{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:09:10Z","timestamp":1789553350484,"version":"build-2803163510"},"reference-count":38,"publisher":"Royal Society of Chemistry (RSC)","issue":"12","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":145,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM144727"],"award-info":[{"award-number":["R01GM144727"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["R01EB030367"],"award-info":[{"award-number":["R01EB030367"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM144727"],"award-info":[{"award-number":["R01GM144727"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EB030367"],"award-info":[{"award-number":["R01EB030367"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Lab Chip"],"abstract":"<jats:p>Narrow, parallelized channels reveal a dynamic loading regime that, when integrated with geometry, flow, single-cell kinematics, and delivery outcomes, defines a mechanistic framework for microfluidic mechanoporation.<\/jats:p>","DOI":"10.1039\/d6lc00143b","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T14:25:19Z","timestamp":1778682319000},"page":"3825-3837","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A parametric study of mechanoporation through microfluidic design to modulate shear, compressive, and adhesion forces and loading rates"],"prefix":"10.1039","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8880-8589","authenticated-orcid":false,"given":"Avi","family":"Gupta","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5905-7474","authenticated-orcid":false,"given":"Jacqueline","family":"Van Zyl","sequence":"additional","affiliation":[{"name":"George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Collin","family":"Bushey","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter School of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Shankles","sequence":"additional","affiliation":[{"name":"George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoseyn A.","family":"Amiri","sequence":"additional","affiliation":[{"name":"George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0247-6470","authenticated-orcid":false,"given":"Guillem","family":"Pratx","sequence":"additional","affiliation":[{"name":"Radiation Oncology \u2013 Radiation Physics, Stanford University, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8285-0003","authenticated-orcid":false,"given":"Alexander","family":"Alexeev","sequence":"additional","affiliation":[{"name":"George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3199-7670","authenticated-orcid":false,"given":"Todd","family":"Sulchek","sequence":"additional","affiliation":[{"name":"George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6LC00143B\/cit1\/1","doi-asserted-by":"crossref","first-page":"21407","DOI":"10.1038\/s41598-021-00893-4","volume":"11","author":"Loo","year":"2021","journal-title":"Sci. Rep."},{"key":"D6LC00143B\/cit2\/1","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1039\/D2LC01115H","volume":"23","author":"Kwon","year":"2023","journal-title":"Lab Chip"},{"key":"D6LC00143B\/cit3\/1","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1093\/stmcls\/sxad063","volume":"41","author":"Bohrer","year":"2023","journal-title":"Stem Cells"},{"issue":"22","key":"D6LC00143B\/cit4\/1","doi-asserted-by":"crossref","first-page":"4804","DOI":"10.1039\/D3LC00311F","volume":"23","author":"Yu","year":"2023","journal-title":"Lab Chip"},{"key":"D6LC00143B\/cit5\/1","doi-asserted-by":"crossref","first-page":"6024","DOI":"10.7150\/thno.39554","volume":"10","author":"Nejadnik","year":"2020","journal-title":"Theranostics"},{"issue":"1","key":"D6LC00143B\/cit6\/1","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1038\/s41598-022-06938-6","volume":"12","author":"Jung","year":"2022","journal-title":"Sci. Rep."},{"key":"D6LC00143B\/cit7\/1","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1039\/b803212b","volume":"8","author":"Adamo","year":"2008","journal-title":"Lab Chip"},{"key":"D6LC00143B\/cit8\/1","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1021\/acs.nanolett.9b03175","volume":"20","author":"Dixit","year":"2020","journal-title":"Nano Lett."},{"key":"D6LC00143B\/cit9\/1","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/bit.21651","volume":"99","author":"Hallow","year":"2008","journal-title":"Biotechnol. Bioeng."},{"key":"D6LC00143B\/cit10\/1","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1039\/C9LC00041K","volume":"19","author":"Kizer","year":"2019","journal-title":"Lab Chip"},{"key":"D6LC00143B\/cit11\/1","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/s41551-020-0570-5","volume":"4","author":"Jung","year":"2020","journal-title":"Nat. Biomed. Eng."},{"key":"D6LC00143B\/cit12\/1","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.mattod.2018.03.002","volume":"21","author":"Liu","year":"2018","journal-title":"Mater. Today"},{"key":"D6LC00143B\/cit13\/1","doi-asserted-by":"crossref","first-page":"1700705","DOI":"10.1002\/smll.201700705","volume":"13","author":"Deng","year":"2017","journal-title":"Small"},{"key":"D6LC00143B\/cit14\/1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41467-023-44447-w","volume":"15","author":"Sevenler","year":"2024","journal-title":"Nat. Commun."