{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:44:31Z","timestamp":1785775471993,"version":"3.56.0"},"reference-count":53,"publisher":"Royal Society of Chemistry (RSC)","issue":"15","license":[{"start":{"date-parts":[[2027,7,15]],"date-time":"2027-07-15T00:00:00Z","timestamp":1815609600000},"content-version":"am","delay-in-days":560,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1304104"],"award-info":[{"award-number":["2022YFA1304104"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20241"],"award-info":[{"award-number":["U23A20241"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2021CFA016"],"award-info":[{"award-number":["2021CFA016"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["CARS-41"],"award-info":[{"award-number":["CARS-41"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["430070"],"award-info":[{"award-number":["430070"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>Licochalcone A, a bioactive flavonoid from licorice, may influence gut microbial composition and metabolite production.<\/jats:p>","DOI":"10.1039\/d6fo02699k","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T06:03:36Z","timestamp":1784095416000},"page":"6956-6968","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>In vitro<\/i>\n                    fermentation characteristics of licochalcone A and its regulatory effects on human gut microbiota\n                    <i>via<\/i>\n                    multi-omics analysis"],"prefix":"10.1039","volume":"17","author":[{"given":"Ali","family":"Asif","sequence":"first","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, China"},{"name":"National Reference Laboratory of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zou","family":"Ziying","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, China"},{"name":"National Reference Laboratory of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, China"},{"name":"National Reference Laboratory of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Narowal Campus, University of Veterinary and Animal Sciences, Lahore 51600, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqiong","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, Jiangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhao","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, China"},{"name":"National Reference Laboratory of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaokat","family":"Ali","sequence":"additional","affiliation":[{"name":"key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of the Ministry of Education Agriculture, Huazhong Agricultural University, Wuhan, Hubei 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mubbashar","family":"Abbas","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, China"},{"name":"National Reference Laboratory of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Tanweer","family":"Khan","sequence":"additional","affiliation":[{"name":"Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4437-7404","authenticated-orcid":false,"given":"Haihong","family":"Hao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, China"},{"name":"National Reference Laboratory of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"Department of Animal Pharmacy, Wuhan Polytechnic University, Wuhan 430023, China"},{"name":"Huazhong Agricultural University, Shenzhen Institute of Nutrition and Health, Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6FO02699K\/cit1\/1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nrmicro2974","volume":"11","author":"Sommer","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"D6FO02699K\/cit2\/1","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1056\/NEJMra1600266","volume":"375","author":"Lynch","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"D6FO02699K\/cit3\/1","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"D6FO02699K\/cit4\/1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.bcp.2017.04.033","volume":"139","author":"Esp\u00edn","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"D6FO02699K\/cit5\/1","doi-asserted-by":"crossref","first-page":"138117","DOI":"10.1016\/j.foodchem.2023.138117","volume":"442","author":"Capanoglu","year":"2024","journal-title":"Food Chem."},{"key":"D6FO02699K\/cit6\/1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241814177","volume":"24","author":"Olloquequi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"D6FO02699K\/cit7\/1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.2174\/1389557518666180601095420","volume":"19","author":"Maria Pia","year":"2019","journal-title":"Mini Rev. Med. Chem."},{"key":"D6FO02699K\/cit8\/1","doi-asserted-by":"publisher","DOI":"10.2174\/0109298673407438250928150854","author":"Ou","year":"2025","journal-title":"Curr. Med. Chem."},{"key":"D6FO02699K\/cit9\/1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26144149","volume":"26","author":"Zhang","year":"2021","journal-title":"Molecules"},{"key":"D6FO02699K\/cit10\/1","doi-asserted-by":"crossref","first-page":"1453426","DOI":"10.3389\/fphar.2024.1453426","volume":"15","author":"Liu","year":"2024","journal-title":"Front. Pharmacol."},{"key":"D6FO02699K\/cit11\/1","doi-asserted-by":"crossref","first-page":"118167","DOI":"10.1016\/j.foodres.2025.118167","volume":"228","author":"Pais","year":"2026","journal-title":"Food Res. Int."},{"key":"D6FO02699K\/cit12\/1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25010060","volume":"25","author":"Xiao","year":"2019","journal-title":"Molecules"},{"key":"D6FO02699K\/cit13\/1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s40168-024-01896-9","volume":"12","author":"Zhang","year":"2024","journal-title":"Microbiome"},{"key":"D6FO02699K\/cit14\/1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s40168-018-0470-z","volume":"6","author":"Bokulich","year":"2018","journal-title":"Microbiome"},{"key":"D6FO02699K\/cit15\/1","doi-asserted-by":"crossref","first-page":"112522","DOI":"10.1016\/j.fct.2021.112522","volume":"156","author":"Sun","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"D6FO02699K\/cit16\/1","first-page":"102089","volume":"25","author":"Ge","year":"2025","journal-title":"Food Chem.: X"},{"key":"D6FO02699K\/cit17\/1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1136\/gut.48.4.571","volume":"48","author":"Nugent","year":"2001","journal-title":"Gut"},{"key":"D6FO02699K\/cit18\/1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/s41575-025-01092-6","volume":"22","author":"Brinck","year":"2025","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"D6FO02699K\/cit19\/1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c04832","author":"Zuo","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"D6FO02699K\/cit20\/1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41538-025-00526-4","volume":"9","author":"Du","year":"2025","journal-title":"NPJ Sci. Food"},{"key":"D6FO02699K\/cit21\/1","doi-asserted-by":"publisher","DOI":"10.3390\/biology14121705","volume":"14","author":"Li","year":"2025","journal-title":"Biology"},{"key":"D6FO02699K\/cit22\/1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s41579-025-01183-w","volume":"23","author":"Mukhopadhya","year":"2025","journal-title":"Nat. Rev. Microbiol."