{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:05:45Z","timestamp":1789571145721,"version":"build-2803163510"},"reference-count":39,"publisher":"Royal Society of Chemistry (RSC)","issue":"18","license":[{"start":{"date-parts":[[2027,8,12]],"date-time":"2027-08-12T00:00:00Z","timestamp":1818028800000},"content-version":"am","delay-in-days":588,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFA1801900"],"award-info":[{"award-number":["2023YFA1801900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572678"],"award-info":[{"award-number":["82572678"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["JJ2024YX0560"],"award-info":[{"award-number":["JJ2024YX0560"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Lab Chip"],"abstract":"<jats:p>\n                    A microscale 3D-printed glomerular spheroid-on-a-chip incorporating human mesangial cells provides an\n                    <jats:italic>in vitro<\/jats:italic>\n                    platform for modeling diabetic nephropathy and evaluating therapeutic responses.\n                  <\/jats:p>","DOI":"10.1039\/d6lc00380j","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T08:08:02Z","timestamp":1786522082000},"page":"4984-4996","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A microscale 3D printing glomerular spheroid-on-a-chip for modeling the pathophysiology of diabetic nephropathy"],"prefix":"10.1039","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0710-6721","authenticated-orcid":false,"given":"Feiyun","family":"Cui","sequence":"first","affiliation":[{"name":"School of Basic Medicine, Harbin Medical University, Harbin 150081, China"},{"name":"Heilongjiang Provincial Key Laboratory of Human Microphysiological Systems and Organoids-on-a-Chip, Harbin Medical University, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Harbin Medical University, Harbin 150081, China"},{"name":"Heilongjiang Provincial Key Laboratory of Human Microphysiological Systems and Organoids-on-a-Chip, Harbin Medical University, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhuo","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Harbin Medical University, Harbin 150081, China"},{"name":"Heilongjiang Provincial Key Laboratory of Human Microphysiological Systems and Organoids-on-a-Chip, Harbin Medical University, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Harbin Medical University, Harbin 150081, China"},{"name":"Heilongjiang Provincial Key Laboratory of Human Microphysiological Systems and Organoids-on-a-Chip, Harbin Medical University, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Li","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Harbin Medical University, Harbin 150081, China"},{"name":"Heilongjiang Provincial Key Laboratory of Human Microphysiological Systems and Organoids-on-a-Chip, Harbin Medical University, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangfu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Harbin Medical University, Harbin 150081, China"},{"name":"Heilongjiang Provincial Key Laboratory of Human Microphysiological Systems and Organoids-on-a-Chip, Harbin Medical University, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixu","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Harbin Medical University, Harbin 150081, China"},{"name":"Heilongjiang Provincial Key Laboratory of Human Microphysiological Systems and Organoids-on-a-Chip, Harbin Medical University, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yincong","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Harbin Medical University, Harbin 150081, China"},{"name":"Heilongjiang Provincial Key Laboratory of Human Microphysiological Systems and Organoids-on-a-Chip, Harbin Medical University, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Li","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Harbin Medical University, Harbin 150081, China"},{"name":"Heilongjiang Provincial Key Laboratory of Human Microphysiological Systems and Organoids-on-a-Chip, Harbin Medical University, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Harbin Medical University, Harbin 150081, China"},{"name":"Heilongjiang Provincial Key Laboratory of Human Microphysiological Systems and Organoids-on-a-Chip, Harbin Medical University, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6LC00380J\/cit1\/1","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.2337\/dc14-1296","volume":"37","author":"Tuttle","year":"2014","journal-title":"Diabetes Care"},{"key":"D6LC00380J\/cit2\/1","doi-asserted-by":"crossref","first-page":"e33366","DOI":"10.1097\/MD.0000000000033366","volume":"102","author":"Sindhu","year":"2023","journal-title":"Medicine"},{"key":"D6LC00380J\/cit3\/1","doi-asserted-by":"crossref","first-page":"973","DOI":"10.3390\/diagnostics15080973","volume":"15","author":"Shetty","year":"2025","journal-title":"Diagnostics"},{"key":"D6LC00380J\/cit4\/1","doi-asserted-by":"crossref","first-page":"e00108","DOI":"10.1002\/adbi.202500108","volume":"9","author":"Miran","year":"2025","journal-title":"Adv. Biol."},{"key":"D6LC00380J\/cit5\/1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0009-8981(00)00240-0","volume":"297","author":"Lehmann","year":"2000","journal-title":"Clin. Chim. Acta"},{"key":"D6LC00380J\/cit6\/1","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1100\/tsw.2009.133","volume":"9","author":"Stitt-Cavanagh","year":"2009","journal-title":"Sci. World J."},{"key":"D6LC00380J\/cit7\/1","doi-asserted-by":"crossref","first-page":"F40","DOI":"10.1152\/ajprenal.00103.2010","volume":"300","author":"Singh","year":"2011","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"D6LC00380J\/cit8\/1","doi-asserted-by":"crossref","first-page":"578","DOI":"10.3390\/toxins11100578","volume":"11","author":"Dou","year":"2019","journal-title":"Toxins"},{"key":"D6LC00380J\/cit9\/1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s12882-022-02794-8","volume":"23","author":"Hofherr","year":"2022","journal-title":"BMC Nephrol."