{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:06:49Z","timestamp":1789477609996,"version":"build-2803163510"},"reference-count":171,"publisher":"Royal Society of Chemistry (RSC)","issue":"72","license":[{"start":{"date-parts":[[2027,8,17]],"date-time":"2027-08-17T00:00:00Z","timestamp":1818460800000},"content-version":"am","delay-in-days":593,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21977058"],"award-info":[{"award-number":["21977058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473840"],"award-info":[{"award-number":["82473840"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005054","name":"Nantong University","doi-asserted-by":"publisher","award":["KFJN2644"],"award-info":[{"award-number":["KFJN2644"]}],"id":[{"id":"10.13039\/501100005054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013058","name":"Jiangsu Provincial Key Research and Development Program","doi-asserted-by":"publisher","award":["BE2021677"],"award-info":[{"award-number":["BE2021677"]}],"id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","award":["20KJA350002"],"award-info":[{"award-number":["20KJA350002"]}],"id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Commun."],"abstract":"<jats:p>TFOs are evolving from sequence-recognition molecules into programmable chemical interfaces connecting triplex chemistry with next-generation biosensing.<\/jats:p>","DOI":"10.1039\/d6cc04538c","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T06:23:03Z","timestamp":1786947783000},"page":"17807-17823","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Triplex-forming oligonucleotides as programmable recognition interfaces for biosensing and translational diagnostics"],"prefix":"10.1039","volume":"62","author":[{"given":"Yue","family":"Gao","sequence":"first","affiliation":[{"name":"School of Pharmacy, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhuo","family":"Lei","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhuang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziming","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anran","family":"Chu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minxuan","family":"Xiong","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3373-011X","authenticated-orcid":false,"given":"Yong","family":"Ling","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6155-6892","authenticated-orcid":false,"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6CC04538C\/cit1\/1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1021\/acs.analchem.6b04190","volume":"89","author":"Du","year":"2017","journal-title":"Anal. Chem."},{"key":"D6CC04538C\/cit1\/2","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1126\/science.aam9321","volume":"356","author":"Gootenberg","year":"2017","journal-title":"Science"},{"key":"D6CC04538C\/cit1\/3","doi-asserted-by":"crossref","first-page":"11631","DOI":"10.1021\/acs.chemrev.9b00121","volume":"119","author":"Xiao","year":"2019","journal-title":"Chem. Rev."},{"key":"D6CC04538C\/cit1\/4","doi-asserted-by":"crossref","first-page":"10469","DOI":"10.1021\/acs.chemrev.1c00241","volume":"121","author":"Li","year":"2021","journal-title":"Chem. Rev."},{"key":"D6CC04538C\/cit1\/5","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1038\/s12276-023-01118-6","volume":"55","author":"Kong","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"D6CC04538C\/cit2\/1","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1093\/nar\/gkx1230","volume":"46","author":"Chandrasekaran","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"D6CC04538C\/cit3\/1","doi-asserted-by":"crossref","first-page":"5055","DOI":"10.1021\/acs.jmedchem.4c02518","volume":"68","author":"Wang","year":"2025","journal-title":"J. Med. Chem."},{"key":"D6CC04538C\/cit4\/1","doi-asserted-by":"crossref","first-page":"15210","DOI":"10.1002\/anie.201701868","volume":"56","author":"Hu","year":"2017","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6CC04538C\/cit5\/1","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.1007\/s00216-022-04058-8","volume":"414","author":"Lin","year":"2022","journal-title":"Anal. Bioanal. Chem."},{"key":"D6CC04538C\/cit6\/1","doi-asserted-by":"crossref","first-page":"13680","DOI":"10.1021\/acs.analchem.8b04052","volume":"90","author":"Cinti","year":"2018","journal-title":"Anal. Chem."