{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T21:57:59Z","timestamp":1782856679141,"version":"3.54.5"},"reference-count":70,"publisher":"Royal Society of Chemistry (RSC)","issue":"12","license":[{"start":{"date-parts":[[2027,5,12]],"date-time":"2027-05-12T00:00:00Z","timestamp":1810080000000},"content-version":"am","delay-in-days":496,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32471473"],"award-info":[{"award-number":["32471473"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62231025"],"award-info":[{"award-number":["62231025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["25JC3201100"],"award-info":[{"award-number":["25JC3201100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["24141900900"],"award-info":[{"award-number":["24141900900"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["YG2026QNB35"],"award-info":[{"award-number":["YG2026QNB35"]}],"id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["YG2023LC04"],"award-info":[{"award-number":["YG2023LC04"]}],"id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Lab Chip"],"abstract":"<jats:p>A open-top microfluidic organ-on-a-chip that integrates stamp-based patterning with sequential cellular assembly to achieve simultaneous construction of organ-specific topological architectures and perfusable vascular networks.<\/jats:p>","DOI":"10.1039\/d6lc00096g","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T14:41:37Z","timestamp":1778596897000},"page":"3686-3702","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["3D stamp-integrated open-top microfluidic organ-on-a-chip for high-fidelity and functional reconstruction of vascularized microtissue models"],"prefix":"10.1039","volume":"26","author":[{"given":"Chenyang","family":"Zhou","sequence":"first","affiliation":[{"name":"School of Integrated Circuits (School of Information Science and Electronic Engineering), Shanghai Jiao Tong University, Shanghai, 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Integrated Circuits (School of Information Science and Electronic Engineering), Shanghai Jiao Tong University, Shanghai, 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Integrated Circuits (School of Information Science and Electronic Engineering), Shanghai Jiao Tong University, Shanghai, 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aochen","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Integrated Circuits (School of Information Science and Electronic Engineering), Shanghai Jiao Tong University, Shanghai, 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanping","family":"Song","sequence":"additional","affiliation":[{"name":"School of Integrated Circuits (School of Information Science and Electronic Engineering), Shanghai Jiao Tong University, Shanghai, 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyao","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Integrated Circuits (School of Information Science and Electronic Engineering), Shanghai Jiao Tong University, Shanghai, 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxiang","family":"Fu","sequence":"additional","affiliation":[{"name":"Research and Early Development, D1Med Technology (Hangzhou) Inc, Shanghai, 200235, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9510-4045","authenticated-orcid":false,"given":"Xiaolin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Integrated Circuits (School of Information Science and Electronic Engineering), Shanghai Jiao Tong University, Shanghai, 200240, China"},{"name":"Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai, 200240, China"},{"name":"National Key Laboratory of Advanced Micro and Nano Manufacture Technology, Shanghai Jiao Tong University, Shanghai, 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6LC00096G\/cit1\/1","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature17040","volume":"529","author":"Rafii","year":"2016","journal-title":"Nature"},{"key":"D6LC00096G\/cit2\/1","doi-asserted-by":"crossref","first-page":"eaal2379","DOI":"10.1126\/science.aal2379","volume":"357","author":"Augustin","year":"2017","journal-title":"Science"},{"key":"D6LC00096G\/cit3\/1","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/j.apsb.2020.09.014","volume":"10","author":"Zhao","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"D6LC00096G\/cit4\/1","doi-asserted-by":"crossref","first-page":"2002030","DOI":"10.1002\/advs.202002030","volume":"7","author":"Ingber","year":"2020","journal-title":"Adv. Sci."