{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:10:23Z","timestamp":1784218223293,"version":"3.55.0"},"reference-count":28,"publisher":"Royal Society of Chemistry (RSC)","issue":"55","license":[{"start":{"date-parts":[[2027,6,22]],"date-time":"2027-06-22T00:00:00Z","timestamp":1813622400000},"content-version":"am","delay-in-days":537,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22H05141"],"award-info":[{"award-number":["JP22H05141"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22K21348"],"award-info":[{"award-number":["JP22K21348"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP25H01220"],"award-info":[{"award-number":["JP25H01220"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JPJSBP120239201"],"award-info":[{"award-number":["JPJSBP120239201"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JPJSBP120252301"],"award-info":[{"award-number":["JPJSBP120252301"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001863","name":"New Energy and Industrial Technology Development Organization","doi-asserted-by":"publisher","award":["21W2K022"],"award-info":[{"award-number":["21W2K022"]}],"id":[{"id":"10.13039\/501100001863","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001863","name":"New Energy and Industrial Technology Development Organization","doi-asserted-by":"publisher","award":["23201347-0"],"award-info":[{"award-number":["23201347-0"]}],"id":[{"id":"10.13039\/501100001863","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001863","name":"New Energy and Industrial Technology Development Organization","doi-asserted-by":"publisher","award":["23201377-0"],"award-info":[{"award-number":["23201377-0"]}],"id":[{"id":"10.13039\/501100001863","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020953","name":"Co-creation place formation support program","doi-asserted-by":"publisher","award":["JPMJPF2009"],"award-info":[{"award-number":["JPMJPF2009"]}],"id":[{"id":"10.13039\/501100020953","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Commun."],"abstract":"<jats:p>Localized stiffness programming enables tunable spatial control of vascular density in 3D hydrogels.<\/jats:p>","DOI":"10.1039\/d6cc02922a","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T06:05:14Z","timestamp":1782108314000},"page":"13777-13780","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Localized stiffness programming enables tunable spatial control of vascular density in 3D hydrogels"],"prefix":"10.1039","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9922-9199","authenticated-orcid":false,"given":"He","family":"Li","sequence":"first","affiliation":[{"name":"Department of Applied Chemistry, Graduate School of Engineering, the University of Osaka, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2453-2314","authenticated-orcid":false,"given":"Fiona","family":"Louis","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, Graduate School of Engineering, the University of Osaka, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan"},{"name":"Joint Research Laboratory (TOPPAN) for Advanced Cell Regulatory Chemistry, Graduate School of Engineering, the University of Osaka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3972-9272","authenticated-orcid":false,"given":"Oju","family":"Jeon","sequence":"additional","affiliation":[{"name":"Departments of Biomedical Engineering University of Illinois Chicago, Chicago, Illinois 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3487-4625","authenticated-orcid":false,"given":"Eben","family":"Alsberg","sequence":"additional","affiliation":[{"name":"Departments of Biomedical Engineering University of Illinois Chicago, Chicago, Illinois 60612, USA"},{"name":"Mechanical & Industrial Engineering University of Illinois Chicago, Chicago, Illinois 60612, USA"},{"name":"Pharmacology & Regenerative Medicine and University of Illinois Chicago, Chicago, Illinois 60612, USA"},{"name":"Orthopaedic Surgery, University of Illinois Chicago, Chicago, Illinois 60612, USA"},{"name":"Jesse Brown Veterans Affairs Medical Center (JBVMC), Chicago, Illinois 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4294-9313","authenticated-orcid":false,"given":"Michiya","family":"Matsusaki","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, Graduate School of Engineering, the University of Osaka, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan"},{"name":"Joint Research Laboratory (TOPPAN) for Advanced Cell Regulatory Chemistry, Graduate School of Engineering, the University of Osaka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6CC02922A\/cit1\/1","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1039\/c3ib40038g","volume":"5","author":"Klumpers","year":"2013","journal-title":"Integr. Biol."},{"key":"D6CC02922A\/cit2\/1","doi-asserted-by":"crossref","first-page":"122716","DOI":"10.1016\/j.biomaterials.2024.122716","volume":"312","author":"Bian","year":"2025","journal-title":"Biomaterials"},{"key":"D6CC02922A\/cit3\/1","doi-asserted-by":"crossref","first-page":"42201","DOI":"10.1038\/srep42201","volume":"7","author":"Campbell","year":"2017","journal-title":"Sci. Rep."},{"key":"D6CC02922A\/cit4\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.11.001","volume":"63","author":"Selvam","year":"2018","journal-title":"Prog. Retinal Eye Res."