},{"key":"D6CC04538C\/cit7\/1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.aca.2018.12.031","volume":"1055","author":"Yang","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"D6CC04538C\/cit8\/1","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1021\/ja01565a074","volume":"79","author":"Felsenfeld","year":"1957","journal-title":"J. Am. Chem. Soc."},{"key":"D6CC04538C\/cit9\/1","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1126\/science.3118463","volume":"238","author":"Moser","year":"1987","journal-title":"Science"},{"key":"D6CC04538C\/cit9\/2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1146\/annurev.bi.64.070195.000433","volume":"64","author":"Frank-Kamenetskii","year":"1995","journal-title":"Annu. Rev. Biochem."},{"key":"D6CC04538C\/cit10\/1","doi-asserted-by":"crossref","first-page":"6078","DOI":"10.1093\/nar\/gkh942","volume":"32","author":"S\u00f8rensen","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"D6CC04538C\/cit11\/1","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1039\/D3CC05409H","volume":"60","author":"Katkevics","year":"2024","journal-title":"Chem. Commun."},{"key":"D6CC04538C\/cit12\/1","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1021\/bi0012639","volume":"40","author":"Cogoi","year":"2001","journal-title":"Biochemistry"},{"key":"D6CC04538C\/cit13\/1","doi-asserted-by":"crossref","first-page":"2302021","DOI":"10.1002\/advs.202302021","volume":"10","author":"Kong","year":"2023","journal-title":"Adv. Sci."},{"key":"D6CC04538C\/cit13\/2","doi-asserted-by":"crossref","first-page":"109427","DOI":"10.1016\/j.cclet.2023.109427","volume":"35","author":"Liu","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"D6CC04538C\/cit13\/3","doi-asserted-by":"crossref","first-page":"110648","DOI":"10.1016\/j.colsurfb.2019.110648","volume":"187","author":"Petralia","year":"2020","journal-title":"Colloids Surf., B"},{"key":"D6CC04538C\/cit14\/1","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.2174\/0929867330666230512114130","volume":"31","author":"Wang","year":"2024","journal-title":"Curr. Med. Chem."},{"key":"D6CC04538C\/cit15\/1","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.chempr.2023.02.018","volume":"9","author":"Zhang","year":"2023","journal-title":"Chem"},{"key":"D6CC04538C\/cit16\/1","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.tibs.2024.03.009","volume":"49","author":"Leisegang","year":"2024","journal-title":"Trends Biochem. Sci."},{"key":"D6CC04538C\/cit17\/1","doi-asserted-by":"crossref","first-page":"12277","DOI":"10.1021\/bi801087g","volume":"47","author":"Vekhoff","year":"2008","journal-title":"Biochemistry"},{"key":"D6CC04538C\/cit17\/2","doi-asserted-by":"crossref","first-page":"4781","DOI":"10.1021\/ja00122a007","volume":"117","author":"Colocci","year":"1995","journal-title":"J. Am. Chem. Soc."},{"key":"D6CC04538C\/cit18\/1","doi-asserted-by":"crossref","first-page":"9396","DOI":"10.1021\/bi010666l","volume":"40","author":"Sugimoto","year":"2001","journal-title":"Biochemistry"},{"key":"D6CC04538C\/cit19\/1","doi-asserted-by":"crossref","first-page":"12692","DOI":"10.1021\/ja016577d","volume":"123","author":"Goobes","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"D6CC04538C\/cit20\/1","doi-asserted-by":"crossref","first-page":"5367","DOI":"10.1021\/bi00184a002","volume":"33","author":"Hacia","year":"1994","journal-title":"Biochemistry"},{"key":"D6CC04538C\/cit21\/1","doi-asserted-by":"crossref","first-page":"11043","DOI":"10.1038\/s41598-017-09147-8","volume":"7","author":"Pabon-Martinez","year":"2017","journal-title":"Sci. Rep."},{"key":"D6CC04538C\/cit22\/1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1021\/acschembio.4c00662","volume":"20","author":"Farshineh Saei","year":"2024","journal-title":"ACS Chem. Biol."},{"key":"D6CC04538C\/cit23\/1","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1093\/nar\/gki726","volume":"33","author":"Brunet","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"D6CC04538C\/cit24\/1","doi-asserted-by":"crossref","first-page":"4498","DOI":"10.1093\/nar\/gkp437","volume":"37","author":"Hansen","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"D6CC04538C\/cit25\/1","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1093\/nar\/gki625","volume":"33","author":"Rusling","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"D6CC04538C\/cit26\/1","doi-asserted-by":"crossref","first-page":"8679","DOI":"10.1093\/nar\/gky704","volume":"46","author":"Wang","