{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:10:20Z","timestamp":1790856620111,"version":"4.1.0"},"reference-count":58,"publisher":"Royal Society of Chemistry (RSC)","license":[{"start":{"date-parts":[[2027,9,22]],"date-time":"2027-09-22T00:00:00Z","timestamp":1821571200000},"content-version":"am","delay-in-days":629,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSC 114-2221-E-007-009-MY3"],"award-info":[{"award-number":["NSC 114-2221-E-007-009-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSC 113-2221-E-007-144-MY3"],"award-info":[{"award-number":["NSC 113-2221-E-007-144-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Lab Chip"],"abstract":"<jats:p>Integrated microfluidic competitive affinity selection device.<\/jats:p>","DOI":"10.1039\/d6lc00515b","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:43:33Z","timestamp":1790077413000},"update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An integrated microfluidic platform for tunable-stringency competitive affinity selection of folate receptor alpha aptamers"],"prefix":"10.1039","author":[{"given":"Yi-Da","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Cheng","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keng-Fu","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6910-9133","authenticated-orcid":false,"given":"Gwo-Bin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan"},{"name":"Institute of Nano Engineering and MicroSystems, National Tsing Hua University, Hsinchu, Taiwan"},{"name":"Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6LC00515B\/cit1\/1","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/346818a0","volume":"346","author":"Ellington","year":"1990","journal-title":"Nature"},{"key":"D6LC00515B\/cit2\/1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1126\/science.2200121","volume":"249","author":"Tuerk","year":"1990","journal-title":"Science"},{"key":"D6LC00515B\/cit3\/1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.biotechadv.2018.11.001","volume":"37","author":"Wang","year":"2019","journal-title":"Biotechnol. Adv."},{"key":"D6LC00515B\/cit4\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3390\/molecules25010003","volume":"25","author":"Odeh","year":"2020","journal-title":"Molecules"},{"key":"D6LC00515B\/cit5\/1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/355564a0","volume":"355","author":"Bock","year":"1992","journal-title":"Nature"},{"key":"D6LC00515B\/cit6\/1","doi-asserted-by":"crossref","first-page":"9500","DOI":"10.1021\/acsami.0c05750","volume":"13","author":"Ni","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D6LC00515B\/cit7\/1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.biochi.2018.09.001","volume":"154","author":"Bayat","year":"2018","journal-title":"Biochimie"},{"key":"D6LC00515B\/cit8\/1","doi-asserted-by":"crossref","first-page":"116528","DOI":"10.1016\/j.bios.2024.116528","volume":"262","author":"Yan","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"D6LC00515B\/cit9\/1","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.3390\/ijms18081683","volume":"18","author":"Ni","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"D6LC00515B\/cit10\/1","doi-asserted-by":"crossref","first-page":"2400267","DOI":"10.1002\/smll.202400267","volume":"20","author":"Wang","year":"2024","journal-title":"Small"},{"key":"D6LC00515B\/cit11\/1","doi-asserted-by":"crossref","first-page":"124387","DOI":"10.1016\/j.ijpharm.2024.124387","volume":"661","author":"Feizpour","year":"2024","journal-title":"Int. J. Pharm."},{"key":"D6LC00515B\/cit12\/1","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41467-018-03675-1","volume":"9","author":"Tapsin","year":"2018","journal-title":"Nat. Commun."},{"key":"D6LC00515B\/cit13\/1","doi-asserted-by":"crossref","first-page":"6642","DOI":"10.1038\/s41598-019-43187-6","volume":"9","author":"Kushwaha","year":"2019","journal-title":"Sci. Rep."},{"key":"D6LC00515B\/cit14\/1","doi-asserted-by":"crossref","first-page":"0076","DOI":"10.1038\/s41570-017-0076","volume":"1","author":"Dunn","year":"2017","journal-title":"Nat. Rev. Chem."},{"key":"D6LC00515B\/cit15\/1","doi-asserted-by":"crossref","first-page":"941","DOI":"10.3390\/molecules24050941","volume":"24","author":"Zhang","year":"2019","journal-title":"Molecules"},{"key":"D6LC00515B\/cit16\/1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.bioeng.2007.03.001","volume":"24","author":"Djordjevic","year":"2007","journal-title":"Biomol. Eng."