{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:44:58Z","timestamp":1790433898973,"version":"4.1.0"},"reference-count":64,"publisher":"Royal Society of Chemistry (RSC)","issue":"63","license":[{"start":{"date-parts":[[2027,7,23]],"date-time":"2027-07-23T00:00:00Z","timestamp":1816300800000},"content-version":"am","delay-in-days":568,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22274005"],"award-info":[{"award-number":["22274005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22574006"],"award-info":[{"award-number":["22574006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Commun."],"abstract":"<jats:p>\n                    This review outlines design principles for\n                    <jats:italic>in situ<\/jats:italic>\n                    self-assembling PROTACs, emphasizing recent nanodelivery platforms that boost solubility, bioavailability, and degradation efficacy while reducing off-target effects and the hook effect.\n                  <\/jats:p>","DOI":"10.1039\/d6cc03311c","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:42:57Z","timestamp":1784774577000},"page":"15686-15694","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>In situ<\/i>\n                    self-assembly of PROTACs for precision cancer therapy"],"prefix":"10.1039","volume":"62","author":[{"given":"Pan","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Chemistry, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongning","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7463-4466","authenticated-orcid":false,"given":"Dongdong","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6CC03311C\/cit1\/1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41392-024-01808-1","volume":"9","author":"Xia","year":"2024","journal-title":"Signal Transduction Targeted Ther."},{"key":"D6CC03311C\/cit2\/1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41392-024-01856-7","volume":"9","author":"Liu","year":"2024","journal-title":"Signal Transduction Targeted Ther."},{"key":"D6CC03311C\/cit3\/1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s12672-025-02198-8","volume":"16","author":"Zafar","year":"2025","journal-title":"Discover Oncol."},{"key":"D6CC03311C\/cit4\/1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nrc2966","volume":"11","author":"Pecot","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"D6CC03311C\/cit5\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2017.01.008","volume":"119","author":"Ofek","year":"2017","journal-title":"Adv. Drug Delivery Rev."},{"key":"D6CC03311C\/cit6\/1","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1002\/anie.201710398","volume":"57","author":"Lategahn","year":"2018","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6CC03311C\/cit7\/1","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1016\/j.apsb.2021.12.022","volume":"12","author":"Pan","year":"2022","journal-title":"Acta Pharm. Sin. B."},{"key":"D6CC03311C\/cit8\/1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41568-024-00690-x","volume":"24","author":"Paul","year":"2024","journal-title":"Nat. Rev. Cancer"},{"key":"D6CC03311C\/cit9\/1","doi-asserted-by":"crossref","first-page":"115608","DOI":"10.1016\/j.addr.2025.115608","volume":"222","author":"Khosravifarsani","year":"2025","journal-title":"Adv. Drug Delivery Rev."},{"key":"D6CC03311C\/cit10\/1","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1038\/s12276-022-00864-3","volume":"54","author":"Min","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"D6CC03311C\/cit11\/1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41392-021-00572-w","volume":"6","author":"Zhong","year":"2021","journal-title":"Signal Transduction Targeted Ther."},{"key":"D6CC03311C\/cit12\/1","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/s41573-021-00195-4","volume":"20","author":"Cohen","year":"2021","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D6CC03311C\/cit13\/1","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/s41573-021-00252-y","volume":"20","author":"Attwood","year":"2021","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D6CC03311C\/cit14\/1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nrd.2018.21","volume":"17","author":"Ferguson","year":"2018","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D6CC03311C\/cit15\/1","doi-asserted-by":"crossref","first-page":"115775","DOI":"10.1016\/j.addr.2026.115775","volume":"230","author":"Fu","year":"2026","journal-title":"Adv. Drug Delivery Rev."},{"key":"D6CC03311C\/cit16\/1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41392-019-0101-6","volume":"4","author":"Sun","year":"2019","journal-title":"Signal Transduction Targeted Ther."