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"D6CC04538C\/cit27\/1","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1021\/bi0012639","volume":"40","author":"Cogoi","year":"2001","journal-title":"Biochemistry"},{"key":"D6CC04538C\/cit27\/2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1021\/bi011122m","volume":"41","author":"Mills","year":"2002","journal-title":"Biochemistry"},{"key":"D6CC04538C\/cit28\/1","doi-asserted-by":"crossref","first-page":"7256","DOI":"10.1093\/nar\/gkab572","volume":"49","author":"Rusling","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"D6CC04538C\/cit29\/1","doi-asserted-by":"crossref","first-page":"gkag520","DOI":"10.1093\/nar\/gkag520","volume":"54","author":"Wang","year":"2026","journal-title":"Nucleic Acids Res."},{"key":"D6CC04538C\/cit30\/1","doi-asserted-by":"crossref","first-page":"2302497","DOI":"10.1002\/adma.202302497","volume":"35","author":"Ng","year":"2023","journal-title":"Adv. Mater."},{"key":"D6CC04538C\/cit30\/2","doi-asserted-by":"crossref","first-page":"13617","DOI":"10.1021\/jacs.4c03413","volume":"146","author":"Kalra","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"D6CC04538C\/cit31\/1","doi-asserted-by":"crossref","first-page":"e202411118","DOI":"10.1002\/anie.202411118","volume":"63","author":"Ouyang","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6CC04538C\/cit32\/1","first-page":"139044","author":"Kang","year":"2025","journal-title":"Sens. Actuators, B"},{"key":"D6CC04538C\/cit32\/2","doi-asserted-by":"crossref","first-page":"7359","DOI":"10.1002\/ange.202016223","volume":"133","author":"Farag","year":"2021","journal-title":"Angew. Chem."},{"key":"D6CC04538C\/cit32\/3","doi-asserted-by":"crossref","first-page":"117415","DOI":"10.1016\/j.saa.2019.117415","volume":"224","author":"Tu","year":"2020","journal-title":"Spectrochim. Acta, Part A"},{"key":"D6CC04538C\/cit33\/1","doi-asserted-by":"crossref","first-page":"139512","DOI":"10.1016\/j.snb.2026.139512","author":"Deng","year":"2026","journal-title":"Sens. Actuators, B"},{"key":"D6CC04538C\/cit34\/1","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1002\/cbic.201000329","volume":"11","author":"Li","year":"2010","journal-title":"ChemBioChem"},{"key":"D6CC04538C\/cit35\/1","doi-asserted-by":"crossref","first-page":"338666","DOI":"10.1016\/j.aca.2021.338666","volume":"1173","author":"Jin","year":"2021","journal-title":"Anal. Chim. Acta"},{"key":"D6CC04538C\/cit36\/1","doi-asserted-by":"crossref","first-page":"111538","DOI":"10.1016\/j.foodres.2022.111538","volume":"158","author":"Zou","year":"2022","journal-title":"Food Res. Int."},{"key":"D6CC04538C\/cit36\/2","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.talanta.2018.01.039","volume":"181","author":"Li","year":"2018","journal-title":"Talanta"},{"key":"D6CC04538C\/cit37\/1","doi-asserted-by":"crossref","first-page":"4291","DOI":"10.1038\/s41598-021-83640-z","volume":"11","author":"Islam","year":"2021","journal-title":"Sci. Rep."},{"key":"D6CC04538C\/cit38\/1","doi-asserted-by":"crossref","first-page":"1802725","DOI":"10.1002\/adma.201802725","volume":"31","author":"Chen","year":"2019","journal-title":"Adv. Mater."},{"key":"D6CC04538C\/cit38\/2","doi-asserted-by":"crossref","first-page":"13410","DOI":"10.1039\/D1CS00632K","volume":"50","author":"De Fazio","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"D6CC04538C\/cit38\/3","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1021\/acsabm.0c01347","volume":"4","author":"Wang","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"D6CC04538C\/cit39\/1","doi-asserted-by":"crossref","first-page":"7333","DOI":"10.1021\/acsnano.9b03846","volume":"13","author":"Chen","year":"2019","journal-title":"ACS Nano"},{"key":"D6CC04538C\/cit39\/2","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1039\/C5SC00594A","volume":"6","author":"Ren","year":"2015","journal-title":"Chem. Sci."},{"key":"D6CC04538C\/cit39\/3","doi-asserted-by":"crossref","first-page":"7803","DOI":"10.1021\/ja300176w","volume":"134","author":"Zhou","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"D6CC04538C\/cit40\/1","doi-asserted-by":"crossref","first-page":"15599","DOI":"10.1021\/acs.analchem.9b03659","volume":"91","author":"Zhu","year":"2019","journal-title":"Anal. Chem."},{"key":"D6CC04538C\/cit41\/1","doi-asserted-by":"crossref","first-page":"9109","DOI":"10.1021\/ac1024528","volume":"82","author":"Patterson","year":"2010","journal-title":"Anal. Chem."