{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:25:39Z","timestamp":1790821539526,"version":"4.1.0"},"reference-count":185,"publisher":"Royal Society of Chemistry (RSC)","issue":"6","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":111,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Chem. Biol."],"abstract":"<jats:p>This review examines advanced formulation and molecular engineering strategies to reduce rapid hepatic clearance of therapeutic proteins.<\/jats:p>","DOI":"10.1039\/d6cb00041j","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:00:45Z","timestamp":1776841245000},"page":"945-963","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Strategies to overcome hepatic clearance of endogenous proteins \u2013 molecular and formulation approaches"],"prefix":"10.1039","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0667-0637","authenticated-orcid":false,"given":"Kirstin","family":"Meiners","sequence":"first","affiliation":[{"name":"Institute of Pharmacy and Food Chemistry, University of W\u00fcrzburg, Am Hubland, W\u00fcrzburg, 97074, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Stepic","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy and Food Chemistry, University of W\u00fcrzburg, Am Hubland, W\u00fcrzburg, 97074, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7549-7627","authenticated-orcid":false,"given":"Lorenz","family":"Meinel","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy and Food Chemistry, University of W\u00fcrzburg, Am Hubland, W\u00fcrzburg, 97074, Germany"},{"name":"Helmholtz Institute for RNA-Based Infection Research (HIRI), Josef-Schneider-Stra\u00dfe 2, 97080 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7552-6435","authenticated-orcid":false,"given":"Tessa","family":"L\u00fchmann","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy and Food Chemistry, University of W\u00fcrzburg, Am Hubland, W\u00fcrzburg, 97074, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"1","key":"D6CB00041J\/cit1\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cld.2016.08.001","volume":"21","author":"Almazroo","year":"2017","journal-title":"Clin. Liver Disease"},{"issue":"3","key":"D6CB00041J\/cit2\/1","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s00281-009-0155-6","volume":"31","author":"Ishibashi","year":"2009","journal-title":"Semin. Immunopathol."},{"issue":"7","key":"D6CB00041J\/cit3\/1","doi-asserted-by":"publisher","first-page":"539","DOI":"10.2165\/00003088-200140070-00005","volume":"40","author":"Harris","year":"2001","journal-title":"Clin. Pharmacokinet."},{"issue":"2","key":"D6CB00041J\/cit4\/1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1152\/physrev.00055.2006","volume":"88","author":"Haraldsson","year":"2008","journal-title":"Physiol. Rev."},{"issue":"7","key":"D6CB00041J\/cit5\/1","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1007\/s00467-004-1494-0","volume":"19","author":"Christensen","year":"2004","journal-title":"Pediatr. Nephrol."},{"issue":"1","key":"D6CB00041J\/cit6\/1","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.kint.2015.11.007","volume":"89","author":"Nielsen","year":"2016","journal-title":"Kidney Int."},{"key":"D6CB00041J\/cit7\/1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.5772\/intechopen.99083","volume":"3","author":"Dutta","year":"2021","journal-title":"Drug Metab."},{"issue":"7","key":"D6CB00041J\/cit8\/1","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.1083\/jcb.201903090","volume":"218","author":"Schulze","year":"2019","journal-title":"J. Cell Biol."},{"issue":"8","key":"D6CB00041J\/cit9\/1","first-page":"13","volume":"4","author":"Ozougwu","year":"2017","journal-title":"Int. J. Res. Pharm. Biosci."},{"issue":"3","key":"D6CB00041J\/cit10\/1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2174\/138920021503140412212905","volume":"15","author":"Shi","year":"2014","journal-title":"Curr. Drug Metab."},{"issue":"1","key":"D6CB00041J\/cit11\/1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/hep.1840160137","volume":"16","author":"Toth","year":"1992","journal-title":"Hepatology"},{"issue":"15","key":"D6CB00041J\/cit12\/1","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.3748\/wjg.v19.i15.2298","volume":"19","author":"Itou","year":"2013","journal-title":"World J. Gastroenterol."},{"issue":"4","key":"D6CB00041J\/cit13\/1","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1016\/S0021-9258(18)94167-0","volume":"264","author":"Skidgel","year":"1989","journal-title":"J. Biol. Chem."},{"key":"D6CB00041J\/cit14\/1","first-page":"173","author":"Nagase","year":"1996","journal-title":"Zinc Metalloproteases Health Dis."},{"issue":"1","key":"D6CB00041J\/cit15\/1","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.bbapap.2011.10.002","volume":"1824","author":"Turk","year":"2012","journal-title":"Biochim. Biophys. Acta, Proteins Proteomics"},{"issue":"5897","key":"D6CB00041J\/cit16\/1","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/301214a0","volume":"301","author":"Pennica","year":"1983","journal-title":"Nature"},{"issue":"3","key":"D6CB00041J\/cit17\/1","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/0167-4838(82)90068-1","volume":"704","author":"R\u00e5nby","year":"1982","journal-title":"Biochim. Biophys. Acta, Protein Struct. Mol. Enzymol."