/0092-8674(93)90312-E","volume":"75","author":"Haass","year":"1993","journal-title":"Cell"},{"issue":"1","key":"D6CB00022C\/cit23\/1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0896-6273(03)00205-8","volume":"38","author":"De Strooper","year":"2003","journal-title":"Neuron"},{"issue":"6347","key":"D6CB00022C\/cit24\/1","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1038\/353844a0","volume":"353","author":"Chartier-Harlin","year":"1991","journal-title":"Nature"},{"issue":"6311","key":"D6CB00022C\/cit25\/1","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/349704a0","volume":"349","author":"Goate","year":"1991","journal-title":"Nature"},{"issue":"6543","key":"D6CB00022C\/cit26\/1","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/376775a0","volume":"376","author":"Rogaev","year":"1995","journal-title":"Nature"},{"issue":"6534","key":"D6CB00022C\/cit27\/1","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/375754a0","volume":"375","author":"Sherrington","year":"1995","journal-title":"Nature"},{"issue":"6602","key":"D6CB00022C\/cit28\/1","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1038\/383710a0","volume":"383","author":"Duff","year":"1996","journal-title":"Nature"},{"issue":"10","key":"D6CB00022C\/cit29\/1","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1038\/nm1096-1146","volume":"2","author":"Lemere","year":"1996","journal-title":"Nat. Med."},{"issue":"6665","key":"D6CB00022C\/cit30\/1","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/34910","volume":"391","author":"De Strooper","year":"1998","journal-title":"Nature"},{"issue":"7","key":"D6CB00022C\/cit31\/1","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/35017105","volume":"2","author":"Herreman","year":"2000","journal-title":"Nat. Cell Biol."},{"issue":"7","key":"D6CB00022C\/cit32\/1","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/35017108","volume":"2","author":"Zhang","year":"2000","journal-title":"Nat. Cell Biol."},{"issue":"5","key":"D6CB00022C\/cit33\/1","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/S0896-6273(00)80230-5","volume":"17","author":"Borchelt","year":"1996","journal-title":"Neuron"},{"issue":"1","key":"D6CB00022C\/cit34\/1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/nm0197-67","volume":"3","author":"Citron","year":"1997","journal-title":"Nat. Med."},{"issue":"5","key":"D6CB00022C\/cit35\/1","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1073\/pnas.94.5.2025","volume":"94","author":"Tomita","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"D6CB00022C\/cit36\/1","doi-asserted-by":"publisher","first-page":"7977","DOI":"10.1074\/jbc.272.12.7977","volume":"272","author":"Xia","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"15","key":"D6CB00022C\/cit37\/1","doi-asserted-by":"publisher","first-page":"4720","DOI":"10.1021\/bi982562p","volume":"38","author":"Wolfe","year":"1999","journal-title":"Biochemistry"},{"issue":"6727","key":"D6CB00022C\/cit38\/1","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/19077","volume":"398","author":"Wolfe","year":"1999","journal-title":"Nature"},{"issue":"5","key":"D6CB00022C\/cit39\/1","doi-asserted-by":"publisher","first-page":"3173","DOI":"10.1074\/jbc.275.5.3173","volume":"275","author":"Kimberly","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"41","key":"D6CB00022C\/cit40\/1","doi-asserted-by":"publisher","first-page":"13602","DOI":"10.1021\/bi991453n","volume":"38","author":"Leimer","year":"1999","journal-title":"Biochemistry"},{"issue":"7","key":"D6CB00022C\/cit41\/1","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/35017062","volume":"2","author":"Esler","year":"2000","journal-title":"Nat. Cell Biol."},{"issue":"6787","key":"D6CB00022C\/cit42\/1","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/35015085","volume":"405","author":"Li","year":"2000","journal-title":"Nature"},{"issue":"6727","key":"D6CB00022C\/cit43\/1","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/19083","volume":"398","author":"De Strooper","year":"1999","journal-title":"Nature"},{"issue":"6683","key":"D6CB00022C\/cit44\/1","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/30756","volume":"393","author":"Schroeter","year":"1998","journal-title":"Nature"},{"issue":"6727","key":"D6CB00022C\/cit45\/1","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/19091","volume":"398","author":"Struhl","year":"1999","journal-title":"Nature"},{"issue":"12","key":"D6CB00022C\/cit46\/1","doi-asserted-by":"publisher","first-page":"6959","DOI":"10.1073\/pnas.96.12.6959","volume":"96","author":"Song","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"20","key":"D6CB00022C\/cit47\/1","doi-asserted-by":"publisher","first-page":"5408","DOI":"10.1093\/emboj\/cdf541","volume":"21","author":"Okochi","year":"2002","journal-title":"EMBO J."},{"issue":"1","key":"D6CB00022C\/cit48\/1","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1021\/bi026888g","volume":"42","author":"Kimberly","year":"2003","journal-title":"Biochemistry"},{"issue":"38","key":"D6CB00022C\/cit49\/1","doi-asserted-by":"publisher","first-page":"35235","DOI":"10.1074\/jbc.C100357200","volume":"276","author":"Gu","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"1","key":"D6CB00022C\/cit50\/1","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0896-6273(00)80291-3","volume":"17","author":"Thinakaran","year":"1996","journal-title":"Neuron"},{"issue":"39","key":"D6CB00022C\/cit51\/1","doi-asserted-by":"publisher","first-page":"24536","DOI":"10.1074\/jbc.272.39.24536","volume":"272","author":"Ratovitski","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"4","key":"D6CB00022C\/cit52\/1","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1006\/nbdi.1997.0129","volume":"3","author":"Podlisny","year":"1997","journal-title":"Neurobiol. Dis."},{"issue":"10","key":"D6CB00022C\/cit53\/1","doi-asserted-by":"publisher","first-page":"5090","DOI":"10.1073\/pnas.94.10.5090","volume":"94","author":"Seeger","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"D6CB00022C\/cit54\/1","doi-asserted-by":"publisher","first-page":"3205","DOI":"10.1074\/jbc.273.6.3205","volume":"273","author":"Capell","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"26","key":"D6CB00022C\/cit55\/1","doi-asserted-by":"publisher","first-page":"16470","DOI":"10.1074\/jbc.273.26.16470","volume":"273","author":"Yu","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"6800","key":"D6CB00022C\/cit56\/1","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/35024009","volume":"407","author":"Yu","year":"2000","journal-title":"Nature"},{"issue":"8","key":"D6CB00022C\/cit57\/1","doi-asserted-by":"publisher","first-page":"3272","DOI":"10.1523\/JNEUROSCI.23-08-03272.2003","volume":"23","author":"Li","year":"2003","journal-title":"J. Neurosci."