},{"key":"D6CC04538C\/cit42\/1","first-page":"139256","author":"Yang","year":"2025","journal-title":"Sens. Actuators, B"},{"key":"D6CC04538C\/cit42\/2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.talanta.2015.05.009","volume":"143","author":"Mao","year":"2015","journal-title":"Talanta"},{"key":"D6CC04538C\/cit43\/1","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s00604-024-06366-5","volume":"191","author":"Wang","year":"2024","journal-title":"Microchim. Acta"},{"key":"D6CC04538C\/cit44\/1","doi-asserted-by":"crossref","first-page":"17493","DOI":"10.1021\/jacs.9b09292","volume":"141","author":"Zhao","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"D6CC04538C\/cit45\/1","doi-asserted-by":"crossref","first-page":"15258","DOI":"10.3390\/ijms232315258","volume":"23","author":"Avino","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"D6CC04538C\/cit46\/1","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.3390\/molecules23082050","volume":"23","author":"Wu","year":"2018","journal-title":"Molecules"},{"key":"D6CC04538C\/cit46\/2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/elan.201300056","volume":"26","author":"Zhu","year":"2014","journal-title":"Electroanalysis"},{"key":"D6CC04538C\/cit46\/3","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1021\/am405676n","volume":"6","author":"Feng","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D6CC04538C\/cit47\/1","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1039\/D2AY00689H","volume":"14","author":"Huang","year":"2022","journal-title":"Anal. Methods"},{"key":"D6CC04538C\/cit48\/1","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s00604-018-2935-y","volume":"185","author":"Wang","year":"2018","journal-title":"Microchim. Acta"},{"key":"D6CC04538C\/cit49\/1","doi-asserted-by":"crossref","first-page":"44212","DOI":"10.1038\/srep44212","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"D6CC04538C\/cit50\/1","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1007\/s11802-022-5004-4","volume":"21","author":"Qi","year":"2022","journal-title":"J. Ocean Univ. China"},{"key":"D6CC04538C\/cit51\/1","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.talanta.2018.03.094","volume":"185","author":"Liu","year":"2018","journal-title":"Talanta"},{"key":"D6CC04538C\/cit52\/1","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1016\/j.nano.2016.05.011","volume":"12","author":"Gao","year":"2016","journal-title":"Nanomed. Nanotechnol."},{"key":"D6CC04538C\/cit53\/1","doi-asserted-by":"crossref","first-page":"125457","DOI":"10.1016\/j.talanta.2023.125457","volume":"269","author":"Pang","year":"2024","journal-title":"Talanta"},{"key":"D6CC04538C\/cit54\/1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.aca.2019.10.020","volume":"1095","author":"Wei","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"D6CC04538C\/cit55\/1","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1021\/acs.analchem.9b04909","volume":"92","author":"Chen","year":"2020","journal-title":"Anal. Chem."},{"key":"D6CC04538C\/cit56\/1","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1021\/acs.analchem.6b04675","volume":"89","author":"Li","year":"2017","journal-title":"Anal. Chem."},{"key":"D6CC04538C\/cit56\/2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jpha.2018.11.004","volume":"9","author":"Zhang","year":"2019","journal-title":"J. Pharm. Anal."},{"key":"D6CC04538C\/cit57\/1","first-page":"1686","volume":"95","author":"Zhang","year":"2022","journal-title":"Anal. Chem."},{"key":"D6CC04538C\/cit57\/2","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.bios.2017.07.016","volume":"98","author":"Feng","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"D6CC04538C\/cit57\/3","doi-asserted-by":"crossref","first-page":"12361","DOI":"10.1021\/acs.analchem.8b04424","volume":"90","author":"Zhou","year":"2018","journal-title":"Anal. Chem."},{"key":"D6CC04538C\/cit58\/1","first-page":"10748306","volume-title":"Investigating molecular mechanisms underlying mild phenotype in Friedreich ataxia patients with G130V missense mutation","author":"Clark","year":"2018","unstructured":"E.Clark ,  Investigating molecular mechanisms underlying mild phenotype in Friedreich ataxia patients with G130V missense mutation ,  University of Pennsylvania ,  2018 ,  p. 10748306"},{"key":"D6CC04538C\/cit59\/1","doi-asserted-by":"crossref","first-page":"124750","DOI":"10.1016\/j.saa.2024.124750","volume":"322","author":"Dargah","year":"2024","journal-title":"Spectrochim. Acta, Part A"},{"key":"D6CC04538C\/cit60\/1","doi-asserted-by":"crossref","first-page":"18092","DOI":"10.1021\/acs.analchem.2c04747","volume":"94","author":"Zhang","year":"2022","journal-title":"Anal. Chem."