},{"issue":"4","key":"D6CB00041J\/cit18\/1","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1182\/blood.V64.4.907.907","volume":"64","author":"Kruithof","year":"1984","journal-title":"Blood"},{"issue":"1","key":"D6CB00041J\/cit19\/1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1432-1033.1988.tb14162.x","volume":"175","author":"Thorsen","year":"1988","journal-title":"Eur. J. Biochem."},{"issue":"5","key":"D6CB00041J\/cit20\/1","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1182\/blood.V78.5.1254.1254","volume":"78","author":"Keijer","year":"1991","journal-title":"Blood"},{"issue":"2","key":"D6CB00041J\/cit21\/1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/clpt.1989.120","volume":"46","author":"Tanswell","year":"1989","journal-title":"Clin. Pharmacol. Ther."},{"issue":"1","key":"D6CB00041J\/cit22\/1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/j.1600-0609.1984.tb02209.x","volume":"33","author":"Nilsson","year":"1984","journal-title":"Scand. J. Haematol."},{"issue":"03","key":"D6CB00041J\/cit23\/1","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1055\/s-0038-1647505","volume":"59","author":"Brommer","year":"1988","journal-title":"Thromb. Haemost."},{"issue":"34","key":"D6CB00041J\/cit24\/1","doi-asserted-by":"publisher","first-page":"18220","DOI":"10.1016\/S0021-9258(19)81348-0","volume":"263","author":"Kuiper","year":"1988","journal-title":"J. Biol. Chem."},{"issue":"2","key":"D6CB00041J\/cit25\/1","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1172\/JCI118105","volume":"96","author":"Narita","year":"1995","journal-title":"J. Clin. Invest."},{"issue":"33","key":"D6CB00041J\/cit26\/1","doi-asserted-by":"publisher","first-page":"21117","DOI":"10.1016\/S0021-9258(17)31937-3","volume":"269","author":"Orth","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"9","key":"D6CB00041J\/cit27\/1","doi-asserted-by":"publisher","first-page":"3421","DOI":"10.1182\/blood.V86.9.3421.bloodjournal8693421","volume":"86","author":"Noorman","year":"1995","journal-title":"Blood"},{"issue":"3","key":"D6CB00041J\/cit28\/1","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1161\/01.CIR.96.3.761","volume":"96","author":"Chandler","year":"1997","journal-title":"Circulation"},{"key":"D6CB00041J\/cit29\/1","unstructured":"European Medicines Agency, Alteplase: Background information and Annex I, 2002,  https:\/\/www.ema.europa.eu\/en\/documents\/referral\/summary-information-referral-opinion-following-arbitration-pursuant-article-29-directive-200183ec-actilyse-international-non-proprietary-name-inn-alteplase-background-information-and-annex-i_en.pdf  (accessed June 27, 2024)"},{"issue":"9136","key":"D6CB00041J\/cit30\/1","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/S0140-6736(98)08020-9","volume":"352","author":"Hacke","year":"1998","journal-title":"The Lancet"},{"issue":"9834","key":"D6CB00041J\/cit31\/1","doi-asserted-by":"publisher","first-page":"2364","DOI":"10.1016\/S0140-6736(12)60738-7","volume":"379","author":"Wardlaw","year":"2012","journal-title":"The Lancet"},{"issue":"21","key":"D6CB00041J\/cit32\/1","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1001\/jama.282.21.2019","volume":"282","author":"Clark","year":"1999","journal-title":"JAMA"},{"issue":"6","key":"D6CB00041J\/cit33\/1","doi-asserted-by":"publisher","first-page":"e0302269","DOI":"10.1371\/journal.pone.0302269","volume":"19","author":"V\u00edte\u010dek","year":"2024","journal-title":"PLoS One"},{"issue":"4","key":"D6CB00041J\/cit34\/1","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1210\/endo-119-4-1467","volume":"119","author":"\u00d8rskov","year":"1986","journal-title":"Endocrinology"},{"issue":"16","key":"D6CB00041J\/cit35\/1","doi-asserted-by":"publisher","first-page":"5007","DOI":"10.1073\/pnas.81.16.5007","volume":"81","author":"Patzelt","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"25","key":"D6CB00041J\/cit36\/1","doi-asserted-by":"publisher","first-page":"11880","DOI":"10.1016\/S0021-9258(18)67324-7","volume":"261","author":"Mojsov","year":"1986","journal-title":"J. Biol. Chem."},{"issue":"5924","key":"D6CB00041J\/cit37\/1","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/304368a0","volume":"304","author":"Bell","year":"1983","journal-title":"Nature"},{"issue":"4","key":"D6CB00041J\/cit38\/1","doi-asserted-by":"publisher","first-page":"535","DOI":"10.2337\/diab.43.4.535","volume":"43","author":"\u00d8rskov","year":"1994","journal-title":"Diabetes"},{"issue":"3","key":"D6CB00041J\/cit39\/1","doi-asserted-by":"publisher","first-page":"338","DOI":"10.2337\/diab.38.3.338","volume":"38","author":"Weir","year":"1989","journal-title":"Diabetes"},{"issue":"3","key":"D6CB00041J\/cit40\/1","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.bbrc.2009.10.054","volume":"390","author":"Arakawa","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"8","key":"D6CB00041J\/cit41\/1","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1007\/s00125-017-4303-6","volume":"60","author":"Kawamori","year":"2017","journal-title":"Diabetologia"},{"key":"D6CB00041J\/cit42\/1","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.molmet.2019.09.010","volume":"30","author":"M\u00fcller","year":"2019","journal-title":"Mol. Metab."