{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:48:53Z","timestamp":1791830933597,"version":"4.3.4"},"reference-count":53,"publisher":"Royal Society of Chemistry (RSC)","issue":"12","license":[{"start":{"date-parts":[[2027,5,27]],"date-time":"2027-05-27T00:00:00Z","timestamp":1811376000000},"content-version":"am","delay-in-days":511,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>Chronic kidney disease (CKD) promotes metabolic dysregulation. Sulforaphane supplementation modulates metabolic pathways and antioxidant defenses, suggesting a potential therapeutic strategy to improve metabolic alterations in CKD.<\/jats:p>","DOI":"10.1039\/d6fo00047a","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T12:56:51Z","timestamp":1779886611000},"page":"5538-5547","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sulforaphane reprograms the metabolomic landscape of chronic kidney disease: insights from NMR-based metabolomics"],"prefix":"10.1039","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4957-3630","authenticated-orcid":false,"given":"Marcia","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Graduate Program in Biological Sciences \u2013 Physiology, Federal University of Rio de Janeiro (UFRJ), Carlos Chagas Filho Institute of Biophysics (CCFIB), Rio de Janeiro (RJ), Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8507-2369","authenticated-orcid":false,"given":"Ludmila F. M. F.","family":"Cardozo","sequence":"additional","affiliation":[{"name":"Graduate Program in Nutrition Sciences, Federal University Fluminense (UFF), Niter\u00f3i, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia A.","family":"Borges","sequence":"additional","affiliation":[{"name":"Graduate Program in Food, Nutrition and Health \u2013 Institute of Nutrition, State University of Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Manh\u00e3es","sequence":"additional","affiliation":[{"name":"Graduate Program in Food, Nutrition and Health \u2013 Institute of Nutrition, State University of Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline D.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Institute of Geography, State University of Rio de Janeiro (UERJ), Cabo Frio, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3395-1684","authenticated-orcid":false,"given":"Mauricio Luis","family":"Sfor\u00e7a","sequence":"additional","affiliation":[{"name":"Brazilian Biosciences National Laboratory (LNBio), Brazilian Centre for Research in Energy and Materials (CNPEM), Campinas, SP, 13083-100, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7377-8532","authenticated-orcid":false,"given":"Gustavo H.","family":"Rodrigues da Silva","sequence":"additional","affiliation":[{"name":"Brazilian Biosciences National Laboratory (LNBio), Brazilian Centre for Research in Energy and Materials (CNPEM), Campinas, SP, 13083-100, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6752-6056","authenticated-orcid":false,"given":"Denise","family":"Mafra","sequence":"additional","affiliation":[{"name":"Graduate Program in Biological Sciences \u2013 Physiology, Federal University of Rio de Janeiro (UFRJ), Carlos Chagas Filho Institute of Biophysics (CCFIB), Rio de Janeiro (RJ), Brazil"},{"name":"Graduate Program in Nutrition Sciences, Federal University Fluminense (UFF), Niter\u00f3i, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6FO00047A\/cit1\/1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41581-020-00345-8","volume":"17","author":"Mafra","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"key":"D6FO00047A\/cit2\/1","first-page":"1","volume":"3","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group","year":"2013","journal-title":"Kidney Int. Suppl."},{"key":"D6FO00047A\/cit3\/1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.freeradbiomed.2024.05.034","volume":"221","author":"Ribeiro","year":"2024","journal-title":"Free Radicals Biol. Med."