},{"key":"D6CC04538C\/cit60\/2","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jpba.2016.11.033","volume":"134","author":"Xu","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"key":"D6CC04538C\/cit61\/1","doi-asserted-by":"crossref","first-page":"339181","DOI":"10.1016\/j.aca.2021.339181","volume":"1188","author":"Wang","year":"2021","journal-title":"Anal. Chim. Acta"},{"key":"D6CC04538C\/cit61\/2","doi-asserted-by":"crossref","first-page":"5875","DOI":"10.1007\/s00216-023-04876-4","volume":"415","author":"Sornambigai","year":"2023","journal-title":"Anal. Bioanal. Chem."},{"key":"D6CC04538C\/cit62\/1","doi-asserted-by":"crossref","first-page":"338919","DOI":"10.1016\/j.aca.2021.338919","volume":"1181","author":"Mahani","year":"2021","journal-title":"Anal. Chim. Acta"},{"key":"D6CC04538C\/cit63\/1","doi-asserted-by":"crossref","first-page":"4484","DOI":"10.1039\/D0CS00955E","volume":"50","author":"Zhao","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"D6CC04538C\/cit63\/2","doi-asserted-by":"crossref","first-page":"114051","DOI":"10.1016\/j.bios.2022.114051","volume":"203","author":"Li","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"D6CC04538C\/cit64\/1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s00604-025-07789-4","volume":"193","author":"Yin","year":"2026","journal-title":"Microchim. Acta"},{"key":"D6CC04538C\/cit64\/2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00604-026-08032-4","volume":"193","author":"Pan","year":"2026","journal-title":"Microchim. Acta"},{"key":"D6CC04538C\/cit64\/3","doi-asserted-by":"crossref","first-page":"19395","DOI":"10.1038\/s41598-025-02430-z","volume":"15","author":"Tungkunaruk","year":"2025","journal-title":"Sci. Rep."},{"key":"D6CC04538C\/cit65\/1","doi-asserted-by":"crossref","first-page":"2303007","DOI":"10.1002\/smll.202303007","volume":"19","author":"Wu","year":"2023","journal-title":"Small"},{"key":"D6CC04538C\/cit65\/2","doi-asserted-by":"crossref","first-page":"1905311","DOI":"10.1002\/adma.201905311","volume":"31","author":"Bruch","year":"2019","journal-title":"Adv. Mater."},{"key":"D6CC04538C\/cit66\/1","doi-asserted-by":"crossref","first-page":"gkaf1392","DOI":"10.1093\/nar\/gkaf1392","volume":"54","author":"Di Pede","year":"2026","journal-title":"Nucleic Acids Res."},{"key":"D6CC04538C\/cit67\/1","doi-asserted-by":"crossref","first-page":"177451","DOI":"10.1016\/j.cej.2026.177451","volume":"540","author":"Wang","year":"2026","journal-title":"Chem. Eng. J."},{"key":"D6CC04538C\/cit68\/1","doi-asserted-by":"crossref","first-page":"113292","DOI":"10.1016\/j.bios.2021.113292","volume":"187","author":"Li","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"D6CC04538C\/cit69\/1","doi-asserted-by":"crossref","first-page":"5178","DOI":"10.1021\/acs.analchem.3c05364","volume":"96","author":"Zhu","year":"2024","journal-title":"Anal. Chem."},{"key":"D6CC04538C\/cit70\/1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1146\/annurev-biochem-060614-034010","volume":"84","author":"Iyer","year":"2015","journal-title":"Annu. Rev. Biochem."},{"key":"D6CC04538C\/cit70\/2","doi-asserted-by":"crossref","first-page":"5223","DOI":"10.1002\/anie.200700289","volume":"46","author":"Grossmann","year":"2007","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6CC04538C\/cit70\/3","doi-asserted-by":"crossref","first-page":"32948","DOI":"10.1021\/acsami.2c08478","volume":"14","author":"Li","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D6CC04538C\/cit71\/1","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1200\/JCO.2025.43.4_suppl.722","volume":"43","author":"Garrido-Laguna","year":"2025","journal-title":"J. Clin. Oncol."},{"key":"D6CC04538C\/cit71\/2","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1039\/C8LC00100F","volume":"18","author":"Gorgannezhad","year":"2018","journal-title":"Lab Chip"},{"key":"D6CC04538C\/cit71\/3","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1476-4598-11-38","volume":"11","author":"Nelson","year":"2012","journal-title":"Mol. Cancer"},{"key":"D6CC04538C\/cit72\/1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1586\/14737159.3.4.481","volume":"3","author":"Potaman","year":"2003","journal-title":"Expert Rev. Mol. Diagn."