{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:51:43Z","timestamp":1791449503031,"version":"4.3.3"},"reference-count":52,"publisher":"Royal Society of Chemistry (RSC)","issue":"10","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":174,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Chem. Biol."],"abstract":"<jats:p>Sydnone-modified nucleosides enable intracellular bioconjugation while fully preserving antisense oligonucleotide target engagement.<\/jats:p>","DOI":"10.1039\/d6cb00100a","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:03:05Z","timestamp":1782291785000},"page":"2059-2068","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sydnone-modified nucleosides as versatile tools for bioorthogonal post-synthetic functionalization of antisense oligonucleotides"],"prefix":"10.1039","volume":"7","author":[{"given":"Alexandra","family":"Bristiel","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, CNRS, Institut de Chimie Mol\u00e9culaire et des Mat\u00e9riaux d'Orsay (ICMMO), UMR 8182, 91400, Orsay, France"},{"name":"Unit\u00e9 Drug Design Small Molecules, Institut de Recherche et D\u00e9veloppement Servier Paris-Saclay, 22 route 128, 91190 Gif-sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Khuu","sequence":"additional","affiliation":[{"name":"Neurology Therapeutic Area, Institut de Recherche et D\u00e9veloppement Servier Paris-Saclay, 22 route 128, 91190 Gif-sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4435-2323","authenticated-orcid":false,"given":"Mathilde","family":"Poulet","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Drug Design Small Molecules, Institut de Recherche et D\u00e9veloppement Servier Paris-Saclay, 22 route 128, 91190 Gif-sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5461-329X","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Taran","sequence":"additional","affiliation":[{"name":"CEA, INRAE, D\u00e9partement M\u00e9dicaments et Technologies pour la Sant\u00e9 (DMTS), SCBM, Universit\u00e9 Paris-Saclay, 91191 Gif-sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7943-5386","authenticated-orcid":false,"given":"Dominique","family":"Urban","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, CNRS, Institut de Chimie Mol\u00e9culaire et des Mat\u00e9riaux d'Orsay (ICMMO), UMR 8182, 91400, Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Guignard","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Drug Design Small Molecules, Institut de Recherche et D\u00e9veloppement Servier Paris-Saclay, 22 route 128, 91190 Gif-sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7722-370X","authenticated-orcid":false,"given":"Dominique","family":"Guianvarc\u2019h","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, CNRS, Institut de Chimie Mol\u00e9culaire et des Mat\u00e9riaux d'Orsay (ICMMO), UMR 8182, 91400, Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6CB00100A\/cit1\/1","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1039\/b911431a","volume":"39","author":"Singh","year":"2010","journal-title":"Chem. Soc. Rev."},{"key":"D6CB00100A\/cit2\/1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.cbpa.2019.07.007","volume":"52","author":"Ivancov\u00e1","year":"2019","journal-title":"Curr. Opin. Chem. Biol."},{"key":"D6CB00100A\/cit3\/1","doi-asserted-by":"crossref","first-page":"7122","DOI":"10.1021\/acs.chemrev.0c00928","volume":"121","author":"Fantoni","year":"2021","journal-title":"Chem. Rev."},{"key":"D6CB00100A\/cit4\/1","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1021\/acs.bioconjchem.0c00072","volume":"31","author":"Krell","year":"2020","journal-title":"Bioconjugate Chem."},{"key":"D6CB00100A\/cit5\/1","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1021\/ol0610946","volume":"8","author":"Gierlich","year":"2006","journal-title":"Org. Lett."},{"key":"D6CB00100A\/cit6\/1","doi-asserted-by":"crossref","first-page":"11271","DOI":"10.1021\/jo401780u","volume":"78","author":"Ingale","year":"2013","journal-title":"J. Org. Chem."},{"key":"D6CB00100A\/cit7\/1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/hlca.200790055","volume":"90","author":"Seela","year":"2007","journal-title":"Helv. Chim. Acta"},{"key":"D6CB00100A\/cit8\/1","doi-asserted-by":"crossref","first-page":"3962","DOI":"10.1021\/acs.orglett.8b01533","volume":"20","author":"Panattoni","year":"2018","journal-title":"Org. Lett."