},{"issue":"3","key":"D6CB00041J\/cit43\/1","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1136\/gut.50.3.341","volume":"50","author":"Schirra","year":"2002","journal-title":"Gut"},{"issue":"4","key":"D6CB00041J\/cit44\/1","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1152\/physrev.00034.2006","volume":"87","author":"Holst","year":"2007","journal-title":"Physiol. Rev."},{"issue":"3","key":"D6CB00041J\/cit45\/1","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1111\/j.1432-1033.1993.tb17986.x","volume":"214","author":"Mentlein","year":"1993","journal-title":"Eur. J. Biochem."},{"issue":"3","key":"D6CB00041J\/cit46\/1","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1210\/jc.80.3.952","volume":"80","author":"Deacon","year":"1995","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"D6CB00041J\/cit47\/1","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1677\/jme.0.0050033","volume":"5","author":"Gallwitz","year":"1990","journal-title":"J. Mol. Endocrinol."},{"issue":"8","key":"D6CB00041J\/cit48\/1","doi-asserted-by":"publisher","first-page":"3585","DOI":"10.1210\/en.136.8.3585","volume":"136","author":"Kieffer","year":"1995","journal-title":"Endocrinology"},{"issue":"3","key":"D6CB00041J\/cit49\/1","doi-asserted-by":"publisher","first-page":"654","DOI":"10.2337\/diabetes.53.3.654","volume":"53","author":"Meier","year":"2004","journal-title":"Diabetes"},{"issue":"12","key":"D6CB00041J\/cit50\/1","doi-asserted-by":"publisher","first-page":"5807","DOI":"10.1016\/S0021-9258(19)70701-7","volume":"255","author":"Elovson","year":"1980","journal-title":"J. Biol. Chem."},{"issue":"8","key":"D6CB00041J\/cit51\/1","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.2337\/diacare.24.8.1416","volume":"24","author":"Larsen","year":"2001","journal-title":"Diabetes Care"},{"issue":"4","key":"D6CB00041J\/cit52\/1","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.beem.2009.03.004","volume":"23","author":"Thornberry","year":"2009","journal-title":"Best Pract. Res., Clin. Endocrinol. Metab."},{"issue":"4","key":"D6CB00041J\/cit53\/1","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1042\/bj0600541","volume":"60","author":"Ryle","year":"1955","journal-title":"Biochem. J."},{"issue":"3","key":"D6CB00041J\/cit54\/1","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1042\/bj0590509","volume":"59","author":"Sanger","year":"1955","journal-title":"Biochem. J."},{"issue":"6","key":"D6CB00041J\/cit55\/1","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/nrm3351","volume":"13","author":"Leto","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"6","key":"D6CB00041J\/cit56\/1","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1111\/j.1600-0854.2011.01163.x","volume":"12","author":"Bryant","year":"2011","journal-title":"Traffic"},{"issue":"5","key":"D6CB00041J\/cit57\/1","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1002\/bip.20734","volume":"88","author":"Mayer","year":"2007","journal-title":"Peptide Sci."},{"issue":"3","key":"D6CB00041J\/cit58\/1","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1152\/physiol.00048.2018","volume":"34","author":"Najjar","year":"2019","journal-title":"Physiology"},{"issue":"3","key":"D6CB00041J\/cit59\/1","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/ng840","volume":"30","author":"Poy","year":"2002","journal-title":"Nat. Genetics"},{"issue":"6","key":"D6CB00041J\/cit60\/1","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.2337\/diabetes.54.6.1649","volume":"54","author":"Meier","year":"2005","journal-title":"Diabetes"},{"issue":"6","key":"D6CB00041J\/cit61\/1","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1210\/jcem-56-6-1294","volume":"56","author":"Eaton","year":"1983","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"D6CB00041J\/cit62\/1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/BF00253868","volume":"22","author":"Home","year":"1982","journal-title":"Diabetologia"},{"issue":"2","key":"D6CB00041J\/cit63\/1","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1210\/jcem-33-2-279","volume":"33","author":"Turner","year":"1971","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"D6CB00041J\/cit64\/1","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1042\/cs0450633","volume":"45","author":"S\u00f6nksen","year":"1973","journal-title":"Clin. Sci. Mol. Med."},{"key":"D6CB00041J\/cit65\/1","doi-asserted-by":"crossref","first-page":"1133352","DOI":"10.3389\/fneph.2023.1133352","volume":"3","author":"Daza-Arnedo","year":"2023","journal-title":"Front. Nephrol."},{"issue":"6","key":"D6CB00041J\/cit66\/1","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1083\/jcb.122.6.1243","volume":"122","author":"Carpentier","year":"1993","journal-title":"J. Cell Biol."},{"issue":"9","key":"D6CB00041J\/cit67\/1","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1007\/s00592-022-01938-4","volume":"59","author":"Bolli","year":"2022","journal-title":"Acta Diabetol."