},{"key":"D6CC04538C\/cit72\/2","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1093\/nar\/gkw021","volume":"44","author":"Geny","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"D6CC04538C\/cit73\/1","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1136\/jcp-2024-209941","volume":"78","author":"Bontoux","year":"2025","journal-title":"J. Clin. Pathol."},{"key":"D6CC04538C\/cit73\/2","doi-asserted-by":"crossref","first-page":"341452","DOI":"10.1016\/j.aca.2023.341452","volume":"1270","author":"Yang","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"D6CC04538C\/cit73\/3","doi-asserted-by":"crossref","first-page":"2200327","DOI":"10.1002\/advs.202200327","volume":"9","author":"Song","year":"2022","journal-title":"Adv. Sci."},{"key":"D6CC04538C\/cit74\/1","doi-asserted-by":"crossref","first-page":"2306793","DOI":"10.1002\/smll.202306793","volume":"20","author":"Yadavalli","year":"2024","journal-title":"Small"},{"key":"D6CC04538C\/cit74\/2","doi-asserted-by":"crossref","first-page":"2007355","DOI":"10.1002\/smll.202007355","volume":"17","author":"Zhou","year":"2021","journal-title":"Small"},{"key":"D6CC04538C\/cit75\/1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.aca.2020.04.037","volume":"1116","author":"Zhao","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"D6CC04538C\/cit76\/1","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s00216-015-9180-6","volume":"408","author":"Avi\u00f1\u00f3","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"key":"D6CC04538C\/cit76\/2","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.snb.2018.09.026","volume":"277","author":"Ribes","year":"2018","journal-title":"Sens. Actuators, B"},{"key":"D6CC04538C\/cit76\/3","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s00216-015-9180-6","volume":"408","author":"Avi\u00f1\u00f3","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"key":"D6CC04538C\/cit77\/1","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1021\/acssensors.8b00996","volume":"3","author":"Lu","year":"2018","journal-title":"ACS Sens."},{"key":"D6CC04538C\/cit77\/2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00604-020-04680-2","volume":"188","author":"Zhao","year":"2021","journal-title":"Microchim. Acta"},{"key":"D6CC04538C\/cit77\/3","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1039\/D3AN01928D","volume":"149","author":"Liao","year":"2024","journal-title":"Analyst"},{"key":"D6CC04538C\/cit78\/1","doi-asserted-by":"crossref","first-page":"7140","DOI":"10.1021\/acsnano.4c16396","volume":"19","author":"Lin","year":"2025","journal-title":"ACS Nano"},{"key":"D6CC04538C\/cit79\/1","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1007\/s00216-020-02713-6","volume":"412","author":"Jingjing","year":"2020","journal-title":"Anal. Bioanal. Chem."},{"key":"D6CC04538C\/cit79\/2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00604-019-4093-2","volume":"187","author":"Li","year":"2020","journal-title":"Microchim. Acta"},{"key":"D6CC04538C\/cit79\/3","first-page":"139002","author":"Zhang","year":"2025","journal-title":"Sens. Actuators, B"},{"key":"D6CC04538C\/cit80\/1","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1021\/acschembio.1c00133","volume":"16","author":"Endoh","year":"2021","journal-title":"ACS Chem. Biol."},{"key":"D6CC04538C\/cit81\/1","doi-asserted-by":"crossref","first-page":"23535","DOI":"10.1021\/acsomega.5c02155","volume":"10","author":"Dominguez","year":"2025","journal-title":"ACS Omega"},{"key":"D6CC04538C\/cit82\/1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/s12917-025-04688-x","volume":"21","author":"Wang","year":"2025","journal-title":"BMC Vet. Res."},{"key":"D6CC04538C\/cit82\/2","doi-asserted-by":"crossref","first-page":"113763","DOI":"10.1016\/j.microc.2025.113763","volume":"213","author":"Liu","year":"2025","journal-title":"Microchem. J."},{"key":"D6CC04538C\/cit82\/3","doi-asserted-by":"crossref","first-page":"103333","DOI":"10.1016\/j.psj.2023.103333","volume":"103","author":"Wen","year":"2024","journal-title":"Poult. Sci."