},{"key":"D6CB00100A\/cit9\/1","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1021\/bc8004864","volume":"20","author":"Berndl","year":"2009","journal-title":"Bioconjugate Chem."},{"key":"D6CB00100A\/cit10\/1","doi-asserted-by":"crossref","first-page":"11618","DOI":"10.1021\/ja3026714","volume":"134","author":"Krishna","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"D6CB00100A\/cit11\/1","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1039\/c0cc04546b","volume":"47","author":"Dai","year":"2011","journal-title":"Chem. Commun."},{"key":"D6CB00100A\/cit12\/1","doi-asserted-by":"crossref","first-page":"11184","DOI":"10.1039\/c2cc35084j","volume":"48","author":"Shelbourne","year":"2012","journal-title":"Chem. Commun."},{"key":"D6CB00100A\/cit13\/1","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1016\/j.bmc.2014.05.050","volume":"22","author":"Ren","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"D6CB00100A\/cit14\/1","first-page":"2724","author":"van\u2009Delft","year":"2011","journal-title":"Synthesis"},{"key":"D6CB00100A\/cit15\/1","doi-asserted-by":"crossref","first-page":"11218","DOI":"10.1039\/C4CC02855D","volume":"50","author":"Stubinitzky","year":"2014","journal-title":"Chem. Commun."},{"key":"D6CB00100A\/cit16\/1","first-page":"270","volume":"35","author":"Efimov","year":"2009","journal-title":"Bioorg. Khim."},{"key":"D6CB00100A\/cit17\/1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1021\/cb200510k","volume":"7","author":"Fauster","year":"2012","journal-title":"ACS Chem. Biol."},{"key":"D6CB00100A\/cit18\/1","doi-asserted-by":"crossref","first-page":"7845","DOI":"10.1039\/D2OB01560A","volume":"20","author":"Moreno","year":"2022","journal-title":"Org. Biomol. Chem."},{"key":"D6CB00100A\/cit19\/1","doi-asserted-by":"crossref","first-page":"6970","DOI":"10.1002\/anie.202015034","volume":"60","author":"Krasheninina","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6CB00100A\/cit20\/1","first-page":"2738","author":"Cser\u00e9p","year":"2015","journal-title":"Synthesis"},{"key":"D6CB00100A\/cit21\/1","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1039\/C5CC05392G","volume":"52","author":"Agustin","year":"2016","journal-title":"Chem. Commun."},{"key":"D6CB00100A\/cit22\/1","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1021\/ol9005322","volume":"11","author":"Gutsmiedl","year":"2009","journal-title":"Org. Lett."},{"key":"D6CB00100A\/cit23\/1","doi-asserted-by":"crossref","first-page":"8846","DOI":"10.1021\/ja102871p","volume":"132","author":"Schoch","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"D6CB00100A\/cit24\/1","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1021\/acs.bioconjchem.3c00284","volume":"34","author":"Bristiel","year":"2023","journal-title":"Bioconjugate Chem."},{"key":"D6CB00100A\/cit25\/1","doi-asserted-by":"crossref","first-page":"e202500529","DOI":"10.1002\/chem.202500529","volume":"31","author":"Xia","year":"2025","journal-title":"Chem. \u2013 Eur. J."},{"key":"D6CB00100A\/cit26\/1","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1021\/bc300181n","volume":"23","author":"Schoch","year":"2012","journal-title":"Bioconjugate Chem."},{"key":"D6CB00100A\/cit27\/1","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1093\/nar\/gkad067","volume":"51","author":"Egli","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"D6CB00100A\/cit28\/1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1073\/pnas.75.1.280","volume":"75","author":"Zamecnik","year":"1978","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D6CB00100A\/cit29\/1","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.1093\/nar\/17.9.3373","volume":"17","author":"Sproat","year":"1989","journal-title":"Nucleic Acids Res."},{"key":"D6CB00100A\/cit30\/1","doi-asserted-by":"crossref","first-page":"17181","DOI":"10.1074\/jbc.M311683200","volume":"279","author":"Wu","year":"2004","journal-title":"J. Biol. Chem."},{"key":"D6CB00100A\/cit31\/1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev-med-041217-010829","volume":"70","author":"Bennett","year":"2019","journal-title":"Annu. Rev. Med."