},{"issue":"47","key":"D6CB00022C\/cit58\/1","doi-asserted-by":"publisher","first-page":"45013","DOI":"10.1074\/jbc.M208164200","volume":"277","author":"Lee","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"2","key":"D6CB00022C\/cit59\/1","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1073\/pnas.022523499","volume":"99","author":"Goutte","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"D6CB00022C\/cit60\/1","doi-asserted-by":"publisher","first-page":"7374","DOI":"10.1074\/jbc.M209499200","volume":"278","author":"Gu","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"1","key":"D6CB00022C\/cit61\/1","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S1534-5807(02)00189-2","volume":"3","author":"Francis","year":"2002","journal-title":"Dev. Cell"},{"issue":"42","key":"D6CB00022C\/cit62\/1","doi-asserted-by":"publisher","first-page":"39062","DOI":"10.1074\/jbc.C200469200","volume":"277","author":"Steiner","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"11","key":"D6CB00022C\/cit63\/1","doi-asserted-by":"publisher","first-page":"6382","DOI":"10.1073\/pnas.1037392100","volume":"100","author":"Kimberly","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"D6CB00022C\/cit64\/1","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/ncb960","volume":"5","author":"Edbauer","year":"2003","journal-title":"Nat. Cell Biol."},{"issue":"6930","key":"D6CB00022C\/cit65\/1","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1038\/nature01506","volume":"422","author":"Takasugi","year":"2003","journal-title":"Nature"},{"issue":"47","key":"D6CB00022C\/cit66\/1","doi-asserted-by":"publisher","first-page":"33985","DOI":"10.1074\/jbc.M705248200","volume":"282","author":"Sato","year":"2007","journal-title":"J. Biol. Chem."},{"key":"D6CB00022C\/cit67\/1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3389\/fnagi.2014.00342","author":"Gertsik","year":"2015","journal-title":"Front. Aging Neurosci."},{"issue":"1","key":"D6CB00022C\/cit68\/1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3233\/JAD-2011-101065","volume":"25","author":"Haapasalo","year":"2011","journal-title":"J. Alzheimer's Dis."},{"issue":"42","key":"D6CB00022C\/cit69\/1","doi-asserted-by":"publisher","first-page":"35352","DOI":"10.1074\/jbc.M507217200","volume":"280","author":"Laudon","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"3","key":"D6CB00022C\/cit70\/1","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.nbd.2003.12.008","volume":"15","author":"Wang","year":"2004","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"D6CB00022C\/cit71\/1","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1111\/j.1471-4159.2005.03548.x","volume":"96","author":"Wang","year":"2006","journal-title":"J. Neurochem."},{"issue":"24","key":"D6CB00022C\/cit72\/1","doi-asserted-by":"publisher","first-page":"6264","DOI":"10.1523\/JNEUROSCI.1163-08.2008","volume":"28","author":"Sato","year":"2008","journal-title":"J. Neurosci."},{"issue":"14","key":"D6CB00022C\/cit73\/1","doi-asserted-by":"publisher","first-page":"3821","DOI":"10.1523\/JNEUROSCI.5354-05.2006","volume":"26","author":"Yamasaki","year":"2006","journal-title":"J. Neurosci."},{"issue":"1","key":"D6CB00022C\/cit74\/1","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1111\/jnc.12124","volume":"125","author":"Kretner","year":"2013","journal-title":"J. Neurochem."},{"key":"D6CB00022C\/cit75\/1","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.brainresbull.2016.04.019","volume":"126","author":"Carroll","year":"2016","journal-title":"Brain Res. Bull."},{"issue":"3","key":"D6CB00022C\/cit76\/1","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.cell.2005.05.022","volume":"122","author":"Shah","year":"2005","journal-title":"Cell"},{"issue":"5","key":"D6CB00022C\/cit77\/1","doi-asserted-by":"publisher","first-page":"E509","DOI":"10.1073\/pnas.1512952113","volume":"113","author":"Bolduc","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"D6CB00022C\/cit78\/1","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1523\/JNEUROSCI.3826-09.2010","volume":"30","author":"Zhao","year":"2010","journal-title":"J. Neurosci."},{"issue":"6","key":"D6CB00022C\/cit79\/1","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1111\/jnc.13518","volume":"136","author":"Hu","year":"2016","journal-title":"J. Neurochem."},{"issue":"13","key":"D6CB00022C\/cit80\/1","doi-asserted-by":"publisher","first-page":"12967","DOI":"10.1074\/jbc.M409829200","volume":"280","author":"Niimura","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"5","key":"D6CB00022C\/cit81\/1","doi-asserted-by":"publisher","first-page":"3685","DOI":"10.1074\/jbc.M310505200","volume":"279","author":"Fortna","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"22","key":"D6CB00022C\/cit82\/1","doi-asserted-by":"publisher","first-page":"20117","DOI":"10.1074\/jbc.M213107200","volume":"278","author":"Crystal","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"22","key":"D6CB00022C\/cit83\/1","doi-asserted-by":"publisher","first-page":"23255","DOI":"10.1074\/jbc.M401789200","volume":"279","author":"Prokop","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"27","key":"D6CB00022C\/cit84\/1","doi-asserted-by":"publisher","first-page":"4393","DOI":"10.1021\/bi500489j","volume":"53","author":"Holmes","year":"2014","journal-title":"Biochemistry"},{"issue":"51","key":"D6CB00022C\/cit85\/1","doi-asserted-by":"publisher","first-page":"41967","DOI":"10.1074\/jbc.M509066200","volume":"280","author":"Watanabe","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"3","key":"D6CB00022C\/cit86\/1","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1074\/jbc.M412404200","volume":"280","author":"Kim","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"27","key":"D6CB00022C\/cit87\/1","doi-asserted-by":"publisher","first-page":"2953","DOI":"10.1021\/acs.biochem.9b00401","volume":"58","author":"Wolfe","year":"2019","journal-title":"Biochemistry"},{"issue":"7513","key":"D6CB00022C\/cit88\/1","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1038\/nature13567","volume":"512","author":"Lu","year":"2014","journal-title":"Nature"},{"issue":"7568","key":"D6CB00022C\/cit89\/1","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1038\/nature14892","volume":"525","author":"Bai","year":"2015","journal-title":"Nature"},{"issue":"1","key":"D6CB00022C\/cit90\/1","doi-asserted-by":"publisher","first-page":"183016","DOI":"10.1016\/j.bbamem.2019.07.004","volume":"1862","author":"Wolfe","year":"2020","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"issue":"19","key":"D6CB00022C\/cit91\/1","doi-asserted-by":"publisher","first-page":"6003","DOI":"10.1073\/pnas.1506242112","volume":"112","author":"Sun","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D6CB00022C\/cit92\/1","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.sbi.2017.05.013","volume":"46","author":"Yang","year":"2017","journal-title":"Curr. Opin. Struct. Biol."