},{"key":"D6CC04538C\/cit83\/1","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1039\/D4AY00713A","volume":"16","author":"Zhang","year":"2024","journal-title":"Anal. Methods"},{"key":"D6CC04538C\/cit84\/1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1089\/oli.2008.0130","volume":"18","author":"Aquino-Jarquin","year":"2008","journal-title":"Oligonucleotides"},{"key":"D6CC04538C\/cit84\/2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1006\/jmbi.1993.1154","volume":"230","author":"Cherny","year":"1993","journal-title":"J. Mol. Biol."},{"key":"D6CC04538C\/cit84\/3","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.1016\/S0021-9258(18)42792-5","volume":"267","author":"Hartman","year":"1992","journal-title":"J. Biol. Chem."},{"key":"D6CC04538C\/cit85\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4161\/adna.1.2.13256","volume":"1","author":"Smolina","year":"2010","journal-title":"Artif. DNA PNA XNA"},{"key":"D6CC04538C\/cit85\/2","doi-asserted-by":"crossref","first-page":"11992","DOI":"10.1021\/ac5018748","volume":"86","author":"Gomez","year":"2014","journal-title":"Anal. Chem."},{"key":"D6CC04538C\/cit86\/1","doi-asserted-by":"crossref","first-page":"6586","DOI":"10.1021\/ac201314y","volume":"83","author":"Zheng","year":"2011","journal-title":"Anal. Chem."},{"key":"D6CC04538C\/cit87\/1","doi-asserted-by":"crossref","first-page":"6272","DOI":"10.1039\/C4AN01320D","volume":"139","author":"Wang","year":"2014","journal-title":"Analyst"},{"key":"D6CC04538C\/cit88\/1","doi-asserted-by":"crossref","first-page":"6294","DOI":"10.1039\/C4AY00807C","volume":"6","author":"Du","year":"2014","journal-title":"Anal. Methods"},{"key":"D6CC04538C\/cit89\/1","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.2116\/analsci.33.1333","volume":"33","author":"Chen","year":"2017","journal-title":"Anal. Sci."},{"key":"D6CC04538C\/cit90\/1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.17350\/HJSE19030000161","volume":"6","author":"Doluca","year":"2019","journal-title":"Hittite J. Sci. Eng."},{"key":"D6CC04538C\/cit91\/1","doi-asserted-by":"crossref","first-page":"795","DOI":"10.3390\/toxics11090795","volume":"11","author":"Gao","year":"2023","journal-title":"Toxics"},{"key":"D6CC04538C\/cit92\/1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4161\/adna.24102","volume":"4","author":"Ikeda","year":"2013","journal-title":"Artif. DNA PNA XNA"},{"key":"D6CC04538C\/cit93\/1","doi-asserted-by":"crossref","first-page":"2311240","DOI":"10.1002\/adfm.202311240","volume":"34","author":"Bhangu","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"D6CC04538C\/cit94\/1","doi-asserted-by":"crossref","first-page":"5852","DOI":"10.1021\/nn5008572","volume":"8","author":"Huo","year":"2014","journal-title":"ACS Nano"},{"key":"D6CC04538C\/cit95\/1","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1039\/C8CC00440D","volume":"54","author":"Zhou","year":"2018","journal-title":"Chem. Commun."},{"key":"D6CC04538C\/cit96\/1","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1093\/nar\/gkl630","volume":"34","author":"Brunet","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"D6CC04538C\/cit97\/1","doi-asserted-by":"crossref","first-page":"90310","DOI":"10.1039\/C6RA19526A","volume":"6","author":"Liu","year":"2016","journal-title":"RSC Adv."},{"key":"D6CC04538C\/cit98\/1","first-page":"139","volume-title":"Biosensors for environmental monitoring","author":"Odoba\u0161i\u0107","year":"2019","unstructured":"A.Odoba\u0161i\u0107 ,  I.\u0160estan  and  S.Begi\u0107 ,  Biosensors for environmental monitoring ,  IntechOpen ,  2019 , ch. 10,  pp. 139\u2013155"},{"key":"D6CC04538C\/cit99\/1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3390\/bios14050257","volume":"14","author":"Chang","year":"2024","journal-title":"Biosensors"},{"key":"D6CC04538C\/cit100\/1","first-page":"1","volume-title":"Handbook of Chemical Biology of Nucleic Acids","author":"Islam","year":"2022","unstructured":"M. A.Islam  and  S.Obika ,  Handbook of Chemical Biology of Nucleic Acids ,  Springer ,  2022 ,  pp. 1\u201346"},{"key":"D6CC04538C\/cit100\/2","doi-asserted-by":"crossref","first-page":"632","DOI":"10.3390\/molecules23030632","volume":"23","author":"Ricciardi","year":"2018","journal-title":"Molecules"},{"key":"D6CC04538C\/cit101\/1","doi-asserted-by":"crossref","first-page":"6952","DOI":"10.1038\/ncomms7952","volume":"6","author":"McNeer","year":"2015","journal-title":"Nat. Commun."