{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:01:16Z","timestamp":1790755276484,"version":"4.1.0"},"reference-count":58,"publisher":"Royal Society of Chemistry (RSC)","issue":"19","license":[{"start":{"date-parts":[[2027,8,18]],"date-time":"2027-08-18T00:00:00Z","timestamp":1818547200000},"content-version":"am","delay-in-days":594,"URL":"http:\/\/rsc.li\/journals-terms-of-use#chorus"}],"funder":[{"DOI":"10.13039\/100006379","name":"Office of Research and Development","doi-asserted-by":"publisher","award":["I01 BX002137"],"award-info":[{"award-number":["I01 BX002137"]}],"id":[{"id":"10.13039\/100006379","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1R01HL164415"],"award-info":[{"award-number":["1R01HL164415"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-21-1-0424"],"award-info":[{"award-number":["W81XWH-21-1-0424"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Lab Chip"],"abstract":"<jats:p>Microphysiological system modeling the sympathetic neuron\u2013cardiac axis. Subject-derived hiPSCs are differentiated into cardiomyocytes and sympathetic neurons, then integrated into a microfluidic device to recapitulate brain\u2013heart interactions.<\/jats:p>","DOI":"10.1039\/d6lc00320f","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T21:23:22Z","timestamp":1787088202000},"page":"5267-5279","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modeling sympathetic neuro\u2013cardiac interactions in a hiPSC-based microphysiological system"],"prefix":"10.1039","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9881-6670","authenticated-orcid":false,"given":"Jean-Baptiste","family":"Reisqs","sequence":"first","affiliation":[{"name":"Cardiovascular Research Program, VA New York Harbor Healthcare System, Brooklyn, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Sleiman","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Program, VA New York Harbor Healthcare System, Brooklyn, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Boutjdir","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Program, VA New York Harbor Healthcare System, Brooklyn, USA"},{"name":"Department of Medicine, Cell Biology and Pharmacology, State University of New York Downstate Health Sciences University, New York, USA"},{"name":"Division of Cardiology, Department of Medicine, NYU Grossmann School of Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"3","key":"D6LC00320F\/cit1\/1","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1152\/physiol.00018.2024","volume":"40","author":"Hafez","year":"2024","journal-title":"Physiology"},{"issue":"6","key":"D6LC00320F\/cit2\/1","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.3390\/biomedicines13061376","volume":"13","author":"Reisqs","year":"2025","journal-title":"Biomedicines"},{"issue":"4","key":"D6LC00320F\/cit3\/1","doi-asserted-by":"publisher","first-page":"204","DOI":"10.4330\/wjc.v7.i4.204","volume":"7","author":"Gordan","year":"2015","journal-title":"World J. Cardiol."},{"key":"D6LC00320F\/cit4\/1","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1113\/JP287569","volume":"603","author":"Mohammadi","year":"2025","journal-title":"J. Physiol."},{"issue":"11","key":"D6LC00320F\/cit5\/1","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/s41583-021-00523-y","volume":"22","author":"Scott-Solomon","year":"2021","journal-title":"Nat. Rev. Neurosci."},{"issue":"5","key":"D6LC00320F\/cit6\/1","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1007\/s12350-016-0725-7","volume":"24","author":"Jamali","year":"2017","journal-title":"J. Nucl. Cardiol."},{"key":"D6LC00320F\/cit7\/1","doi-asserted-by":"publisher","first-page":"1483482","DOI":"10.3389\/fcvm.2024.1483482","volume":"11","author":"Qi","year":"2024","journal-title":"Front. Cardiovasc. Med."},{"issue":"4","key":"D6LC00320F\/cit8\/1","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3390\/jcdd7040054","volume":"7","author":"Fedele","year":"2020","journal-title":"J. Cardiovasc. Dev. Dis."