{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:23:14Z","timestamp":1783020194122,"version":"3.54.6"},"reference-count":54,"publisher":"Royal Society of Chemistry (RSC)","issue":"12","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":130,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81502808"],"award-info":[{"award-number":["81502808"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>Dihydromyricetin protects against diabetes-associated platelet hyperactivity and thrombosis through inhibition of intraplatelet ROS generation.<\/jats:p>","DOI":"10.1039\/d6fo00232c","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T06:01:58Z","timestamp":1778479318000},"page":"5491-5505","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dihydromyricetin attenuates platelet hyperactivity in HFD\/STZ-induced diabetic mice by inhibiting intraplatelet ROS generation"],"prefix":"10.1039","volume":"17","author":[{"given":"Fenglin","family":"Song","sequence":"first","affiliation":[{"name":"School of Food Science, Guangdong Pharmaceutical University, Zhongshan, Guangdong Province, 528458, China"},{"name":"Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, 999077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafang","family":"Ding","sequence":"additional","affiliation":[{"name":"School of Food Science, Guangdong Pharmaceutical University, Zhongshan, Guangdong Province, 528458, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Food Science, Guangdong Pharmaceutical University, Zhongshan, Guangdong Province, 528458, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangzhen","family":"Ge","sequence":"additional","affiliation":[{"name":"School of Food Science, Guangdong Pharmaceutical University, Zhongshan, Guangdong Province, 528458, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixue","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Food Science, Guangdong Pharmaceutical University, Zhongshan, Guangdong Province, 528458, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6902-3006","authenticated-orcid":false,"given":"Fangfang","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Food Science, Guangdong Pharmaceutical University, Zhongshan, Guangdong Province, 528458, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong Province, 510062, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren-You","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, 999077, China"},{"name":"Research Institute for Future Food, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, 999077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5615-1682","authenticated-orcid":false,"given":"Zhen-Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Food Science, Guangdong Pharmaceutical University, Zhongshan, Guangdong Province, 528458, China"},{"name":"School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6FO00232C\/cit1\/1","doi-asserted-by":"crossref","first-page":"2467383","DOI":"10.1080\/09537104.2025.2467383","volume":"36","author":"Zhang","year":"2025","journal-title":"Platelets"},{"key":"D6FO00232C\/cit2\/1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12933-018-0763-3","volume":"17","author":"Kaur","year":"2018","journal-title":"Cardiovasc. Diabetol."},{"key":"D6FO00232C\/cit3\/1","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.3390\/nu16213717","volume":"16","author":"Duttaroy","year":"2024","journal-title":"Nutrients"},{"key":"D6FO00232C\/cit4\/1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ecl.2021.05.005","volume":"50","author":"Crasto","year":"2021","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"D6FO00232C\/cit5\/1","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.jdiacomp.2015.04.005","volume":"29","author":"Papazafiropoulou","year":"2015","journal-title":"J. Diabetes Complications"},{"key":"D6FO00232C\/cit6\/1","first-page":"e13508","volume":"74","author":"Wang","year":"2020","journal-title":"Int. J. Clin. Pract."},{"key":"D6FO00232C\/cit7\/1","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1111\/j.1538-7836.2004.00836.x","volume":"2","author":"Ferroni","year":"2004","journal-title":"J. Thromb. Haemost."},{"key":"D6FO00232C\/cit8\/1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.4093\/dmj.2013.37.6.423","volume":"37","author":"Kim","year":"2013","journal-title":"Diabetes Metab. J."},{"key":"D6FO00232C\/cit9\/1","doi-asserted-by":"crossref","first-page":"1221438","DOI":"10.3389\/fnut.2023.1221438","volume":"10","author":"Das","year":"2023","journal-title":"Front. Nutr."