{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T19:47:31Z","timestamp":1782935251986,"version":"3.54.5"},"reference-count":73,"publisher":"Royal Society of Chemistry (RSC)","issue":"25","license":[{"start":{"date-parts":[[2027,6,11]],"date-time":"2027-06-11T00:00:00Z","timestamp":1812672000000},"content-version":"am","delay-in-days":526,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100020584","name":"Raunv\u00edsindastofnun, H\u00e1sk\u00f3li \u00cdslands","doi-asserted-by":"publisher","award":["KKD-2025"],"award-info":[{"award-number":["KKD-2025"]}],"id":[{"id":"10.13039\/501100020584","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Dalton Trans."],"abstract":"<jats:p>\n                    Anticancer agents based on organotin(\n                    <jats:sc>iv<\/jats:sc>\n                    ) complexes that may offer different DNA-targeting mechanisms of action, which could overcome the limitations of cisplatin.\n                  <\/jats:p>","DOI":"10.1039\/d6dt00812g","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T09:43:10Z","timestamp":1781170990000},"page":"9767-9781","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Organotin(\n                    <scp>iv<\/scp>\n                    ) compounds with potent cytotoxicity, DNA damage, cell cycle arrest, and pro-apoptotic effects"],"prefix":"10.1039","volume":"55","author":[{"given":"Shubham","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Chemistry, Science Institute, University of Iceland, 107, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margr\u00e9t H.","family":"\u00d6gmundsd\u00f3ttir","sequence":"additional","affiliation":[{"name":"Biomedical Center, Faculty of Medicine, University of Iceland, Sturlugata 8, 102, Reykjavik, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5976-5970","authenticated-orcid":false,"given":"Helga M.","family":"\u00d6gmundsd\u00f3ttir","sequence":"additional","affiliation":[{"name":"Biomedical Center, Faculty of Medicine, University of Iceland, Sturlugata 8, 102, Reykjavik, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2492-1456","authenticated-orcid":false,"given":"Snorri Th.","family":"Sigurdsson","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Science Institute, University of Iceland, 107, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9741-2997","authenticated-orcid":false,"given":"Krishna K.","family":"Damodaran","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Science Institute, University of Iceland, 107, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6DT00812G\/cit1\/1","first-page":"229","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"D6DT00812G\/cit2\/1","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.3390\/ijms21093233","volume":"21","author":"Bukowski","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"D6DT00812G\/cit3\/1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2147\/DDDT.S119488","volume":"11","author":"Ndagi","year":"2017","journal-title":"Drug Des., Dev. Ther."},{"key":"D6DT00812G\/cit4\/1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1595\/003214079X2339098","volume":"23","author":"Wiltshaw","year":"1979","journal-title":"Platinum Met. Rev."},{"key":"D6DT00812G\/cit5\/1","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s00280-016-2976-z","volume":"77","author":"Dilruba","year":"2016","journal-title":"Cancer Chemother. Pharmacol."},{"key":"D6DT00812G\/cit6\/1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nm.4291","volume":"23","author":"Bruno","year":"2017","journal-title":"Nat. Med."},{"key":"D6DT00812G\/cit7\/1","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1039\/D2CS00757F","volume":"52","author":"Peng","year":"2023","journal-title":"Chem. Soc. Rev."},{"key":"D6DT00812G\/cit8\/1","doi-asserted-by":"crossref","first-page":"e202406392","DOI":"10.1002\/anie.202406392","volume":"63","author":"Li","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6DT00812G\/cit9\/1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41568-020-00308-y","volume":"21","author":"Rottenberg","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"D6DT00812G\/cit10\/1","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1021\/acs.chemrev.0c00383","volume":"121","author":"Ward","year":"2021","journal-title":"Chem. Rev."