},{"key":"D6CC03311C\/cit17\/1","doi-asserted-by":"crossref","first-page":"103387","DOI":"10.1016\/j.drudis.2022.103387","volume":"28","author":"Saraswat","year":"2023","journal-title":"Drug Discover Today."},{"key":"D6CC03311C\/cit18\/1","doi-asserted-by":"crossref","first-page":"5214","DOI":"10.1039\/D2CS00193D","volume":"51","author":"Li","year":"2022","journal-title":"Chem. Soc. Rev."},{"key":"D6CC03311C\/cit19\/1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1021\/acsnano.4c11903","volume":"19","author":"Lv","year":"2025","journal-title":"ACS Nano"},{"key":"D6CC03311C\/cit20\/1","doi-asserted-by":"crossref","first-page":"28502","DOI":"10.1021\/acsnano.4c09800","volume":"18","author":"Wu","year":"2024","journal-title":"ACS Nano"},{"key":"D6CC03311C\/cit21\/1","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1126\/science.aam7340","volume":"355","author":"Salami","year":"2017","journal-title":"Science"},{"key":"D6CC03311C\/cit22\/1","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41589-020-0596-8","volume":"16","author":"Pisa","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"D6CC03311C\/cit23\/1","doi-asserted-by":"crossref","first-page":"5330","DOI":"10.1039\/D1CS00762A","volume":"51","author":"Chen","year":"2022","journal-title":"Chem. Soc. Rev."},{"key":"D6CC03311C\/cit24\/1","doi-asserted-by":"crossref","first-page":"6092","DOI":"10.1021\/ja311795d","volume":"135","author":"Douglass","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"D6CC03311C\/cit25\/1","doi-asserted-by":"crossref","first-page":"e202308049","DOI":"10.1002\/ange.202308049","volume":"135","author":"Zhang","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6CC03311C\/cit26\/1","doi-asserted-by":"crossref","first-page":"123621","DOI":"10.1016\/j.biomaterials.2025.123621","volume":"325","author":"Liu","year":"2026","journal-title":"Biomaterials"},{"key":"D6CC03311C\/cit27\/1","doi-asserted-by":"crossref","first-page":"4895","DOI":"10.1039\/C7CS00184C","volume":"46","author":"Oliveira","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"D6CC03311C\/cit28\/1","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1039\/D1CS00451D","volume":"51","author":"Wu","year":"2022","journal-title":"Chem. Soc. Rev."},{"key":"D6CC03311C\/cit29\/1","doi-asserted-by":"crossref","first-page":"7737","DOI":"10.1039\/D2CS00889K","volume":"52","author":"Fu","year":"2023","journal-title":"Chem. Soc. Rev."},{"key":"D6CC03311C\/cit30\/1","doi-asserted-by":"crossref","first-page":"14155","DOI":"10.1021\/jacs.3c05159","volume":"145","author":"Chang","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"D6CC03311C\/cit31\/1","doi-asserted-by":"crossref","first-page":"7218","DOI":"10.1021\/jacs.2c12809","volume":"145","author":"Jin","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"D6CC03311C\/cit32\/1","doi-asserted-by":"crossref","first-page":"7579","DOI":"10.1039\/D2CS00998F","volume":"52","author":"Fu","year":"2023","journal-title":"Chem. Soc. Rev."},{"key":"D6CC03311C\/cit33\/1","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.2147\/IJN.S448684","volume":"19","author":"Song","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"D6CC03311C\/cit34\/1","doi-asserted-by":"crossref","first-page":"6608","DOI":"10.1038\/s41467-024-50735-w","volume":"15","author":"Gao","year":"2024","journal-title":"Nat. Commun."},{"key":"D6CC03311C\/cit35\/1","doi-asserted-by":"crossref","first-page":"114673","DOI":"10.1016\/j.jconrel.2026.114673","volume":"392","author":"Zhang","year":"2026","journal-title":"J. Controlled Release."},{"key":"D6CC03311C\/cit36\/1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1021\/jacs.5c11564","volume":"148","author":"Sun","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"D6CC03311C\/cit37\/1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1021\/acs.jmedchem.6b01781","volume":"61","author":"Wurz","year":"2018","journal-title":"J. Med. Chem."},{"key":"D6CC03311C\/cit38\/1","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1021\/acscentsci.6b00280","volume":"2","author":"Lebraud","year":"2016","journal-title":"ACS Cent. Sci."},{"key":"D6CC03311C\/cit39\/1","doi-asserted-by":"crossref","first-page":"5635","DOI":"10.1021\/jacsau.5c01131","volume":"5","author":"Zhu","year":"2025","journal-title":"JACS Au"},{"key":"D6CC03311C\/cit40\/1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jconrel.2023.07.062","volume":"361","author":"Huang","year":"2023","journal-title":"J. Controlled Release."},{"key":"D6CC03311C\/cit41\/1","doi-asserted-by":"crossref","first-page":"122038","DOI":"10.1016\/j.biomaterials.2023.122038","volume":"295","author":"Cho","year":"2023","journal-title":"Biomaterials"},{"key":"D6CC03311C\/cit42\/1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12943-025-02270-5","volume":"24","author":"Maksymova","year":"2025","journal-title":"Mol. Cancer"},{"key":"D6CC03311C\/cit43\/1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.abst.2026.01.006","volume":"8","author":"Rajendran","year":"2026","journal-title":"Adv. Biomarker Sci. Technol."