},{"issue":"22","key":"D6CB00041J\/cit68\/1","doi-asserted-by":"publisher","first-page":"11813","DOI":"10.1073\/pnas.94.22.11813","volume":"94","author":"Karpusas","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D6CB00041J\/cit69\/1","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.ejpb.2022.02.006","volume":"172","author":"Hauptstein","year":"2022","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"1","key":"D6CB00041J\/cit70\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0022-3565(25)22069-9","volume":"227","author":"Tokazewski-Chen","year":"1983","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"2","key":"D6CB00041J\/cit71\/1","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1099\/0022-1317-60-2-397","volume":"60","author":"Bocci","year":"1982","journal-title":"J. Gen. Virol."},{"issue":"1","key":"D6CB00041J\/cit72\/1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.2165\/00044011-199714010-00005","volume":"14","author":"Alam","year":"1997","journal-title":"Clin. Drug Invest."},{"issue":"24_suppl_4","key":"D6CB00041J\/cit73\/1","doi-asserted-by":"publisher","first-page":"S8","DOI":"10.1212\/01.wnl.0000277703.74115.d2","volume":"68","author":"Markowitz","year":"2007","journal-title":"Neurology"},{"key":"D6CB00041J\/cit74\/1","unstructured":"European Medicines Agency, Avonex: EPAR  \u2013  Product Information, 2009,  https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/avonex-epar-product-information_en.pdf  (accessed June 28, 2024)"},{"key":"D6CB00041J\/cit75\/1","unstructured":"European Medicines Agency, Rebif: EPAR  \u2013  Product Information, 2009,  https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/rebif-epar-product-information_en.pdf  (accessed June 28, 2024)"},{"issue":"3","key":"D6CB00041J\/cit76\/1","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/S1367-5931(00)00206-4","volume":"5","author":"Morrison","year":"2001","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"7","key":"D6CB00041J\/cit77\/1","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1002\/pro.2684","volume":"24","author":"Wang","year":"2015","journal-title":"Protein Sci."},{"issue":"4","key":"D6CB00041J\/cit78\/1","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1093\/glycob\/1.4.411","volume":"1","author":"Howard","year":"1991","journal-title":"Glycobiology"},{"issue":"05","key":"D6CB00041J\/cit79\/1","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1055\/s-0038-1647041","volume":"60","author":"Hotchkiss","year":"1988","journal-title":"Thromb. Haemostasis"},{"issue":"8","key":"D6CB00041J\/cit80\/1","doi-asserted-by":"publisher","first-page":"5191","DOI":"10.1016\/S0021-9258(19)67773-2","volume":"266","author":"Bennett","year":"1991","journal-title":"J. Biol. Chem."},{"issue":"9","key":"D6CB00041J\/cit81\/1","doi-asserted-by":"publisher","first-page":"3530","DOI":"10.1073\/pnas.87.9.3530","volume":"87","author":"Madison","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"D6CB00041J\/cit82\/1","doi-asserted-by":"publisher","first-page":"3670","DOI":"10.1073\/pnas.91.9.3670","volume":"91","author":"Keyt","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"D6CB00041J\/cit83\/1","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/cpt.33","volume":"97","author":"Gurman","year":"2015","journal-title":"Clin. Pharmacol. Ther."},{"issue":"11","key":"D6CB00041J\/cit84\/1","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1136\/heart.89.11.1358","volume":"89","author":"Nordt","year":"2003","journal-title":"Heart"},{"issue":"5","key":"D6CB00041J\/cit85\/1","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1177\/00912700022009125","volume":"40","author":"Modi","year":"2000","journal-title":"J. Clin. Pharmacol."},{"key":"D6CB00041J\/cit86\/1","unstructured":"European Medicines Agency, Metalyse: EPAR  \u2013  Assessment report  \u2013  Variation (Reference Number EMA\/37096\/2024), 2023,  https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/metalyse  (accessed March 23, 2026)"},{"key":"D6CB00041J\/cit87\/1","unstructured":"U.S. Food and Drug Administration, FDA Roundup: March 4, 2025, 2025,  https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-roundup-march-4-2025  (accessed March 23, 2026)"},{"issue":"1","key":"D6CB00041J\/cit88\/1","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0167-0115(99)00095-6","volume":"86","author":"Gallwitz","year":"2000","journal-title":"Regul. Pept."},{"issue":"9","key":"D6CB00041J\/cit89\/1","doi-asserted-by":"publisher","first-page":"6275","DOI":"10.1016\/S0021-9258(17)37366-0","volume":"269","author":"Adelhorst","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"3","key":"D6CB00041J\/cit90\/1","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s001250050903","volume":"41","author":"Deacon","year":"1998","journal-title":"Diabetologia"},{"issue":"3","key":"D6CB00041J\/cit91\/1","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1093\/protein\/1.3.205","volume":"1","author":"Markussen","year":"1987","journal-title":"Protein Eng., Des. Sel."