},{"key":"D6DT00812G\/cit11\/1","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1021\/acs.chemrev.8b00271","volume":"119","author":"Kenny","year":"2019","journal-title":"Chem. Rev."},{"key":"D6DT00812G\/cit12\/1","doi-asserted-by":"crossref","first-page":"e202204866","DOI":"10.1002\/anie.202204866","volume":"61","author":"Xiong","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6DT00812G\/cit13\/1","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.3390\/pharmaceutics13101540","volume":"13","author":"Rubio","year":"2021","journal-title":"Pharmaceutics"},{"key":"D6DT00812G\/cit14\/1","doi-asserted-by":"crossref","first-page":"954","DOI":"10.3390\/pharmaceutics14050954","volume":"14","author":"Ferraro","year":"2022","journal-title":"Pharmaceutics"},{"key":"D6DT00812G\/cit15\/1","doi-asserted-by":"crossref","first-page":"e202205900","DOI":"10.1002\/anie.202205900","volume":"61","author":"Amarsy","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6DT00812G\/cit16\/1","doi-asserted-by":"crossref","first-page":"5805","DOI":"10.1021\/acs.jmedchem.7b01689","volume":"61","author":"Thota","year":"2018","journal-title":"J. Med. Chem."},{"key":"D6DT00812G\/cit17\/1","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1039\/C5DT03919C","volume":"45","author":"Allardyce","year":"2016","journal-title":"Dalton Trans."},{"key":"D6DT00812G\/cit18\/1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s12672-021-00439-0","volume":"12","author":"Abdalbari","year":"2021","journal-title":"Discover Oncol."},{"key":"D6DT00812G\/cit19\/1","doi-asserted-by":"crossref","first-page":"657599","DOI":"10.3389\/fchem.2021.657599","volume":"9","author":"Syed Annuar","year":"2021","journal-title":"Front. Chem."},{"key":"D6DT00812G\/cit20\/1","doi-asserted-by":"crossref","first-page":"5841","DOI":"10.3390\/molecules28155841","volume":"28","author":"Abd Aziz","year":"2023","journal-title":"Molecules"},{"key":"D6DT00812G\/cit21\/1","doi-asserted-by":"crossref","first-page":"100955","DOI":"10.1016\/j.rechem.2023.100955","volume":"5","author":"Joshi","year":"2023","journal-title":"Results Chem."},{"key":"D6DT00812G\/cit22\/1","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1021\/acs.jmedchem.4c01728","volume":"68","author":"Sharma","year":"2025","journal-title":"J. Med. Chem."},{"key":"D6DT00812G\/cit23\/1","doi-asserted-by":"crossref","first-page":"921","DOI":"10.2174\/187152011797927670","volume":"11","author":"Lima","year":"2011","journal-title":"Adv. Anticancer Agents Med. Chem."},{"key":"D6DT00812G\/cit24\/1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.2174\/1871520617666171106125114","volume":"18","author":"Jai","year":"2018","journal-title":"Adv. Anticancer Agents Med. Chem."},{"key":"D6DT00812G\/cit25\/1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s40995-016-0048-1","volume":"42","author":"Ali","year":"2018","journal-title":"Iran. J. Sci. Technol., Trans. A: Sci."},{"key":"D6DT00812G\/cit26\/1","doi-asserted-by":"crossref","first-page":"119464","DOI":"10.1016\/j.ica.2020.119464","volume":"505","author":"Khan","year":"2020","journal-title":"Inorg. Chim. Acta"},{"key":"D6DT00812G\/cit27\/1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0010-8545(89)80003-7","volume":"95","author":"Saxena","year":"1989","journal-title":"Coord. Chem. Rev."},{"key":"D6DT00812G\/cit28\/1","doi-asserted-by":"crossref","first-page":"13119","DOI":"10.1039\/D2DT01127A","volume":"51","author":"Balogov\u00e1","year":"2022","journal-title":"Dalton Trans."},{"key":"D6DT00812G\/cit29\/1","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/med.21278","volume":"33","author":"Sheng","year":"2013","journal-title":"Med. Res. Rev."},{"key":"D6DT00812G\/cit30\/1","doi-asserted-by":"crossref","first-page":"1474337","DOI":"10.3389\/fphar.2024.1474337","volume":"15","author":"Qian","year":"2024","journal-title":"Front. Pharmacol."},{"key":"D6DT00812G\/cit31\/1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.2478\/raon-2019-0018","volume":"53","author":"Makovec","year":"2019","journal-title":"Radiol. Oncol."},{"key":"D6DT00812G\/cit32\/1","doi-asserted-by":"crossref","first-page":"16092","DOI":"10.1021\/ja062851y","volume":"128","author":"Komeda","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"D6DT00812G\/cit33\/1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0010-8545(98)00268-9","volume":"185\u2013186","author":"Yang","year":"1999","journal-title":"Coord. Chem. Rev."