},{"key":"D6FO00047A\/cit4\/1","doi-asserted-by":"crossref","first-page":"e1700665","DOI":"10.1002\/mnfr.201700665","volume":"62","author":"Housley","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"D6FO00047A\/cit5\/1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3390\/toxins17040178","volume":"17","author":"Xiao","year":"2025","journal-title":"Toxins"},{"key":"D6FO00047A\/cit6\/1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS231810407","author":"Podg\u00f3rska","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"D6FO00047A\/cit7\/1","doi-asserted-by":"crossref","first-page":"9832","DOI":"10.3390\/ijms24129832","volume":"24","author":"Santos","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"D6FO00047A\/cit8\/1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3390\/metabo9070123","volume":"9","author":"Emwas","year":"2019","journal-title":"Metabolites"},{"key":"D6FO00047A\/cit9\/1","doi-asserted-by":"publisher","DOI":"10.1039\/D5MO00018A","author":"Gupta","year":"2025","journal-title":"Mol. Omics"},{"key":"D6FO00047A\/cit10\/1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2023.115339","author":"Fonseca","year":"2023","journal-title":"J. Pharm. Biomed. Anal."},{"key":"D6FO00047A\/cit11\/1","doi-asserted-by":"publisher","DOI":"10.3389\/FENDO.2024.1406690","author":"Gan","year":"2024","journal-title":"Front. Endocrinol."},{"key":"D6FO00047A\/cit12\/1","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1039\/D5MO00019J","volume":"21","author":"Sahu","year":"2025","journal-title":"Mol. Omics"},{"key":"D6FO00047A\/cit13\/1","first-page":"2191","volume":"20","author":"World Medical Association","year":"2013","journal-title":"JAMA"},{"key":"D6FO00047A\/cit14\/1","author":"World Health Organization","year":"2000","unstructured":"World Health Organization . Obesity: preventing and managing the global epidemic. WHO Technical Report Series,  2000"},{"key":"D6FO00047A\/cit15\/1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin. Chem."},{"key":"D6FO00047A\/cit16\/1","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"D6FO00047A\/cit17\/1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"D6FO00047A\/cit18\/1","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0076-6879(90)86141-H","volume":"186","author":"Levine","year":"1990","journal-title":"Methods Enzymol."},{"key":"D6FO00047A\/cit19\/1","doi-asserted-by":"crossref","first-page":"D608","DOI":"10.1093\/nar\/gkx1089","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"D6FO00047A\/cit20\/1","doi-asserted-by":"crossref","first-page":"612","DOI":"10.4161\/epi.24710","volume":"8","author":"Rajendran","year":"2013","journal-title":"Epigenetics"},{"key":"D6FO00047A\/cit21\/1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF02310879","volume":"6","author":"Shigematsu","year":"1983","journal-title":"J. Inherited Metab. Dis."},{"key":"D6FO00047A\/cit22\/1","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/ijo.2017.70","volume":"41","author":"Pallister","year":"2017","journal-title":"Int. J. Obes."},{"key":"D6FO00047A\/cit23\/1","doi-asserted-by":"crossref","first-page":"2473506","DOI":"10.1080\/19490976.2025.2473506","volume":"17","author":"Wu","year":"2025","journal-title":"Gut Microbes"},{"key":"D6FO00047A\/cit24\/1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.2147\/DMSO.S336736","volume":"15","author":"Hu","year":"2022","journal-title":"Diabetes, Metab. Syndr. Obes."},{"key":"D6FO00047A\/cit25\/1","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1002\/jnr.22655","volume":"89","author":"Piscopo","year":"2011","journal-title":"J. Neurosci. Res."},{"key":"D6FO00047A\/cit26\/1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.brainres.2010.02.018","volume":"1324","author":"Amaral","year":"2010","journal-title":"Brain Res."},{"key":"D6FO00047A\/cit27\/1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ebiom.2016.10.013","volume":"13","author":"Zhang","year":"2016","journal-title":"EBioMedicine"},{"key":"D6FO00047A\/cit28\/1","doi-asserted-by":"crossref","first-page":"4948","DOI":"10.1111\/jcmm.13759","volume":"22","author":"Zhenyukh","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"D6FO00047A\/cit29\/1","doi-asserted-by":"publisher","DOI":"10.3389\/FNUT.2022.849767","author":"Jian","year":"2022","journal-title":"Front. Nutr."},{"key":"D6FO00047A\/cit30\/1","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.cmet.2021.03.025","volume":"33","author":"Yu","year":"2021","journal-title":"Cell Metab."},{"key":"D6FO00047A\/cit31\/1","doi-asserted-by":"crossref","first-page":"7722","DOI":"10.1021\/acsomega.2c06469","volume":"8","author":"Gupta","year":"2023","journal-title":"ACS Omega"},{"key":"D6FO00047A\/cit32\/1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.jacl.2020.06.003","volume":"14","author":"Hirayama","year":"2020","journal-title":"J. Clin. Lipidol."