},{"issue":"6428","key":"D6CB00022C\/cit93\/1","doi-asserted-by":"publisher","first-page":"eaaw0930","DOI":"10.1126\/science.aaw0930","volume":"363","author":"Zhou","year":"2019","journal-title":"Science"},{"issue":"7738","key":"D6CB00022C\/cit94\/1","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/s41586-018-0813-8","volume":"565","author":"Yang","year":"2019","journal-title":"Nature"},{"key":"D6CB00022C\/cit95\/1","doi-asserted-by":"publisher","first-page":"e11182","DOI":"10.7554\/eLife.11182","volume":"4","author":"Bai","year":"2015","journal-title":"eLife"},{"issue":"2","key":"D6CB00022C\/cit96\/1","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.cell.2020.11.049","volume":"184","author":"Yang","year":"2021","journal-title":"Cell"},{"key":"D6CB00022C\/cit97\/1","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.semcdb.2020.04.008","volume":"105","author":"Hitzenberger","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"issue":"1","key":"D6CB00022C\/cit98\/1","doi-asserted-by":"publisher","first-page":"174","DOI":"10.4103\/NRR.NRR-D-23-01781","volume":"20","author":"Miao","year":"2025","journal-title":"Neural Regen. Res."},{"issue":"6","key":"D6CB00022C\/cit99\/1","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1021\/acscentsci.0c00296","volume":"6","author":"Bhattarai","year":"2020","journal-title":"ACS Cent. Sci."},{"issue":"23","key":"D6CB00022C\/cit100\/1","doi-asserted-by":"publisher","first-page":"4216","DOI":"10.1021\/acschemneuro.3c00594","volume":"14","author":"Do","year":"2023","journal-title":"ACS Chem. Neurosci."},{"key":"D6CB00022C\/cit101\/1","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.semcdb.2020.05.019","volume":"105","author":"G\u00fcner","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"issue":"10","key":"D6CB00022C\/cit102\/1","doi-asserted-by":"publisher","first-page":"e257","DOI":"10.1371\/journal.pbio.0060257","volume":"6","author":"Hemming","year":"2008","journal-title":"PLoS Biol."},{"issue":"3","key":"D6CB00022C\/cit103\/1","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/S1097-2765(00)00061-7","volume":"6","author":"Struhl","year":"2000","journal-title":"Mol. Cell"},{"issue":"9","key":"D6CB00022C\/cit104\/1","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1007\/s00018-008-7462-2","volume":"65","author":"Beel","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"issue":"2","key":"D6CB00022C\/cit105\/1","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1523\/JNEUROSCI.1575-04.2005","volume":"25","author":"Qi-Takahara","year":"2005","journal-title":"J. Neurosci."},{"issue":"47","key":"D6CB00022C\/cit106\/1","doi-asserted-by":"publisher","first-page":"44754","DOI":"10.1074\/jbc.M206872200","volume":"277","author":"Lammich","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"6","key":"D6CB00022C\/cit107\/1","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nrm1406","volume":"5","author":"Kopan","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"D6CB00022C\/cit108\/1","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.semcdb.2008.12.011","volume":"20","author":"Wolfe","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"issue":"1","key":"D6CB00022C\/cit109\/1","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1750-1326-6-27","volume":"6","author":"Zheng","year":"2011","journal-title":"Mol. Neurodegener."},{"issue":"5","key":"D6CB00022C\/cit110\/1","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.tips.2016.01.005","volume":"37","author":"Deyts","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"issue":"18","key":"D6CB00022C\/cit111\/1","doi-asserted-by":"publisher","first-page":"3157","DOI":"10.1242\/jcs.03481","volume":"120","author":"Wolfe","year":"2007","journal-title":"J. Cell Sci."},{"issue":"5440","key":"D6CB00022C\/cit112\/1","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1126\/science.286.5440.735","volume":"286","author":"Vassar","year":"1999","journal-title":"Science"},{"issue":"6","key":"D6CB00022C\/cit113\/1","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1006\/mcne.1999.0811","volume":"14","author":"Hussain","year":"1999","journal-title":"Mol. Cell. Neurosci."},{"issue":"6761","key":"D6CB00022C\/cit114\/1","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/990107","volume":"402","author":"Yan","year":"1999","journal-title":"Nature"},{"issue":"6761","key":"D6CB00022C\/cit115\/1","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/990114","volume":"402","author":"Sinha","year":"1999","journal-title":"Nature"},{"issue":"4","key":"D6CB00022C\/cit116\/1","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1073\/pnas.97.4.1456","volume":"97","author":"Lin","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"44","key":"D6CB00022C\/cit117\/1","doi-asserted-by":"publisher","first-page":"29615","DOI":"10.1074\/jbc.R800019200","volume":"283","author":"Thinakaran","year":"2008","journal-title":"J. Biol. Chem."},{"key":"D6CB00022C\/cit118\/1","doi-asserted-by":"publisher","first-page":"100489","DOI":"10.1016\/j.jbc.2021.100489","volume":"296","author":"Checler","year":"2021","journal-title":"J. Biol. Chem."},{"issue":"7","key":"D6CB00022C\/cit119\/1","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1002\/pro.3606","volume":"28","author":"Castro","year":"2019","journal-title":"Protein Sci."},{"issue":"11","key":"D6CB00022C\/cit120\/1","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1016\/S1357-2725(03)00133-X","volume":"35","author":"Ling","year":"2003","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"9","key":"D6CB00022C\/cit121\/1","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/nrm2009","volume":"7","author":"Bray","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"D6CB00022C\/cit122\/1","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1152\/physrev.00005.2017","volume":"97","author":"Siebel","year":"2017","journal-title":"Physiol. Rev."},{"key":"D6CB00022C\/cit123\/1","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.eng.2023.11.011","volume":"34","author":"Meng","year":"2024","journal-title":"Engineering"},{"issue":"1","key":"D6CB00022C\/cit124\/1","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/s41392-024-01828-x","volume":"9","author":"Shi","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"issue":"2","key":"D6CB00022C\/cit125\/1","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S1097-2765(00)80417-7","volume":"5","author":"Brou","year":"2000","journal-title":"Mol. Cell"},{"issue":"3","key":"D6CB00022C\/cit126\/1","doi-asserted-by":"publisher","first-page":"dev172148","DOI":"10.1242\/dev.172148","volume":"146","author":"Henrique","year":"2019","journal-title":"Development"},{"issue":"2","key":"D6CB00022C\/cit127\/1","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S1097-2765(00)80416-5","volume":"5","author":"Mumm","year":"2000","journal-title":"Mol. Cell"},{"issue":"5","key":"D6CB00022C\/cit128\/1","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1021\/acschemneuro.4c00790","volume":"16","author":"Malvankar","year":"2025","journal-title":"ACS Chem. Neurosci."