},{"key":"D6FO00232C\/cit10\/1","doi-asserted-by":"crossref","first-page":"706","DOI":"10.3390\/antiox10050706","volume":"10","author":"Vaidya","year":"2021","journal-title":"Antioxidants"},{"key":"D6FO00232C\/cit11\/1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.2337\/dc06-1625","volume":"30","author":"Geisler","year":"2007","journal-title":"Diabetes Care"},{"key":"D6FO00232C\/cit12\/1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.freeradbiomed.2014.12.010","volume":"80","author":"Santilli","year":"2015","journal-title":"Free Radicals Biol. Med."},{"key":"D6FO00232C\/cit13\/1","first-page":"e14476","volume":"46","author":"Das","year":"2022","journal-title":"J. Food Biochem."},{"key":"D6FO00232C\/cit14\/1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s12013-015-0612-x","volume":"73","author":"Zhang","year":"2015","journal-title":"Cell Biochem. Biophys."},{"key":"D6FO00232C\/cit15\/1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.fct.2018.01.022","volume":"113","author":"Santhakumar","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"D6FO00232C\/cit16\/1","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1039\/D2FO03958C","volume":"14","author":"Zhou","year":"2023","journal-title":"Food Funct."},{"key":"D6FO00232C\/cit17\/1","doi-asserted-by":"crossref","first-page":"1663245","DOI":"10.3389\/fnut.2025.1663245","volume":"12","author":"Bi","year":"2025","journal-title":"Front. Nutr."},{"key":"D6FO00232C\/cit18\/1","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.foodchem.2014.09.090","volume":"172","author":"Ye","year":"2015","journal-title":"Food Chem."},{"key":"D6FO00232C\/cit19\/1","doi-asserted-by":"crossref","first-page":"1053617","DOI":"10.1155\/2017\/1053617","author":"Li","year":"2017","journal-title":"J. Evidence-Based Complementary Altern. Med."},{"key":"D6FO00232C\/cit20\/1","doi-asserted-by":"crossref","first-page":"105540","DOI":"10.1016\/j.phrs.2021.105540","volume":"167","author":"Chen","year":"2021","journal-title":"Pharmacol. Res."},{"key":"D6FO00232C\/cit21\/1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3390\/nu12010220","volume":"12","author":"Yuan","year":"2020","journal-title":"Nutrients"},{"key":"D6FO00232C\/cit22\/1","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.4014\/jmb.2406.06048","volume":"34","author":"Kang","year":"2024","journal-title":"J. Microbiol. Biotechnol."},{"key":"D6FO00232C\/cit23\/1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1080\/10495398.2021.2006204","volume":"33","author":"Guo","year":"2022","journal-title":"Anim. Biotechnol."},{"key":"D6FO00232C\/cit24\/1","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1160\/th13-12-1002","volume":"112","author":"Song","year":"2014","journal-title":"Thromb. Haemostasis"},{"key":"D6FO00232C\/cit25\/1","doi-asserted-by":"crossref","first-page":"e37323","DOI":"10.1371\/journal.pone.0037323","volume":"7","author":"Yang","year":"2012","journal-title":"PLoS One"},{"key":"D6FO00232C\/cit26\/1","doi-asserted-by":"crossref","first-page":"1255069","DOI":"10.3389\/fphar.2023.1255069","volume":"14","author":"Ye","year":"2023","journal-title":"Front. Pharmacol."},{"key":"D6FO00232C\/cit27\/1","doi-asserted-by":"crossref","first-page":"932","DOI":"10.2337\/db18-0981","volume":"68","author":"Fidler","year":"2019","journal-title":"Diabetes"},{"key":"D6FO00232C\/cit28\/1","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.3390\/biomedicines12071493","volume":"12","author":"Baneu","year":"2024","journal-title":"Biomedicines"},{"key":"D6FO00232C\/cit29\/1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1515\/jccm-2015-0021","volume":"2","author":"Marginean","year":"2016","journal-title":"J. Crit. Care Med."},{"key":"D6FO00232C\/cit30\/1","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1182\/blood-2017-03-773614","volume":"130","author":"Durrant","year":"2017","journal-title":"Blood"},{"key":"D6FO00232C\/cit31\/1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cca.2008.09.018","volume":"399","author":"Ferroni","year":"2009","journal-title":"Clin. Chim. Acta"},{"key":"D6FO00232C\/cit32\/1","first-page":"87","volume":"97","author":"Halushka","year":"1981","journal-title":"J. Lab. Clin. Med."},{"key":"D6FO00232C\/cit33\/1","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1161\/01.ATV.17.11.2309","volume":"17","author":"Patrono","year":"1997","journal-title":"Arterioscler., Thromb., Vasc. Biol."