},{"key":"D6LC00096G\/cit5\/1","doi-asserted-by":"crossref","first-page":"1425618","DOI":"10.3389\/fphys.2024.1425618","volume":"15","author":"Martier","year":"2024","journal-title":"Front. Physiol."},{"key":"D6LC00096G\/cit6\/1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1146\/annurev-bioeng-103023-115236","volume":"27","author":"Shin","year":"2025","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"D6LC00096G\/cit7\/1","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1039\/D5LC00014A","volume":"25","author":"Breuil","year":"2025","journal-title":"Lab Chip"},{"key":"D6LC00096G\/cit8\/1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41378-025-00956-w","volume":"11","author":"Liu","year":"2025","journal-title":"Microsyst. Nanoeng."},{"key":"D6LC00096G\/cit9\/1","doi-asserted-by":"crossref","first-page":"2408131","DOI":"10.1002\/advs.202408131","volume":"12","author":"Gonzalez-Rubio","year":"2025","journal-title":"Adv. Sci."},{"key":"D6LC00096G\/cit10\/1","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1039\/D1LC00767J","volume":"22","author":"Li","year":"2022","journal-title":"Lab Chip"},{"key":"D6LC00096G\/cit11\/1","doi-asserted-by":"crossref","first-page":"2304263","DOI":"10.1002\/adhm.202304263","volume":"13","author":"Ghosh","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"D6LC00096G\/cit12\/1","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1631\/bdm.2500091","volume":"8","author":"Zhou","year":"2025","journal-title":"Bio-Des. Manuf."},{"key":"D6LC00096G\/cit13\/1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1039\/C5LC01050K","volume":"16","author":"Wang","year":"2016","journal-title":"Lab Chip"},{"key":"D6LC00096G\/cit14\/1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s10456-017-9559-4","volume":"20","author":"Shirure","year":"2017","journal-title":"Angiogenesis"},{"key":"D6LC00096G\/cit15\/1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2217\/rme-2016-0152","volume":"12","author":"Haase","year":"2017","journal-title":"Regener. Med."},{"key":"D6LC00096G\/cit16\/1","doi-asserted-by":"crossref","first-page":"2102581","DOI":"10.1002\/adhm.202102581","volume":"11","author":"Kim","year":"2022","journal-title":"Adv. Healthcare Mater."},{"key":"D6LC00096G\/cit17\/1","doi-asserted-by":"crossref","first-page":"2300423","DOI":"10.1002\/adhm.202300423","volume":"12","author":"Zhang","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"D6LC00096G\/cit18\/1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41586-024-08175-5","volume":"636","author":"Sundaram","year":"2024","journal-title":"Nature"},{"key":"D6LC00096G\/cit19\/1","doi-asserted-by":"crossref","first-page":"1703156","DOI":"10.1002\/adma.201703156","volume":"29","author":"Arakawa","year":"2017","journal-title":"Adv. Mater."},{"key":"D6LC00096G\/cit20\/1","doi-asserted-by":"crossref","first-page":"eaay7243","DOI":"10.1126\/sciadv.aay7243","volume":"6","author":"Arakawa","year":"2020","journal-title":"Sci. Adv."},{"key":"D6LC00096G\/cit21\/1","doi-asserted-by":"crossref","first-page":"2000546","DOI":"10.1002\/smll.202000546","volume":"16","author":"Mao","year":"2020","journal-title":"Small"},{"key":"D6LC00096G\/cit22\/1","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1021\/acsbiomaterials.0c00236","volume":"7","author":"Lin","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"key":"D6LC00096G\/cit23\/1","doi-asserted-by":"crossref","first-page":"122864","DOI":"10.1016\/j.biomaterials.2024.122864","volume":"314","author":"Pavlou","year":"2025","journal-title":"Biomaterials"},{"key":"D6LC00096G\/cit24\/1","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.stemcr.2023.06.001","volume":"18","author":"Arslan","year":"2023","journal-title":"Stem Cell Rep."},{"key":"D6LC00096G\/cit25\/1","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.tcb.2018.08.001","volume":"28","author":"Santos","year":"2018","journal-title":"Trends Cell Biol."},{"key":"D6LC00096G\/cit26\/1","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1039\/D3LC00211J","volume":"23","author":"Sotra","year":"2023","journal-title":"Lab Chip"},{"key":"D6LC00096G\/cit27\/1","doi-asserted-by":"crossref","first-page":"2200217","DOI":"10.1002\/adma.202200217","volume":"34","author":"Ahrens","year":"2022","journal-title":"Adv. Mater."