},{"key":"D6DT00812G\/cit34\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1021\/jm100020w","volume":"54","author":"Gasser","year":"2011","journal-title":"J. Med. Chem."},{"key":"D6DT00812G\/cit35\/1","doi-asserted-by":"crossref","first-page":"15964","DOI":"10.1039\/D5DT01567G","volume":"54","author":"Castro-Ram\u00edrez","year":"2025","journal-title":"Dalton Trans."},{"key":"D6DT00812G\/cit36\/1","doi-asserted-by":"crossref","first-page":"7314","DOI":"10.3390\/ijms25137314","volume":"25","author":"Andr\u00e9s","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"D6DT00812G\/cit37\/1","doi-asserted-by":"crossref","first-page":"7268","DOI":"10.1021\/ic061354f","volume":"46","author":"Gerasimchuk","year":"2007","journal-title":"Inorg. Chem."},{"key":"D6DT00812G\/cit38\/1","doi-asserted-by":"crossref","first-page":"14609","DOI":"10.1002\/anie.202005758","volume":"59","author":"Hanif","year":"2020","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6DT00812G\/cit39\/1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/cmdc.201800693","volume":"14","author":"Rodriguez","year":"2019","journal-title":"ChemMedChem"},{"key":"D6DT00812G\/cit40\/1","doi-asserted-by":"crossref","first-page":"9764","DOI":"10.1021\/jm501105n","volume":"57","author":"Smith","year":"2014","journal-title":"J. Med. Chem."},{"key":"D6DT00812G\/cit41\/1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000502979","volume":"98","author":"King","year":"2019","journal-title":"Oncology"},{"key":"D6DT00812G\/cit42\/1","doi-asserted-by":"crossref","first-page":"428","DOI":"10.2165\/00003495-199142030-00006","volume":"42","author":"Dechant","year":"1991","journal-title":"Drugs"},{"key":"D6DT00812G\/cit43\/1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41389-020-00295-7","volume":"10","author":"Huang","year":"2021","journal-title":"Oncogenesis"},{"key":"D6DT00812G\/cit44\/1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00109-023-02414-4","volume":"102","author":"Karsa","year":"2024","journal-title":"J. Mol. Med."},{"key":"D6DT00812G\/cit45\/1","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1200\/JCO.1994.12.6.1126","volume":"12","author":"Loprinzi","year":"1994","journal-title":"J. Clin. Oncol."},{"key":"D6DT00812G\/cit46\/1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/1097-0142(19870201)59:3<406::AID-CNCR2820590309>3.0.CO;2-W","volume":"59","author":"Chlebowski","year":"1987","journal-title":"Cancer"},{"key":"D6DT00812G\/cit47\/1","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.3891\/acta.chem.scand.23-1061","volume":"23","author":"Anthoni","year":"1969","journal-title":"Acta Chem. Scand."},{"key":"D6DT00812G\/cit48\/1","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1016\/j.poly.2008.07.022","volume":"27","author":"How","year":"2008","journal-title":"Polyhedron"},{"key":"D6DT00812G\/cit49\/1","first-page":"1862","volume":"50","author":"Sair","year":"2022","journal-title":"Mater. Today: Proc."},{"key":"D6DT00812G\/cit50\/1","doi-asserted-by":"crossref","first-page":"e5815","DOI":"10.1002\/aoc.5815","volume":"34","author":"Devi","year":"2020","journal-title":"Appl. Organomet. Chem."},{"key":"D6DT00812G\/cit51\/1","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1590\/S0103-50532009000800006","volume":"20","author":"de Sousa","year":"2009","journal-title":"J. Braz. Chem. Soc."},{"key":"D6DT00812G\/cit52\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S2053229614024218","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Crystallogr., Sect. C: Cryst. Struct. Commun."},{"key":"D6DT00812G\/cit53\/1","doi-asserted-by":"crossref","first-page":"e202400351","DOI":"10.1002\/cplu.202400351","volume":"89","author":"Kristinsson","year":"2024","journal-title":"ChemPlusChem"},{"key":"D6DT00812G\/cit54\/1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.ccr.2017.01.002","volume":"352","author":"Levina","year":"2017","journal-title":"Coord. Chem. Rev."},{"key":"D6DT00812G\/cit55\/1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/978-1-61779-080-5_20","volume-title":"Cancer Cell Culture: Methods and Protocols","author":"van Meerloo","year":"2011","unstructured":"J.van Meerloo ,  G. J. L.Kaspers  and  J.Cloos , in  Cancer Cell Culture: Methods and Protocols , ed.  