{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:02:01Z","timestamp":1790989321500,"version":"4.1.0"},"reference-count":39,"publisher":"Royal Society of Chemistry (RSC)","license":[{"start":{"date-parts":[[2027,10,3]],"date-time":"2027-10-03T00:00:00Z","timestamp":1822521600000},"content-version":"am","delay-in-days":640,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K05495"],"award-info":[{"award-number":["22K05495"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>In this study, we investigated the effects of repeated isothiocyanate (ITC) pretreatment on cytotoxicity, cytoprotective gene expression, and chromatin accessibility in rat gastric epithelial RGM1 cells.<\/jats:p>","DOI":"10.1039\/d6fo02569b","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:49:13Z","timestamp":1790988553000},"update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of repetitive pretreatment with isothiocyanates on the stress resistance capacity of RGM1 cells"],"prefix":"10.1039","author":[{"given":"Manami","family":"Takeyasu","sequence":"first","affiliation":[{"name":"Department of Food Science and Nutrition, School of Human Science and Environment, University of Hyogo, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiho","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, School of Human Science and Environment, University of Hyogo, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akari","family":"Ishisaka","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, School of Human Science and Environment, University of Hyogo, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5694-2828","authenticated-orcid":false,"given":"Akira","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, School of Human Science and Environment, University of Hyogo, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6FO02569B\/cit1\/1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3164\/jcbn.17-91","volume":"62","author":"Nakamura","year":"2018","journal-title":"J. Clin. Biochem. Nutr."},{"key":"D6FO02569B\/cit2\/1","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.3389\/fmicb.2016.01403","volume":"7","author":"Lu","year":"2016","journal-title":"Front. Microbiol."},{"key":"D6FO02569B\/cit3\/1","doi-asserted-by":"publisher","first-page":"6902","DOI":"10.3390\/molecules28196902","volume":"28","author":"Olaniyan","year":"2023","journal-title":"Molecules"},{"key":"D6FO02569B\/cit4\/1","doi-asserted-by":"publisher","first-page":"4407","DOI":"10.1021\/jf070159w","volume":"55","author":"Nakamura","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"D6FO02569B\/cit5\/1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1158\/1940-6207.CAPR-21-0353","volume":"15","author":"Bonorden","year":"2022","journal-title":"Cancer Prev. Res."},{"key":"D6FO02569B\/cit6\/1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1093\/carcin\/bgr255","volume":"33","author":"Zhang","year":"2012","journal-title":"Carcinogenesis"},{"key":"D6FO02569B\/cit7\/1","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1271\/bbb.90734","volume":"74","author":"Nakamura","year":"2010","journal-title":"Biosci., Biotechnol., Biochem."},{"key":"D6FO02569B\/cit8\/1","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1186\/1471-2407-10-269","volume":"10","author":"Xiang","year":"2010","journal-title":"BMC Cancer"},{"key":"D6FO02569B\/cit9\/1","doi-asserted-by":"publisher","first-page":"5490","DOI":"10.3892\/ol.2019.10874","volume":"18","author":"Ling","year":"2019","journal-title":"Oncol. Lett."},{"key":"D6FO02569B\/cit10\/1","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1093\/carcin\/bgr109","volume":"32","author":"Mi","year":"2011","journal-title":"Carcinogenesis"},{"key":"D6FO02569B\/cit11\/1","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1093\/carcin\/bgm208","volume":"29","author":"Keum","year":"2008","journal-title":"Carcinogenesis"},{"key":"D6FO02569B\/cit12\/1","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.fct.2017.08.006","volume":"108","author":"Liu","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"D6FO02569B\/cit13\/1","doi-asserted-by":"publisher","first-page":"3585","DOI":"10.3390\/nu12113585","volume":"12","author":"Kim","year":"2020","journal-title":"Nutrients"},{"key":"D6FO02569B\/cit14\/1","doi-asserted-by":"publisher","first-page":"3456","DOI":"10.1074\/jbc.M110244200","volume":"277","author":"Morimitsu","year":"2001","journal-title":"J. Biol. Chem."},{"key":"D6FO02569B\/cit15\/1","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1007\/s12017-008-8037-y","volume":"10","author":"Son","year":"2008","journal-title":"NeuroMol.\nMed."