},{"key":"D6LC00515B\/cit17\/1","doi-asserted-by":"crossref","first-page":"e223","DOI":"10.1038\/mtna.2014.74","volume":"4","author":"Blind","year":"2015","journal-title":"Mol. Ther.--Nucleic Acids"},{"key":"D6LC00515B\/cit18\/1","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1007\/s12033-024-01256-w","volume":"67","author":"Didarian","year":"2025","journal-title":"Mol. Biotechnol."},{"key":"D6LC00515B\/cit19\/1","doi-asserted-by":"crossref","first-page":"107902","DOI":"10.1016\/j.biotechadv.2021.107902","volume":"55","author":"Qi","year":"2022","journal-title":"Biotechnol. Adv."},{"key":"D6LC00515B\/cit20\/1","doi-asserted-by":"crossref","first-page":"e114693","DOI":"10.1371\/journal.pone.0114693","volume":"9","author":"Tolle","year":"2014","journal-title":"PLoS One"},{"key":"D6LC00515B\/cit21\/1","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1002\/bab.2244","volume":"69","author":"Kohlberger","year":"2022","journal-title":"Biotechnol. Appl. Biochem."},{"key":"D6LC00515B\/cit22\/1","doi-asserted-by":"crossref","first-page":"32681","DOI":"10.1039\/D3RA04686A","volume":"13","author":"Lin","year":"2023","journal-title":"RSC Adv."},{"key":"D6LC00515B\/cit23\/1","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.3390\/ijms18102142","volume":"18","author":"Zhuo","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"D6LC00515B\/cit24\/1","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.jtbi.2006.06.001","volume":"242","author":"Lalam","year":"2006","journal-title":"J. Theor. Biol."},{"key":"D6LC00515B\/cit25\/1","doi-asserted-by":"crossref","first-page":"8966","DOI":"10.1128\/AEM.71.12.8966-8969.2005","volume":"71","author":"Acinas","year":"2005","journal-title":"Appl. Environ. Microbiol."},{"key":"D6LC00515B\/cit26\/1","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.3390\/molecules24193598","volume":"24","author":"Komarova","year":"2019","journal-title":"Molecules"},{"key":"D6LC00515B\/cit27\/1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.aca.2009.02.038","volume":"638","author":"Zhang","year":"2009","journal-title":"Anal. Chim. Acta"},{"key":"D6LC00515B\/cit28\/1","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.biotechadv.2015.02.008","volume":"33","author":"Darmostuk","year":"2015","journal-title":"Biotechnol. Adv."},{"key":"D6LC00515B\/cit29\/1","doi-asserted-by":"crossref","first-page":"e82667","DOI":"10.1371\/journal.pone.0082667","volume":"8","author":"Szeto","year":"2013","journal-title":"PLoS One"},{"key":"D6LC00515B\/cit30\/1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3390\/bios14070350","volume":"14","author":"Fang","year":"2024","journal-title":"Biosensors"},{"key":"D6LC00515B\/cit31\/1","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1039\/D4LC00859F","volume":"25","author":"Chung","year":"2025","journal-title":"Lab Chip"},{"key":"D6LC00515B\/cit32\/1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1021\/ja037832s","volume":"126","author":"Mendonsa","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"D6LC00515B\/cit33\/1","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1021\/ja056943j","volume":"128","author":"Berezovski","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"D6LC00515B\/cit34\/1","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/nprot.2006.200","volume":"1","author":"Berezovski","year":"2006","journal-title":"Nat. Protoc."},{"key":"D6LC00515B\/cit35\/1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.aca.2018.07.029","volume":"1038","author":"Lisi","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"D6LC00515B\/cit36\/1","doi-asserted-by":"crossref","first-page":"52553","DOI":"10.18632\/oncotarget.9651","volume":"7","author":"Cheung","year":"2016","journal-title":"Oncotarget"},{"key":"D6LC00515B\/cit37\/1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/ijc.21712","volume":"119","author":"Kelemen","year":"2006","journal-title":"Int. J. Cancer"},{"key":"D6LC00515B\/cit38\/1","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1002\/ijc.29937","volume":"138","author":"Kurosaki","year":"2016","journal-title":"Int. J. Cancer"},{"key":"D6LC00515B\/cit39\/1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s10404-010-0669-1","volume":"10","author":"Weng","year":"2011","journal-title":"Microfluid. Nanofluid."},{"key":"D6LC00515B\/cit40\/1","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s10404-012-1095-3","volume":"14","author":"Weng","year":"2013","journal-title":"Microfluid. Nanofluid."