I. A. Cree ,  Humana Press ,  Totowa, NJ ,  2011 , pp.  237\u2013245"},{"key":"D6DT00812G\/cit56\/1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1517\/17460441.2012.714363","volume":"7","author":"Arnott","year":"2012","journal-title":"Expert Opin. Drug Discovery"},{"key":"D6DT00812G\/cit57\/1","doi-asserted-by":"crossref","first-page":"111544","DOI":"10.1016\/j.ejmech.2019.07.047","volume":"181","author":"Ullah","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"D6DT00812G\/cit58\/1","doi-asserted-by":"crossref","first-page":"19475","DOI":"10.1021\/acs.jmedchem.4c01806","volume":"67","author":"Choroba","year":"2024","journal-title":"J. Med. Chem."},{"key":"D6DT00812G\/cit59\/1","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41416-022-02020-0","volume":"128","author":"N\u00f6ssing","year":"2023","journal-title":"Br. J. Cancer"},{"key":"D6DT00812G\/cit60\/1","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1021\/acs.jmedchem.6b01243","volume":"60","author":"Dharmaraja","year":"2017","journal-title":"J. Med. Chem."},{"key":"D6DT00812G\/cit61\/1","doi-asserted-by":"crossref","first-page":"20011","DOI":"10.1021\/acs.jmedchem.5c00523","volume":"68","author":"Kar","year":"2025","journal-title":"J. Med. Chem."},{"key":"D6DT00812G\/cit62\/1","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1039\/D5MD00235D","volume":"16","author":"Jug","year":"2025","journal-title":"RSC Med. Chem."},{"key":"D6DT00812G\/cit63\/1","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1021\/acs.jmedchem.3c01276","volume":"67","author":"Gonzalo-Navarro","year":"2024","journal-title":"J. Med. Chem."},{"key":"D6DT00812G\/cit64\/1","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1021\/acs.jmedchem.2c01374","volume":"66","author":"Romani","year":"2023","journal-title":"J. Med. Chem."},{"key":"D6DT00812G\/cit65\/1","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1021\/cr900134a","volume":"109","author":"Haas","year":"2009","journal-title":"Chem. Rev."},{"key":"D6DT00812G\/cit66\/1","doi-asserted-by":"crossref","first-page":"123442","DOI":"10.1016\/j.molliq.2023.123442","volume":"391","author":"Pooyan","year":"2023","journal-title":"J. Mol. Liq."},{"key":"D6DT00812G\/cit67\/1","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1039\/D3NJ04401G","volume":"48","author":"Paul","year":"2024","journal-title":"New J. Chem."},{"key":"D6DT00812G\/cit68\/1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0022-328X(86)80450-8","volume":"315","author":"Hole\u010dek","year":"1986","journal-title":"J. Organomet. Chem."},{"key":"D6DT00812G\/cit69\/1","doi-asserted-by":"crossref","first-page":"19153","DOI":"10.1021\/acs.jmedchem.5c01229","volume":"68","author":"Pathi","year":"2025","journal-title":"J. Med. Chem."},{"key":"D6DT00812G\/cit70a\/1","doi-asserted-by":"publisher","year":"2026","unstructured":"CCDC 2530292: Experimental Crystal Structure Determination ,  2026 ,  10.5517\/ccdc.csd.cc2qxzbz","DOI":"10.5517\/ccdc.csd.cc2qxzbz"},{"key":"D6DT00812G\/cit70b\/1","doi-asserted-by":"publisher","year":"2026","unstructured":"CCDC 2530293: Experimental Crystal Structure Determination ,  2026 ,  10.5517\/ccdc.csd.cc2qxzc0","DOI":"10.5517\/ccdc.csd.cc2qxzc0"},{"key":"D6DT00812G\/cit70c\/1","doi-asserted-by":"publisher","year":"2026","unstructured":"CCDC 2530294: Experimental Crystal Structure Determination ,  2026 ,  10.5517\/ccdc.csd.cc2qxzd1","DOI":"10.5517\/ccdc.csd.cc2qxzd1"},{"key":"D6DT00812G\/cit70d\/1","doi-asserted-by":"publisher","year":"2026","unstructured":"CCDC 2530295: Experimental Crystal Structure Determination ,  2026 ,  10.5517\/ccdc.csd.cc2qxzf2","DOI":"10.5517\/ccdc.csd.cc2qxzf2"}],"container-title":["Dalton Transactions"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/DT\/D6DT00812G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:06:43Z","timestamp":1782929203000},"score":1,"resource":{"primary":{"URL":"https:\/\/xlink.rsc.org\/?DOI=D6DT00812G"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":73,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1039\/d6dt00812g","relation":{},"ISSN":["1477-9226","1477-9234"],"issn-type":[{"value":"1477-9226","type":"print"},{"value":"1477-9234","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}