},{"key":"D6LC00096G\/cit28\/1","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/s41586-020-2724-8","volume":"585","author":"Nikolaev","year":"2020","journal-title":"Nature"},{"key":"D6LC00096G\/cit29\/1","doi-asserted-by":"crossref","first-page":"123573","DOI":"10.1016\/j.biomaterials.2025.123573","volume":"325","author":"Zeng","year":"2026","journal-title":"Biomaterials"},{"key":"D6LC00096G\/cit30\/1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.cell.2025.11.012","volume":"189","author":"Wang","year":"2026","journal-title":"Cell"},{"key":"D6LC00096G\/cit31\/1","doi-asserted-by":"crossref","first-page":"e1904181","DOI":"10.1002\/adma.201904181","volume":"32","author":"Ma","year":"2020","journal-title":"Adv. Mater."},{"key":"D6LC00096G\/cit32\/1","doi-asserted-by":"crossref","first-page":"12072","DOI":"10.1021\/acsnano.2c10704","volume":"17","author":"Ren","year":"2023","journal-title":"ACS Nano"},{"key":"D6LC00096G\/cit33\/1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biomaterials.2017.03.005","volume":"128","author":"Wang","year":"2017","journal-title":"Biomaterials"},{"key":"D6LC00096G\/cit34\/1","doi-asserted-by":"crossref","first-page":"eadr6472","DOI":"10.1126\/scirobotics.adr6472","volume":"10","author":"Zimmerman","year":"2025","journal-title":"Sci. Robot."},{"key":"D6LC00096G\/cit35\/1","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/s41467-024-45710-4","volume":"15","author":"Quintard","year":"2024","journal-title":"Nat. Commun."},{"key":"D6LC00096G\/cit36\/1","doi-asserted-by":"crossref","first-page":"28832","DOI":"10.1038\/srep28832","volume":"6","author":"Seo","year":"2016","journal-title":"Sci. Rep."},{"key":"D6LC00096G\/cit37\/1","first-page":"115","volume":"28","author":"Rajasekar","year":"2022","journal-title":"Tissue Eng., Part A"},{"key":"D6LC00096G\/cit38\/1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1039\/C2LC40787F","volume":"13","author":"Hsu","year":"2013","journal-title":"Lab Chip"},{"key":"D6LC00096G\/cit39\/1","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.1039\/C6LC00910G","volume":"16","author":"Kim","year":"2016","journal-title":"Lab Chip"},{"key":"D6LC00096G\/cit40\/1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10456-017-9562-9","volume":"20","author":"Viallard","year":"2017","journal-title":"Angiogenesis"},{"key":"D6LC00096G\/cit41\/1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12943-020-01288-1","volume":"20","author":"Wei","year":"2021","journal-title":"Mol. Cancer"},{"key":"D6LC00096G\/cit42\/1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0002-9440(10)63273-7","volume":"165","author":"Inai","year":"2004","journal-title":"Am. J. Pathol."},{"key":"D6LC00096G\/cit43\/1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.canlet.2021.03.018","volume":"508","author":"Ashrafizaveh","year":"2021","journal-title":"Cancer Lett."},{"key":"D6LC00096G\/cit44\/1","doi-asserted-by":"crossref","first-page":"114576","DOI":"10.1016\/j.biopha.2023.114576","volume":"162","author":"Podyacheva","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"D6LC00096G\/cit45\/1","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/978-3-031-50419-8_20","volume-title":"ADME Processes in Pharmaceutical Sciences: Dosage, Design, and Pharmacotherapy","author":"Fagiolino","year":"2024","unstructured":"P.Fagiolino ,  A.Talevi ,  M.V\u00e1zquez  and  M.Ibarra , in  ADME Processes in Pharmaceutical Sciences: Dosage, Design, and Pharmacotherapy , ed.  A. Talevi  and  P. A. Quiroga ,  Springer Nature Switzerland ,  Cham ,  2024 ,  pp. 459\u2013488 ,  10.1007\/978-3-031-50419-8_20"},{"key":"D6LC00096G\/cit46\/1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.jconrel.2023.09.017","volume":"362","author":"Wang","year":"2023","journal-title":"J. Controlled Release"},{"key":"D6LC00096G\/cit47\/1","doi-asserted-by":"crossref","first-page":"107190","DOI":"10.1016\/j.compbiomed.2023.107190","volume":"163","author":"Salavati","year":"2023","journal-title":"Comput. Biol. Med."},{"key":"D6LC00096G\/cit48\/1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13045-022-01252-0","volume":"15","author":"Jiang","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"D6LC00096G\/cit49\/1","doi-asserted-by":"crossref","first-page":"e24965","DOI":"10.4161\/tisb.24965","volume":"1","author":"De Mey","year":"2013","journal-title":"Tissue Barriers"},{"key":"D6LC00096G\/cit50\/1","doi-asserted-by":"crossref","first-page":"1506976","DOI":"10.3389\/fbioe.2024.1506976","volume":"12","author":"Massaro","year":"2024","journal-title":"Front. Bioeng. Biotechnol."