},{"key":"D6LC00515B\/cit41\/1","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1039\/D1LC00177A","volume":"21","author":"Chung","year":"2021","journal-title":"Lab Chip"},{"key":"D6LC00515B\/cit42\/1","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1063\/1.168744","volume":"12","author":"Weller","year":"1998","journal-title":"Comput. Phys."},{"key":"D6LC00515B\/cit43\/1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.bios.2018.09.040","volume":"122","author":"Sinha","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"D6LC00515B\/cit44\/1","doi-asserted-by":"crossref","first-page":"341531","DOI":"10.1016\/j.aca.2023.341531","volume":"1274","author":"Wu","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"D6LC00515B\/cit45\/1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.sbi.2006.05.010","volume":"16","author":"Mathews","year":"2006","journal-title":"Curr. Opin. Struct. Biol."},{"key":"D6LC00515B\/cit46\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-60327-429-6_1","volume":"453","author":"Markham","year":"2008","journal-title":"Methods Mol. Biol."},{"key":"D6LC00515B\/cit47\/1","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1093\/nar\/gkg595","volume":"31","author":"Zuker","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"D6LC00515B\/cit48\/1","doi-asserted-by":"crossref","first-page":"1177932218821383","DOI":"10.1177\/1177932218821383","volume":"13","author":"Kr\u00e4mer","year":"2019","journal-title":"Bioinf. Biol. Insights"},{"key":"D6LC00515B\/cit49\/1","doi-asserted-by":"crossref","first-page":"9043","DOI":"10.1021\/acs.langmuir.1c01053","volume":"37","author":"Tapp","year":"2021","journal-title":"Langmuir"},{"key":"D6LC00515B\/cit50\/1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/nat.2012.0406","volume":"23","author":"Avci-Adali","year":"2013","journal-title":"Nucleic Acid Ther."},{"key":"D6LC00515B\/cit51\/1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1021\/acscombsci.8b00048","volume":"20","author":"Tapp","year":"2018","journal-title":"ACS Comb. Sci."},{"key":"D6LC00515B\/cit52\/1","doi-asserted-by":"crossref","first-page":"5490","DOI":"10.1021\/ac900759k","volume":"81","author":"Soh","year":"2009","journal-title":"Anal. Chem."},{"key":"D6LC00515B\/cit53\/1","doi-asserted-by":"crossref","first-page":"15373","DOI":"10.1073\/pnas.1009331107","volume":"107","author":"Cho","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D6LC00515B\/cit54\/1","doi-asserted-by":"crossref","first-page":"11397","DOI":"10.1021\/jp303518b","volume":"116","author":"Zhao","year":"2012","journal-title":"J. Phys. Chem. B"},{"key":"D6LC00515B\/cit55\/1","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.bpj.2011.07.054","volume":"101","author":"Neundlinger","year":"2011","journal-title":"Biophys. J."},{"key":"D6LC00515B\/cit56\/1","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1021\/acs.analchem.8b04278","volume":"91","author":"Zheng","year":"2019","journal-title":"Anal. Chem."},{"key":"D6LC00515B\/cit57\/1","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1021\/ac404107s","volume":"86","author":"P\u00e9rez-Ruiz","year":"2014","journal-title":"Anal. Chem."},{"key":"D6LC00515B\/cit58\/1","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.3390\/molecules24081572","volume":"24","author":"Sullivan","year":"2019","journal-title":"Molecules"}],"container-title":["Lab on a Chip"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/LC\/article-pdf\/doi\/10.1039\/D6LC00515B\/0\/D6LC00515B.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:51:49Z","timestamp":1790855509000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/LC\/article-lookup\/doi\/10.1039\/D6LC00515B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":58,"URL":"https:\/\/doi.org\/10.1039\/d6lc00515b","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D6LC00515B\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6LC00515B\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6LC00515B\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6LC00515B\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6LC00515B\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6LC00515B\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1473-0197","1473-0189"],"issn-type":[{"value":"1473-0197","type":"print"},{"value":"1473-0189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}