{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:56:23Z","timestamp":1791982583752,"version":"4.4.0"},"reference-count":74,"publisher":"Royal Society of Chemistry (RSC)","issue":"39","license":[{"start":{"date-parts":[[2027,9,3]],"date-time":"2027-09-03T00:00:00Z","timestamp":1819929600000},"content-version":"am","delay-in-days":610,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Phys. Chem. Chem. Phys."],"abstract":"<jats:p>Generation of different states of lysozyme in presence of HFIP and TFE at pH 2 and pH 11.<\/jats:p>","DOI":"10.1039\/d6cp02473d","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T01:03:27Z","timestamp":1788397407000},"page":"24252-24276","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural and thermodynamic characterization of native-like and helical molten globule states of lysozyme: ANS binding and molecular docking insights"],"prefix":"10.1039","volume":"28","author":[{"given":"Sukanya","family":"Sarkar","sequence":"first","affiliation":[{"name":"Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai \u2013 400 076, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7624-3824","authenticated-orcid":false,"given":"Nand","family":"Kishore","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai \u2013 400 076, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"2","key":"D6CP02473D\/cit1\/1","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1140\/epje\/i2010-10621-4","volume":"32","author":"Maiti","year":"2010","journal-title":"Eur. Phys. J. E"},{"issue":"41","key":"D6CP02473D\/cit2\/1","doi-asserted-by":"crossref","first-page":"12504","DOI":"10.1021\/bi00207a018","volume":"33","author":"Fink","year":"1994","journal-title":"Biochemistry"},{"key":"D6CP02473D\/cit3\/1","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1002\/pro.5560040401","author":"Dill","year":"1995","journal-title":"Protein Sci."},{"issue":"2","key":"D6CP02473D\/cit4\/1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1002\/prot.340160202","volume":"16","author":"Haynie","year":"1993","journal-title":"Proteins: Struct., Funct., Bioinf."},{"issue":"2","key":"D6CP02473D\/cit5\/1","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1140\/epje\/i2010-10621-4","volume":"32","author":"Maiti","year":"2010","journal-title":"Eur. Phys. J. E"},{"key":"D6CP02473D\/cit6\/1","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.jphotobiol.2016.06.047","volume":"162","author":"Millan","year":"2016","journal-title":"J. Photochem. Photobiol., B"},{"issue":"1","key":"D6CP02473D\/cit7\/1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/0014-5793(94)80231-9","volume":"341","author":"Ptitsyn","year":"1994","journal-title":"FEBS Lett."},{"issue":"5","key":"D6CP02473D\/cit8\/1","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1002\/pro.5560060513","volume":"6","author":"Bhattacharjya","year":"1997","journal-title":"Protein Sci."},{"issue":"21","key":"D6CP02473D\/cit9\/1","doi-asserted-by":"publisher","first-page":"6475","DOI":"10.1021\/bi992560k","volume":"39","author":"Sasahara","year":"2000","journal-title":"Biochemistry"},{"key":"D6CP02473D\/cit10\/1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF00247759","volume":"6","author":"Imoto","year":"1987","journal-title":"J. Protein Chem."},{"issue":"2","key":"D6CP02473D\/cit11\/1","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3390\/biom10020269","volume":"10","author":"Kuroda","year":"2020","journal-title":"Biomolecules"},{"key":"D6CP02473D\/cit12\/1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0065-3233(00)53005-8","volume":"53","author":"Arai","year":"2000","journal-title":"Adv. Protein Chem."},{"issue":"2","key":"D6CP02473D\/cit13\/1","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1006\/abbi.1998.0794","volume":"357","author":"Bhakuni","year":"1998","journal-title":"Biochem. Biophys."},{"issue":"12","key":"D6CP02473D\/cit14\/1","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.1002\/pro.5560021206","volume":"2","author":"Thomas","year":"1993","journal-title":"Protein Sci."