},{"key":"D6LC00143B\/cit15\/1","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1038\/s41598-019-40147-y","volume":"9","author":"Jarrell","year":"2019","journal-title":"Sci. Rep."},{"key":"D6LC00143B\/cit16\/1","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1021\/acsnano.9b07930","volume":"14","author":"Kang","year":"2020","journal-title":"ACS Nano"},{"key":"D6LC00143B\/cit17\/1","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1073\/pnas.1218705110","volume":"110","author":"Sharei","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D6LC00143B\/cit18\/1","doi-asserted-by":"crossref","first-page":"30550","DOI":"10.1038\/srep30550","volume":"6","author":"Bar-Kochba","year":"2016","journal-title":"Sci. Rep."},{"key":"D6LC00143B\/cit19\/1","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/s41592-020-0818-8","volume":"17","author":"Urbanska","year":"2020","journal-title":"Nat. Methods"},{"key":"D6LC00143B\/cit20\/1","doi-asserted-by":"crossref","first-page":"19828","DOI":"10.1073\/pnas.1910336116","volume":"116","author":"Qiang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D6LC00143B\/cit21\/1","doi-asserted-by":"crossref","first-page":"15369","DOI":"10.1038\/srep15369","volume":"5","author":"Shigematsu","year":"2015","journal-title":"Sci. Rep."},{"key":"D6LC00143B\/cit22\/1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bpj.2015.05.029","volume":"109","author":"Lange","year":"2015","journal-title":"Biophys. J."},{"key":"D6LC00143B\/cit23\/1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.bpj.2020.06.016","volume":"119","author":"Razizadeh","year":"2020","journal-title":"Biophys. J."},{"key":"D6LC00143B\/cit24\/1","doi-asserted-by":"crossref","first-page":"C646","DOI":"10.1152\/ajpcell.00099.2011","volume":"301","author":"Rahimzadeh","year":"2011","journal-title":"Am. J. Physiol."},{"key":"D6LC00143B\/cit25\/1","doi-asserted-by":"crossref","first-page":"e2019347118","DOI":"10.1073\/pnas.2019347118","volume":"118","author":"Esfahani","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D6LC00143B\/cit26\/1","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1080\/07391102.2018.1453376","volume":"37","author":"Murphy","year":"2019","journal-title":"J. Biomol. Struct. Dyn."},{"key":"D6LC00143B\/cit27\/1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1186\/s12951-024-02730-y","volume":"22","author":"Maremonti","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"D6LC00143B\/cit28\/1","doi-asserted-by":"crossref","first-page":"1167338","DOI":"10.3389\/fphy.2023.1167338","volume":"11","author":"Jaganathan","year":"2023","journal-title":"Front. Phys."},{"key":"D6LC00143B\/cit29\/1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cherd.2025.07.048","volume":"221","author":"Peterson","year":"2025","journal-title":"Chem. Eng. Res. Des."},{"key":"D6LC00143B\/cit30\/1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.ijmultiphaseflow.2007.02.005","volume":"33","author":"Dorgan","year":"2007","journal-title":"Int. J. Multiphase Flow"},{"key":"D6LC00143B\/cit31\/1","doi-asserted-by":"crossref","first-page":"1903857","DOI":"10.1002\/smll.201903857","volume":"16","author":"Liu","year":"2020","journal-title":"Small"},{"key":"D6LC00143B\/cit32\/1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1017\/jfm.2018.95","volume":"840","author":"Asmolov","year":"2018","journal-title":"J. Fluid Mech."},{"key":"D6LC00143B\/cit33\/1","doi-asserted-by":"crossref","first-page":"034104","DOI":"10.1063\/5.0080510","volume":"16","author":"Young","year":"2022","journal-title":"Biomicrofluidics"},{"key":"D6LC00143B\/cit34\/1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1039\/b513524a","volume":"6","author":"Gervais","year":"2006","journal-title":"Lab Chip"},{"key":"D6LC00143B\/cit35\/1","volume-title":"A treatise on hydrodynamics: with numerous examples","author":"Basset","year":"1888","unstructured":"A. B.Basset ,  A treatise on hydrodynamics: with numerous examples ,  Cambridge ,  1888"},{"key":"D6LC00143B\/cit36\/1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1177\/001316447403400115","volume":"34","author":"Kaiser","year":"1974","journal-title":"Educ. Psychol. Meas."},{"key":"D6LC00143B\/cit37\/1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1109\/TPAMI.1979.4766909","volume":"1","author":"Davies","year":"1979","journal-title":"IEEE Trans. Pattern Anal. Mach. Intell."},{"key":"D6LC00143B\/cit38\/1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s12195-021-00677-w","volume":"14","author":"Ujihara","year":"2021","journal-title":"Cell. Mol. Bioeng."}],"container-title":["Lab on a Chip"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/LC\/article-pdf\/doi\/10.1039\/D6LC00143B\/0\/D6LC00143B.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:01:22Z","timestamp":1789552882000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/LC\/article-lookup\/doi\/10.1039\/D6LC00143B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,6,16]]}},"URL":"https:\/\/doi.org\/10.1039\/d6lc00143b","relation":{},"ISSN":["1473-0197","1473-0189"],"issn-type":[{"value":"1473-0197","type":"print"},{"value":"1473-0189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}