},{"issue":"4","key":"D6CB00022C\/cit129\/1","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/S0092-8674(00)81193-9","volume":"93","author":"Struhl","year":"1998","journal-title":"Cell"},{"issue":"1","key":"D6CB00022C\/cit130\/1","doi-asserted-by":"publisher","first-page":"7333","DOI":"10.1038\/ncomms8333","volume":"6","author":"Laurent","year":"2015","journal-title":"Nat. Commun."},{"issue":"1","key":"D6CB00022C\/cit131\/1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s12974-016-0479-9","volume":"13","author":"Glebov","year":"2016","journal-title":"J. Neuroinflammation"},{"issue":"3","key":"D6CB00022C\/cit132\/1","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1084\/jem.20160844","volume":"214","author":"Zhong","year":"2017","journal-title":"J. Exp. Med."},{"issue":"11","key":"D6CB00022C\/cit133\/1","doi-asserted-by":"publisher","first-page":"5971","DOI":"10.1074\/jbc.M115.679076","volume":"291","author":"Chhibber-Goel","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"10","key":"D6CB00022C\/cit134\/1","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1038\/sj.onc.1206298","volume":"22","author":"Murakami","year":"2003","journal-title":"Oncogene"},{"issue":"1","key":"D6CB00022C\/cit135\/1","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/nrm1004","volume":"4","author":"Ponta","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"8","key":"D6CB00022C\/cit136\/1","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1093\/emboj\/21.8.1948","volume":"21","author":"Marambaud","year":"2002","journal-title":"EMBO J."},{"issue":"5","key":"D6CB00022C\/cit137\/1","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.cell.2003.08.008","volume":"114","author":"Marambaud","year":"2003","journal-title":"Cell"},{"issue":"3","key":"D6CB00022C\/cit138\/1","doi-asserted-by":"publisher","first-page":"a003053","DOI":"10.1101\/cshperspect.a003053","volume":"1","author":"Shapiro","year":"2009","journal-title":"Cold Spring Harbor Perspect. Biol."},{"issue":"7","key":"D6CB00022C\/cit139\/1","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1083\/jcb.201008173","volume":"193","author":"Oda","year":"2011","journal-title":"J. Cell Biol."},{"issue":"1","key":"D6CB00022C\/cit140\/1","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.conb.2007.01.011","volume":"17","author":"Craig","year":"2007","journal-title":"Curr. Opin. Neurobiol."},{"issue":"7215","key":"D6CB00022C\/cit141\/1","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1038\/nature07456","volume":"455","author":"S\u00fcdhof","year":"2008","journal-title":"Nature"},{"issue":"4","key":"D6CB00022C\/cit142\/1","doi-asserted-by":"publisher","first-page":"e19430","DOI":"10.1371\/journal.pone.0019430","volume":"6","author":"Saura","year":"2011","journal-title":"PLoS One"},{"issue":"4","key":"D6CB00022C\/cit143\/1","doi-asserted-by":"publisher","first-page":"2762","DOI":"10.1074\/jbc.M110.142521","volume":"286","author":"Bot","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"2","key":"D6CB00022C\/cit144\/1","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.neuron.2012.10.003","volume":"76","author":"Suzuki","year":"2012","journal-title":"Neuron"},{"issue":"2","key":"D6CB00022C\/cit145\/1","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.neuron.2012.07.006","volume":"76","author":"Peixoto","year":"2012","journal-title":"Neuron"},{"key":"D6CB00022C\/cit146\/1","doi-asserted-by":"publisher","first-page":"31","DOI":"10.37349\/en.2022.00003","author":"Longart","year":"2022","journal-title":"Explor. Neurosci."},{"issue":"22","key":"D6CB00022C\/cit147\/1","doi-asserted-by":"publisher","first-page":"3123","DOI":"10.1091\/mbc.e17-04-0261","volume":"28","author":"Merilahti","year":"2017","journal-title":"Mol. Biol. Cell"},{"issue":"19","key":"D6CB00022C\/cit148\/1","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.4155\/fmc-2022-0178","volume":"14","author":"Wolfe","year":"2022","journal-title":"Future Med. Chem."},{"issue":"38","key":"D6CB00022C\/cit149\/1","doi-asserted-by":"publisher","first-page":"35235","DOI":"10.1074\/jbc.C100357200","volume":"276","author":"Gu","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"8","key":"D6CB00022C\/cit150\/1","doi-asserted-by":"publisher","first-page":"2825","DOI":"10.1021\/bi015794o","volume":"41","author":"Weidemann","year":"2002","journal-title":"Biochemistry"},{"issue":"27","key":"D6CB00022C\/cit151\/1","doi-asserted-by":"publisher","first-page":"24294","DOI":"10.1074\/jbc.M211161200","volume":"278","author":"Sato","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"21","key":"D6CB00022C\/cit152\/1","doi-asserted-by":"publisher","first-page":"14776","DOI":"10.1074\/jbc.M513453200","volume":"281","author":"Kakuda","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"42","key":"D6CB00022C\/cit153\/1","doi-asserted-by":"publisher","first-page":"13532","DOI":"10.1021\/bi049399k","volume":"43","author":"Funamoto","year":"2004","journal-title":"Biochemistry"},{"issue":"2","key":"D6CB00022C\/cit154\/1","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1074\/jbc.M707103200","volume":"283","author":"Yagishita","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"41","key":"D6CB00022C\/cit155\/1","doi-asserted-by":"publisher","first-page":"13042","DOI":"10.1523\/JNEUROSCI.2362-09.2009","volume":"29","author":"Takami","year":"2009","journal-title":"J. Neurosci."},{"issue":"1","key":"D6CB00022C\/cit156\/1","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.celrep.2012.11.028","volume":"3","author":"Okochi","year":"2013","journal-title":"Cell Rep."},{"issue":"8","key":"D6CB00022C\/cit157\/1","doi-asserted-by":"publisher","first-page":"5109","DOI":"10.1074\/jbc.M113.510131","volume":"289","author":"Matsumura","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"18","key":"D6CB00022C\/cit158\/1","doi-asserted-by":"publisher","first-page":"3434","DOI":"10.1021\/jm000100f","volume":"43","author":"Moore","year":"2000","journal-title":"J. Med. Chem."