},{"key":"D6LC00096G\/cit51\/1","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1039\/C3LC51353J","volume":"14","author":"Wang","year":"2014","journal-title":"Lab Chip"},{"key":"D6LC00096G\/cit52\/1","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/s41586-020-2724-8","volume":"585","author":"Nikolaev","year":"2020","journal-title":"Nature"},{"key":"D6LC00096G\/cit53\/1","doi-asserted-by":"crossref","first-page":"015018","DOI":"10.1088\/1758-5090\/ae2cf2","volume":"18","author":"Massaro","year":"2026","journal-title":"Biofabrication"},{"key":"D6LC00096G\/cit54\/1","doi-asserted-by":"crossref","first-page":"e191538","DOI":"10.1172\/jci.insight.191538","volume":"10","author":"Naydenov","year":"2025","journal-title":"JCI insight"},{"key":"D6LC00096G\/cit55\/1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/organoids4010006","volume":"4","author":"Takahashi","year":"2025","journal-title":"Organoids"},{"key":"D6LC00096G\/cit56\/1","doi-asserted-by":"crossref","first-page":"135371","DOI":"10.1016\/j.ijbiomac.2024.135371","volume":"279","author":"Zhang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"D6LC00096G\/cit57\/1","doi-asserted-by":"crossref","first-page":"112784","DOI":"10.1016\/j.yexcr.2021.112784","volume":"407","author":"Li","year":"2021","journal-title":"Exp. Cell Res."},{"key":"D6LC00096G\/cit58\/1","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.3389\/fimmu.2019.02759","volume":"10","author":"Gschwandtner","year":"2019","journal-title":"Front. Immunol."},{"key":"D6LC00096G\/cit59\/1","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1038\/s41596-021-00497-2","volume":"16","author":"Campostrini","year":"2021","journal-title":"Nat. Protoc."},{"key":"D6LC00096G\/cit60\/1","doi-asserted-by":"crossref","first-page":"121351","DOI":"10.1016\/j.biomaterials.2021.121351","volume":"281","author":"Takada","year":"2022","journal-title":"Biomaterials"},{"key":"D6LC00096G\/cit61\/1","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.3390\/cells10113220","volume":"10","author":"Verheule","year":"2021","journal-title":"Cells"},{"key":"D6LC00096G\/cit62\/1","doi-asserted-by":"crossref","first-page":"121351","DOI":"10.1016\/j.biomaterials.2021.121351","volume":"281","author":"Takada","year":"2022","journal-title":"Biomaterials"},{"key":"D6LC00096G\/cit63\/1","doi-asserted-by":"crossref","first-page":"213680","DOI":"10.1016\/j.bioadv.2023.213680","volume":"155","author":"Cyr","year":"2023","journal-title":"Biomater. Adv."},{"key":"D6LC00096G\/cit64\/1","doi-asserted-by":"crossref","first-page":"35376","DOI":"10.1021\/acsami.2c07326","volume":"14","author":"Strimaityte","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D6LC00096G\/cit65\/1","doi-asserted-by":"crossref","first-page":"eaaw2459","DOI":"10.1126\/sciadv.aaw2459","volume":"5","author":"Skylar-Scott","year":"2019","journal-title":"Sci. Adv."},{"key":"D6LC00096G\/cit66\/1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/s41596-025-01217-w","volume":"21","author":"Tu","year":"2026","journal-title":"Nat. Protoc."},{"key":"D6LC00096G\/cit67\/1","doi-asserted-by":"crossref","first-page":"100626","DOI":"10.1016\/j.mtbio.2023.100626","volume":"20","author":"Zhang","year":"2023","journal-title":"Mater. Today Bio"},{"key":"D6LC00096G\/cit68\/1","doi-asserted-by":"crossref","first-page":"100280","DOI":"10.1016\/j.crmeth.2022.100280","volume":"2","author":"King","year":"2022","journal-title":"Cells Rep. Methods"},{"key":"D6LC00096G\/cit69\/1","doi-asserted-by":"crossref","first-page":"e18909","DOI":"10.1002\/adma.202418909","volume":"37","author":"Kim","year":"2025","journal-title":"Adv. Mater."},{"key":"D6LC00096G\/cit70\/1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.stem.2012.09.013","volume":"12","author":"Tohyama","year":"2013","journal-title":"Cell Stem Cell"}],"container-title":["Lab on a Chip"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/LC\/D6LC00096G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:49:46Z","timestamp":1782852586000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/lc\/article\/26\/12\/3686-3702\/1244370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":70,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,6,16]]}},"URL":"https:\/\/doi.org\/10.1039\/d6lc00096g","relation":{},"ISSN":["1473-0197","1473-0189"],"issn-type":[{"value":"1473-0197","type":"print"},{"value":"1473-0189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}