},{"issue":"9228","key":"D6CB00041J\/cit92\/1","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/S0140-6736(00)02546-0","volume":"356","author":"Bolli","year":"2000","journal-title":"The Lancet"},{"issue":"6","key":"D6CB00041J\/cit93\/1","doi-asserted-by":"publisher","first-page":"813","DOI":"10.2337\/diacare.23.6.813","volume":"23","author":"Owens","year":"2000","journal-title":"Diabetes Care"},{"issue":"4","key":"D6CB00041J\/cit94\/1","doi-asserted-by":"publisher","first-page":"950","DOI":"10.2337\/diacare.28.4.950","volume":"28","author":"Rosenstock","year":"2005","journal-title":"Diabetes Care"},{"issue":"1","key":"D6CB00041J\/cit95\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5414\/cp203269","volume":"57","author":"Lindauer","year":"2019","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"issue":"6","key":"D6CB00041J\/cit96\/1","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1021\/acs.biomac.8b00248","volume":"19","author":"Wang","year":"2018","journal-title":"Biomacromolecules"},{"issue":"32","key":"D6CB00041J\/cit97\/1","doi-asserted-by":"publisher","first-page":"14404","DOI":"10.1021\/jacs.2c00129","volume":"144","author":"Taylor","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"D6CB00041J\/cit98\/1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.ejpb.2023.09.017","volume":"192","author":"Meiners","year":"2023","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"D6CB00041J\/cit99\/1","first-page":"161","volume-title":"Advances in Protein Chemistry","author":"Peters","year":"1985","unstructured":"T.Peters ,  Serum Albumin , in  Advances in Protein Chemistry , ed.  C. B. Anfinsen ,  J. T. Edsall  and  F. M. Richards ,  Academic Press ,  1985 , vol. 37,  pp. 161\u2013245"},{"key":"D6CB00041J\/cit100\/1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.jconrel.2022.05.038","volume":"348","author":"Linciano","year":"2022","journal-title":"J. Controlled Release"},{"issue":"2","key":"D6CB00041J\/cit101\/1","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s00125-001-0719-z","volume":"45","author":"Agers\u00f8","year":"2002","journal-title":"Diabetologia"},{"key":"D6CB00041J\/cit102\/1","doi-asserted-by":"crossref","first-page":"440904","DOI":"10.3389\/fendo.2019.00155","volume":"10","author":"Knudsen","year":"2019","journal-title":"Front. Endocrinol."},{"issue":"9","key":"D6CB00041J\/cit103\/1","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1021\/jm9909645","volume":"43","author":"Knudsen","year":"2000","journal-title":"J. Med. Chem."},{"issue":"18","key":"D6CB00041J\/cit104\/1","doi-asserted-by":"publisher","first-page":"7370","DOI":"10.1021\/acs.jmedchem.5b00726","volume":"58","author":"Lau","year":"2015","journal-title":"J. Med. Chem."},{"issue":"5","key":"D6CB00041J\/cit105\/1","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1002\/jcph.443","volume":"55","author":"Kapitza","year":"2015","journal-title":"J. Clin. Pharmacol."},{"key":"D6CB00041J\/cit106\/1","unstructured":"European Medicines Agency, Ozempic: EPAR  \u2013  Product information, 2018,  https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/ozempic-epar-product-information_en.pdf  (accessed July 02, 2024)"},{"issue":"9","key":"D6CB00041J\/cit107\/1","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.3390\/healthcare9091125","volume":"9","author":"Alsugair","year":"2021","journal-title":"Healthcare"},{"issue":"3","key":"D6CB00041J\/cit108\/1","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1042\/bj3120725","volume":"312","author":"Kurtzhals","year":"1995","journal-title":"Biochem. J."},{"issue":"3","key":"D6CB00041J\/cit109\/1","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/BF00418343","volume":"39","author":"Markussen","year":"1996","journal-title":"Diabetologia"},{"key":"D6CB00041J\/cit110\/1","unstructured":"European Medicines Agency,\nProtaphane: EPAR  \u2013  Product Information, 2009,  https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/protaphane-epar-product-information_en.pdf  (accessed July 03, 2024)"},{"key":"D6CB00041J\/cit111\/1","unstructured":"European Medicines Agency, Levemir: EPAR  \u2013  Product Information, 2009,  https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/levemir-epar-product-information_en.pdf  (accessed July 03, 2024)"},{"issue":"2","key":"D6CB00041J\/cit112\/1","doi-asserted-by":"publisher","first-page":"296","DOI":"10.2337\/diacare.24.2.296","volume":"24","author":"Hermansen","year":"2001","journal-title":"Diabetes Care"},{"issue":"3","key":"D6CB00041J\/cit113\/1","doi-asserted-by":"publisher","first-page":"590","DOI":"10.2337\/diacare.26.3.590","volume":"26","author":"Vague","year":"2003","journal-title":"Diabetes Care"},{"issue":"8","key":"D6CB00041J\/cit114\/1","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.1007\/s11095-012-0739-z","volume":"29","author":"Jonassen","year":"2012","journal-title":"Pharm. Res."},{"issue":"1 Suppl","key":"D6CB00041J\/cit115\/1","first-page":"15","volume":"62","author":"Unnikrishnan","year":"2014","journal-title":"J. Assoc. Physicians India"},{"issue":"8","key":"D6CB00041J\/cit116\/1","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1517\/17425255.2015.1058779","volume":"11","author":"Heise","year":"2015","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"issue":"1","key":"D6CB00041J\/cit117\/1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2174\/138920012798356934","volume":"13","author":"Milla","year":"2012","journal-title":"Curr. Drug Metab."