},{"issue":"8","key":"D6CB00022C\/cit159\/1","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1016\/j.bmcl.2004.01.077","volume":"14","author":"Esler","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D6CB00022C\/cit160\/1","doi-asserted-by":"publisher","first-page":"e17578","DOI":"10.7554\/eLife.17578","volume":"5","author":"Bolduc","year":"2016","journal-title":"eLife"},{"issue":"6700","key":"D6CB00022C\/cit161\/1","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1126\/science.adn5820","volume":"384","author":"Guo","year":"2024","journal-title":"Science"},{"issue":"14","key":"D6CB00022C\/cit162\/1","doi-asserted-by":"publisher","first-page":"2991","DOI":"10.1021\/acs.biochem.5c00095","volume":"64","author":"Malvankar","year":"2025","journal-title":"Biochemistry"},{"issue":"10284","key":"D6CB00022C\/cit163\/1","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"key":"D6CB00022C\/cit164\/1","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/bs.apcsb.2019.08.003","volume-title":"Advances in Protein Chemistry and Structural Biology","author":"Liyanage","year":"2019","unstructured":"S. I.Liyanage  and  D. F.Weaver ,  Misfolded proteins as a therapeutic target in Alzheimer's disease , in  Advances in Protein Chemistry and Structural Biology ,  Elsevier ,  2019 , vol. 118,  pp. 371\u2013411 10.1016\/bs.apcsb.2019.08.003"},{"issue":"4","key":"D6CB00022C\/cit165\/1","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s43657-023-00098-x","volume":"3","author":"Quan","year":"2023","journal-title":"Phenomics"},{"key":"D6CB00022C\/cit166\/1","doi-asserted-by":"publisher","first-page":"106735","DOI":"10.1016\/j.bpc.2021.106735","volume":"281","author":"Tang","year":"2022","journal-title":"Biophys. Chem."},{"issue":"1","key":"D6CB00022C\/cit167\/1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/s41392-019-0063-8","volume":"4","author":"Liu","year":"2019","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"D6CB00022C\/cit168\/1","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/s41392-024-01911-3","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"D6CB00022C\/cit169\/1","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.brainresbull.2019.01.004","volume":"146","author":"Madav","year":"2019","journal-title":"Brain Res. Bull."},{"key":"D6CB00022C\/cit170\/1","doi-asserted-by":"publisher","first-page":"106549","DOI":"10.1016\/j.cct.2021.106549","volume":"109","author":"Gupta","year":"2021","journal-title":"Contemp. Clin. Trials"},{"issue":"2","key":"D6CB00022C\/cit171\/1","doi-asserted-by":"publisher","first-page":"e70251","DOI":"10.1002\/trc2.70251","volume":"12","author":"Cummings","year":"2026","journal-title":"Alzheimers Dement.: Transl. Res. Clin. Interventions"},{"key":"D6CB00022C\/cit172\/1","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/0165-6147(91)90609-V","volume":"12","author":"Hardy","year":"1991","journal-title":"Trends Pharmacol. Sci."},{"issue":"5054","key":"D6CB00022C\/cit173\/1","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1126\/science.1566067","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"issue":"4","key":"D6CB00022C\/cit174\/1","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/0896-6273(91)90052-2","volume":"6","author":"Selkoe","year":"1991","journal-title":"Neuron"},{"issue":"6","key":"D6CB00022C\/cit175\/1","doi-asserted-by":"publisher","first-page":"595","DOI":"10.15252\/emmm.201606210","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. Med."},{"issue":"4","key":"D6CB00022C\/cit176\/1","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1111\/j.1471-4159.2009.06181.x","volume":"110","author":"Hardy","year":"2009","journal-title":"J. Neurochem."},{"issue":"1","key":"D6CB00022C\/cit177\/1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/0896-6273(94)90458-8","volume":"13","author":"Iwatsubo","year":"1994","journal-title":"Neuron"},{"issue":"22","key":"D6CB00022C\/cit178\/1","doi-asserted-by":"publisher","first-page":"10836","DOI":"10.1073\/pnas.90.22.10836","volume":"90","author":"Roher","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"D6CB00022C\/cit179\/1","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1038\/nm0896-864","volume":"2","author":"Scheuner","year":"1996","journal-title":"Nat. Med."},{"issue":"2","key":"D6CB00022C\/cit180\/1","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","volume":"81","author":"Selkoe","year":"2001","journal-title":"Physiol. Rev."},{"issue":"3\u20134","key":"D6CB00022C\/cit181\/1","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/S0928-4257(98)80035-1","volume":"92","author":"Younkin","year":"1998","journal-title":"J. Physiol."},{"issue":"189","key":"D6CB00022C\/cit182\/1","doi-asserted-by":"publisher","first-page":"189ra77","DOI":"10.1126\/scitranslmed.3005615","volume":"5","author":"Potter","year":"2013","journal-title":"Sci. Transl. Med."},{"issue":"6012","key":"D6CB00022C\/cit183\/1","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1126\/science.1197623","volume":"330","author":"Mawuenyega","year":"2010","journal-title":"Science"},{"issue":"3","key":"D6CB00022C\/cit184\/1","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1002\/ana.24454","volume":"78","author":"Patterson","year":"2015","journal-title":"Ann. Neurol."},{"issue":"1","key":"D6CB00022C\/cit185\/1","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/ene.13439","volume":"25","author":"Lane","year":"2018","journal-title":"Eur. J. Neurol."},{"issue":"7409","key":"D6CB00022C\/cit186\/1","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/nature11283","volume":"488","author":"Jonsson","year":"2012","journal-title":"Nature"},{"issue":"s1","key":"D6CB00022C\/cit187\/1","doi-asserted-by":"publisher","first-page":"S41","DOI":"10.3233\/JAD-231258","volume":"101","author":"Watkins","year":"2024","journal-title":"J. Alzheimer's Dis."},{"issue":"4","key":"D6CB00022C\/cit188\/1","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/s12276-022-00754-8","volume":"54","author":"Hur","year":"2022","journal-title":"Exp. Mol. Med."},{"issue":"9","key":"D6CB00022C\/cit189\/1","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1056\/NEJMoa1202753","volume":"367","author":"Bateman","year":"2012","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"D6CB00022C\/cit190\/1","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1007\/s13311-023-01405-0","volume":"20","author":"Yadollahikhales","year":"2023","journal-title":"Neurotherapeutics"},{"issue":"3","key":"D6CB00022C\/cit191\/1","doi-asserted-by":"publisher","first-page":"e00570","DOI":"10.1016\/j.neurot.2025.e00570","volume":"22","author":"Cummings","year":"2025","journal-title":"Neurotherapeutics"},{"issue":"7","key":"D6CB00022C\/cit192\/1","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s40265-023-01858-9","volume":"83","author":"Cummings","year":"2023","journal-title":"Drugs"},{"issue":"1","key":"D6CB00022C\/cit193\/1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s40259-023-00633-2","volume":"38","author":"Cummings","year":"2024","journal-title":"BioDrugs"},{"issue":"2","key":"D6CB00022C\/cit194\/1","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/d41573-023-00004-0","volume":"22","author":"Mullard","year":"2023","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D6CB00022C\/cit195\/1","doi-asserted-by":"publisher","first-page":"d41586-024-01726-w","DOI":"10.1038\/d41586-024-01726-w","author":"Reardon","year":"2024","journal-title":"Nature"},{"issue":"9","key":"D6CB00022C\/cit196\/1","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1038\/s41582-025-01123-5","volume":"21","author":"Rafii","year":"2025","journal-title":"Nat. Rev. Neurol."