},{"key":"D6CC03311C\/cit44\/1","doi-asserted-by":"crossref","first-page":"e202503776","DOI":"10.1002\/ange.202503776","volume":"137","author":"Shi","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6CC03311C\/cit45\/1","doi-asserted-by":"crossref","first-page":"eabq2216","DOI":"10.1126\/sciadv.abq2216","volume":"8","author":"Do","year":"2022","journal-title":"Sci. Adv."},{"key":"D6CC03311C\/cit46\/1","doi-asserted-by":"crossref","first-page":"e202423057","DOI":"10.1002\/anie.202423057","volume":"64","author":"Sun","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6CC03311C\/cit47\/1","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1016\/j.molcel.2021.08.018","volume":"81","author":"Lennicke","year":"2021","journal-title":"Mol. Cell"},{"key":"D6CC03311C\/cit48\/1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41568-021-00435-0","volume":"22","author":"Cheung","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"D6CC03311C\/cit49\/1","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1126\/science.adf3208","volume":"382","author":"Snieckute","year":"2023","journal-title":"Science"},{"key":"D6CC03311C\/cit50\/1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41583-019-0132-6","volume":"20","author":"Butterfield","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"key":"D6CC03311C\/cit51\/1","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1038\/s41467-026-68771-z","volume":"17","author":"Ming","year":"2026","journal-title":"Nat. Commun."},{"key":"D6CC03311C\/cit52\/1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41573-021-00371-6","volume":"21","author":"B\u00e9k\u00e9s","year":"2022","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D6CC03311C\/cit53\/1","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.1039\/D3NR06059D","volume":"16","author":"Zhong","year":"2024","journal-title":"Nanoscale"},{"key":"D6CC03311C\/cit54\/1","first-page":"e2021114957","volume":"61","author":"Zhang","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6CC03311C\/cit55\/1","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1038\/s41467-021-23194-w","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."},{"key":"D6CC03311C\/cit56\/1","doi-asserted-by":"crossref","first-page":"e202421713","DOI":"10.1002\/anie.202421713","volume":"64","author":"Xie","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6CC03311C\/cit57\/1","doi-asserted-by":"crossref","first-page":"39987","DOI":"10.1021\/jacs.5c15945","volume":"147","author":"Ouyang","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"D6CC03311C\/cit58\/1","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1021\/acs.chemrev.3c00705","volume":"124","author":"Beach","year":"2024","journal-title":"Chem. Rev."},{"key":"D6CC03311C\/cit59\/1","doi-asserted-by":"crossref","first-page":"168598","DOI":"10.1016\/j.cej.2025.168598","volume":"523","author":"Wang","year":"2025","journal-title":"Chem. Eng. J."},{"key":"D6CC03311C\/cit60\/1","doi-asserted-by":"crossref","first-page":"102147","DOI":"10.1016\/j.nantod.2024.102147","volume":"55","author":"Zheng","year":"2024","journal-title":"Nano Today"},{"key":"D6CC03311C\/cit61\/1","doi-asserted-by":"crossref","first-page":"1907210","DOI":"10.1002\/adma.201907210","volume":"32","author":"Hou","year":"2020","journal-title":"Adv. Mater."},{"key":"D6CC03311C\/cit62\/1","doi-asserted-by":"crossref","first-page":"2307818","DOI":"10.1002\/adma.202307818","volume":"36","author":"Chen","year":"2024","journal-title":"Adv. Mater."},{"key":"D6CC03311C\/cit63\/1","doi-asserted-by":"crossref","first-page":"eadp9071","DOI":"10.1126\/sciadv.adp9071","volume":"10","author":"Huang","year":"2024","journal-title":"Sci. Adv."},{"key":"D6CC03311C\/cit64\/1","first-page":"e20774","author":"Dong","year":"2026","journal-title":"Angew. Chem., Int. Ed."}],"container-title":["Chemical Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/CC\/article-pdf\/doi\/10.1039\/D6CC03311C\/0\/D6CC03311C.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:49:48Z","timestamp":1786636188000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/CC\/article-lookup\/doi\/10.1039\/D6CC03311C"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":64,"journal-issue":{"issue":"63","published-print":{"date-parts":[[2026,8,13]]}},"URL":"https:\/\/doi.org\/10.1039\/d6cc03311c","relation":{},"ISSN":["1359-7345","1364-548X"],"issn-type":[{"value":"1359-7345","type":"print"},{"value":"1364-548X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}