},{"issue":"10","key":"D6CB00041J\/cit118\/1","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1016\/j.drudis.2014.06.002","volume":"19","author":"Baumann","year":"2014","journal-title":"Drug Discovery Today"},{"issue":"2","key":"D6CB00041J\/cit119\/1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.pep.2003.11.004","volume":"34","author":"Arduini","year":"2004","journal-title":"Protein Expression Purif."},{"issue":"1","key":"D6CB00041J\/cit120\/1","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1021\/bc050237q","volume":"17","author":"Baker","year":"2006","journal-title":"Bioconjugate Chem."},{"issue":"6","key":"D6CB00041J\/cit121\/1","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1177\/0091270011407068","volume":"52","author":"Hu","year":"2012","journal-title":"J. Clin. Pharmacol."},{"issue":"7","key":"D6CB00041J\/cit122\/1","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/S1474-4422(14)70068-7","volume":"13","author":"Calabresi","year":"2014","journal-title":"Lancet Neurol."},{"issue":"4","key":"D6CB00041J\/cit123\/1","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s40259-015-0133-6","volume":"29","author":"Strohl","year":"2015","journal-title":"BioDrugs"},{"issue":"9","key":"D6CB00041J\/cit124\/1","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/nri2155","volume":"7","author":"Roopenian","year":"2007","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"D6CB00041J\/cit125\/1","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s00281-009-0160-9","volume":"31","author":"Baker","year":"2009","journal-title":"Semin. Immunopathol."},{"key":"D6CB00041J\/cit126\/1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/978-981-10-2116-9_4","volume-title":"Albumin in Medicine: Pathological and Clinical Applications","author":"Maruyama","year":"2016","unstructured":"T.Maruyama ,  V. T. G.Chuang  and  M.Otagiri ,  Albumin Fusion Protein , in  Albumin in Medicine: Pathological and Clinical Applications , ed.  M. Otagiri  and  V. T. G. Chuang ,  Springer ,  Singapore ,  2016 ,  pp. 71\u201389"},{"issue":"4","key":"D6CB00041J\/cit127\/1","doi-asserted-by":"crossref","first-page":"19360","DOI":"10.4238\/2015.December.29.46","volume":"14","author":"Yang","year":"2015","journal-title":"GMR, Genet. Mol. Res."},{"issue":"14","key":"D6CB00041J\/cit128\/1","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.2174\/1381612821666150302120047","volume":"21","author":"Rogers","year":"2015","journal-title":"Curr. Pharm. Des."},{"key":"D6CB00041J\/cit129\/1","unstructured":"European Medicines Agency, Eperzan: EPAR  \u2013  Product Information, 2014,  https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/eperzan-epar-product-information_en.pdf  (accessed July 04, 2024)"},{"issue":"9","key":"D6CB00041J\/cit130\/1","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1358\/dof.2010.35.9.1516042","volume":"35","author":"Rosenstock","year":"2010","journal-title":"Drugs Future"},{"issue":"6","key":"D6CB00041J\/cit131\/1","doi-asserted-by":"publisher","first-page":"2278","DOI":"10.1021\/acs.molpharmaceut.9b00308","volume":"16","author":"Alavi","year":"2019","journal-title":"Mol. Pharma."},{"issue":"12","key":"D6CB00041J\/cit132\/1","doi-asserted-by":"publisher","first-page":"4810","DOI":"10.1210\/jc.2008-1518","volume":"93","author":"Matthews","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"10","key":"D6CB00041J\/cit133\/1","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.2337\/dc09-0366","volume":"32","author":"Rosenstock","year":"2009","journal-title":"Diabetes Care"},{"issue":"5","key":"D6CB00041J\/cit134\/1","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1111\/j.1463-1326.2008.00992.x","volume":"11","author":"Bush","year":"2009","journal-title":"Diabetes, Obe. Metab."},{"key":"D6CB00041J\/cit135\/1","unstructured":"European Medicines Agency, Public statement on Eperzan: Withdrawal of the marketing authorisation in the European Union, 2019,  https:\/\/www.ema.europa.eu\/en\/documents\/assessment-report\/public-statement-eperzan-withdrawal-marketing-authorisation-european-union_en.pdf  (accessed July 04, 2024)"},{"issue":"10","key":"D6CB00041J\/cit136\/1","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1002\/emmm.201201379","volume":"4","author":"Czajkowsky","year":"2012","journal-title":"EMBO Mol. Med."},{"issue":"16","key":"D6CB00041J\/cit137\/1","doi-asserted-by":"publisher","first-page":"3716","DOI":"10.1182\/blood-2008-09-179754","volume":"113","author":"Bruhns","year":"2009","journal-title":"Blood"},{"issue":"12","key":"D6CB00041J\/cit138\/1","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.2174\/0929867324666170113112759","volume":"24","author":"Jafari","year":"2017","journal-title":"Curr. Med. Chem."},{"issue":"4","key":"D6CB00041J\/cit139\/1","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1002\/dmrr.1080","volume":"26","author":"Glaesner","year":"2010","journal-title":"Diabetes\/Metab. Res. Rev."