},{"issue":"12","key":"D6CB00022C\/cit197\/1","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/s41582-025-01154-y","volume":"21","author":"Llibre-Guerra","year":"2025","journal-title":"Nat. Rev. Neurol."},{"issue":"4","key":"D6CB00022C\/cit198\/1","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/S1474-4422(25)00024-9","volume":"24","author":"Bateman","year":"2025","journal-title":"Lancet Neurol."},{"key":"D6CB00022C\/cit199\/1","doi-asserted-by":"publisher","first-page":"100281","DOI":"10.1016\/j.jbc.2021.100281","volume":"296","author":"Devkota","year":"2021","journal-title":"J. Biol. Chem."},{"issue":"4","key":"D6CB00022C\/cit200\/1","doi-asserted-by":"publisher","first-page":"E476","DOI":"10.1073\/pnas.1618657114","volume":"114","author":"Sun","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"D6CB00022C\/cit201\/1","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1038\/s41374-019-0231-z","volume":"99","author":"Castellani","year":"2019","journal-title":"Lab. Invest."},{"issue":"7","key":"D6CB00022C\/cit202\/1","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.4103\/1673-5374.385847","volume":"19","author":"Ye","year":"2024","journal-title":"Neural Regen. Res."},{"issue":"2","key":"D6CB00022C\/cit203\/1","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1021\/acschemneuro.8b00457","volume":"10","author":"Chu","year":"2019","journal-title":"ACS Chem. Neurosci."},{"issue":"1","key":"D6CB00022C\/cit204\/1","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s40035-024-00429-6","volume":"13","author":"Zhang","year":"2024","journal-title":"Transl. Neurodegener."},{"issue":"6","key":"D6CB00022C\/cit205\/1","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1007\/s11596-020-2282-1","volume":"40","author":"Gu","year":"2020","journal-title":"Curr. Med. Sci."},{"issue":"2","key":"D6CB00022C\/cit206\/1","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3390\/life14020196","volume":"14","author":"Reiss","year":"2024","journal-title":"Life"},{"issue":"1","key":"D6CB00022C\/cit207\/1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.mehy.2003.12.045","volume":"63","author":"Swerdlow","year":"2004","journal-title":"Med. Hypotheses"},{"issue":"8","key":"D6CB00022C\/cit208\/1","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1016\/j.bbadis.2013.09.010","volume":"1842","author":"Swerdlow","year":"2014","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"issue":"4","key":"D6CB00022C\/cit209\/1","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.3233\/JAD-161088","volume":"57","author":"T\u00f6nnies","year":"2017","journal-title":"J. Alzheimer's Dis."},{"issue":"8","key":"D6CB00022C\/cit210\/1","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.3390\/molecules24081583","volume":"24","author":"Singh","year":"2019","journal-title":"Molecules"},{"issue":"12","key":"D6CB00022C\/cit211\/1","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1080\/15216540601047767","volume":"58","author":"Chen","year":"2006","journal-title":"IUBMB Life"},{"issue":"29","key":"D6CB00022C\/cit212\/1","doi-asserted-by":"publisher","first-page":"10726","DOI":"10.1073\/pnas.0403649101","volume":"101","author":"Coskun","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"D6CB00022C\/cit213\/1","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.neuron.2009.06.026","volume":"63","author":"Kim","year":"2009","journal-title":"Neuron"},{"key":"D6CB00022C\/cit214\/1","doi-asserted-by":"publisher","first-page":"104784","DOI":"10.1016\/j.nbd.2020.104784","volume":"138","author":"Wisniewski","year":"2020","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"D6CB00022C\/cit215\/1","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","volume":"9","author":"Liu","year":"2013","journal-title":"Nat. Rev. Neurol."},{"issue":"10","key":"D6CB00022C\/cit216\/1","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1523\/JNEUROSCI.4315-03.2004","volume":"24","author":"Brecht","year":"2004","journal-title":"J. Neurosci."},{"issue":"2","key":"D6CB00022C\/cit217\/1","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.neuron.2017.02.042","volume":"94","author":"Ulrich","year":"2017","journal-title":"Neuron"},{"issue":"2","key":"D6CB00022C\/cit218\/1","doi-asserted-by":"publisher","first-page":"113761","DOI":"10.1016\/j.celrep.2024.113761","volume":"43","author":"Devkota","year":"2024","journal-title":"Cell Rep."},{"key":"D6CB00022C\/cit219\/1","doi-asserted-by":"publisher","first-page":"acs.biochem.4c00830","DOI":"10.1021\/acs.biochem.4c00830","author":"Wolfe","year":"2025","journal-title":"Biochemistry"},{"issue":"6007","key":"D6CB00022C\/cit220\/1","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1126\/science.1196284","volume":"330","author":"Wang","year":"2010","journal-title":"Science"},{"key":"D6CB00022C\/cit221\/1","doi-asserted-by":"publisher","DOI":"10.1101\/2025.07.16.665161","volume-title":"A C. elegans model of familial Alzheimer's disease shows age-dependent synaptic degeneration independent of amyloid \u03b2-peptide","author":"Nagarajan","year":"2025","unstructured":"V.Nagarajan ,  C. L.Libowitz ,  B. D.Ackley  and  M. S.Wolfe ,  A C. elegans model of familial Alzheimer's disease shows age-dependent synaptic degeneration independent of amyloid \u03b2-peptide ,  2025 10.1101\/2025.07.16.665161"},{"issue":"34","key":"D6CB00022C\/cit222\/1","doi-asserted-by":"publisher","first-page":"e2409343121","DOI":"10.1073\/pnas.2409343121","volume":"121","author":"Yan","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"D6CB00022C\/cit223\/1","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.nrleng.2015.07.008","volume":"33","author":"Rius-P\u00e9rez","year":"2018","journal-title":"Neurologia (Engl. Ed.)"},{"issue":"4","key":"D6CB00022C\/cit224\/1","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.3233\/JAD-200473","volume":"76","author":"Solis","year":"2020","journal-title":"J. Alzheimer's Dis."},{"issue":"s4","key":"D6CB00022C\/cit225\/1","doi-asserted-by":"publisher","first-page":"S411","DOI":"10.3233\/JAD-141467","volume":"42","author":"Wierenga","year":"2014","journal-title":"J. Alzheimer's Dis."},{"issue":"4","key":"D6CB00022C\/cit226\/1","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1161\/ATVBAHA.120.311911","volume":"41","author":"Scheffer","year":"2021","journal-title":"Arterioscler., Thromb., Vasc. Biol."},{"key":"D6CB00022C\/cit227\/1","doi-asserted-by":"publisher","first-page":"224","DOI":"10.3389\/fnagi.2018.00224","volume":"10","author":"Fulop","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"D6CB00022C\/cit228\/1","doi-asserted-by":"publisher","first-page":"awz244","DOI":"10.1093\/brain\/awz244","author":"Panza","year":"2019","journal-title":"Brain"},{"issue":"3","key":"D6CB00022C\/cit229\/1","doi-asserted-by":"publisher","first-page":"e9505","DOI":"10.1371\/journal.pone.0009505","volume":"5","author":"Soscia","year":"2010","journal-title":"PLoS One"},{"issue":"4","key":"D6CB00022C\/cit230\/1","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.3233\/JAD-150652","volume":"50","author":"Bourgade","year":"2016","journal-title":"J. Alzheimer's Dis."