},{"key":"D6LC00320F\/cit9\/1","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3389\/fcvm.2019.00092","volume":"6","author":"Baltogiannis","year":"2019","journal-title":"Front. Cardiovasc. Med."},{"issue":"4","key":"D6LC00320F\/cit10\/1","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1111\/j.1542-474X.2002.tb00182.x","volume":"7","author":"Shimizu","year":"2006","journal-title":"Ann. Noninvasive Electrocardiol."},{"issue":"8","key":"D6LC00320F\/cit11\/1","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1016\/j.hrthm.2013.10.037","volume":"11","author":"Paul","year":"2014","journal-title":"Heart Rhythm"},{"issue":"12","key":"D6LC00320F\/cit12\/1","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1038\/s44161-025-00746-7","volume":"4","author":"Patsy","year":"2025","journal-title":"Nat. Cardiovasc. Res."},{"key":"D6LC00320F\/cit13\/1","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1101\/2024.04.04.588174","volume":"603","author":"Tompkins","year":"2025","journal-title":"J. Physiol."},{"issue":"2","key":"D6LC00320F\/cit14\/1","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s00441-020-03279-6","volume":"382","author":"Ernsberger","year":"2020","journal-title":"Cell Tissue Res."},{"key":"D6LC00320F\/cit15\/1","doi-asserted-by":"publisher","first-page":"1086912","DOI":"10.3389\/fvets.2022.1086912","volume":"9","author":"Gray","year":"2022","journal-title":"Front. Vet. Sci."},{"issue":"1","key":"D6LC00320F\/cit16\/1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.stem.2011.12.013","volume":"10","author":"Burridge","year":"2012","journal-title":"Cell Stem Cell"},{"issue":"1","key":"D6LC00320F\/cit17\/1","doi-asserted-by":"publisher","first-page":"12865","DOI":"10.1038\/s41598-018-31256-1","volume":"8","author":"Kirino","year":"2018","journal-title":"Sci. Rep."},{"issue":"5","key":"D6LC00320F\/cit18\/1","doi-asserted-by":"publisher","first-page":"H927","DOI":"10.1152\/ajpheart.00546.2020","volume":"319","author":"Winbo","year":"2020","journal-title":"Am. J. Physiol."},{"issue":"21","key":"D6LC00320F\/cit19\/1","doi-asserted-by":"publisher","first-page":"e15498","DOI":"10.14814\/phy2.15498","volume":"10","author":"Narkar","year":"2022","journal-title":"Physiol. Rep."},{"issue":"8","key":"D6LC00320F\/cit20\/1","doi-asserted-by":"publisher","first-page":"4921","DOI":"10.1016\/j.ymthe.2026.03.034","volume":"34","author":"Cattelan","year":"2026","journal-title":"Mol. Ther."},{"key":"D6LC00320F\/cit21\/1","doi-asserted-by":"publisher","first-page":"100227","DOI":"10.1016\/j.crphar.2025.100227","volume":"9","author":"Ferreira","year":"2025","journal-title":"Curr. Res. Pharmacol. Drug Discovery"},{"key":"D6LC00320F\/cit22\/1","doi-asserted-by":"publisher","first-page":"38856","DOI":"10.1038\/srep38856","volume":"6","author":"Wevers","year":"2016","journal-title":"Sci. Rep."},{"issue":"9","key":"D6LC00320F\/cit23\/1","doi-asserted-by":"publisher","first-page":"e2000133","DOI":"10.1002\/adbi.202000133","volume":"4","author":"Soucy","year":"2020","journal-title":"Adv. Biosyst."},{"issue":"1","key":"D6LC00320F\/cit24\/1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.therap.2024.12.002","volume":"80","author":"Mottet","year":"2025","journal-title":"Therapie"},{"issue":"11","key":"D6LC00320F\/cit25\/1","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1113\/JP275693","volume":"596","author":"Prando","year":"2018","journal-title":"J. Physiol."