},{"key":"D6FO00047A\/cit33\/1","first-page":"F1087","volume":"311","author":"Spoto","year":"2016","journal-title":"Am. J. Physiol.: Regul., Integr. Comp. Physiol."},{"key":"D6FO00047A\/cit34\/1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4093\/dmj.2021.0280","volume":"46","author":"Lee","year":"2021","journal-title":"Diabetes Metab. J."},{"key":"D6FO00047A\/cit35\/1","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1080\/00365513.2021.1904282","volume":"81","author":"Lebeck","year":"2021","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"D6FO00047A\/cit36\/1","doi-asserted-by":"publisher","DOI":"10.1177\/1179551418792257","author":"Kosmas","year":"2018","journal-title":"Clin. Med. Insights:Endocrinol. Diabetes"},{"key":"D6FO00047A\/cit37\/1","doi-asserted-by":"crossref","first-page":"13066","DOI":"10.1021\/acs.jafc.1c04933","volume":"69","author":"Tian","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"D6FO00047A\/cit38\/1","doi-asserted-by":"publisher","DOI":"10.3390\/MOLECULES30081838","author":"Drevet Mulard","year":"2025","journal-title":"Molecules"},{"key":"D6FO00047A\/cit39\/1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3390\/toxins14030176","volume":"14","author":"Lohia","year":"2022","journal-title":"Toxins"},{"key":"D6FO00047A\/cit40\/1","doi-asserted-by":"crossref","first-page":"7067","DOI":"10.1039\/D5FO00761E","volume":"16","author":"Klier","year":"2025","journal-title":"Food Funct."},{"key":"D6FO00047A\/cit41\/1","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.3390\/life15091393","volume":"15","author":"Ribeiro","year":"2025","journal-title":"Life"},{"key":"D6FO00047A\/cit42\/1","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1080\/21655979.2021.1952368","volume":"12","author":"Jie Zhang","year":"2021","journal-title":"Bioengineered"},{"key":"D6FO00047A\/cit43\/1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jare.2022.11.003","volume":"52","author":"Wang","year":"2022","journal-title":"J. Adv. Res."},{"key":"D6FO00047A\/cit44\/1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s13568-020-01053-z","volume":"10","author":"Zhang","year":"2020","journal-title":"AMB Express"},{"key":"D6FO00047A\/cit45\/1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1152\/physrev.00034.2014","volume":"95","author":"Dorokhov","year":"2015","journal-title":"Physiol. Rev."},{"key":"D6FO00047A\/cit46\/1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1161\/CIRCULATIONAHA.107.698316","volume":"117","author":"Dulak","year":"2008","journal-title":"Circulation"},{"key":"D6FO00047A\/cit47\/1","doi-asserted-by":"crossref","first-page":"103247","DOI":"10.1016\/j.redox.2024.103247","volume":"75","author":"Chudy","year":"2024","journal-title":"Redox Biol."},{"key":"D6FO00047A\/cit48\/1","doi-asserted-by":"crossref","first-page":"6935","DOI":"10.1016\/j.psj.2020.09.042","volume":"99","author":"Ruan","year":"2020","journal-title":"Poult. Sci."},{"key":"D6FO00047A\/cit49\/1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.aninu.2023.04.006","volume":"14","author":"Zhang","year":"2023","journal-title":"Anim. Nutr."},{"key":"D6FO00047A\/cit50\/1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.foodchem.2014.06.091","volume":"167","author":"Wang","year":"2015","journal-title":"Food Chem."},{"key":"D6FO00047A\/cit51\/1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12929-023-00924-4","volume":"30","author":"Hung","year":"2023","journal-title":"J. Biomed. Sci."},{"key":"D6FO00047A\/cit52\/1","doi-asserted-by":"crossref","first-page":"13967","DOI":"10.1007\/s00210-025-04017-x","volume":"398","author":"Bishr","year":"2025","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"D6FO00047A\/cit53\/1","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1038\/sj.ki.5000315","volume":"69","author":"Homsi","year":"2006","journal-title":"Kidney Int."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/FO\/D6FO00047A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:24:13Z","timestamp":1782883453000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/17\/12\/5538-5547\/1224373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":53,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,6,22]]}},"URL":"https:\/\/doi.org\/10.1039\/d6fo00047a","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}