},{"key":"D6LC00380J\/cit10\/1","doi-asserted-by":"crossref","first-page":"3656","DOI":"10.1038\/s41467-019-11577-z","volume":"10","author":"Petrosyan","year":"2019","journal-title":"Nat. Commun."},{"key":"D6LC00380J\/cit11\/1","first-page":"e45615","volume":"15","author":"Kumar","year":"2023","journal-title":"Cureus"},{"key":"D6LC00380J\/cit12\/1","doi-asserted-by":"crossref","first-page":"110592","DOI":"10.1016\/j.diabres.2023.110592","volume":"198","author":"Yang","year":"2023","journal-title":"Diabetes Res. Clin. Pract."},{"key":"D6LC00380J\/cit13\/1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41576-022-00466-9","volume":"23","author":"Ingber","year":"2022","journal-title":"Nat. Rev. Genet."},{"key":"D6LC00380J\/cit14\/1","doi-asserted-by":"crossref","first-page":"6889","DOI":"10.3390\/s22186889","volume":"22","author":"Wang","year":"2022","journal-title":"Sensors"},{"key":"D6LC00380J\/cit15\/1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/ndt\/gfaf157","volume":"41","author":"Podest\u00e0","year":"2026","journal-title":"Nephrol., Dial., Transplant."},{"key":"D6LC00380J\/cit16\/1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1017\/S0007114517002227","volume":"120","author":"Clark","year":"2018","journal-title":"Br. J. Nutr."},{"key":"D6LC00380J\/cit17\/1","doi-asserted-by":"crossref","first-page":"110760","DOI":"10.1016\/j.isci.2024.110760","volume":"27","author":"Ma","year":"2024","journal-title":"iScience"},{"key":"D6LC00380J\/cit18\/1","doi-asserted-by":"crossref","first-page":"123349","DOI":"10.1016\/j.biomaterials.2025.123349","volume":"322","author":"Clerkin","year":"2025","journal-title":"Biomaterials"},{"key":"D6LC00380J\/cit19\/1","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1039\/C7LC00134G","volume":"17","author":"Wang","year":"2017","journal-title":"Lab Chip"},{"key":"D6LC00380J\/cit20\/1","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1007\/s00018-024-05433-7","volume":"81","author":"Wu","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"D6LC00380J\/cit21\/1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s13206-024-00160-4","volume":"18","author":"Kim","year":"2024","journal-title":"BioChip J."},{"key":"D6LC00380J\/cit22\/1","first-page":"1769","volume":"44","author":"Jiang","year":"2024","journal-title":"Nanfang Yike Daxue Xuebao"},{"key":"D6LC00380J\/cit23\/1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s42242-020-00112-5","volume":"4","author":"Mehta","year":"2021","journal-title":"Bio-Des. Manuf."},{"key":"D6LC00380J\/cit24\/1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3390\/bios13010070","volume":"13","author":"Li","year":"2023","journal-title":"Biosensors"},{"key":"D6LC00380J\/cit25\/1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2147\/IJNRD.S344725","volume":"15","author":"Doi","year":"2022","journal-title":"Int. J. Nephrol. Renovasc. Dis."},{"key":"D6LC00380J\/cit26\/1","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1039\/D2LC01177H","volume":"23","author":"Su","year":"2023","journal-title":"Lab Chip"},{"key":"D6LC00380J\/cit27\/1","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/s41467-024-45710-4","volume":"15","author":"Quintard","year":"2024","journal-title":"Nat. Commun."},{"key":"D6LC00380J\/cit28\/1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/s41378-023-00607-y","volume":"9","author":"Poskus","year":"2023","journal-title":"Microsyst. Nanoeng."},{"key":"D6LC00380J\/cit29\/1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s12964-024-01502-3","volume":"22","author":"Hu","year":"2024","journal-title":"Cell Commun. Signaling"},{"key":"D6LC00380J\/cit30\/1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1146\/annurev-bioeng-072623-044010","volume":"26","author":"Musah","year":"2024","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"D6LC00380J\/cit31\/1","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/s42003-021-02868-7","volume":"4","author":"Tuffin","year":"2021","journal-title":"Commun. Biol."},{"key":"D6LC00380J\/cit32\/1","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1046\/j.1523-1755.2001.00725.x","volume":"59","author":"Steffes","year":"2001","journal-title":"Kidney Int."},{"key":"D6LC00380J\/cit33\/1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00441-019-03118-3","volume":"379","author":"Miyaki","year":"2020","journal-title":"Cell Tissue Res."},{"key":"D6LC00380J\/cit34\/1","doi-asserted-by":"crossref","first-page":"e2414587","DOI":"10.1002\/advs.202414587","volume":"12","author":"Xuan","year":"2025","journal-title":"Adv. Sci."},{"key":"D6LC00380J\/cit35\/1","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/s41581-021-00474-8","volume":"17","author":"Avraham","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"key":"D6LC00380J\/cit36\/1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/s41581-021-00528-x","volume":"18","author":"Valverde","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"key":"D6LC00380J\/cit37\/1","doi-asserted-by":"crossref","first-page":"5121","DOI":"10.3390\/ijms25105121","volume":"25","author":"Kim","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"D6LC00380J\/cit38\/1","doi-asserted-by":"crossref","first-page":"e14045","DOI":"10.1111\/apha.14045","volume":"239","author":"Boi","year":"2023","journal-title":"Acta Physiol."},{"key":"D6LC00380J\/cit39\/1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41581-020-0329-y","volume":"17","author":"Naylor","year":"2021","journal-title":"Nat. Rev. Nephrol."}],"container-title":["Lab on a Chip"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/LC\/article-pdf\/doi\/10.1039\/D6LC00380J\/0\/D6LC00380J.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:47:59Z","timestamp":1789570079000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/LC\/article-lookup\/doi\/10.1039\/D6LC00380J"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":39,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2026,9,16]]}},"URL":"https:\/\/doi.org\/10.1039\/d6lc00380j","relation":{},"ISSN":["1473-0197","1473-0189"],"issn-type":[{"value":"1473-0197","type":"print"},{"value":"1473-0189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}