},{"key":"D6LC00320F\/cit26\/1","doi-asserted-by":"publisher","first-page":"112854","DOI":"10.1016\/j.bios.2020.112854","volume":"175","author":"Xu","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"D6LC00320F\/cit27\/1","doi-asserted-by":"publisher","DOI":"10.64898\/2025.12.15.694396","volume-title":"bioRxiv","author":"Reisqs","year":"2025","unstructured":"J. B.Reisqs ,  Y.Sleiman ,  I.Gando ,  M.Cupelli ,  V. K. M.Ginjupalli ,  H.Delanoe-Ayari ,  W.Coetzee ,  Y. S.Qu ,  M.Delmar ,  F.Cecchin ,  R. B.Tan ,  M.Chahine  and  M.Boutjdir , Electrophysiological abnormalities associated with a CACNA1D variant are rescued by AAV6-Cav1.3-C-terminus gene therapy in patient-iPSC-CMs,  bioRxiv ,  2025 , preprint, 2025.12.15.694396,  10.64898\/2025.12.15.694396"},{"issue":"1","key":"D6LC00320F\/cit28\/1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41531-024-00862-4","volume":"11","author":"Fujise","year":"2025","journal-title":"npj Parkinsons Dis."},{"issue":"14","key":"D6LC00320F\/cit29\/1","doi-asserted-by":"publisher","first-page":"eadj9305","DOI":"10.1126\/sciadv.adj9305","volume":"10","author":"Cortes","year":"2024","journal-title":"Sci. Adv."},{"issue":"11","key":"D6LC00320F\/cit30\/1","doi-asserted-by":"publisher","first-page":"7312","DOI":"10.1167\/iovs.14-15140","volume":"55","author":"Cottrell","year":"2014","journal-title":"Invest. Ophthalmol. Visual Sci."},{"issue":"3","key":"D6LC00320F\/cit31\/1","doi-asserted-by":"publisher","first-page":"e319","DOI":"10.1002\/ctm2.319","volume":"11","author":"Moreau","year":"2021","journal-title":"Clin. Transl. Med."},{"issue":"3","key":"D6LC00320F\/cit32\/1","doi-asserted-by":"publisher","first-page":"e748","DOI":"10.1002\/ctm2.748","volume":"12","author":"Reisqs","year":"2022","journal-title":"Clin. Transl. Med."},{"issue":"1","key":"D6LC00320F\/cit33\/1","doi-asserted-by":"publisher","first-page":"9464","DOI":"10.1038\/s41598-020-66303-3","volume":"10","author":"Takayama","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"D6LC00320F\/cit34\/1","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.stem.2016.05.002","volume":"19","author":"Oh","year":"2016","journal-title":"Cell Stem Cell"},{"key":"D6LC00320F\/cit35\/1","doi-asserted-by":"publisher","first-page":"170661","DOI":"10.1016\/j.peptides.2021.170661","volume":"146","author":"Qin","year":"2021","journal-title":"Peptides"},{"issue":"4","key":"D6LC00320F\/cit36\/1","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.hlc.2019.11.002","volume":"29","author":"Winbo","year":"2020","journal-title":"Heart, Lung Circ."},{"issue":"8","key":"D6LC00320F\/cit37\/1","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.3390\/cancers11081121","volume":"11","author":"Berends","year":"2019","journal-title":"Cancers"},{"issue":"15","key":"D6LC00320F\/cit38\/1","doi-asserted-by":"publisher","first-page":"R817","DOI":"10.1016\/j.cub.2022.06.060","volume":"32","author":"Costa","year":"2022","journal-title":"Curr. Biol."},{"issue":"2","key":"D6LC00320F\/cit39\/1","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1073\/pnas.75.2.1016","volume":"75","author":"Carbonetto","year":"1978","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"D6LC00320F\/cit40\/1","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1161\/01.CIR.98.6.528","volume":"98","author":"Narkiewicz","year":"1998","journal-title":"Circulation"},{"issue":"38","key":"D6LC00320F\/cit41\/1","doi-asserted-by":"publisher","first-page":"24024","DOI":"10.1074\/jbc.272.38.24024","volume":"272","author":"Chen","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"6","key":"D6LC00320F\/cit42\/1","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1124\/mol.61.6.1416","volume":"61","author":"Rush","year":"2002","journal-title":"Mol. Pharmacol."},{"issue":"5","key":"D6LC00320F\/cit43\/1","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/S0301-0082(02)00106-5","volume":"68","author":"Wang","year":"2002","journal-title":"Prog. Neurobiol."},{"issue":"23","key":"D6LC00320F\/cit44\/1","doi-asserted-by":"publisher","first-page":"3764","DOI":"10.3390\/cells11233764","volume":"11","author":"Bernardin","year":"2022","journal-title":"Cells"},{"key":"D6LC00320F\/cit45\/1","doi-asserted-by":"publisher","first-page":"103153","DOI":"10.1016\/j.scr.2023.103153","volume":"71","author":"Li","year":"2023","journal-title":"Stem Cell Res."