},{"issue":"340","key":"D6CB00022C\/cit231\/1","doi-asserted-by":"publisher","first-page":"340ra72","DOI":"10.1126\/scitranslmed.aaf1059","volume":"8","author":"Kumar","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"D6CB00022C\/cit232\/1","doi-asserted-by":"publisher","first-page":"118627","DOI":"10.1016\/j.lfs.2020.118627","volume":"264","author":"Kesika","year":"2021","journal-title":"Life Sci."},{"key":"D6CB00022C\/cit233\/1","doi-asserted-by":"publisher","first-page":"111560","DOI":"10.1016\/j.mad.2021.111560","volume":"199","author":"Liu","year":"2021","journal-title":"Mech. Ageing Dev."},{"issue":"2","key":"D6CB00022C\/cit234\/1","doi-asserted-by":"publisher","first-page":"408","DOI":"10.3390\/biomedicines11020408","volume":"11","author":"Mehta","year":"2023","journal-title":"Biomedicines"},{"issue":"4","key":"D6CB00022C\/cit235\/1","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.3233\/JAD-240088","volume":"100","author":"Reive","year":"2024","journal-title":"J. Alzheimer's Dis."},{"issue":"2","key":"D6CB00022C\/cit236\/1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3390\/toxics8020021","volume":"8","author":"Tang","year":"2020","journal-title":"Toxics"},{"issue":"11","key":"D6CB00022C\/cit237\/1","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.3390\/biom12111676","volume":"12","author":"Fi\u0161ar","year":"2022","journal-title":"Biomolecules"},{"issue":"11","key":"D6CB00022C\/cit238\/1","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.3390\/antiox11112167","volume":"11","author":"Jurc\u0103u","year":"2022","journal-title":"Antioxidants"},{"issue":"21","key":"D6CB00022C\/cit239\/1","doi-asserted-by":"publisher","first-page":"11720","DOI":"10.3390\/ijms252111720","volume":"25","author":"Kazemeini","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"D6CB00022C\/cit240\/1","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.1016\/j.bbamem.2013.04.016","volume":"1828","author":"Jurisch-Yaksi","year":"2013","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"issue":"4","key":"D6CB00022C\/cit241\/1","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.pneurobio.2008.05.002","volume":"85","author":"M\u00fcller","year":"2008","journal-title":"Prog. Neurobiol."},{"issue":"1","key":"D6CB00022C\/cit242\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0301-0082(03)00089-3","volume":"70","author":"Turner","year":"2003","journal-title":"Prog. Neurobiol."},{"issue":"2","key":"D6CB00022C\/cit243\/1","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1074\/jbc.M114.599852","volume":"290","author":"Takei","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"4","key":"D6CB00022C\/cit244\/1","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1042\/BST20221445","volume":"51","author":"Liu","year":"2023","journal-title":"Biochem. Soc. Trans."},{"issue":"1","key":"D6CB00022C\/cit245\/1","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1080\/21623945.2020.1788235","volume":"9","author":"Sparling","year":"2020","journal-title":"Adipocyte"},{"issue":"34","key":"D6CB00022C\/cit246\/1","doi-asserted-by":"publisher","first-page":"12083","DOI":"10.1523\/JNEUROSCI.2513-11.2011","volume":"31","author":"Restituito","year":"2011","journal-title":"J. Neurosci."},{"issue":"24","key":"D6CB00022C\/cit247\/1","doi-asserted-by":"publisher","first-page":"8973","DOI":"10.1073\/pnas.1408554111","volume":"111","author":"Lee","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"28","key":"D6CB00022C\/cit248\/1","doi-asserted-by":"publisher","first-page":"9775","DOI":"10.1073\/pnas.0800507105","volume":"105","author":"Dejaegere","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"D6CB00022C\/cit249\/1","doi-asserted-by":"publisher","first-page":"3681","DOI":"10.1158\/0008-5472.CAN-05-3870","volume":"66","author":"Pelletier","year":"2006","journal-title":"Cancer Res."},{"issue":"30","key":"D6CB00022C\/cit250\/1","doi-asserted-by":"publisher","first-page":"25001","DOI":"10.1074\/jbc.M112.348904","volume":"287","author":"Na","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"3","key":"D6CB00022C\/cit251\/1","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1111\/j.1582-4934.2008.00274.x","volume":"12","author":"Boulton","year":"2008","journal-title":"J. Cell. Mol. Med."},{"issue":"12","key":"D6CB00022C\/cit252\/1","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.3390\/jpm11121294","volume":"11","author":"Sen","year":"2021","journal-title":"J. Pers. Med."},{"issue":"5","key":"D6CB00022C\/cit253\/1","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.tem.2015.02.006","volume":"26","author":"Bi","year":"2015","journal-title":"Trends Endocrinol. Metab."},{"issue":"4","key":"D6CB00022C\/cit254\/1","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.cmet.2018.02.010","volume":"27","author":"Kim","year":"2018","journal-title":"Cell Metab."},{"issue":"3","key":"D6CB00022C\/cit255\/1","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/nm1712","volume":"14","author":"Engin","year":"2008","journal-title":"Nat. Med."},{"issue":"3","key":"D6CB00022C\/cit256\/1","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1210\/er.2016-1002","volume":"37","author":"Zanotti","year":"2016","journal-title":"Endocr. Rev."},{"issue":"11","key":"D6CB00022C\/cit257\/1","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/s41580-020-00279-w","volume":"21","author":"Salhotra","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"D6CB00022C\/cit258\/1","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1038\/jid.2012.372","volume":"133","author":"Pink","year":"2013","journal-title":"J. Invest. Dermatol."},{"issue":"8","key":"D6CB00022C\/cit259\/1","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1016\/j.jid.2021.01.023","volume":"141","author":"Vellaichamy","year":"2021","journal-title":"J. Invest. Dermatol."},{"issue":"5","key":"D6CB00022C\/cit260\/1","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1159\/000512455","volume":"237","author":"Wang","year":"2021","journal-title":"Dermatology"},{"key":"D6CB00022C\/cit261\/1","doi-asserted-by":"publisher","first-page":"104867","DOI":"10.1016\/j.antiviral.2020.104867","volume":"183","author":"Lee","year":"2020","journal-title":"Antiviral Res."},{"issue":"10","key":"D6CB00022C\/cit262\/1","doi-asserted-by":"publisher","first-page":"3545","DOI":"10.1083\/jcb.201804171","volume":"217","author":"Inoue","year":"2018","journal-title":"J. Cell Biol."},{"key":"D6CB00022C\/cit263\/1","doi-asserted-by":"publisher","first-page":"eaax7533","DOI":"10.3389\/fncel.2014.00427","volume":"8","author":"Zhang","year":"2014","journal-title":"Front. Cell. Neurosci."