},{"key":"D6CP02473D\/cit15\/1","doi-asserted-by":"crossref","first-page":"12884","DOI":"10.1021\/bi00039a051","volume":"34","author":"Liu","year":"1995","journal-title":"Biochemistry"},{"issue":"1\u20133","key":"D6CP02473D\/cit16\/1","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0014-5793(01)03284-7","volume":"511","author":"Chang","year":"2002","journal-title":"FEBS Lett."},{"key":"D6CP02473D\/cit17\/1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.plrev.2004.03.001","author":"Finkelstein","year":"2004","journal-title":"Phys. Life Rev."},{"issue":"31","key":"D6CP02473D\/cit18\/1","doi-asserted-by":"crossref","first-page":"22975","DOI":"10.1016\/S0021-9258(19)49413-1","volume":"268","author":"Li","year":"1993","journal-title":"J. Biol. Chem."},{"issue":"2","key":"D6CP02473D\/cit19\/1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1006\/jmbi.1994.0015","volume":"245","author":"Shiraki","year":"1995","journal-title":"J. Mol. Biol."},{"key":"D6CP02473D\/cit20\/1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/bbrc.1996.0693","volume":"222","author":"Jayaraman","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1\u20132","key":"D6CP02473D\/cit21\/1","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.abb.2010.05.005","volume":"499","author":"Dave","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"issue":"9","key":"D6CP02473D\/cit22\/1","doi-asserted-by":"publisher","first-page":"e30258","DOI":"10.1016\/j.heliyon.2024.e30258","volume":"10","author":"Adimas","year":"2024","journal-title":"Heliyon"},{"key":"D6CP02473D\/cit23\/1","doi-asserted-by":"publisher","first-page":"116460","DOI":"10.1016\/j.molliq.2021.116460","volume":"337","author":"He","year":"2021","journal-title":"J. Mol. Liq."},{"issue":"4","key":"D6CP02473D\/cit24\/1","doi-asserted-by":"publisher","first-page":"556","DOI":"10.3390\/foods13040556","volume":"13","author":"Govindaraju","year":"2024","journal-title":"Foods"},{"issue":"13","key":"D6CP02473D\/cit25\/1","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.3390\/nu16132032","volume":"16","author":"Palus","year":"2024","journal-title":"Nutrients"},{"key":"D6CP02473D\/cit26\/1","doi-asserted-by":"publisher","first-page":"205","DOI":"10.33549\/physiolres.933381","author":"Semla","year":"2017","journal-title":"Phys. Res."},{"key":"D6CP02473D\/cit27\/1","doi-asserted-by":"publisher","first-page":"123844","DOI":"10.1016\/j.molliq.2023.123844","volume":"395","author":"Niu","year":"2024","journal-title":"J. Mol. Liq."},{"issue":"3","key":"D6CP02473D\/cit28\/1","doi-asserted-by":"publisher","first-page":"240","DOI":"10.3803\/EnM.2014.29.3.240","volume":"29","author":"Sun","year":"2014","journal-title":"Endocrinol. Metab."},{"issue":"12","key":"D6CP02473D\/cit29\/1","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.3390\/antibiotics10121534","volume":"10","author":"Ferraboschi","year":"2021","journal-title":"Antibiotics"},{"issue":"10","key":"D6CP02473D\/cit30\/1","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.1016\/S0021-9258(19)41460-9","volume":"250","author":"Formoso","year":"1975","journal-title":"J. Biol. Chem."},{"issue":"5","key":"D6CP02473D\/cit31\/1","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1073\/pnas.69.5.1151","volume":"69","author":"Imoto","year":"1971","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"D6CP02473D\/cit32\/1","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1271\/bbb.63.329","volume":"63","author":"Nishimoto","year":"1999","journal-title":"Biosci., Biotechnol., Biochem."},{"key":"D6CP02473D\/cit33\/1","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.jphotobiol.2016.06.047","volume":"162","author":"Millan","year":"2016","journal-title":"J. Photochem. Photobiol., B"},{"issue":"2","key":"D6CP02473D\/cit34\/1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1140\/epje\/i2010-10621-4","volume":"32","author":"Maiti","year":"2010","journal-title":"Eur. Phys. J. E"},{"issue":"34","key":"D6CP02473D\/cit35\/1","doi-asserted-by":"publisher","first-page":"10182","DOI":"10.1021\/jp303898g","volume":"116","author":"James","year":"2012","journal-title":"J. Phys. Chem. B"},{"issue":"5","key":"D6CP02473D\/cit36\/1","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1110\/ps.3960102","volume":"11","author":"Guez","year":"2002","journal-title":"Protein Sci."