},{"key":"D6CC04538C\/cit102\/1","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.1093\/nar\/gkg782","volume":"31","author":"James","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"D6CC04538C\/cit102\/2","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1093\/nar\/25.16.3269","volume":"25","author":"Paes","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"D6CC04538C\/cit103\/1","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1016\/j.bpj.2012.10.029","volume":"103","author":"Lee","year":"2012","journal-title":"Biophys. J."},{"key":"D6CC04538C\/cit104\/1","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1021\/acssensors.0c02254","volume":"5","author":"Masson","year":"2020","journal-title":"ACS Sens."},{"key":"D6CC04538C\/cit105\/1","doi-asserted-by":"crossref","first-page":"10193","DOI":"10.1039\/D2SC01793H","volume":"13","author":"Dalla Pozza","year":"2022","journal-title":"Chem. Sci."},{"key":"D6CC04538C\/cit106\/1","doi-asserted-by":"crossref","first-page":"2109764","DOI":"10.1002\/adma.202109764","volume":"34","author":"Chan","year":"2022","journal-title":"Adv. Mater."},{"key":"D6CC04538C\/cit107\/1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3390\/ijms20020423","volume":"20","author":"Campuzano","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"D6CC04538C\/cit108\/1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.3390\/s150100547","volume":"15","author":"Bunyakul","year":"2014","journal-title":"Sensors"},{"key":"D6CC04538C\/cit109\/1","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1016\/j.csbj.2023.05.016","volume":"21","author":"Cicconetti","year":"2023","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"D6CC04538C\/cit109\/2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3390\/ncrna9010010","volume":"9","author":"Warwick","year":"2023","journal-title":"Non-Coding RNA"},{"key":"D6CC04538C\/cit110\/1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1186\/s12859-020-03864-0","volume":"21","author":"Zhang","year":"2020","journal-title":"BMC Bioinf."},{"key":"D6CC04538C\/cit110\/2","doi-asserted-by":"crossref","first-page":"btad134","DOI":"10.1093\/bioinformatics\/btad134","volume":"39","author":"Amatria-Barral","year":"2023","journal-title":"Bioinformatics"},{"key":"D6CC04538C\/cit111\/1","doi-asserted-by":"crossref","first-page":"bbad186","DOI":"10.1093\/bib\/bbad186","volume":"24","author":"Sato","year":"2023","journal-title":"Briefings Bioinf."},{"key":"D6CC04538C\/cit112\/1","doi-asserted-by":"crossref","first-page":"20139","DOI":"10.1039\/D5SC06176H","volume":"16","author":"Hu","year":"2025","journal-title":"Chem. Sci."},{"key":"D6CC04538C\/cit113\/1","doi-asserted-by":"crossref","first-page":"8498","DOI":"10.1039\/C8CC04615H","volume":"54","author":"Qi","year":"2018","journal-title":"Chem. Commun."},{"key":"D6CC04538C\/cit114\/1","doi-asserted-by":"crossref","first-page":"9864","DOI":"10.1039\/D3RA00536D","volume":"13","author":"Qi","year":"2023","journal-title":"RSC Adv."},{"key":"D6CC04538C\/cit115\/1","doi-asserted-by":"crossref","first-page":"5854","DOI":"10.1021\/acs.analchem.5b01233","volume":"87","author":"Yang","year":"2015","journal-title":"Anal. Chem."},{"key":"D6CC04538C\/cit116\/1","doi-asserted-by":"crossref","first-page":"14410","DOI":"10.1021\/jp503608t","volume":"118","author":"Gao","year":"2014","journal-title":"J. Phys. Chem. C"},{"key":"D6CC04538C\/cit116\/2","doi-asserted-by":"crossref","first-page":"1120791","DOI":"10.3389\/fgene.2023.1120791","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Genet."},{"key":"D6CC04538C\/cit117\/1","doi-asserted-by":"crossref","first-page":"e2411305","DOI":"10.1002\/advs.202411305","volume":"12","author":"Huang","year":"2025","journal-title":"Adv. Sci."},{"key":"D6CC04538C\/cit118\/1","doi-asserted-by":"crossref","first-page":"101076","DOI":"10.1016\/j.crmeth.2025.101076","volume":"5","author":"Wang","year":"2025","journal-title":"Cell Rep. Methods"}],"container-title":["Chemical Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/CC\/article-pdf\/doi\/10.1039\/D6CC04538C\/0\/D6CC04538C.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:38:56Z","timestamp":1789475936000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/CC\/article-lookup\/doi\/10.1039\/D6CC04538C"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":171,"journal-issue":{"issue":"72","published-print":{"date-parts":[[2026,9,15]]}},"URL":"https:\/\/doi.org\/10.1039\/d6cc04538c","relation":{},"ISSN":["1359-7345","1364-548X"],"issn-type":[{"value":"1359-7345","type":"print"},{"value":"1364-548X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}