},{"key":"D6FO00232C\/cit34\/1","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1001\/jama.287.19.2570","volume":"287","author":"Beckman","year":"2002","journal-title":"J. Am. Med. Assoc."},{"key":"D6FO00232C\/cit35\/1","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1056\/NEJMoa0802987","volume":"358","author":"Group","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"D6FO00232C\/cit36\/1","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1111\/dom.15511","volume":"26","author":"Kunutsor","year":"2024","journal-title":"Diabetes. Obes. Metab."},{"key":"D6FO00232C\/cit37\/1","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.biopha.2017.07.121","volume":"94","author":"Gaiz","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"D6FO00232C\/cit38\/1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.diabres.2009.01.011","volume":"84","author":"Henry","year":"2009","journal-title":"Diabetes Res. Clin. Pract."},{"key":"D6FO00232C\/cit39\/1","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.2337\/diacare.24.8.1476","volume":"24","author":"Vinik","year":"2001","journal-title":"Diabetes Care"},{"key":"D6FO00232C\/cit40\/1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s12265-013-9449-0","volume":"6","author":"Rollini","year":"2013","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"D6FO00232C\/cit41\/1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.4239\/wjd.v6.i3.423","volume":"6","author":"Kubisz","year":"2015","journal-title":"World J. Diabetes"},{"key":"D6FO00232C\/cit42\/1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.thromres.2009.11.023","volume":"125","author":"Kowalska","year":"2010","journal-title":"Thromb. Res."},{"key":"D6FO00232C\/cit43\/1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1161\/01.CIR.103.4.491","volume":"103","author":"Ridker","year":"2001","journal-title":"Circulation"},{"key":"D6FO00232C\/cit44\/1","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.2337\/dc13-2718","volume":"37","author":"Israels","year":"2014","journal-title":"Diabetes Care"},{"key":"D6FO00232C\/cit45\/1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/09533710022149395","volume":"13","author":"Wachowicz","year":"2002","journal-title":"Platelets"},{"key":"D6FO00232C\/cit46\/1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.thromres.2011.11.052","volume":"129","author":"Vazzana","year":"2012","journal-title":"Thromb. Res."},{"key":"D6FO00232C\/cit47\/1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0008-6363(00)00118-8","volume":"47","author":"Mezzetti","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"D6FO00232C\/cit48\/1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1475-2840-10-43","volume":"10","author":"Gibson","year":"2011","journal-title":"Cardiovasc. Diabetol."},{"key":"D6FO00232C\/cit49\/1","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1161\/CIRCULATIONAHA.113.005224","volume":"129","author":"Tang","year":"2014","journal-title":"Circulation"},{"key":"D6FO00232C\/cit50\/1","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1161\/ATVBAHA.116.307308","volume":"36","author":"Delaney","year":"2016","journal-title":"Arterioscler., Thromb., Vasc. Biol."},{"key":"D6FO00232C\/cit51\/1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s11239-017-1594-x","volume":"45","author":"Ebara","year":"2018","journal-title":"J. Thromb. Thrombolysis"},{"key":"D6FO00232C\/cit52\/1","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1007\/s10068-018-0469-z","volume":"27","author":"Kim","year":"2018","journal-title":"Food Sci. Biotechnol."},{"key":"D6FO00232C\/cit53\/1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ddtec.2010.06.003","volume":"7","author":"Miao","year":"2010","journal-title":"Drug Discovery Today: Dis. Models"},{"key":"D6FO00232C\/cit54\/1","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/s41430-018-0282-z","volume":"73","author":"Ran","year":"2019","journal-title":"Eur. J. Clin. Nutr."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/FO\/D6FO00232C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:01:55Z","timestamp":1783015315000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/17\/12\/5491-5505\/1223843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":54,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,6,22]]}},"URL":"https:\/\/doi.org\/10.1039\/d6fo00232c","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}