},{"issue":"2","key":"D6CP02473D\/cit37\/1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1021\/bi00053a036","volume":"32","author":"Buck","year":"1993","journal-title":"Biochemistry"},{"issue":"2","key":"D6CP02473D\/cit38\/1","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1080\/07391102.2021.2006090","volume":"41","author":"Cer\u00f3n","year":"2023","journal-title":"J. Biomol. Struct. Dyn."},{"key":"D6CP02473D\/cit39\/1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.biochi.2021.10.008","volume":"193","author":"Ghosh","year":"2022","journal-title":"Biochimie"},{"issue":"6","key":"D6CP02473D\/cit40\/1","doi-asserted-by":"publisher","first-page":"929","DOI":"10.15625\/2525-2518\/16459","volume":"60","author":"Quan","year":"2022","journal-title":"Vietnam J. Sci. Technol."},{"issue":"11","key":"D6CP02473D\/cit41\/1","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.3390\/biom12111613","volume":"12","author":"Sarimov","year":"2022","journal-title":"Biomolecules"},{"issue":"16","key":"D6CP02473D\/cit42\/1","doi-asserted-by":"publisher","first-page":"9131","DOI":"10.1021\/acsomega.9b04291","volume":"5","author":"Ali","year":"2020","journal-title":"ACS Omega"},{"key":"D6CP02473D\/cit43\/1","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1021\/jz101619f","author":"Oladepo","year":"2011","journal-title":"J. Phys. Chem. Lett."},{"issue":"8","key":"D6CP02473D\/cit44\/1","doi-asserted-by":"publisher","first-page":"5416","DOI":"10.1039\/c7sc00880e","volume":"8","author":"Prasad","year":"2017","journal-title":"Chem. Sci."},{"issue":"6","key":"D6CP02473D\/cit45\/1","doi-asserted-by":"publisher","first-page":"89","DOI":"10.55218\/jasr.202213615","volume":"13","author":"Mathew","year":"2022","journal-title":"J. Adv. Sci. Res."},{"key":"D6CP02473D\/cit46\/1","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1021\/acs.biochem.5c00222","volume":"64","author":"Ahari","year":"2025","journal-title":"Biochemistry"},{"issue":"4","key":"D6CP02473D\/cit47\/1","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1111\/j.1751-1097.1989.tb09183.x","volume":"49","author":"Tallmadge","year":"1989","journal-title":"Photochem. Photobiol."},{"issue":"5","key":"D6CP02473D\/cit48\/1","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1073\/pnas.69.5.1151","volume":"69","author":"Imoto","year":"1971","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"D6CP02473D\/cit49\/1","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/s00249-004-0402-7","volume":"33","author":"Raghuraman","year":"2004","journal-title":"Eur. Biophys. J."},{"issue":"1\u20132","key":"D6CP02473D\/cit50\/1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.bbamem.2004.06.008","volume":"1665","author":"Raghuraman","year":"2004","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"issue":"6","key":"D6CP02473D\/cit51\/1","doi-asserted-by":"publisher","first-page":"89","DOI":"10.55218\/jasr.202213615","volume":"13","author":"Mathew","year":"2022","journal-title":"J. Adv. Sci. Res."},{"key":"D6CP02473D\/cit52\/1","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/jp970217o","volume":"101","author":"Valentine","year":"1997","journal-title":"J. Phys. Chem. B"},{"issue":"10","key":"D6CP02473D\/cit53\/1","doi-asserted-by":"publisher","first-page":"3704","DOI":"10.1529\/biophysj.105.078980","volume":"90","author":"Duy","year":"2006","journal-title":"Biophys. J."},{"issue":"47","key":"D6CP02473D\/cit54\/1","doi-asserted-by":"publisher","first-page":"22655","DOI":"10.1021\/jp053757r","volume":"109","author":"Banerjee","year":"2005","journal-title":"J. Phys. Chem. B"},{"issue":"27","key":"D6CP02473D\/cit55\/1","doi-asserted-by":"publisher","first-page":"23759","DOI":"10.1021\/acsomega.2c02424","volume":"7","author":"Koppal","year":"2022","journal-title":"ACS Omega"},{"issue":"4","key":"D6CP02473D\/cit56\/1","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1093\/jb\/mvm057","volume":"141","author":"Hameed","year":"2007","journal-title":"J. Biochem."},{"issue":"3","key":"D6CP02473D\/cit57\/1","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.bbapap.2007.01.002","volume":"1774","author":"Gasymov","year":"2007","journal-title":"Biochim. Biophys. Acta Proteins Proteomics"},{"issue":"5","key":"D6CP02473D\/cit58\/1","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1016\/S0006-3495(01)76183-8","volume":"80","author":"Vivian","year":"2001","journal-title":"Biophys. J."