{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:14:34Z","timestamp":1790010874289,"version":"4.0.1"},"reference-count":25,"publisher":"Royal Society of Chemistry (RSC)","issue":"18","license":[{"start":{"date-parts":[[2027,8,6]],"date-time":"2027-08-06T00:00:00Z","timestamp":1817510400000},"content-version":"am","delay-in-days":582,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","award":["24KJB360001"],"award-info":[{"award-number":["24KJB360001"]}],"id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>Guaijaverin alleviates high-fat diet-induced NAFLD and restores metabolic homeostasis by remodeling the gut microbiota, enhancing short-chain fatty acid (SCFA) production, and inhibiting hepatic ferroptosis.<\/jats:p>","DOI":"10.1039\/d6fo03414d","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:03:24Z","timestamp":1785974604000},"page":"8231-8243","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Guaijaverin, a guava-derived flavonoid, attenuates high-fat diet-induced MASLD\n                    <i>via<\/i>\n                    regulating the gut microbiota\u2013SCFA\u2013ferroptosis axis"],"prefix":"10.1039","volume":"17","author":[{"given":"Xuan-xuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery, Affiliated Hospital of Jiangsu University, Jiangsu, China"},{"name":"Department of Pharmacy, Jiangsu University, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Affiliated Hospital of Jiangsu University, Jiangsu, China"},{"name":"Department of Pharmacy, Jiangsu University, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-jun","family":"Hang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Affiliated Hospital of Jiangsu University, Jiangsu, China"},{"name":"Department of Pharmacy, Jiangsu University, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-zhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Affiliated Hospital of Jiangsu University, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Affiliated Hospital of Jiangsu University, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Xiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Affiliated Hospital of Jiangsu University, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Affiliated Hospital of Jiangsu University, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-hao","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Jiangsu University, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Affiliated Hospital of Jiangsu University, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6FO03414D\/cit1\/1","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.jhep.2014.12.012","volume":"62","author":"Byrne","year":"2015","journal-title":"J. Hepatol."},{"key":"D6FO03414D\/cit2\/1","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"key":"D6FO03414D\/cit3\/1","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1136\/gutjnl-2020-320622","volume":"69","author":"Targher","year":"2020","journal-title":"Gut"},{"key":"D6FO03414D\/cit4\/1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"D6FO03414D\/cit5\/1","doi-asserted-by":"crossref","first-page":"103910","DOI":"10.1016\/j.drudis.2024.103910","volume":"29","author":"Wei","year":"2024","journal-title":"Drug Discovery Today"},{"key":"D6FO03414D\/cit6\/1","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrgastro.2016.85","volume":"13","author":"Leung","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"D6FO03414D\/cit7\/1","doi-asserted-by":"crossref","first-page":"101341","DOI":"10.1016\/j.xcrm.2023.101341","volume":"4","author":"Quesada-Vazquez","year":"2023","journal-title":"Cell Rep. Med."},{"key":"D6FO03414D\/cit8\/1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41575-020-0269-9","volume":"17","author":"Aron-Wisnewsky","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"D6FO03414D\/cit9\/1","doi-asserted-by":"crossref","first-page":"997018","DOI":"10.3389\/fcimb.2022.997018","volume":"12","author":"Fang","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"D6FO03414D\/cit10\/1","doi-asserted-by":"crossref","first-page":"e13316","DOI":"10.1111\/obr.13316","volume":"22","author":"Zhang","year":"2021","journal-title":"Obes. Rev."},{"key":"D6FO03414D\/cit11\/1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.cmet.2024.10.006","volume":"37","author":"Zha","year":"2025","journal-title":"Cell Metab."},{"key":"D6FO03414D\/cit12\/1","doi-asserted-by":"crossref","first-page":"e13807","DOI":"10.1111\/acel.13807","volume":"22","author":"Guan","year":"2023","journal-title":"Aging Cell"},{"key":"D6FO03414D\/cit13\/1","doi-asserted-by":"crossref","first-page":"1462145","DOI":"10.3389\/fmed.2025.1462145","volume":"12","author":"Li","year":"2025","journal-title":"Front. Med."},{"key":"D6FO03414D\/cit14\/1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41418-022-00941-0","volume":"29","author":"Chen","year":"2022","journal-title":"Cell Death Differ."},{"key":"D6FO03414D\/cit15\/1","doi-asserted-by":"crossref","first-page":"e202300379","DOI":"10.1002\/anie.202300379","volume":"62","author":"Zeng","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6FO03414D\/cit16\/1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","volume":"12","author":"Koppula","year":"2021","journal-title":"Protein Cell"},{"key":"D6FO03414D\/cit17\/1","doi-asserted-by":"crossref","first-page":"e70029","DOI":"10.1002\/bio.70029","volume":"39","author":"Gao","year":"2024","journal-title":"Luminescence"},{"key":"D6FO03414D\/cit18\/1","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1089\/jmf.2024.k.0183","volume":"27","author":"Park","year":"2024","journal-title":"J. Med. Food"},{"key":"D6FO03414D\/cit19\/1","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.3390\/nu14173662","volume":"14","author":"Xu","year":"2022","journal-title":"Nutrients"},{"key":"D6FO03414D\/cit20\/1","doi-asserted-by":"crossref","first-page":"e01707","DOI":"10.1002\/advs.202501707","volume":"12","author":"Hua","year":"2025","journal-title":"Adv. Sci."},{"key":"D6FO03414D\/cit21\/1","doi-asserted-by":"crossref","first-page":"5214","DOI":"10.3390\/ijms21155214","volume":"21","author":"Chen","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"D6FO03414D\/cit22\/1","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.cmet.2023.08.002","volume":"35","author":"Ni","year":"2023","journal-title":"Cell Metab."},{"key":"D6FO03414D\/cit23\/1","doi-asserted-by":"crossref","first-page":"2304159","DOI":"10.1080\/19490976.2024.2304159","volume":"16","author":"Li","year":"2024","journal-title":"Gut Microbes"},{"key":"D6FO03414D\/cit24\/1","doi-asserted-by":"crossref","first-page":"109546","DOI":"10.1016\/j.jnutbio.2023.109546","volume":"125","author":"Zhang","year":"2024","journal-title":"J. Nutr. Biochem."},{"key":"D6FO03414D\/cit25\/1","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.jhep.2023.07.005","volume":"79","author":"Song","year":"2023","journal-title":"J. Hepatol."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/FO\/article-pdf\/doi\/10.1039\/D6FO03414D\/0\/D6FO03414D.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:54:20Z","timestamp":1790009660000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/FO\/article-lookup\/doi\/10.1039\/D6FO03414D"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":25,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2026,9,21]]}},"URL":"https:\/\/doi.org\/10.1039\/d6fo03414d","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D6FO03414D\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6FO03414D\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6FO03414D\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6FO03414D\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6FO03414D\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}