},{"key":"D6CB00041J\/cit140\/1","unstructured":"European Medicines Agency, Trulicity: EPAR  \u2013  Product information, 2014,  https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/trulicity-epar-product-information_en.pdf  (accessed July 04, 2024)"},{"issue":"4","key":"D6CB00041J\/cit141\/1","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/S2213-8587(18)30024-X","volume":"6","author":"Pratley","year":"2018","journal-title":"Lancet Diabetes Endocrinol."},{"key":"D6CB00041J\/cit142\/1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jconrel.2016.02.019","volume":"227","author":"Koudelka","year":"2016","journal-title":"J. Controlled Release"},{"issue":"2","key":"D6CB00041J\/cit143\/1","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1080\/17425247.2018.1384464","volume":"15","author":"Liu","year":"2018","journal-title":"Expert Opin. Drug Delivery"},{"issue":"6","key":"D6CB00041J\/cit144\/1","doi-asserted-by":"publisher","first-page":"2100047","DOI":"10.1002\/adtp.202100047","volume":"4","author":"Refaat","year":"2021","journal-title":"Adv. Ther."},{"issue":"5","key":"D6CB00041J\/cit145\/1","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s00592-017-1086-7","volume":"55","author":"Moonschi","year":"2018","journal-title":"Acta Diabetol."},{"issue":"8","key":"D6CB00041J\/cit146\/1","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1080\/1061186X.2021.1894434","volume":"29","author":"Poudwal","year":"2021","journal-title":"J. Drug Targeting"},{"issue":"1","key":"D6CB00041J\/cit147\/1","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.ijpharm.2018.07.041","volume":"549","author":"Wong","year":"2018","journal-title":"Int. J. Pharm."},{"issue":"11","key":"D6CB00041J\/cit148\/1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3390\/pharmaceutics11110597","volume":"11","author":"Espona-Noguera","year":"2019","journal-title":"Pharmaceutics"},{"issue":"10","key":"D6CB00041J\/cit149\/1","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.3390\/pharmaceutics13101533","volume":"13","author":"Ramos","year":"2021","journal-title":"Pharmaceutics"},{"issue":"5","key":"D6CB00041J\/cit150\/1","doi-asserted-by":"publisher","first-page":"5785","DOI":"10.1021\/acsnano.9b01383","volume":"13","author":"Poon","year":"2019","journal-title":"ACS Nano"},{"issue":"9","key":"D6CB00041J\/cit151\/1","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/nbt.3330","volume":"33","author":"Blanco","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"D6CB00041J\/cit152\/1","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.jconrel.2016.01.020","volume":"240","author":"Zhang","year":"2016","journal-title":"J. Controlled Release"},{"issue":"4","key":"D6CB00041J\/cit153\/1","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1080\/08982100600993003","volume":"16","author":"Ntimenou","year":"2006","journal-title":"J. Liposome Res."},{"issue":"2","key":"D6CB00041J\/cit154\/1","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0005-2736(92)90194-Q","volume":"1105","author":"Woodle","year":"1992","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"issue":"03","key":"D6CB00041J\/cit155\/1","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1055\/s-0038-1653802","volume":"73","author":"Heeremans","year":"1995","journal-title":"Thromb. Haemostasis"},{"issue":"8","key":"D6CB00041J\/cit156\/1","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1097\/01.Wcb.0000072570.46552.Df","volume":"23","author":"Asahi","year":"2003","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"1","key":"D6CB00041J\/cit157\/1","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.ijpharm.2011.05.061","volume":"415","author":"Park","year":"2011","journal-title":"Int. J. Pharm."},{"issue":"8","key":"D6CB00041J\/cit158\/1","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.1016\/j.xphs.2018.04.011","volume":"107","author":"Shalaby","year":"2018","journal-title":"J. Pharm. Sci."},{"issue":"2","key":"D6CB00041J\/cit159\/1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3390\/nano10020190","volume":"10","author":"Inglut","year":"2020","journal-title":"Nanomaterials"},{"issue":"2","key":"D6CB00041J\/cit160\/1","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.jconrel.2008.11.014","volume":"134","author":"Kamei","year":"2009","journal-title":"J. Controlled Release"},{"issue":"2","key":"D6CB00041J\/cit161\/1","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.ijpharm.2013.08.038","volume":"456","author":"Kondiah","year":"2013","journal-title":"Int. J. Pharm."},{"key":"D6CB00041J\/cit162\/1","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.jconrel.2020.11.019","volume":"331","author":"Gonz\u00e1lez","year":"2021","journal-title":"J. Controlled Release"},{"key":"D6CB00041J\/cit163\/1","unstructured":"European Medicines Agency, Bydureon: EPAR  \u2013  Product Information, 2011,  https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/bydureon-epar-product-information_en.pdf  (accessed July 06, 2024)"},{"key":"D6CB00041J\/cit164\/1","doi-asserted-by":"publisher","first-page":"963","DOI":"10.2147\/DDDT.S46970","volume":"7","author":"Cai","year":"2013","journal-title":"Drug Des., Dev. Ther."