},{"issue":"4","key":"D6CB00022C\/cit264\/1","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.3233\/JAD-150940","volume":"52","author":"Otto","year":"2016","journal-title":"J. Alzheimer's Dis."},{"issue":"1","key":"D6CB00022C\/cit265\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cellsig.2015.10.006","volume":"28","author":"Duggan","year":"2016","journal-title":"Cell. Signalling"},{"issue":"2","key":"D6CB00022C\/cit266\/1","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S1474-4422(09)70332-1","volume":"9","author":"Bergmans","year":"2010","journal-title":"Lancet Neurol."},{"issue":"14","key":"D6CB00022C\/cit267\/1","doi-asserted-by":"publisher","first-page":"10516","DOI":"10.1074\/jbc.M611572200","volume":"282","author":"Dunys","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"1","key":"D6CB00022C\/cit268\/1","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/j.1471-4159.2009.05952.x","volume":"109","author":"Pardossi-Piquard","year":"2009","journal-title":"J. Neurochem."},{"issue":"1","key":"D6CB00022C\/cit269\/1","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1046\/j.1471-4159.2001.00012.x","volume":"76","author":"Dovey","year":"2001","journal-title":"J. Neurochem."},{"issue":"4","key":"D6CB00022C\/cit270\/1","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.bcp.2004.11.015","volume":"69","author":"Anderson","year":"2005","journal-title":"Biochem. Pharmacol."},{"issue":"13","key":"D6CB00022C\/cit271\/1","doi-asserted-by":"publisher","first-page":"12876","DOI":"10.1074\/jbc.M311652200","volume":"279","author":"Wong","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"3","key":"D6CB00022C\/cit272\/1","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1097\/01.wnf.0000167360.27670.29","volume":"28","author":"Siemers","year":"2005","journal-title":"Clin. Neuropharmacol."},{"issue":"4","key":"D6CB00022C\/cit273\/1","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1056\/NEJMoa1210951","volume":"369","author":"Doody","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"11","key":"D6CB00022C\/cit274\/1","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1001\/archneurol.2012.2194","volume":"69","author":"Coric","year":"2012","journal-title":"Arch. Neurol."},{"issue":"24","key":"D6CB00022C\/cit275\/1","doi-asserted-by":"publisher","first-page":"7580","DOI":"10.1021\/bi034310g","volume":"42","author":"Lewis","year":"2003","journal-title":"Biochemistry"},{"key":"D6CB00022C\/cit276\/1","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.semcdb.2020.03.002","volume":"105","author":"Nie","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"issue":"8","key":"D6CB00022C\/cit277\/1","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1038\/nm.2378","volume":"17","author":"Pajvani","year":"2011","journal-title":"Nat. Med."},{"issue":"6","key":"D6CB00022C\/cit278\/1","doi-asserted-by":"publisher","first-page":"6878","DOI":"10.1021\/acsnano.0c01007","volume":"14","author":"Richter","year":"2020","journal-title":"ACS Nano"},{"key":"D6CB00022C\/cit279\/1","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.bone.2014.12.007","volume":"73","author":"Wang","year":"2015","journal-title":"Bone"},{"issue":"16","key":"D6CB00022C\/cit280\/1","doi-asserted-by":"publisher","first-page":"5089","DOI":"10.7150\/ijbs.87334","volume":"19","author":"Song","year":"2023","journal-title":"Int. J. Biol. Sci."},{"issue":"4","key":"D6CB00022C\/cit281\/1","doi-asserted-by":"publisher","first-page":"e608","DOI":"10.1002\/onco.13627","volume":"26","author":"McCaw","year":"2021","journal-title":"Oncologist"},{"issue":"10","key":"D6CB00022C\/cit282\/1","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1056\/NEJMoa2210140","volume":"388","author":"Gounder","year":"2023","journal-title":"N. Engl. J. Med."},{"issue":"19","key":"D6CB00022C\/cit283\/1","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1182\/blood.2019000050","volume":"134","author":"Pont","year":"2019","journal-title":"Blood"},{"issue":"2","key":"D6CB00022C\/cit284\/1","doi-asserted-by":"publisher","first-page":"388","DOI":"10.3390\/molecules26020388","volume":"26","author":"Wolfe","year":"2021","journal-title":"Molecules"},{"issue":"16","key":"D6CB00022C\/cit285\/1","doi-asserted-by":"publisher","first-page":"7389","DOI":"10.1021\/acs.jmedchem.5b01960","volume":"59","author":"Bursavich","year":"2016","journal-title":"J. Med. Chem."},{"issue":"6860","key":"D6CB00022C\/cit286\/1","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1038\/35102591","volume":"414","author":"Weggen","year":"2001","journal-title":"Nature"},{"issue":"34","key":"D6CB00022C\/cit287\/1","doi-asserted-by":"publisher","first-page":"31831","DOI":"10.1074\/jbc.M303592200","volume":"278","author":"Weggen","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"42","key":"D6CB00022C\/cit288\/1","doi-asserted-by":"publisher","first-page":"43419","DOI":"10.1074\/jbc.M404937200","volume":"279","author":"Beher","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"3","key":"D6CB00022C\/cit289\/1","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1111\/jcmm.17146","volume":"26","author":"Weber","year":"2022","journal-title":"J. Cell. Mol. Med."},{"issue":"19","key":"D6CB00022C\/cit290\/1","doi-asserted-by":"publisher","first-page":"3197","DOI":"10.1021\/bi400377p","volume":"52","author":"Crump","year":"2013","journal-title":"Biochemistry"},{"issue":"6","key":"D6CB00022C\/cit291\/1","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1021\/acsmedchemlett.0c00109","volume":"11","author":"Ratni","year":"2020","journal-title":"ACS Med. Chem. Lett."},{"issue":"4","key":"D6CB00022C\/cit292\/1","doi-asserted-by":"publisher","first-page":"e20202560","DOI":"10.1084\/jem.20202560","volume":"218","author":"Rynearson","year":"2021","journal-title":"J. Exp. Med."},{"issue":"1","key":"D6CB00022C\/cit293\/1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s13195-025-01680-3","volume":"17","author":"Trambauer","year":"2025","journal-title":"Alzheimer's Res. Ther."},{"issue":"1","key":"D6CB00022C\/cit294\/1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1080\/17460441.2023.2277350","volume":"19","author":"Wolfe","year":"2024","journal-title":"Expert Opin. Drug Discovery"}],"container-title":["RSC Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/CB\/article-pdf\/doi\/10.1039\/D6CB00022C\/0\/D6CB00022C.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:50:31Z","timestamp":1785937831000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/CB\/article-lookup\/doi\/10.1039\/D6CB00022C"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":294,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8,5]]}},"URL":"https:\/\/doi.org\/10.1039\/d6cb00022c","relation":{},"ISSN":["2633-0679"],"issn-type":[{"value":"2633-0679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}