},{"key":"D6CC02922A\/cit5\/1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40580-024-00416-7","volume":"11","author":"Li","year":"2024","journal-title":"Nano Convergence"},{"key":"D6CC02922A\/cit6\/1","doi-asserted-by":"crossref","first-page":"100551","DOI":"10.1016\/j.mtbio.2023.100551","volume":"19","author":"Rana","year":"2023","journal-title":"Mater. Today Bio."},{"key":"D6CC02922A\/cit7\/1","doi-asserted-by":"crossref","first-page":"034104","DOI":"10.1088\/1758-5090\/ac6282","volume":"14","author":"Terpstra","year":"2022","journal-title":"Biofabrication"},{"key":"D6CC02922A\/cit8\/1","doi-asserted-by":"crossref","first-page":"101539","DOI":"10.1016\/j.tice.2021.101539","volume":"72","author":"Azarpira","year":"2021","journal-title":"Tissue Cell"},{"key":"D6CC02922A\/cit9\/1","doi-asserted-by":"crossref","first-page":"a041234","DOI":"10.1101\/cshperspect.a041234","volume":"14","author":"Legrand","year":"2022","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"D6CC02922A\/cit10\/1","doi-asserted-by":"crossref","first-page":"156908","DOI":"10.1016\/j.cyto.2025.156908","volume":"189","author":"Shi","year":"2025","journal-title":"Cytokine"},{"key":"D6CC02922A\/cit11\/1","doi-asserted-by":"crossref","first-page":"151997","DOI":"10.1016\/j.anndiagpath.2022.151997","volume":"60","author":"Bonsang","year":"2022","journal-title":"Ann. Diagn. Pathol."},{"key":"D6CC02922A\/cit12\/1","doi-asserted-by":"crossref","first-page":"101969","DOI":"10.1016\/j.tice.2022.101969","volume":"80","author":"Mogha","year":"2023","journal-title":"Tissue Cell"},{"key":"D6CC02922A\/cit13\/1","first-page":"S1369702125003578","author":"Zhang","year":"2025","journal-title":"Mater. Today"},{"key":"D6CC02922A\/cit14\/1","doi-asserted-by":"crossref","first-page":"6865","DOI":"10.1039\/D5BM00981B","volume":"13","author":"Li","year":"2025","journal-title":"Biomater. Sci."},{"key":"D6CC02922A\/cit15\/1","doi-asserted-by":"crossref","first-page":"124136","DOI":"10.1016\/j.biomaterials.2026.124136","volume":"331","author":"Zhang","year":"2026","journal-title":"Biomaterials"},{"key":"D6CC02922A\/cit16\/1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.actbio.2024.05.018","volume":"182","author":"Zhao","year":"2024","journal-title":"Acta Biomater."},{"key":"D6CC02922A\/cit17\/1","doi-asserted-by":"crossref","first-page":"5647","DOI":"10.1073\/pnas.1618239114","volume":"114","author":"Hadden","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D6CC02922A\/cit18\/1","doi-asserted-by":"crossref","first-page":"111661","DOI":"10.1016\/j.matdes.2023.111661","volume":"226","author":"Nazir","year":"2023","journal-title":"Mater. Des."},{"key":"D6CC02922A\/cit19\/1","doi-asserted-by":"crossref","first-page":"15997","DOI":"10.3390\/ijms160715997","volume":"16","author":"Liu","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"D6CC02922A\/cit20\/1","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1038\/s41467-023-38838-2","volume":"14","author":"He","year":"2023","journal-title":"Nat. Commun."},{"key":"D6CC02922A\/cit21\/1","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1364\/BOE.7.000894","volume":"7","author":"Wang","year":"2016","journal-title":"Biomed. Opt. Express, BOE"},{"key":"D6CC02922A\/cit22\/1","doi-asserted-by":"crossref","first-page":"25247","DOI":"10.3402\/arb.v1.25247","volume":"1","author":"LaValley","year":"2014","journal-title":"Adv. Regener. Biol."},{"key":"D6CC02922A\/cit23\/1","doi-asserted-by":"crossref","first-page":"6780","DOI":"10.1038\/s41598-018-24671-x","volume":"8","author":"Megone","year":"2018","journal-title":"Sci. Rep."},{"key":"D6CC02922A\/cit24\/1","doi-asserted-by":"crossref","first-page":"22668","DOI":"10.1038\/s41598-021-01036-5","volume":"11","author":"Gandin","year":"2021","journal-title":"Sci. Rep."},{"key":"D6CC02922A\/cit25\/1","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1021\/acsabm.9b00445","volume":"2","author":"Lu","year":"2019","journal-title":"ACS Appl. Bio Mater."},{"key":"D6CC02922A\/cit26\/1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1021\/acsbiomaterials.5b00064","volume":"1","author":"Schweller","year":"2015","journal-title":"ACS Biomater. Sci. Eng."},{"key":"D6CC02922A\/cit27\/1","doi-asserted-by":"crossref","first-page":"eaaw6171","DOI":"10.1126\/sciadv.aaw6171","volume":"5","author":"Nam","year":"2019","journal-title":"Sci. Adv."},{"issue":"45","key":"D6CC02922A\/cit28\/1","doi-asserted-by":"crossref","first-page":"eadr3997","DOI":"10.1126\/sciadv.adr3997","volume":"10","author":"Bakhshandeh","year":"2024","journal-title":"Sci. Adv."}],"container-title":["Chemical Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/CC\/article-pdf\/doi\/10.1039\/D6CC02922A\/0\/D6CC02922A.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T15:50:31Z","timestamp":1784217031000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/CC\/article-lookup\/doi\/10.1039\/D6CC02922A"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":28,"journal-issue":{"issue":"55","published-print":{"date-parts":[[2026,7,16]]}},"URL":"https:\/\/doi.org\/10.1039\/d6cc02922a","relation":{},"ISSN":["1359-7345","1364-548X"],"issn-type":[{"value":"1359-7345","type":"print"},{"value":"1364-548X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}