},{"key":"D6FO02569B\/cit16\/1","doi-asserted-by":"publisher","first-page":"e114764","DOI":"10.1371\/journal.pone.0114764","volume":"9","author":"Bao","year":"2014","journal-title":"PLoS One"},{"key":"D6FO02569B\/cit17\/1","doi-asserted-by":"publisher","first-page":"28142","DOI":"10.1038\/srep28142","volume":"6","author":"Kumar","year":"2016","journal-title":"Sci. Rep."},{"key":"D6FO02569B\/cit18\/1","doi-asserted-by":"publisher","first-page":"103074","DOI":"10.1016\/j.copbio.2023.103074","volume":"86","author":"Murakami","year":"2024","journal-title":"Curr. Opin. Biotechnol."},{"key":"D6FO02569B\/cit19\/1","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S0741-8329(01)00174-7","volume":"25","author":"Oneta","year":"2001","journal-title":"Alcohol"},{"key":"D6FO02569B\/cit20\/1","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1158\/1535-7163.MCT-10-1099","volume":"10","author":"Dos Santos","year":"2011","journal-title":"Mol. Cancer Ther."},{"key":"D6FO02569B\/cit21\/1","doi-asserted-by":"publisher","first-page":"103537","DOI":"10.1016\/j.drudis.2023.103537","volume":"28","author":"Patil","year":"2023","journal-title":"Drug Discovery Today"},{"key":"D6FO02569B\/cit22\/1","doi-asserted-by":"publisher","first-page":"23440","DOI":"10.1074\/jbc.M112.347922","volume":"287","author":"Chujo","year":"2012","journal-title":"J. Biol. Chem."},{"key":"D6FO02569B\/cit23\/1","doi-asserted-by":"publisher","first-page":"68","DOI":"10.26599\/JFB.2025.95030416","volume":"30","author":"Kawaguchi","year":"2025","journal-title":"J. Food Bioact."},{"key":"D6FO02569B\/cit24\/1","doi-asserted-by":"publisher","first-page":"e3444","DOI":"10.21769\/BioProtoc.3444","volume":"9","author":"Brook","year":"2019","journal-title":"Bio. Protoc."},{"key":"D6FO02569B\/cit25\/1","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1017\/S0007114507824093","volume":"99","author":"Hanlon","year":"2008","journal-title":"Br. J. Nutr."},{"key":"D6FO02569B\/cit26\/1","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.tem.2013.09.002","volume":"25","author":"Newman","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"D6FO02569B\/cit27\/1","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1126\/science.1227166","volume":"339","author":"Shimazu","year":"2013","journal-title":"Science"},{"key":"D6FO02569B\/cit28\/1","first-page":"219","volume":"60","author":"Nakamura","year":"2000","journal-title":"Cancer Res."},{"key":"D6FO02569B\/cit29\/1","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1101\/gad.11.9.1140","volume":"11","author":"Itoh","year":"1997","journal-title":"Genes Dev."},{"key":"D6FO02569B\/cit30\/1","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.tibs.2008.12.008","volume":"34","author":"Hayes","year":"2009","journal-title":"Trends Biochem. Sci."},{"key":"D6FO02569B\/cit31\/1","doi-asserted-by":"publisher","first-page":"e161","DOI":"10.1002\/mco2.161","volume":"3","author":"Chen","year":"2022","journal-title":"MedComm"},{"key":"D6FO02569B\/cit32\/1","doi-asserted-by":"publisher","first-page":"e58641","DOI":"10.1371\/journal.pone.0058641","volume":"8","author":"Ohnishi","year":"2013","journal-title":"PLoS One"},{"key":"D6FO02569B\/cit33\/1","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.phrs.2007.01.009","volume":"55","author":"Higdon","year":"2007","journal-title":"Pharmacol. Res."},{"key":"D6FO02569B\/cit34\/1","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1021\/tx800439x","volume":"22","author":"Nakamura","year":"2009","journal-title":"Chem. Res. Toxicol."},{"key":"D6FO02569B\/cit35\/1","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1093\/carcin\/21.6.1175","volume":"21","author":"Zhang","year":"2000","journal-title":"Carcinogenesis"},{"key":"D6FO02569B\/cit36\/1","doi-asserted-by":"publisher","first-page":"6409","DOI":"10.1158\/0008-5472.CAN-06-3761","volume":"67","author":"Mi","year":"2007","journal-title":"Cancer Res."},{"key":"D6FO02569B\/cit37\/1","doi-asserted-by":"publisher","first-page":"20299","DOI":"10.1074\/jbc.M109.000877","volume":"284","author":"Doyen","year":"2009","journal-title":"J. Biol. Chem."},{"key":"D6FO02569B\/cit38\/1","doi-asserted-by":"publisher","first-page":"2018306","DOI":"10.1155\/2018\/2018306","volume":"2018","author":"Di Fiore","year":"2018","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"D6FO02569B\/cit39\/1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12979-016-0078-8","volume":"13","author":"Trovato","year":"2016","journal-title":"Immun. Ageing"}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/FO\/article-pdf\/doi\/10.1039\/D6FO02569B\/0\/D6FO02569B.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:49:14Z","timestamp":1790988554000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/FO\/article-lookup\/doi\/10.1039\/D6FO02569B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":39,"URL":"https:\/\/doi.org\/10.1039\/d6fo02569b","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}