},{"issue":"11","key":"D6CB00041J\/cit165\/1","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.1007\/s11095-009-9966-3","volume":"26","author":"Kwak","year":"2009","journal-title":"Pharm. Res."},{"issue":"1","key":"D6CB00041J\/cit166\/1","doi-asserted-by":"publisher","first-page":"2405954","DOI":"10.1155\/2016\/2405954","volume":"2016","author":"Khan","year":"2016","journal-title":"Int. J. Genomics"},{"issue":"10","key":"D6CB00041J\/cit167\/1","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1016\/j.addr.2012.09.039","volume":"65","author":"Chen","year":"2013","journal-title":"Adv. Drug Delivery Rev."},{"issue":"2","key":"D6CB00041J\/cit168\/1","first-page":"99","volume":"25","author":"Srivastava","year":"2021","journal-title":"J. Res. Pharm."},{"issue":"1","key":"D6CB00041J\/cit169\/1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1208\/s12248-023-00873-8","volume":"26","author":"Marsh","year":"2023","journal-title":"AAPS J."},{"issue":"1","key":"D6CB00041J\/cit170\/1","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1021\/acsabm.8b00644","volume":"2","author":"Li","year":"2019","journal-title":"ACS Appl. Bio Mater."},{"issue":"6774","key":"D6CB00041J\/cit171\/1","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1126\/science.adx1708","volume":"390","author":"Landers","year":"2025","journal-title":"Science"},{"key":"D6CB00041J\/cit172\/1","doi-asserted-by":"publisher","first-page":"114462","DOI":"10.1016\/j.ejpb.2024.114462","volume":"203","author":"Hamm","year":"2024","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"D6CB00041J\/cit173\/1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jconrel.2018.04.009","volume":"279","author":"Braun","year":"2018","journal-title":"J. Controlled Release"},{"issue":"1","key":"D6CB00041J\/cit174\/1","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1111\/j.1749-6632.2001.tb03516.x","volume":"936","author":"Lorand","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"24","key":"D6CB00041J\/cit175\/1","doi-asserted-by":"publisher","first-page":"e202500569","DOI":"10.1002\/cbic.202500569","volume":"26","author":"Mergenthaler","year":"2025","journal-title":"ChemBioChem"},{"key":"D6CB00041J\/cit176\/1","unstructured":"European Medicines Agency, Metalyse: EPAR  \u2013  Product Information, 2009,  https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/metalyse-epar-product-information_en.pdf  (accessed July 08, 2024)"},{"key":"D6CB00041J\/cit177\/1","unstructured":"European Medicines Agency, Victoza: EPAR  \u2013  Product Information, 2009,  https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/victoza-epar-product-information_en.pdf  (accessed July 08, 2024)"},{"key":"D6CB00041J\/cit178\/1","unstructured":"European Medicines Agency, Saxenda: EPAR  \u2013  Product Information, 2015,  https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/saxenda-epar-product-information_en.pdf  (accessed July 08, 2024)"},{"key":"D6CB00041J\/cit179\/1","unstructured":"European Medicines Agency, Rybelsus: EPAR  \u2013  Product information, 2020,  https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/rybelsus-epar-product-information_en.pdf  (accessed July 08, 2024)"},{"key":"D6CB00041J\/cit180\/1","unstructured":"European Medicines Agency, Wegovy: EPAR  \u2013  Product Information, 2022,  https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/wegovy-epar-product-information_en.pdf  (accessed July 08, 2024)"},{"key":"D6CB00041J\/cit181\/1","unstructured":"European Medicines Agency, Byetta: EPAR  \u2013  Product Information, 2009,  https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/byetta-epar-product-information_en.pdf  (accessed July 06, 2024)"},{"key":"D6CB00041J\/cit182\/1","unstructured":"European Medicines Agency, Insuman: EPAR  \u2013  Product Information, 2009,  https:\/\/www.ema.europa.eu\/en\/documents\/overview\/insuman-epar-summary-public_en.pdf  (accessed July 08, 2024)"},{"key":"D6CB00041J\/cit183\/1","unstructured":"European Medicines Agency, Lantus: EPAR  \u2013  Product Information, 2009,  https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/lantus-epar-product-information_en.pdf  (accessed July 08, 2024)"},{"key":"D6CB00041J\/cit184\/1","unstructured":"European Medicines Agency, Tresiba: EPAR  \u2013  Product Information, 2013,  https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/tresiba-epar-product-information_en.pdf  (accessed July 08, 2024)"},{"key":"D6CB00041J\/cit185\/1","unstructured":"European Medicines Agency, Plegridy: EPAR  \u2013  Product Information, 2014,  https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/plegridy-epar-product-information_en.pdf  (accessed July 08, 2024)"}],"container-title":["RSC Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/CB\/D6CB00041J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:21:42Z","timestamp":1782966102000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/cb\/article\/7\/6\/945-963\/1229811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":185,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,11]]}},"URL":"https:\/\/doi.org\/10.1039\/d6cb00041j","relation":{},"ISSN":["2633-0679"],"issn-type":[{"value":"2633-0679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}