{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:14:23Z","timestamp":1788362063612,"version":"build-2803163510"},"reference-count":45,"publisher":"Royal Society of Chemistry (RSC)","issue":"17","license":[{"start":{"date-parts":[[2027,7,29]],"date-time":"2027-07-29T00:00:00Z","timestamp":1816819200000},"content-version":"am","delay-in-days":574,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-NR077274"],"award-info":[{"award-number":["RS-2023-NR077274"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>\n                    Crude proline (CP) from heat-killed\n                    <jats:italic>E. faecium<\/jats:italic>\n                    FBL1 modulated gut microbiota and attenuated curli-associated \u03b1-synuclein pathology and inflammation along the microbiota\u2013gut\u2013brain axis.\n                  <\/jats:p>","DOI":"10.1039\/d6fo02214f","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:03:45Z","timestamp":1785305025000},"page":"7670-7686","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Crude proline modulates the microbiota\u2013gut\u2013brain axis by attenuating curli-associated \u03b1-synuclein accumulation and regulating Wnt\/\u03b2-catenin signaling in Parkinson's disease"],"prefix":"10.1039","volume":"17","author":[{"given":"Dahye","family":"Song","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition, Gangseo University, 47 Kkachisan-ro 24-gil, Gangseo-gu, Seoul, 07661, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Rim","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Integrative Bioengineering, Sogang University, Seoul 04107, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Min","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Integrative Bioengineering, Sogang University, Seoul 04107, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2431-144X","authenticated-orcid":false,"given":"Jeung Hee","family":"An","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Gangseo University, 47 Kkachisan-ro 24-gil, Gangseo-gu, Seoul, 07661, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6FO02214F\/cit1\/1","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.jnutbio.2018.06.010","volume":"61","author":"Jayachandran","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"D6FO02214F\/cit2\/1","doi-asserted-by":"publisher","first-page":"140772","DOI":"10.1016\/j.foodchem.2024.140772","volume":"460","author":"Feng","year":"2024","journal-title":"Food Chem."},{"key":"D6FO02214F\/cit3\/1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s40795-022-00500-3","volume":"8","author":"Matsuoka","year":"2022","journal-title":"BMC Nutr."},{"key":"D6FO02214F\/cit4\/1","doi-asserted-by":"publisher","first-page":"3708","DOI":"10.1111\/jam.15808","volume":"133","author":"Huang","year":"2022","journal-title":"J. Appl. Microbiol."},{"key":"D6FO02214F\/cit5\/1","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1007\/s12275-024-00176-3","volume":"62","author":"Kim","year":"2024","journal-title":"J. Microbiol."},{"key":"D6FO02214F\/cit6\/1","doi-asserted-by":"publisher","first-page":"e2504020","DOI":"10.4014\/jmb.2504.04020","volume":"35","author":"Kim","year":"2025","journal-title":"J. Microbiol. Biotechnol."},{"key":"D6FO02214F\/cit7\/1","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"D6FO02214F\/cit8\/1","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.neuron.2019.05.035","volume":"103","author":"Kim","year":"2019","journal-title":"Neuron"},{"issue":"3","key":"D6FO02214F\/cit9\/1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-022-00755-1","volume":"19","author":"Wood","year":"2023","journal-title":"Nat. Rev. Neurol."},{"key":"D6FO02214F\/cit10\/1","doi-asserted-by":"publisher","first-page":"10609","DOI":"10.3748\/wjg.v21.i37.10609","volume":"21","author":"Mulak","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"D6FO02214F\/cit11\/1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41531-016-0002-0","volume":"3","author":"Houser","year":"2017","journal-title":"npj Parkinson's Dis."},{"key":"D6FO02214F\/cit12\/1","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1016\/j.cell.2016.11.018","volume":"167","author":"Sampson","year":"2016","journal-title":"Cell"},{"key":"D6FO02214F\/cit13\/1","doi-asserted-by":"publisher","first-page":"e1006654","DOI":"10.1371\/journal.ppat.1006654","volume":"13","author":"Friedland","year":"2017","journal-title":"PLoS Pathog."},{"key":"D6FO02214F\/cit14\/1","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1038\/nn.4030","volume":"18","author":"Erny","year":"2015","journal-title":"Nat. Neurosci."},{"key":"D6FO02214F\/cit15\/1","doi-asserted-by":"publisher","first-page":"3745","DOI":"10.1007\/s12035-021-02375-0","volume":"58","author":"Liang","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"D6FO02214F\/cit16\/1","doi-asserted-by":"publisher","first-page":"3367","DOI":"10.1007\/s11033-022-08038-0","volume":"50","author":"Swer","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"D6FO02214F\/cit17\/1","doi-asserted-by":"publisher","first-page":"728576","DOI":"10.3389\/fcell.2021.728576","volume":"9","author":"Patriarca","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"D6FO02214F\/cit18\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-018-0126-x","volume":"50","author":"Chelakkot","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"D6FO02214F\/cit19\/1","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"D6FO02214F\/cit20\/1","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"D6FO02214F\/cit21\/1","doi-asserted-by":"publisher","first-page":"e65088","DOI":"10.7554\/eLife.65088","volume":"10","author":"Beghini","year":"2021","journal-title":"eLife"},{"key":"D6FO02214F\/cit22\/1","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1038\/s41592-018-0176-y","volume":"15","author":"Franzosa","year":"2018","journal-title":"Nat. Methods"},{"key":"D6FO02214F\/cit23\/1","doi-asserted-by":"publisher","first-page":"R611","DOI":"10.1016\/j.cub.2015.05.040","volume":"25","author":"Segata","year":"2015","journal-title":"Curr. Biol."