},{"key":"D6FO02699K\/cit23\/1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41577-024-01014-8","volume":"24","author":"Mann","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"D6FO02699K\/cit24\/1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrendo.2015.128","volume":"11","author":"Canfora","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"key":"D6FO02699K\/cit25\/1","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1194\/jlr.R036012","volume":"54","author":"den Besten","year":"2013","journal-title":"J. Lipid Res."},{"key":"D6FO02699K\/cit26\/1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3389\/fimmu.2019.00277","volume":"10","author":"Parada Venegas","year":"2019","journal-title":"Front. Immunol."},{"key":"D6FO02699K\/cit27\/1","doi-asserted-by":"crossref","first-page":"2485s","DOI":"10.1093\/jn\/133.7.2485S","volume":"133","author":"Davie","year":"2003","journal-title":"J. Nutr."},{"key":"D6FO02699K\/cit28\/1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7010019","volume":"7","author":"Diether","year":"2019","journal-title":"Microorganisms"},{"key":"D6FO02699K\/cit29\/1","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1039\/C6FO01248E","volume":"7","author":"Chen","year":"2016","journal-title":"Food Funct."},{"key":"D6FO02699K\/cit30\/1","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/s42255-020-0188-7","volume":"2","author":"Frampton","year":"2020","journal-title":"Nat. Metab."},{"key":"D6FO02699K\/cit31\/1","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1111\/mmi.14905","volume":"117","author":"Hertli","year":"2022","journal-title":"Mol. Microbiol."},{"key":"D6FO02699K\/cit32\/1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jff.2019.01.032","volume":"54","author":"Herrera-Cazares","year":"2019","journal-title":"J. Funct. Foods"},{"key":"D6FO02699K\/cit33\/1","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.3390\/molecules29112574","volume":"29","author":"Dong","year":"2024","journal-title":"Molecules"},{"key":"D6FO02699K\/cit34\/1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.intimp.2009.12.013","volume":"10","author":"Kumar","year":"2010","journal-title":"Int. Immunopharmacol."},{"key":"D6FO02699K\/cit35\/1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.fmrre.2005.04.006","volume":"29","author":"Kilstrup","year":"2005","journal-title":"FEMS Microbiol. Rev."},{"key":"D6FO02699K\/cit36\/1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nri2515","volume":"9","author":"Round","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"D6FO02699K\/cit37\/1","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature12820","volume":"505","author":"David","year":"2014","journal-title":"Nature"},{"key":"D6FO02699K\/cit38\/1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3389\/fmicb.2016.00455","volume":"7","author":"Mosca","year":"2016","journal-title":"Front. Microbiol."},{"key":"D6FO02699K\/cit39\/1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.4161\/gmic.19897","volume":"3","author":"Flint","year":"2012","journal-title":"Gut Microbes"},{"key":"D6FO02699K\/cit40\/1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s40168-019-0704-8","volume":"7","author":"Oliphant","year":"2019","journal-title":"Microbiome"},{"key":"D6FO02699K\/cit41\/1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41579-021-00559-y","volume":"19","author":"Tett","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"D6FO02699K\/cit42\/1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.cmet.2015.10.001","volume":"22","author":"Kovatcheva-Datchary","year":"2015","journal-title":"Cell Metab."},{"key":"D6FO02699K\/cit43\/1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrgastro.2012.14","volume":"9","author":"Mukhopadhya","year":"2012","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"D6FO02699K\/cit44\/1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1101\/gr.126573.111","volume":"22","author":"Kostic","year":"2012","journal-title":"Genome Res."},{"key":"D6FO02699K\/cit45\/1","doi-asserted-by":"crossref","first-page":"8903","DOI":"10.1039\/D3FO00861D","volume":"14","author":"Luo","year":"2023","journal-title":"Food Funct."},{"key":"D6FO02699K\/cit46\/1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24193487","volume":"24","author":"Lim","year":"2019","journal-title":"Molecules"},{"key":"D6FO02699K\/cit47\/1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24193487","volume":"9","author":"Battista","year":"2019","journal-title":"Biomolecules"},{"key":"D6FO02699K\/cit48\/1","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s13105-023-00981-1","volume":"79","author":"Gade","year":"2023","journal-title":"J. Physiol. Biochem."},{"key":"D6FO02699K\/cit49\/1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.lfs.2015.04.008","volume":"132","author":"Zhou","year":"2015","journal-title":"Life Sci."},{"key":"D6FO02699K\/cit50\/1","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.3390\/foods13213369","volume":"13","author":"Peres Fabbri","year":"2024","journal-title":"Foods"},{"key":"D6FO02699K\/cit51\/1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3390\/foods6050032","volume":"6","author":"Daliri","year":"2017","journal-title":"Foods"},{"key":"D6FO02699K\/cit52\/1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c01622","author":"Wang","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"D6FO02699K\/cit53\/1","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.chom.2018.05.003","volume":"23","author":"Agus","year":"2018","journal-title":"Cell Host Microbe"}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/FO\/article-pdf\/doi\/10.1039\/D6FO02699K\/0\/D6FO02699K.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:47:21Z","timestamp":1785772041000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/FO\/article-lookup\/doi\/10.1039\/D6FO02699K"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":53,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2026,8,3]]}},"URL":"https:\/\/doi.org\/10.1039\/d6fo02699k","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}