},{"key":"D6CB00100A\/cit32\/1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41573-020-0075-7","volume":"19","author":"Roberts","year":"2020","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D6CB00100A\/cit33\/1","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1021\/acs.molpharmaceut.0c01238","volume":"18","author":"Mendon\u00e7a","year":"2021","journal-title":"Mol. Pharmaceutics"},{"key":"D6CB00100A\/cit34\/1","doi-asserted-by":"crossref","first-page":"632","DOI":"10.2119\/molmed.2015.00210","volume":"22","author":"Satake","year":"2016","journal-title":"Mol. Med."},{"key":"D6CB00100A\/cit35\/1","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1007\/s11307-022-01744-y","volume":"24","author":"Cook","year":"2022","journal-title":"Mol. Imaging Biol."},{"key":"D6CB00100A\/cit36\/1","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1021\/acs.bioconjchem.4c00068","volume":"35","author":"Lincy-Bianchi","year":"2024","journal-title":"Bioconjugate Chem."},{"key":"D6CB00100A\/cit37\/1","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1039\/C3SC53332H","volume":"5","author":"Wallace","year":"2014","journal-title":"Chem. Sci."},{"key":"D6CB00100A\/cit38\/1","doi-asserted-by":"crossref","first-page":"9376","DOI":"10.1039\/C4CC03816A","volume":"50","author":"Plougastel","year":"2014","journal-title":"Chem. Commun."},{"key":"D6CB00100A\/cit39\/1","doi-asserted-by":"crossref","first-page":"12073","DOI":"10.1002\/anie.201606495","volume":"55","author":"Liu","year":"2016","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6CB00100A\/cit40\/1","doi-asserted-by":"crossref","first-page":"16093","DOI":"10.1002\/chem.202103026","volume":"27","author":"Krell","year":"2021","journal-title":"Chem. \u2013 Eur. J."},{"key":"D6CB00100A\/cit41\/1","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1002\/cbic.201000623","volume":"11","author":"Richardson","year":"2010","journal-title":"ChemBioChem"},{"key":"D6CB00100A\/cit42\/1","doi-asserted-by":"crossref","first-page":"11184","DOI":"10.1039\/c2cc35084j","volume":"48","author":"Shelbourne","year":"2012","journal-title":"Chem. Commun."},{"key":"D6CB00100A\/cit43\/1","doi-asserted-by":"crossref","first-page":"9376","DOI":"10.1039\/C4CC03816A","volume":"50","author":"Plougastel","year":"2014","journal-title":"Chem. Commun."},{"key":"D6CB00100A\/cit44\/1","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1021\/acs.joc.7b03004","volume":"83","author":"Favre","year":"2018","journal-title":"J. Org. Chem."},{"key":"D6CB00100A\/cit45\/1","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1016\/S0040-4039(00)84506-2","volume":"27","author":"Marugg","year":"1986","journal-title":"Tetrahedron Lett."},{"key":"D6CB00100A\/cit46\/1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nbt.3779","volume":"35","author":"Crooke","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"D6CB00100A\/cit47\/1","doi-asserted-by":"crossref","first-page":"552035","DOI":"10.3389\/fbioe.2020.552035","volume":"8","author":"Cavaco","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"D6CB00100A\/cit48\/1","doi-asserted-by":"crossref","first-page":"12970","DOI":"10.1093\/nar\/gkab1198","volume":"49","author":"Liang","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"D6CB00100A\/cit49\/1","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/s42003-021-02772-0","volume":"4","author":"Kapustin","year":"2021","journal-title":"Commun. Biol."},{"key":"D6CB00100A\/cit50\/1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1089\/nat.2016.0641","volume":"27","author":"Gonz\u00e1lez-Barriga","year":"2017","journal-title":"Nucleic Acid Ther."},{"key":"D6CB00100A\/cit51\/1","first-page":"e323","volume":"5","author":"Scoles","year":"2019","journal-title":"Neurol.: Genet."},{"key":"D6CB00100A\/cit52\/1","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0026-895X(25)09229-6","volume":"41","author":"Bennett","year":"1992","journal-title":"Mol. Pharmacol."}],"container-title":["RSC Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/CB\/article-pdf\/doi\/10.1039\/D6CB00100A\/0\/D6CB00100A.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:13:03Z","timestamp":1791447183000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/CB\/article-lookup\/doi\/10.1039\/D6CB00100A"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":52,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,8]]}},"URL":"https:\/\/doi.org\/10.1039\/d6cb00100a","relation":{},"ISSN":["2633-0679"],"issn-type":[{"value":"2633-0679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}