},{"key":"D6CP02473D\/cit59\/1","doi-asserted-by":"publisher","first-page":"2977","DOI":"10.1111\/1541-4337.13169","author":"Chen","year":"2023","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"D6CP02473D\/cit60\/1","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.molliq.2024.124571","author":"Sun","year":"2024","journal-title":"J. Mol. Liq."},{"issue":"1","key":"D6CP02473D\/cit61\/1","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/S0014-5793(97)01172-1","volume":"416","author":"Hoshino","year":"1997","journal-title":"FEBS Lett."},{"issue":"6","key":"D6CP02473D\/cit62\/1","doi-asserted-by":"publisher","first-page":"4318","DOI":"10.1039\/c7sc00586e","volume":"8","author":"Li","year":"2017","journal-title":"Chem. Sci."},{"issue":"5\u20136","key":"D6CP02473D\/cit63\/1","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1002\/bip.20834","volume":"87","author":"Kar","year":"2007","journal-title":"Biopolymers"},{"issue":"4","key":"D6CP02473D\/cit64\/1","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1002\/bip.20014","volume":"73","author":"Kundu","year":"2004","journal-title":"Biopolymers"},{"issue":"2","key":"D6CP02473D\/cit65\/1","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1006\/jmbi.2001.5122","volume":"314","author":"Bai","year":"2001","journal-title":"J. Mol. Biol."},{"key":"D6CP02473D\/cit66\/1","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1002\/pro.3015","author":"Malhotra","year":"2016","journal-title":"Protein Sci."},{"issue":"19","key":"D6CP02473D\/cit67\/1","doi-asserted-by":"publisher","first-page":"6312","DOI":"10.1021\/jp2008978","volume":"115","author":"Anand","year":"2011","journal-title":"J. Phys. Chem. B"},{"issue":"4","key":"D6CP02473D\/cit68\/1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0006-3495(87)83384-2","volume":"51","author":"Alcala","year":"1987","journal-title":"Biophys. J."},{"key":"D6CP02473D\/cit69\/1","first-page":"3738","volume":"25","author":"Formoso","year":"1975","journal-title":"J. Biol. Chem."},{"issue":"8","key":"D6CP02473D\/cit70\/1","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.jlumin.2010.03.011","volume":"130","author":"Evale","year":"2010","journal-title":"J. Lumin."},{"issue":"7","key":"D6CP02473D\/cit71\/1","doi-asserted-by":"publisher","first-page":"e40845","DOI":"10.1371\/journal.pone.0040845","volume":"7","author":"Kuznetsova","year":"2012","journal-title":"PLoS One"},{"issue":"5","key":"D6CP02473D\/cit72\/1","doi-asserted-by":"crossref","first-page":"L39","DOI":"10.1529\/biophysj.106.088773","volume":"91","author":"Chen","year":"2006","journal-title":"Biophys. J."},{"key":"D6CP02473D\/cit73\/1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jphotobiol.2016.05.007","volume":"161","author":"Panja","year":"2016","journal-title":"J. Photochem. Photobiol., B"},{"issue":"8","key":"D6CP02473D\/cit74\/1","doi-asserted-by":"crossref","first-page":"e23020","DOI":"10.1002\/bip.23020","volume":"107","author":"Durell","year":"2017","journal-title":"Biopolymers"}],"container-title":["Physical Chemistry Chemical Physics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/CP\/article-pdf\/doi\/10.1039\/D6CP02473D\/0\/D6CP02473D.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:42:39Z","timestamp":1791981759000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/CP\/article-lookup\/doi\/10.1039\/D6CP02473D"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":74,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2026,10,14]]}},"URL":"https:\/\/doi.org\/10.1039\/d6cp02473d","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D6CP02473D\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6CP02473D\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6CP02473D\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6CP02473D\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6CP02473D\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6CP02473D\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1463-9076","1463-9084"],"issn-type":[{"value":"1463-9076","type":"print"},{"value":"1463-9084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}