},{"key":"D6FO02214F\/cit24\/1","doi-asserted-by":"publisher","first-page":"525","DOI":"10.3390\/metabo12060525","volume":"12","author":"Kim","year":"2022","journal-title":"Metabolites"},{"key":"D6FO02214F\/cit25\/1","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.molcel.2014.12.025","volume":"57","author":"Evans","year":"2015","journal-title":"Mol. Cell"},{"key":"D6FO02214F\/cit26\/1","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S1474-4422(19)30356-4","volume":"19","author":"Cryan","year":"2020","journal-title":"Lancet Neurol."},{"key":"D6FO02214F\/cit27\/1","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.3390\/nu15092211","volume":"15","author":"Fusco","year":"2023","journal-title":"Nutrients"},{"key":"D6FO02214F\/cit28\/1","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1002\/mds.26307","volume":"30","author":"Keshavarzian","year":"2015","journal-title":"Mov. Disord."},{"key":"D6FO02214F\/cit29\/1","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1002\/mds.26942","volume":"32","author":"Hill-Burns","year":"2017","journal-title":"Mov. Disord."},{"key":"D6FO02214F\/cit30\/1","doi-asserted-by":"publisher","first-page":"349","DOI":"10.3233\/JAD-142841","volume":"45","author":"Friedland","year":"2015","journal-title":"J. Alzheimer's Dis."},{"key":"D6FO02214F\/cit31\/1","doi-asserted-by":"publisher","first-page":"34477","DOI":"10.1038\/srep34477","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"D6FO02214F\/cit32\/1","doi-asserted-by":"publisher","first-page":"e2106504118","DOI":"10.1073\/pnas.2106504118","volume":"118","author":"Wang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D6FO02214F\/cit33\/1","doi-asserted-by":"publisher","first-page":"e53111","DOI":"10.7554\/eLife.53111","volume":"9","author":"Sampson","year":"2020","journal-title":"eLife"},{"key":"D6FO02214F\/cit34\/1","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1111\/j.1462-5822.2010.01485.x","volume":"12","author":"T\u00fckel","year":"2010","journal-title":"Cell. Microbiol."},{"key":"D6FO02214F\/cit35\/1","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1146\/annurev.micro.60.080805.142106","volume":"60","author":"Barnhart","year":"2006","journal-title":"Annu. Rev. Microbiol."},{"key":"D6FO02214F\/cit36\/1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1742-2094-7-16","volume":"7","author":"Tanabe","year":"2010","journal-title":"J. Neuroinflammation"},{"key":"D6FO02214F\/cit37\/1","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.3390\/ijms19102973","volume":"19","author":"Bohush","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"D6FO02214F\/cit38\/1","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1111\/1440-1681.13709","volume":"49","author":"Guo","year":"2022","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"D6FO02214F\/cit39\/1","doi-asserted-by":"publisher","first-page":"10578","DOI":"10.3390\/ijms231810578","volume":"23","author":"Hong","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"D6FO02214F\/cit40\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.diff.2017.08.003","volume":"97","author":"Koch","year":"2017","journal-title":"Differentiation."},{"key":"D6FO02214F\/cit41\/1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/1750-1326-6-49","volume":"6","author":"L'Episcopo","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"D6FO02214F\/cit42\/1","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.1002\/stem.1708","volume":"32","author":"L'Episcopo","year":"2014","journal-title":"Stem Cells"},{"key":"D6FO02214F\/cit43\/1","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","volume":"169","author":"Nusse","year":"2017","journal-title":"Cell"},{"key":"D6FO02214F\/cit44\/1","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.ijbiomac.2022.12.030","volume":"226","author":"Ratih","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"D6FO02214F\/cit45\/1","doi-asserted-by":"publisher","first-page":"108292","DOI":"10.1016\/j.fbio.2026.108292","volume":"76","author":"Song","year":"2026","journal-title":"Food Biosci."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/FO\/article-pdf\/doi\/10.1039\/D6FO02214F\/0\/D6FO02214F.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T14:25:55Z","timestamp":1788359155000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/FO\/article-lookup\/doi\/10.1039\/D6FO02214F"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":45,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.1039\/d6fo02214f","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D6FO02214F\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6FO02214F\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6FO02214F\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6FO02214F\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6FO02214F\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6FO02214F\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6FO02214F\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6FO02214F\/v3\/decision1","asserted-by":"object"}]},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}