},{"issue":"23","key":"D6LC00320F\/cit46\/1","doi-asserted-by":"publisher","first-page":"5057","DOI":"10.1113\/JP270917","volume":"593","author":"Kreipke","year":"2015","journal-title":"J. Physiol."},{"issue":"22","key":"D6LC00320F\/cit47\/1","doi-asserted-by":"publisher","first-page":"e157956","DOI":"10.1172\/jci.insight.157956","volume":"8","author":"Dajani","year":"2023","journal-title":"JCI Insight"},{"issue":"4","key":"D6LC00320F\/cit48\/1","doi-asserted-by":"publisher","first-page":"289","DOI":"10.2174\/157340309789317904","volume":"5","author":"Ieda","year":"2009","journal-title":"Curr. Cardiol. Rev."},{"key":"D6LC00320F\/cit49\/1","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.jneumeth.2013.09.005","volume":"221","author":"Freeman","year":"2014","journal-title":"J. Neurosci. Methods"},{"issue":"20","key":"D6LC00320F\/cit50\/1","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.3390\/cells13201674","volume":"13","author":"Parichatikanond","year":"2024","journal-title":"Cells"},{"issue":"1","key":"D6LC00320F\/cit51\/1","doi-asserted-by":"publisher","first-page":"e327497","DOI":"10.1161\/CIRCRESAHA.125.327497","volume":"138","author":"Torre","year":"2026","journal-title":"Circ. Res."},{"issue":"10","key":"D6LC00320F\/cit52\/1","doi-asserted-by":"publisher","first-page":"110468","DOI":"10.1016\/j.celrep.2022.110468","volume":"38","author":"Tan","year":"2022","journal-title":"Cell Rep."},{"issue":"12","key":"D6LC00320F\/cit53\/1","doi-asserted-by":"publisher","first-page":"3919","DOI":"10.1113\/JP273120","volume":"595","author":"Zaglia","year":"2017","journal-title":"J. Physiol."},{"issue":"1","key":"D6LC00320F\/cit54\/1","doi-asserted-by":"publisher","first-page":"124","DOI":"10.7150\/thno.19441","volume":"8","author":"Besser","year":"2018","journal-title":"Theranostics"},{"key":"D6LC00320F\/cit55\/1","doi-asserted-by":"publisher","first-page":"850645","DOI":"10.3389\/fcell.2022.850645","volume":"10","author":"Kowalski","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"14","key":"D6LC00320F\/cit56\/1","doi-asserted-by":"publisher","first-page":"3853","DOI":"10.1113\/JP271840","volume":"594","author":"Habecker","year":"2016","journal-title":"J. Physiol."},{"issue":"6 Pt 2","key":"D6LC00320F\/cit57\/1","doi-asserted-by":"publisher","first-page":"H1727","DOI":"10.1152\/ajpheart.1991.261.6.H1727","volume":"261","author":"Millar","year":"1991","journal-title":"Am. J. Physiol."},{"key":"D6LC00320F\/cit58\/1","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.3389\/fphys.2018.01281","volume":"9","author":"Tan","year":"2018","journal-title":"Front. Physiol."}],"container-title":["Lab on a Chip"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/LC\/article-pdf\/doi\/10.1039\/D6LC00320F\/0\/D6LC00320F.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/pubs.rsc.org\/LC\/article-pdf\/doi\/10.1039\/D6LC00320F\/0\/D6LC00320F.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:42:19Z","timestamp":1790754139000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/LC\/article-lookup\/doi\/10.1039\/D6LC00320F"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":58,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026,9,29]]}},"URL":"https:\/\/doi.org\/10.1039\/d6lc00320f","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D6LC00320F\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6LC00320F\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6LC00320F\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6LC00320F\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6LC00320F\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6LC00320F\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1473-0197","1473-0189"],"issn-type":[{"value":"1473-0197","type":"print"},{"value":"1473-0189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}